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Jun 30, 2018
06/18
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A. Skopal; H. Drechsel; T. N. Tarasova; T. Kato; M. Fujii; F. Teyssier; O. Garde; J. Guarro; J. Edlin; C. Buil; D. Antao; J. N. Terry; T. Lemoult; S. Charbonnel; T. Bohlsen; A. Favaro; K. Graham
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We determine the temporal evolution of the luminosity L(WD), radius R(WD) and effective temperature Teff of the white dwarf (WD) pseudophotosphere of V339 Del from its discovery to around day 40. Another main objective was studying the ionization structure of the ejecta. These aims were achieved by modelling the optical/near-IR spectral energy distribution (SED) using low-resolution spectroscopy (3500 - 9200 A), UBVRcIc and JHKLM photometry. During the fireball stage (Aug. 14.8 - 19.9, 2013),...
Topics: Astrophysics, Solar and Stellar Astrophysics
Source: http://arxiv.org/abs/1407.8212
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66
Oct 4, 2014
10/14
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AFONSO, JULIETA; LONGATTO-FILHO, ADHEMAR; DA SILVA, VITOR MOREIRA; AMARO, TERESINA; SANTOS, LUCIO L.
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This article is from Oncology Letters , volume 8 . Abstract Urothelial bladder carcinoma (UBC) is heterogeneous in its pathology and clinical behaviour. Evaluation of prognostic and predictive biomarkers is necessary, in order to produce personalised treatment options. The present study used immunohistochemistry to evaluate UBC sections containing tumour and non-tumour areas from 76 patients, for the detection of p-mTOR, CD31 and D2-40 (blood and lymphatic vessels identification, respectively)....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156165
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Oct 11, 2014
10/14
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Abbott, Danielle S.; Chin-Smith, Evonne C.; Seed, Paul T.; Chandiramani, Manju; Shennan, Andrew H.; Tribe, Rachel M.
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This article is from PLoS ONE , volume 9 . Abstract Early spontaneous preterm birth is associated with inflammation/infection and shortening of the cervix. We hypothesised that cervico-vaginal production of trappin2/elafin (peptidase inhibitor 3) and cathelicidin antimicrobial peptide (cathelicidin), key components of the innate immune system, are altered in women who have a spontaneous preterm birth. The aim was to determine the relationship between cervico-vaginal fluid (CVF) trappin2/elafin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116119
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65
Oct 9, 2014
10/14
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Ahn, Jem Ma; Paik, Yong-Han; Kim, So Hyun; Lee, Jun Hee; Cho, Ju Yeon; Sohn, Won; Gwak, Geum-Youn; Choi, Moon Seok; Lee, Joon Hyeok; Koh, Kwang Cheol; Paik, Seung Woon; Yoo, Byung Chul
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This article is from Journal of Korean Medical Science , volume 29 . Abstract High prevalence of diabetes mellitus in patients with liver cirrhosis has been reported in many studies. The aim of our study was to evaluate the relationship of hepatic fibrosis and steatosis assessed by transient elastography with diabetes in patients with chronic liver disease. The study population consisted of 979 chronic liver disease patients. Liver fibrosis and steatosis were assessed by liver stiffness...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129204
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5.0
Jun 30, 2018
06/18
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Alexandru Dimca; Stefan Papadima; Alexandru Suciu
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We relate the geometry of the resonance varieties associated to a commutative differential graded algebra model of a space to the finiteness properties of the completions of its Alexander-type invariants. We also describe in simple algebraic terms the non-translated components of the degree-one characteristic varieties for a class of non-proper complex manifolds.
Topics: Mathematics, Algebraic Topology, Algebraic Geometry
Source: http://arxiv.org/abs/1407.8027
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Oct 8, 2014
10/14
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Alonso-Moran, Edurne; Satylganova, Altynai; Orueta, Juan F; Nuno-Solinis, Roberto
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This article is from BMC Public Health , volume 14 . Abstract Background: The aim of the study was to estimate the prevalence of depression in the population diagnosed with diabetes type 2 and to test the hypothesis that the presence of depression in such cases was associated with a) worse glycaemic control, and b) higher healthcare costs. Methods: We conducted a cross-sectional analysis, from 1st September 2010 to 31st August 2011, among patients with type 2 diabetes aged 35 years and over in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129099
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4.0
Jun 30, 2018
06/18
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Andreas Buhr; Christian Engwer; Mario Ohlberger; Stephan Rave
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The Reduced Basis (RB) method is a well established method for the model order reduction of problems formulated as parametrized partial differential equations. One crucial requirement for the application of RB schemes is the availability of an a posteriori error estimator to reliably estimate the error introduced by the reduction process. However, straightforward implementations of standard residual based estimators show poor numerical stability, rendering them unusable if high accuracy is...
