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Horimoto, Yoshiya; Arakawa, Atsushi; Tanabe, Masahiko; Sonoue, Hiroshi; Igari, Fumie; Senuma, Koji; Tokuda, Emi; Shimizu, Hideo; Kosaka, Taijiro; Saito, Mitsue
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This article is from BMC Cancer , volume 14 . Abstract Background: Patients with luminal HER2-negative tumours have a favourable prognosis. However, there is a subpopulation in which poorer outcomes are obtained with endocrine therapy alone. This subpopulation is considered to benefit from chemotherapy. However, the significance of chemotherapy for those with luminal tumours has decreased due to recent changes in treatment strategies. Thus, it is often difficult to determine whether we should...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124146
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Oct 12, 2014
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Mehrabadi, Azar; Liu, Shiliang; Bartholomew, Sharon; Hutcheon, Jennifer A; Magee, Laura A; Kramer, Michael S; Liston, Robert M; Joseph, K S
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This article is from BMJ : British Medical Journal , volume 349 . Abstract Objective To examine whether changes in postpartum haemorrhage, hypertensive disorders of pregnancy, or other risk factors explain the increase in obstetric acute renal failure in Canada.Design Retrospective cohort study.Setting Canada (excluding the province of Quebec).Participants All hospital deliveries from 2003 to 2010 (n=2 193 425).Main outcome measures Obstetric acute renal failure identified by ICD-10...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115671
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Oct 12, 2014
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Xavier, Basil Britto; Sabirova, Julia; Pieter, Moons; Hernalsteens, Jean-Pierre; de Greve, Henri; Goossens, Herman; Malhotra-Kumar, Surbhi
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This article is from BMC Research Notes , volume 7 . Abstract Background: De novo genome assembly can be challenging due to inherent properties of the reads, even when using current state-of-the-art assembly tools based on de Bruijn graphs. Often users are not bio-informaticians and, in a black box approach, utilise assembly parameters such as contig length and N50 to generate whole genome sequences, potentially resulting in mis-assemblies. Findings: Utilising several assembly tools based on de...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118782
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Oct 12, 2014
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Chen, Hongfei; Xia, Yun; Zhu, Binbin; Hu, Xiawei; Xu, Shihao; Chen, Limei; Papadimos, Thomas J; Wang, Wantie; Wang, Quanguang; Xu, Xuzhong
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This article is from BMC Anesthesiology , volume 14 . Abstract Background: The reversal efficacy of 2% lipid emulsion in cardiac asystole induced by different concentrations of bupivacaine is poorly defined and needs to be determined. Methods: Forty-two male Sprague–Dawley rats were randomly divided into seven groups: B40, B60, B80, B100, B120, B140 and B160, n = 6. The Langendorff isolated heart perfusion model was used, which consisted of a balanced perfusion with Krebs-Henseleit...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118607
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Oct 11, 2014
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Melville, Jane; Smith, Katie; Hobson, Rod; Hunjan, Sumitha; Shoo, Luke
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This article is from PLoS ONE , volume 9 . Abstract Molecular phylogenetics is increasingly highlighting the prevalence of cryptic species, where morphologically similar organisms have long independent evolutionary histories. When such cryptic species are known to be declining in numbers and are at risk of extinction due to a range of threatening processes, the disjunction between molecular systematics research and conservation policy becomes a significant problem. We investigate the taxonomic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116116
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Oct 11, 2014
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Regan, Fran H.; Hockenhull, Jo; Pritchard, Joy C.; Waterman-Pearson, Avril E.; Whay, Helen R.
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This article is from PLoS ONE , volume 9 . Abstract Background: The donkey has a reputation for stoicism and its behavioural repertoire in clinical contexts is under-reported. Lack of understanding of the norms of donkey behaviour and how it may vary over time can compromise use of behavioural measures as indicators of pain or emotional state. The objective of this study was to find out whether the behaviour of working donkeys was influenced by gender, the time of day or differed between days...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116118
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Harper, Diane M.; Else, Britney M.; Bartley, Mitchell J.; Arey, Anne M.; Barnett, Angela L.; Rosemergey, Beth E.; Paynter, Christopher A.; Verdenius, Inge; Harper, Sean M.; Harris, George D.; Groner, Jennifer A.; Malnar, Gerard J.; Wall, Jeffrey; Bonham, Aaron J.
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This article is from PLoS ONE , volume 9 . Abstract Objectives: Obesity adversely inhibits antibody response to vaccination. Three doses of HPV4 may or may not provide adequate long term protection against HPV 16/18 in obese females. The aim of this study was to determine whether adherence to HPV4 vaccination in a safety net population was reduced with increasing body mass index (BMI). Methods: We designed a historical prospective study evaluating the number and dates of HPV4 dosing that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116139
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Nagy, Alexander; Cernikova, Lenka; Jirincova, Helena; Havlickova, Martina; Hornickova, Jitka
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This article is from PLoS ONE , volume 9 . Abstract Influenza A virus (IAV) in wild bird reservoir hosts is characterized by the perpetuation in a plethora of subtype and genotype constellations. Multiyear monitoring studies carried out during the last two decades worldwide have provided a large body of knowledge regarding the ecology of IAV in wild birds. Nevertheless, other issues of avian IAV evolution have not been fully elucidated, such as the complexity and dynamics of genetic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116140
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Oct 11, 2014
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Ullal-Gupta, Sangeeta; Hannon, Erin E.; Snyder, Joel S.
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This article is from PLoS ONE , volume 9 . Abstract Musical meters vary considerably across cultures, yet relatively little is known about how culture-specific experience influences metrical processing. In Experiment 1, we compared American and Indian listeners' synchronous tapping to slow sequences. Inter-tone intervals contained silence or to-be-ignored rhythms that were designed to induce a simple meter (familiar to Americans and Indians) or a complex meter (familiar only to Indians). A...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116158
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Oct 11, 2014
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Liu, Ya-Wei; Huang, Yi-Tsau
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This article is from PLoS ONE , volume 9 . Abstract Background: Anti-inflammation via inhibition of NF-κB pathways in hepatic stellate cells (HSCs) is one therapeutic approach to hepatic fibrosis. Tanshinone IIA (C19H18O3, Tan IIA) is a lipophilic diterpene isolated from Salvia miltiorrhiza Bunge, with reported anti-inflammatory activity. We tested whether Tan IIA could inhibit HSC activation. Materials and Methods: The cell line of rat hepatic stellate cells (HSC-T6) was stimulated with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116159
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Oct 11, 2014
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Chang, Yi-Shin; Owen, Julia P.; Desai, Shivani S.; Hill, Susanna S.; Arnett, Anne B.; Harris, Julia; Marco, Elysa J.; Mukherjee, Pratik
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This article is from PLoS ONE , volume 9 . Abstract Over 90% of children with Autism Spectrum Disorders (ASD) demonstrate atypical sensory behaviors. In fact, hyper- or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment is now included in the DSM-5 diagnostic criteria. However, there are children with sensory processing differences who do not meet an ASD diagnosis but do show atypical sensory behaviors to the same or greater degree as ASD children. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116166
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Oct 11, 2014
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Viguiliouk, Effie; Kendall, Cyril W. C.; Blanco Mejia, Sonia; Cozma, Adrian I.; Ha, Vanessa; Mirrahimi, Arash; Jayalath, Viranda H.; Augustin, Livia S. A.; Chiavaroli, Laura; Leiter, Lawrence A.; de Souza, Russell J.; Jenkins, David J. A.; Sievenpiper, John L.
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This article is from PLoS ONE , volume 9 . Abstract Background: Tree nut consumption has been associated with reduced diabetes risk, however, results from randomized trials on glycemic control have been inconsistent. Objective: To provide better evidence for diabetes guidelines development, we conducted a systematic review and meta-analysis of randomized controlled trials to assess the effects of tree nuts on markers of glycemic control in individuals with diabetes. Data Sources: MEDLINE,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116170
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Oct 11, 2014
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Hessamfar, Mojgan; Colin, Celine; Bruyand, Mathias; Decoin, Madeleine; Bonnet, Fabrice; Mercie, Patrick; Neau, Didier; Cazanave, Charles; Pellegrin, Jean-Luc; Dabis, Francois; Morlat, Philippe; Chene, Genevieve
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This article is from PLoS ONE , volume 9 . Abstract Objective: To describe trends and determinants of severe morbidity in HIV-infected women and men. Design: A French prospective cohort of HIV-infected patients of both sexes and all transmission categories. Methods: We used hospital admission data from January 2000 to December 2008. A severe morbid event (SME) was defined as a clinical event requiring hospitalization for ≥48 h, several events could be reported during hospitalization. Yearly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116171
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Oct 11, 2014
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Golden-Mason, Lucy; Hahn, Young S.; Strong, Michael; Cheng, Linling; Rosen, Hugo R.