Topics: Mathematics, Numerical Analysis
Source: http://arxiv.org/abs/1407.8005
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4.0
Jun 30, 2018
06/18
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Andrew Duncan; Shuohao Liao; Tomas Vejchodsky; Radek Erban; Ramon Grima
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The noisy dynamics of chemical systems is commonly studied using either the chemical master equation (CME) or the chemical Fokker-Planck equation (CFPE). The latter is a continuum approximation of the discrete CME approach. We here show that the CFPE may fail to capture the CME's prediction of noise-induced multistability. In particular we find a simple chemical system for which the CME's marginal probability distribution changes from unimodal to multimodal as the system-size decreases below a...
Topics: Quantitative Methods, Quantitative Biology, Subcellular Processes
Source: http://arxiv.org/abs/1407.8256
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Oct 11, 2014
10/14
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Bartels, Tim; Kim, Nora C.; Luth, Eric S.; Selkoe, Dennis J.
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This article is from PLoS ONE , volume 9 . Abstract A switch in the conformational properties of α-synuclein (αS) is hypothesized to be a key step in the pathogenic mechanism of Parkinson’s disease (PD). Whereas the beta-sheet-rich state of αS has long been associated with its pathological aggregation in PD, a partially alpha-helical state was found to be related to physiological lipid binding; this suggests a potential role of the alpha-helical state in controlling synaptic vesicle...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116227
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Oct 11, 2014
10/14
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Berumen, Michael L.; Braun, Camrin D.; Cochran, Jesse E. M.; Skomal, Gregory B.; Thorrold, Simon R.
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This article is from PLoS ONE , volume 9 . Abstract Conservation efforts aimed at the whale shark, Rhincodon typus, remain limited by a lack of basic information on most aspects of its ecology, including global population structure, population sizes and movement patterns. Here we report on the movements of 47 Red Sea whale sharks fitted with three types of satellite transmitting tags from 2009–2011. Most of these sharks were tagged at a single aggregation site near Al-Lith, on the central...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116204
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Oct 11, 2014
10/14
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Blaho, Miklos; Herczeg, Tamas; Kriska, Gyorgy; Egri, Adam; Szaz, Denes; Farkas, Alexandra; Tarjanyi, Nikolett; Czinke, Laszlo; Barta, Andras; Horvath, Gabor
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This article is from PLoS ONE , volume 9 . Abstract The horizontally polarizing surface parts of shiny black cars (the reflection-polarization characteristics of which are similar to those of water surfaces) attract water-leaving polarotactic insects. Thus, shiny black cars are typical sources of polarized light pollution endangering water-leaving insects. A new fashion fad is to make car-bodies matt black or grey. Since rough (matt) surfaces depolarize the reflected light, one of the ways of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116178
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109
Oct 7, 2014
10/14
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Bortoletto, Carolina Carvalho; Cordeiro da Silva, Fernanda; Silva, Paula Fernanda da Costa; Leal de Godoy, Camila Haddad; Albertini, Regiane; Motta, Lara J; Mesquita-Ferrari, Raquel Agnelli; Fernandes, Kristianne Porta Santos; Romano, Renata; Bussadori, Sandra Kalil
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This article is from Journal of Physical Therapy Science , volume 26 . Abstract [Purpose] The aim of the present study was to evaluate the effect of a biteplate on the cranio-cervical posture of children with bruxism. [Subjects and Methods] Twelve male and female children aged six to 10 years with a diagnosis of bruxism participated in this study. The children used a biteplate during sleep for 30 days and were submitted to three postural evaluations: initial, immediately following placement...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135211
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3.0
Jun 30, 2018
06/18
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Bruno Rousseau; François Lapointe; Minh Nguyen; Maxime Biron; Etienne Gaufrès; Saman Choubak; Zheng Han; Vincent Bouchiat; Patrick Desjardins; Michel Côté; Richard Martel
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Herein, intervalley scattering is exploited to account for anomalous antiresonances in the infrared spectra of doped and disordered single layer graphene. We present infrared spectroscopy measurements of graphene grafted with iodophenyl moieties in both reflection microscopy and transmission configurations. Asymmetric transparency windows at energies corresponding to phonon modes near the {\Gamma} and K points are observed, in contrast to the featureless spectrum of pristine graphene. These...