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This article is from PLoS ONE , volume 9 . Abstract Background: Hepatitis C viral (HCV) proteins, including core, demonstrate immuno-modulatory properties; however, the effect of extracellular core on natural killer (NK) cells has not previously been investigated. Aims: To characterise NKs in acute HCV infection over time, and, to examine the effect of exogenous HCV-core protein on NK cell phenotype and function. Methods: Acute HCV patients (n = 22), including 10 subjects who spontaneously...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116173
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Oct 11, 2014
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Horacio, Andreia N.; Lopes, Joana P.; Ramirez, Mario; Melo-Cristino, Jose
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This article is from PLoS ONE , volume 9 . Abstract There is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance. Serotypes and antimicrobial susceptibility profiles of a sample of 1300 isolates recovered from adult patients (≥18 yrs) between 1999 and 2011...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116175
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Shamshirband, Shahaboddin; Petkovic, Dalibor; Hashim, Roslan; Motamedi, Shervin
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This article is from PLoS ONE , volume 9 . Abstract Wind turbine noise is one of the major obstacles for the widespread use of wind energy. Noise tone can greatly increase the annoyance factor and the negative impact on human health. Noise annoyance caused by wind turbines has become an emerging problem in recent years, due to the rapid increase in number of wind turbines, triggered by sustainable energy goals set forward at the national and international level. Up to now, not all aspects of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116176
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Oct 11, 2014
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Oct 11, 2014
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Blaho, Miklos; Herczeg, Tamas; Kriska, Gyorgy; Egri, Adam; Szaz, Denes; Farkas, Alexandra; Tarjanyi, Nikolett; Czinke, Laszlo; Barta, Andras; Horvath, Gabor
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This article is from PLoS ONE , volume 9 . Abstract The horizontally polarizing surface parts of shiny black cars (the reflection-polarization characteristics of which are similar to those of water surfaces) attract water-leaving polarotactic insects. Thus, shiny black cars are typical sources of polarized light pollution endangering water-leaving insects. A new fashion fad is to make car-bodies matt black or grey. Since rough (matt) surfaces depolarize the reflected light, one of the ways of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116178
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Oct 11, 2014
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Oct 11, 2014
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Webber, Amanda D.; Hill, Catherine M.
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This article is from PLoS ONE , volume 9 . Abstract Considering how people perceive risks to their livelihoods from local wildlife is central to (i) understanding the impact of crop damage by animals on local people and (ii) recognising how this influences their interactions with, and attitudes towards, wildlife. Participatory risk mapping (PRM) is a simple, analytical tool that can be used to identify and classify risk within communities. Here we use it to explore local people's perceptions of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116180
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Oct 11, 2014
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Davis, Michael S.; Bonen, Arend; Snook, Laelie A.; Jain, Swati S.; Bartels, Kenneth; Geor, Raymond; Hueffer, Karsten
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This article is from PLoS ONE , volume 9 . Abstract Endurance exercise relies on transsarcolemmal flux of substrates in order to avoid depletion of intramuscular reserves. Previous studies of endurance trained sled dogs have shown a remarkable capacity of these dogs to adapt rapidly to endurance exercise by decreasing the utilization of intramuscular reserves. The current study tested the hypothesis that the dogs' glycogen-sparing phenotype is due to increased sarcolemmal transport of glucose...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116179
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Oct 11, 2014
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Puechmaille, Sebastien J.; Borissov, Ivailo M.; Zsebok, Sandor; Allegrini, Benjamin; Hizem, Mohammed; Kuenzel, Sven; Schuchmann, Maike; Teeling, Emma C.; Siemers, Bjorn M.
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This article is from PLoS ONE , volume 9 . Abstract Animals employ an array of signals (i.e. visual, acoustic, olfactory) for communication. Natural selection favours signals, receptors, and signalling behaviour that optimise the received signal relative to background noise. When the signal is used for more than one function, antagonisms amongst the different signalling functions may constrain the optimisation of the signal for any one function. Sexual selection through mate choice can strongly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116191
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Oct 11, 2014
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Oct 11, 2014
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Pelletier, Caroline C.; Koppe, Laetitia; Alix, Pascaline M.; Kalbacher, Emilie; Croze, Marine L.; Hadj-Aissa, Aoumeur; Fouque, Denis; Guebre-Egziabher, Fitsum; Soulage, Christophe O.
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This article is from PLoS ONE , volume 9 . Abstract Zinc-α2-glycoprotein (ZAG), a potent cachectic factor, is increased in patients undergoing maintenance dialysis. However, there is no data for patients before initiation of renal replacement therapy. The purpose of the present study was to assess the relationship between plasma ZAG concentration and renal function in patients with a large range of glomerular filtration rate (GFR). Plasma ZAG concentration and its relationship to GFR were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116200
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Oct 11, 2014
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Oct 11, 2014
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Xie, Ni; Mou, Lisha; Yuan, Jianhui; Liu, Wenlan; Deng, Tingting; Li, Zigang; Jin, Yi; Hu, Zhangli
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This article is from PLoS ONE , volume 9 . Abstract Background: The BCRP/ABCG2 transporter, which mediates drug resistance in many types of cells, depends on energy provided by ATP hydrolysis. Here, a retrovirus encoding a shRNA targeting the ATP-binding domain of this protein was used to screen for highly efficient agents that could reverse drug resistance and improve cell sensitivity to drugs, thus laying the foundation for further studies and applications. Methodology/Principal Findings: To...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116202
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Oct 11, 2014
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Oct 11, 2014
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Pisano, Fabio; Heine, Wiebke; Rosenheinrich, Maik; Schweer, Janina; Nuss, Aaron M.; Dersch, Petra
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This article is from PLoS ONE , volume 9 . Abstract The two-component regulatory system PhoP/PhoQ has been shown to (i) control expression of virulence-associated traits, (ii) confer survival and growth within macrophages and (iii) play a role in Yersinia infections. However, the influence of PhoP on virulence varied greatly between different murine models of infection and its role in natural oral infections with frequently used representative isolates of Y. pseudotuberculosis was unknown. To...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116203
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Oct 11, 2014
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Oct 11, 2014
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Dvorkin-Gheva, Anna; Hassell, John A.
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This article is from PLoS ONE , volume 9 . Abstract The molecular classification of human breast tumors has afforded insights into subtype specific biological processes, patient prognosis and response to therapies. However, using current methods roughly one quarter of breast tumors cannot be classified into one or another molecular subtype. To explore the possibility that the unclassifiable samples might comprise one or more novel subtypes we employed a collection of publically available breast...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116208
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Oct 11, 2014
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Oct 11, 2014
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Choi, Jaesung; Song, Nan; Han, Sohee; Chung, Seokang; Sung, Hyuna; Lee, Ji-young; Jung, Sunjae; Park, Sue K.; Yoo, Keun-Young; Han, Wonshik; Lee, Jong Won; Noh, Dong-Young; Kang, Daehee; Choi, Ji-Yeob
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This article is from PLoS ONE , volume 9 . Abstract We investigated the role of common genetic variation in immune-related genes on breast cancer disease-free survival (DFS) in Korean women. 107 breast cancer patients of the Seoul Breast Cancer Study (SEBCS) were selected for this study. A total of 2,432 tag single nucleotide polymorphisms (SNPs) in 283 immune-related genes were genotyped with the GoldenGate Oligonucleotide pool assay (OPA). A multivariate Cox-proportional hazard model and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116221
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Oct 11, 2014
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Hu, Xiaowen; Yi, Eunhee S.; Ryu, Jay H.