Topics: Mesoscale and Nanoscale Physics, Materials Science, Condensed Matter
Source: http://arxiv.org/abs/1407.8141
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57
Oct 10, 2014
10/14
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Budowle, Bruce; Connell, Nancy D; Bielecka-Oder, Anna; Colwell, Rita R; Corbett, Cindi R; Fletcher, Jacqueline; Forsman, Mats; Kadavy, Dana R; Markotic, Alemka; Morse, Stephen A; Murch, Randall S; Sajantila, Antti; Schmedes, Sarah E; Ternus, Krista L; Turner, Stephen D; Minot, Samuel
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This article is from Investigative Genetics , volume 5 . Abstract High throughput sequencing (HTS) generates large amounts of high quality sequence data for microbial genomics. The value of HTS for microbial forensics is the speed at which evidence can be collected and the power to characterize microbial-related evidence to solve biocrimes and bioterrorist events. As HTS technologies continue to improve, they provide increasingly powerful sets of tools to support the entire field of microbial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123828
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70
Oct 7, 2014
10/14
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Bunno, Yoshibumi; Yurugi, Yuko; Onigata, Chieko; Suzuki, Toshiaki; Iwatsuki, Hiroyasu
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This article is from Journal of Physical Therapy Science , volume 26 . Abstract [Purpose] This study aimed to determine the differences in the excitability of spinal motor neurons during motor imagery of a muscle contraction at different contraction strengths. [Methods] We recorded the F-wave in 15 healthy subjects. First, in a trial at rest, the muscle was relaxed during F-wave recording. Next, during motor imagery, subjects were instructed to imagine maximum voluntary contractions of 10%,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135200
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4.0
Jun 30, 2018
06/18
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Caihua Chen; Shiqian Ma; Junfeng Yang
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eye 4
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In this paper, we first propose a general inertial proximal point method for the mixed variational inequality (VI) problem. Based on our knowledge, without stronger assumptions, convergence rate result is not known in the literature for inertial type proximal point methods. Under certain conditions, we are able to establish the global convergence and a $o(1/k)$ convergence rate result (under certain measure) of the proposed general inertial proximal point method. We then show that the...
Topics: Mathematics, Optimization and Control
Source: http://arxiv.org/abs/1407.8238
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79
Oct 11, 2014
10/14
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Calabro, Sarah R.; Maczurek, Annette E.; Morgan, Alison J.; Tu, Thomas; Wen, Victoria W.; Yee, Christine; Mridha, Auvro; Lee, Maggie; d'Avigdor, William; Locarnini, Stephen A.; McCaughan, Geoffrey W.; Warner, Fiona J.; McLennan, Susan V.; Shackel, Nicholas A.
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This article is from PLoS ONE , volume 9 . Abstract Background: The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulated by a number of mechanisms including expression of the glycoprotein CD147. Previously, we have shown that CD147 is expressed on hepatocytes but not within the fibrotic septa in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116334
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73
Oct 8, 2014
10/14
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Castellazzi, Gloria; Palesi, Fulvia; Casali, Stefano; Vitali, Paolo; Sinforiani, Elena; Wheeler-Kingshott, Claudia A. M.; D'Angelo, Egidio
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This article is from Frontiers in Neuroscience , volume 8 . Abstract In resting state fMRI (rs-fMRI), only functional connectivity (FC) reductions in the default mode network (DMN) are normally reported as a biomarker for Alzheimer's disease (AD). In this investigation we have developed a comprehensive strategy to characterize the FC changes occurring in multiple networks and applied it in a pilot study of subjects with AD and Mild Cognitive Impairment (MCI), compared to healthy controls (HC)....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115623
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3.0
Jun 30, 2018
06/18
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Chan-Kao Chang; Adam Waszczak; Hsing-Wen Lin; Wing-Huen Ip; Thomas. A. Prince; Shrinivas R. Kulkarni; Russ Laher; Jason Surace
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Asteroids of size larger than 150 m generally do not have rotation periods smaller than 2.2 hours. This spin cutoff is believed to be due to the gravitationally bound rubble-pile structures of the asteroids. Rotation with periods exceeding this critical value will cause asteroid breakup. Up until now, only one object, 2001 OE84, has been found to be an exception to this spin cutoff. We report the discovery of a new super-fast rotator, (335433) 2005 UW163, spinning with a period of 1.290 hours...