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This article is from PLoS ONE , volume 9 . Abstract Background: Aspiration can cause a diverse spectrum of pulmonary disorders some of which can lead to death but can be difficult to diagnose. Patients and Methods: The medical records and autopsy findings of 57 consecutive patients in whom aspiration was the immediate cause of death at Mayo Clinic (Rochester, MN, USA) over a 9-yr period, from January 1 2004 to December 31 2012 were analyzed. Results: The median age at death was 72 years (range,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116222
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Oct 11, 2014
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Oct 11, 2014
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Hui, Fengli; Ren, Yongcheng; Chen, Liang; Li, Ying; Zhang, Lin; Niu, Qiuhong
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This article is from PLoS ONE , volume 9 . Abstract Four strains of a novel ascomycetous yeast species were recovered from the frass of wood-boring beetles collected from the Baotianman Nature Reserve and the Laojieling Nature Reserve in Henan Province, China. This species produced unconjugated and deliquescent asci with hemispheroid or helmet-shaped ascospores. Analysis of gene sequences for the D1/D2 domain of the large subunit (LSU) rRNA, as well as analysis of concatenated gene sequences...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116224
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Thevenard, Jessica; Verzeaux, Laurie; Devy, Jerome; Etique, Nicolas; Jeanne, Albin; Schneider, Christophe; Hachet, Cathy; Ferracci, Geraldine; David, Marion; Martiny, Laurent; Charpentier, Emmanuelle; Khrestchatisky, Michel; Rivera, Santiago; Dedieu, Stephane; Emonard, Herve
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This article is from PLoS ONE , volume 9 . Abstract Tissue inhibitor of metalloproteinases-1 (TIMP-1) regulates the extracellular matrix turnover by inhibiting the proteolytic activity of matrix metalloproteinases (MMPs). TIMP-1 also displays MMP-independent activities that influence the behavior of various cell types including neuronal plasticity, but the underlying molecular mechanisms remain mostly unknown. The trans-membrane receptor low-density lipoprotein receptor-related protein-1...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116228
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Oct 11, 2014
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Mucha, Joanna; Majchrzak, Kinga; Taciak, Bartlomiej; Hellmen, Eva; Krol, Magdalena
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This article is from PLoS ONE , volume 9 . Abstract Background: Myeloid-derived suppressor cells (MDSCs) function in immunosuppression and tumor development by induction of angiogenesis in a STAT3-dependent manner. Knowledge of MDSC biology is mainly limited to mice studies, and more clinical investigations using spontaneous tumor models are required. Here we performed in vitro experiments and clinical data analysis obtained from canine patients. Methods: Using microarrays we examined changes...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116234
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Oct 11, 2014
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Vallverdu, Josep; Saladie, Palmira; Rosas, Antonio; Huguet, Rosa; Caceres, Isabel; Mosquera, Marina; Garcia-Tabernero, Antonio; Estalrrich, Almudena; Lozano-Fernandez, Ivan; Pineda-Alcala, Antonio; Carrancho, Angel; Villalain, Juan Jose; Bourles, Didier; Braucher, Regis; Lebatard, Anne; Vilalta, Jaume; Esteban-Nadal, Montserrat; Bennasar, Maria Lluc; Bastir, Marcus; Lopez-Polin, Lucia; Olle, Andreu; Verges, Josep Maria; Ros-Montoya, Sergio; Martinez-Navarro, Bienvenido; Garcia, Ana; Martinell,...