Topics: Earth and Planetary Astrophysics, Astrophysics
Source: http://arxiv.org/abs/1407.8264
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68
Oct 10, 2014
10/14
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Chang, Chih-Han; Lei, Yao-Ning; Ho, Yi-Hung; Sung, Yu-Hsing; Lin, Ting-Sheng
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This article is from BioMedical Engineering OnLine , volume 13 . Abstract Background: The biomechanical property of the periodontal ligament (PDL) is important in orthodontics and prosthodontics. The objective of this study was to evaluate the feasibility of measuring the biomechanical behavior of the periodontal ligament using micro-computed tomography (micro-CT). Methods: A custom-made apparatus measured the force and displacement of a porcine PDL specimen within the micro-CT environment....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122535
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113
Oct 11, 2014
10/14
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Choi, Jaesung; Song, Nan; Han, Sohee; Chung, Seokang; Sung, Hyuna; Lee, Ji-young; Jung, Sunjae; Park, Sue K.; Yoo, Keun-Young; Han, Wonshik; Lee, Jong Won; Noh, Dong-Young; Kang, Daehee; Choi, Ji-Yeob
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This article is from PLoS ONE , volume 9 . Abstract We investigated the role of common genetic variation in immune-related genes on breast cancer disease-free survival (DFS) in Korean women. 107 breast cancer patients of the Seoul Breast Cancer Study (SEBCS) were selected for this study. A total of 2,432 tag single nucleotide polymorphisms (SNPs) in 283 immune-related genes were genotyped with the GoldenGate Oligonucleotide pool assay (OPA). A multivariate Cox-proportional hazard model and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116221
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45
Oct 11, 2014
10/14
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Choi, KyungOh; Ghaddar, Bassel; Moya, Colby; Shi, Hai; Sridharan, Gautham V.; Lee, Kyongbum; Jayaraman, Arul
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This article is from PLoS ONE , volume 9 . Abstract Lipid accumulation in adipocytes reflects a balance between enzymatic pathways leading to the formation and breakdown of esterified lipids, primarily triglycerides. This balance is extremely important, as both high and low lipid levels in adipocytes can have deleterious consequences. The enzymes responsible for lipid synthesis and breakdown (lipogenesis and lipolysis, respectively) are regulated through the coordinated actions of several...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116336
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49
Oct 11, 2014
10/14
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Chou, Hong; Wu, Keh-Gong; Yeh, Chang-Ching; Tai, Hsiao-Yun; Tam, Ming F.; Chen, Yu-Sen; Shen, Horng-Der
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This article is from PLoS ONE , volume 9 . Abstract Fusarium species are among airborne fungi and recognized as causative agents of human atopic disorders. However, Fusarium allergens have not been well characterized and the lack of information limits clinical diagnosis and treatment of fungal allergy. The purpose of this study is to identify and characterize important allergens of F. proliferatum. IgE-reacting F. proliferatum components were identified by immunoblot using serum samples from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116196
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5.0
Jun 30, 2018
06/18
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Christoph Baranec; Reed Riddle; Nicholas M. Law; A. N. Ramaprakash; Shriharsh Tendulkar; Kristina Hogstrom; Khanh Bui; Mahesh Burse; Pravin Chordia; Hillol Das; Richard Dekany; Shrinivas Kulkarni; Sujit Punnadi
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eye 5
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As new large-scale astronomical surveys greatly increase the number of objects targeted and discoveries made, the requirement for efficient follow-up observations is crucial. Adaptive optics imaging, which compensates for the image-blurring effects of Earth's turbulent atmosphere, is essential for these surveys, but the scarcity, complexity and high demand of current systems limits their availability for following up large numbers of targets. To address this need, we have engineered and...
Topics: Instrumentation and Methods for Astrophysics, Astrophysics
Source: http://arxiv.org/abs/1407.8179
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7.0
Jun 30, 2018
06/18
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Christopher B. Johnson; R. I. Hynes; T. Maccarone; C T. Britt; H. Davis; P. G. Jonker; M. A. P. Torres; D. Steeghs; S. Greiss; G. Nelemans
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We present the results of a spectroscopic and photometric analysis of HD314884, a slowly pulsating B star (SPB) in a binary system with detected soft X-ray emission. We spectrally classify the B star as a B5V-B6V star with T$_{eff}$ = 15,490 $\pm$ 310 K, log $g$ = 3.75 $\pm$ 0.25 dex, and a photometric period of P$_{0}$ = 0.889521(12) days. A spectroscopic period search reveals an orbital period for the system of P$_{orb}$ = 1.3654(11) days. The discrepancy in the two periods and the...
Topics: Astrophysics, Solar and Stellar Astrophysics
Source: http://arxiv.org/abs/1407.7938
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5.0
Jun 30, 2018
06/18
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Coralie Neiner; Maryline Briquet; Stéphane Mathis; Pieter Degroote
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Asteroseismology and spectropolarimetry have allowed us to progress significantly in our understanding of the physics of hot stars over the last decade. It is now possible to combine these two techniques to learn even more information about hot stars and constrain their models. While only a few magnetic pulsating hot stars are known as of today and have been studied with both seismology and spectropolarimetry, new opportunities - in particular Kepler2 and BRITE - are emerging and will allow us...
Topics: Astrophysics, Solar and Stellar Astrophysics
Source: http://arxiv.org/abs/1407.8087
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Oct 8, 2014
10/14
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Cuevas, Carlos A.; Notario, Alberto; Adame, Jose Antonio; Hilboll, Andreas; Richter, Andreas; Burrows, John P.; Saiz-Lopez, Alfonso
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This article is from Scientific Reports , volume 4 . Abstract We report on the evolution of tropospheric nitrogen dioxide (NO2) over Spain, focusing on the densely populated cities of Barcelona, Bilbao, Madrid, Sevilla and Valencia, during 17 years, from 1996 to 2012. This data series combines observations from in-situ air quality monitoring networks and the satellite-based instruments GOME and SCIAMACHY. The results in these five cities show a smooth decrease in the NO2 concentrations of ~2%...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115208
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Oct 11, 2014
10/14
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Davis, Michael S.; Bonen, Arend; Snook, Laelie A.; Jain, Swati S.; Bartels, Kenneth; Geor, Raymond; Hueffer, Karsten
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This article is from PLoS ONE , volume 9 . Abstract Endurance exercise relies on transsarcolemmal flux of substrates in order to avoid depletion of intramuscular reserves. Previous studies of endurance trained sled dogs have shown a remarkable capacity of these dogs to adapt rapidly to endurance exercise by decreasing the utilization of intramuscular reserves. The current study tested the hypothesis that the dogs' glycogen-sparing phenotype is due to increased sarcolemmal transport of glucose...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116179
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4.0
Jun 30, 2018
06/18
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Donald Gavel; Renate Kupke; Daren Dillon; Andrew Norton; Chris Ratliff; Jerry Cabak; Andrew Phillips; Connie Rockosi; Rosalie McGurk; Srikar Srinath; Michael Peck; William Deich; Kyle Lanclos; John Gates; Michael Saylor; Jim Ward; Terry Pfister
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A new high-order adaptive optics system is now being commissioned at the Lick Observatory Shane 3-meter telescope in California. This system uses a high return efficiency sodium beacon and a combination of low and high-order deformable mirrors to achieve diffraction-limited imaging over a wide spectrum of infrared science wavelengths covering 0.8 to 2.2 microns. We present the design performance goals and the first on-sky test results. We discuss several innovations that make this system a...
Topics: Instrumentation and Methods for Astrophysics, Astrophysics
Source: http://arxiv.org/abs/1407.8207
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7.0
Jun 30, 2018
06/18
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Dušan Jovanović; Renato Fedele; Milivoj Belić; Sergio De Nicola
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The interaction of a multi-Petawatt, pancake-shaped laser pulse with an unmagnetized plasma is studied analytically and numerically in the regime of fully relativistic electron jitter velocities and in the context of the laser wakefield acceleration scheme. The study is applied to the specifications available at present time, or planned for the near future, of the Ti:Sa Frascati Laser for Acceleration and Multidisciplinary Experiments (FLAME) in Frascati. Novel nonlinear equation is derived by...