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This article is from PLoS ONE , volume 9 . Abstract The first arrivals of hominin populations into Eurasia during the Early Pleistocene are currently considered to have occurred as short and poorly dated biological dispersions. Questions as to the tempo and mode of these early prehistoric settlements have given rise to debates concerning the taxonomic significance of the lithic assemblages, as trace fossils, and the geographical distribution of the technological traditions found in the Lower...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116235
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Eduardo, Eduard; Lamb, Matthew R.; Kandula, Sasi; Howard, Andrea; Mugisha, Veronicah; Kimanga, Davies; Kilama, Bonita; El-Sadr, Wafaa; Elul, Batya
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This article is from PLoS ONE , volume 9 . Abstract Background: Limited information exists on adults ≥50 years receiving HIV care in sub-Saharan Africa. Methodology: Using routinely-collected longitudinal patient-level data among 391,111 adults ≥15 years enrolling in HIV care from January 2005–December 2010 and 184,689 initiating ART, we compared characteristics and outcomes between older (≥50 years) and younger adults at 199 clinics in Kenya, Mozambique, Rwanda, and Tanzania. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116238
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Hafstrom, Ingiald; Engvall, Inga-Lill; Ronnelid, Johan; Boonen, Annelies; van der Heijde, Desiree; Svensson, Bjorn
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This article is from BMJ Open , volume 4 . Abstract Objective: To analyse if predictors of radiographic progression differ between patients treated with or without prednisolone in early rheumatoid arthritis (RA). Radiographs of hands and feet were assessed using the modified Sharp/van der Heijde score and radiographic progression was defined as an increase in the total Sharp score above 5.8 (the smallest detectable change). Design: Prospective, randomised study of patients with early RA....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120364
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Smith, Samuel C; Heal, Clare F; Buttner, Petra G
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This article is from BMJ Open , volume 4 . Abstract Objectives: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb. Design: Prospective double-blinded placebo-controlled trial testing for difference in infection rates. Setting: Primary care in regional North Queensland, Australia. Participants: 52 patients undergoing lower limb skin lesion excision....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120377
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Schoeneberg, Carsten; Schilling, Marc; Keitel, Judith; Burggraf, Manuel; Hussmann, Bjoern; Lendemans, Sven
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This article is from BMC Pediatrics , volume 14 . Abstract Background: Trauma in pediatric patients is a major cause of death. This study investigated differences between decedents and survivors. Furthermore, an analysis of preventable and potential preventable trauma deaths was conducted and errors in the acute trauma care were investigated. Methods: All patients aged less than 16 years with an Injury Severity Score (ISS) ≥ 16 upon primary admission to the hospital between July 2002 and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121010
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Hernandez-Duran, Silvia; Yeh-Hsieh, Tze-Yu; Salazar-Araya, Carlos
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This article is from Surgical Neurology International , volume 5 . Abstract Background:: Subependymomas are rare benign, noninvasive tumors, classified by the World Health Organization as low grade neoplasms. International data estimate their frequency between 0.2% and 0.7% of the intracranial tumors, and they usually are an incidental finding in autopsies. Preferably located in the fourth ventricle, these tumors tend to become symptomatic when they cause hydrocephalous by obstructing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123265
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Wheeler, Anne C; Bailey Jr, Donald B; Berry-Kravis, Elizabeth; Greenberg, Jan; Losh, Molly; Mailick, Marsha; Mila, Montserrat; Olichney, John M; Rodriguez-Revenga, Laia; Sherman, Stephanie; Smith, Leann; Summers, Scott; Yang, Jin-Chen; Hagerman, Randi
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This article is from Journal of Neurodevelopmental Disorders , volume 6 . Abstract Changes in the fragile X mental retardation 1 gene (FMR1) have been associated with specific phenotypes, most specifically those of fragile X syndrome (FXS), fragile X tremor/ataxia syndrome (FXTAS), and fragile X primary ovarian insufficiency (FXPOI). Evidence of increased risk for additional medical, psychiatric, and cognitive features and conditions is now known to exist for individuals with a premutation,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121434
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Piegeler, Tobias; Dreessen, Pamela; Graber, Sereina M; Haile, Sarah R; Schmid, Daniel Max; Beck-Schimmer, Beatrice
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This article is from BMC Anesthesiology , volume 14 . Abstract Background: Robotic-assisted laparoscopic prostatectomy (RALP) gained much popularity during the last decade. Although the influence of intraoperative fluid management on patients’ outcome has been largely discussed in general, its impact on perioperative complications and length of hospitalization in patients undergoing RALP has not been examined so far. We hypothesized that a more restrictive fluid management might lead to a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123305
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Hodzic, Adnan; Latrofa, Maria Stefania; Annoscia, Giada; Alic, Amer; Beck, Relja; Lia, Riccardo Paolo; Dantas-Torres, Filipe; Otranto, Domenico