Topics: Physics, Plasma Physics
Source: http://arxiv.org/abs/1407.8026
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70
Oct 11, 2014
10/14
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Egekwu, Noble; Sonenshine, Daniel E.; Bissinger, Brooke W.; Roe, R. Michael
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This article is from PLoS ONE , volume 9 . Abstract Illumina and 454 pyrosequencing were used to characterize genes from the synganglion of female Ixodes scapularis. GO term searching success for biological processes was similar for samples sequenced by both methods. However, for molecular processes, it was more successful for the Illumina samples than for 454 samples. Functional assignments of transcripts predicting neuropeptides, neuropeptide receptors, neurotransmitter receptors and other...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116169
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5.0
Jun 30, 2018
06/18
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Elizabeth N. Davison; Kimberly J. Schlesinger; Danielle S. Bassett; Mary-Ellen Lynall; Michael B. Miller; Scott T. Grafton; Jean M. Carlson
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Activity in the human brain moves between diverse functional states to meet the demands of our dynamic environment, but fundamental principles guiding these transitions remain poorly understood. Here, we capitalize on recent advances in network science to analyze patterns of functional interactions between brain regions. We use dynamic network representations to probe the landscape of brain reconfigurations that accompany task performance both within and between four cognitive states: a...
Topics: Quantitative Biology, Neurons and Cognition
Source: http://arxiv.org/abs/1407.8234
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Oct 6, 2014
10/14
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Fagan, Vincent; Toth, Istvan; Simerska, Pavla
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This article is from Beilstein Journal of Organic Chemistry , volume 10 . Abstract A novel convergent synthetic strategy for the construction of multicomponent self-adjuvanting lipopeptide vaccines was developed. A tetraalkyne-functionalized glucose derivative and lipidated Fmoc-lysine were prepared by novel efficient and convenient syntheses. The carbohydrate building block was coupled to the self-adjuvanting lipidic moiety (three lipidated Fmoc-lysines) on solid support. Four copies of a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143089
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10.0
Jun 30, 2018
06/18
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Fei Yu; Michal Rybar; Caroline Uhler; Stephen E. Fienberg
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eye 10
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Following the publication of an attack on genome-wide association studies (GWAS) data proposed by Homer et al., considerable attention has been given to developing methods for releasing GWAS data in a privacy-preserving way. Here, we develop an end-to-end differentially private method for solving regression problems with convex penalty functions and selecting the penalty parameters by cross-validation. In particular, we focus on penalized logistic regression with elastic-net regularization, a...
Topics: Machine Learning, Applications, Computing Research Repository, Statistics, Learning
Source: http://arxiv.org/abs/1407.8067
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Oct 11, 2014
10/14
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Ferrero, Valentina Elisabetta Viviana; Pedotti, Mattia; Chiado, Alessandro; Simonelli, Luca; Calzolai, Luigi; Varani, Luca; Lettieri, Teresa
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This article is from PLoS ONE , volume 9 . Abstract In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding domain. By combining sequence alignment and structural analysis of known estrogen receptor-ligand complexes with computational analysis, we were able to predict estrogen receptor mutants with altered binding properties. These predictions were experimentally confirmed by producing single...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116177
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Oct 10, 2014
10/14
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Fitzcharles, Mary-Ann; Ste-Marie, Peter A; Clauw, Daniel J; Jamal, Shahin; Karsh, Jacob; LeClercq, Sharon; McDougall, Jason J; Shir, Yoram; Shojania, Kam; Walsh, Zach
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This article is from BMC Musculoskeletal Disorders , volume 15 . Abstract Background: Arthritis pain is reported as one of the most common reasons for persons using medical herbal cannabis in North America. “Severe arthritis” is the condition justifying legal use of cannabis in over half of all authorizations in Canada, where cannabis remains a controlled substance. As champions for the care of persons with arthritis, rheumatologists must be knowledgeable of treatment modalities both...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121007
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Oct 11, 2014
10/14
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Florez-Vargas, Oscar; Bramhall, Michael; Noyes, Harry; Cruickshank, Sheena; Stevens, Robert; Brass, Andy
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This article is from PLoS ONE , volume 9 . Abstract There is a growing concern both inside and outside the scientific community over the lack of reproducibility of experiments. The depth and detail of reported methods are critical to the reproducibility of findings, but also for making it possible to compare and integrate data from different studies. In this study, we evaluated in detail the methods reporting in a comprehensive set of trypanosomiasis experiments that should enable valid...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116335
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Oct 8, 2014
10/14
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Foret, Michael R.; Sandstrom, Richard S.; Rhodes, Christopher T.; Wang, Yufeng; Berger, Mitchel S.; Lin, Chin-Hsing Annie
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This article is from Frontiers in Genetics , volume 5 . Abstract Histone 3 Lysine 9 (H3K9) methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3) is enriched in an adult neural stem cell niche- the subventricular zone (SVZ) on the walls of the lateral ventricle in both rodent and non-human primate baboon brain. Previous studies have shown that there is significant correlation between...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115620
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12
Jun 30, 2018
06/18
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G. A. Beer; Y. Fujiwara; S. Hirota; K. Ishida; M. Iwasaki; S. Kanda; H. Kawai; N. Kawamura; R. Kitamura; S. Lee; W. Lee G. M. Marshall; T. Mibe; Y. Miyake; S. Okada; K. Olchanski; A. Olin; Y. Oishi; H. Onishi; M. Otani; N. Saito; K. Shimomura; P. Strasser; M. Tabata; D. Tomono; K. Ueno; K. Yokoyama; E. Won
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Emission of muonium ($\mu^+e^-$) atoms from a laser-processed aerogel surface into vacuum was studied for the first time. Laser ablation was used to create hole-like regions with diameter of about 270$~\mu$m in a triangular pattern with hole separation in the range of 300--500$~\mu$m. The emission probability for the laser-processed aerogel sample is at least eight times higher than for a uniform one.
Topics: Physics, High Energy Physics - Experiment, Atomic Physics, Instrumentation and Detectors
Source: http://arxiv.org/abs/1407.8248
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6.0
Jun 30, 2018
06/18
by
Gang Liao; Wenxiang Sun; Shirou Wang
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We prove that entropy map is upper semi-continuous for C1 nonuniformly hyperbolic systems with domination, while it is not true for C1+alpha nonuniformly hyperbolic systems in general. This goes a little against a common intuition that conclusions are parallel between C1+domination systems and C1+alpha systems.
Topics: Mathematics, Dynamical Systems
Source: http://arxiv.org/abs/1407.8102
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6.0
Jun 30, 2018
06/18
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Giovanni Amelino-Camelia; Leonardo Barcaroli; Giulia Gubitosi; Stefano Liberati; Niccoló Loret
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Finsler geometry is a well known generalization of Riemannian geometry which allows to account for a possibly non trivial structure of the space of configurations of relativistic particles. We here establish a link between Finsler geometry and the sort of models with curved momentum space and DSR-relativistic symmetries which have been recently of interest in the quantum-gravity literature. We use as case study the much-studied scenario which is inspired by the $\kappa$-Poincar\'e quantum...
Topics: High Energy Physics - Theory, General Relativity and Quantum Cosmology
Source: http://arxiv.org/abs/1407.8143
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56
Oct 11, 2014
10/14
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Golden-Mason, Lucy; Hahn, Young S.; Strong, Michael; Cheng, Linling; Rosen, Hugo R.
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This article is from PLoS ONE , volume 9 . Abstract Background: Hepatitis C viral (HCV) proteins, including core, demonstrate immuno-modulatory properties; however, the effect of extracellular core on natural killer (NK) cells has not previously been investigated. Aims: To characterise NKs in acute HCV infection over time, and, to examine the effect of exogenous HCV-core protein on NK cell phenotype and function. Methods: Acute HCV patients (n = 22), including 10 subjects who spontaneously...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116173
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Oct 11, 2014
10/14
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Goodreau, Steven M.; Carnegie, Nicole B.; Vittinghoff, Eric; Lama, Javier R.; Fuchs, Jonathan D.; Sanchez, Jorge; Buchbinder, Susan P.
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This article is from PLoS ONE , volume 9 . Abstract Background: Three trials have demonstrated the prophylactic effect of male circumcision (MC) for HIV acquisition among heterosexuals, and MC interventions are underway throughout sub-Saharan Africa. Similar efforts for men who have sex with men (MSM) are stymied by the potential for circumcised MSM to acquire HIV easily through receptive sex and transmit easily through insertive sex. Existing work suggests that MC for MSM should reach its...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116164
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64
Oct 7, 2014
10/14
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Grigsby, Jim; Cornish, Kim; Hocking, Darren; Kraan, Claudine; Olichney, John M; Rivera, Susan M; Schneider, Andrea; Sherman, Stephanie; Wang, Jun Yi; Yang, Jin-Chen
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This article is from Journal of Neurodevelopmental Disorders , volume 6 . Abstract The fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting a subset of carriers of the FMR1 (fragile X mental retardation 1) premutation. Penetrance and expression appear to be significantly higher in males than females. Although the most obvious aspect of the phenotype is the movement disorder that gives FXTAS its name, the disorder is also accompanied by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135346
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54
Oct 12, 2014
10/14
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Guerrero, Erick G; Villatoro, Jorge Ameth; Kong, Yinfei; Fleiz, Clara; Vega, William A; Strathdee, Steffanie A; Medina-Mora, Maria Elena
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This article is from Substance Abuse Treatment, Prevention, and Policy , volume 9 . Abstract Background: We examined Mexican migrants’ perceived barriers to entering substance abuse treatment and potential differences by gender. Methods: This study analyzed a subset of household data collected in Mexico in 2011 via the Encuesta Nacional de Adicciones (National Survey of Addictions). A sample of 1,143 individuals who reported using illicit drugs was analyzed using multivariate negative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118628
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Oct 10, 2014
10/14
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Hafstrom, Ingiald; Engvall, Inga-Lill; Ronnelid, Johan; Boonen, Annelies; van der Heijde, Desiree; Svensson, Bjorn
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This article is from BMJ Open , volume 4 . Abstract Objective: To analyse if predictors of radiographic progression differ between patients treated with or without prednisolone in early rheumatoid arthritis (RA). Radiographs of hands and feet were assessed using the modified Sharp/van der Heijde score and radiographic progression was defined as an increase in the total Sharp score above 5.8 (the smallest detectable change). Design: Prospective, randomised study of patients with early RA....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120364
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Oct 7, 2014
10/14
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Hall, Deborah A; Birch, Rachael C; Anheim, Mathieu; J?nch, Aia E; Pintado, Elizabeth; O'Keefe, Joanne; Trollor, Julian N; Stebbins, Glenn T; Hagerman, Randi J; Fahn, Stanley; Berry-Kravis, Elizabeth; Leehey, Maureen A
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This article is from Journal of Neurodevelopmental Disorders , volume 6 . Abstract This paper summarizes key emerging issues in fragile X-associated tremor/ataxia syndrome (FXTAS) as presented at the First International Conference on the FMR1 Premutation: Basic Mechanisms & Clinical Involvement in 2013.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141265
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7.0
Jun 30, 2018
06/18
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Henryk Czyz; Johann H. Kuhn; Szymon Tracz
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New parametrisation for the electric and the magnetic form factors of proton and neutron are presented. The proton form factors describe well the recent measurements by BaBar collaboration and earlier ones of the ratio of the form factors in space-like region. The neutron form factors are consistent with earlier measurements of neutron pair production and ratio of the form factors in the space-like region. These form factors are implemented into the generator PHOKHARA, which simulates the...
Topic: High Energy Physics - Phenomenology
Source: http://arxiv.org/abs/1407.7995
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Oct 10, 2014
10/14
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Hernandez-Duran, Silvia; Yeh-Hsieh, Tze-Yu; Salazar-Araya, Carlos
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This article is from Surgical Neurology International , volume 5 . Abstract Background:: Subependymomas are rare benign, noninvasive tumors, classified by the World Health Organization as low grade neoplasms. International data estimate their frequency between 0.2% and 0.7% of the intracranial tumors, and they usually are an incidental finding in autopsies. Preferably located in the fourth ventricle, these tumors tend to become symptomatic when they cause hydrocephalous by obstructing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123265
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8.0
Jun 30, 2018
06/18
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Hilding R. Neilson; Alexandra C. Bisol; Ed Guinan; Scott Engle
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Measurements of secular period change probe real-time stellar evolution of classical Cepheids making these measurements powerful constraints for stellar evolution models, especially when coupled with interferometric measurements. In this work, we present stellar evolution models and measured rates of period change for two Galactic Cepheids: Polaris and l Carinae, both important Cepheids for anchoring the Cepheid Leavitt law (period-luminosity relation). The combination of previously-measured...
Topics: Astrophysics, Solar and Stellar Astrophysics
Source: http://arxiv.org/abs/1407.8098