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This article is from Parasites & Vectors , volume 7 . Abstract Background: Thelazia callipaeda (Spirurida, Thelaziidae), also known as “oriental eyeworm”, is a small nematode parasite that lives in the conjunctival sac of domestic and wild carnivores, rabbits and even humans, causing mild (e.g., conjunctivitis, epiphora, and ocular discharge) to severe (e.g., keratitis, and corneal ulcers) ocular disease. This study reports, for the first time, the occurrence of T. callipaeda infection...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124150
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Oct 10, 2014
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Oct 10, 2014
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Yao, Xuan; Hou, Sarina; Zhang, Duo; Xia, Hongfeng; Wang, Yu-Cheng; Jiang, Jingjing; Yin, Huiyong; Ying, Hao
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This article is from Cell & Bioscience , volume 4 . Abstract Background: Thyroid hormones (THs) are potent hormones modulating liver lipid homeostasis. The perturbation of lipid homeostasis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a very common liver disorder. It was reported that NAFLD patients were associated with higher incidence of hypothyroidism. However, whether abnormal thyroid function contributes to the pathogenesis of NAFLD remains unclear. Results: We used in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124172
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Oct 10, 2014
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Hanly, Narelle; Mireskandari, Shab; Juraskova, Ilona
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This article is from BMC Urology , volume 14 . Abstract Background: Despite the growing body of literature which highlights the potential for significant and enduring side-effects of prostate cancer treatment, there is limited research exploring the experience of living with the treatment-induced side-effects such as sexual dysfunction, and their repercussions for men and their partners. The aim of this qualitative study was to explore factors influencing psychosexual adjustment,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124511
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Oct 10, 2014
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Oct 10, 2014
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Chang, Chih-Han; Lei, Yao-Ning; Ho, Yi-Hung; Sung, Yu-Hsing; Lin, Ting-Sheng
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This article is from BioMedical Engineering OnLine , volume 13 . Abstract Background: The biomechanical property of the periodontal ligament (PDL) is important in orthodontics and prosthodontics. The objective of this study was to evaluate the feasibility of measuring the biomechanical behavior of the periodontal ligament using micro-computed tomography (micro-CT). Methods: A custom-made apparatus measured the force and displacement of a porcine PDL specimen within the micro-CT environment....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122535
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Oct 10, 2014
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Oct 10, 2014
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Zheng, Wenwen; Huang, Wan; Liu, Shue; Levitt, Roy C; Candiotti, Keith A; Lubarsky, David A; Hao, Shuanglin
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This article is from Molecular Pain , volume 10 . Abstract Background: HIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active antiretroviral therapy (HAART). Evidence shows that painful HIV sensory neuropathy is influenced by neuroinflammatory events that include the proinflammatory molecules, MAP Kinase, tumor necrosis factor-α (TNFα), stromal cell-derived factor 1-α (SDF1α), and C-X-C chemokine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126348
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Oct 10, 2014
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Yrigollen, Carolyn M; Martorell, Loreto; Durbin-Johnson, Blythe; Naudo, Montserrat; Genoves, Jordi; Murgia, Alessandra; Polli, Roberta; Zhou, Lili; Barbouth, Deborah; Rupchock, Abigail; Finucane, Brenda; Latham, Gary J; Hadd, Andrew; Berry-Kravis, Elizabeth; Tassone, Flora
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This article is from Journal of Neurodevelopmental Disorders , volume 6 . Abstract Background: The presence of AGG interruptions in the CGG repeat locus of the fragile X mental retardation 1 (FMR1) gene decreases the instability of the allele during transmission from parent to child, and decreases the risk of expansion of a premutation allele to a full mutation allele (the predominant cause of fragile X syndrome) during maternal transmission. Methods: To strengthen recent findings on the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126815
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Oct 10, 2014
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Zhou, Lili; Zheng, Shouyan; Xiao, Qiuyan; Ren, Luo; Xie, Xiaohong; Luo, Jian; Wang, Lijia; Huang, Ailong; Liu, Wei; Liu, Enmei
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This article is from BMC Infectious Diseases , volume 14 . Abstract Background: Human bocavirus is a newly discovered parvovirus. Multiple studies have confirmed the presence of human bocavirus1 (HBoV1) in respiratory tract samples of children. The viral load, presentation of single detection and its role as a causative agent of severe respiratory tract infections have not been thoroughly elucidated. Methods: We investigated the presence of HBoV1 by quantitative polymerase chain reaction (PCR)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125703
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Oct 10, 2014
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Oct 10, 2014
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Yan, Yongda; Sun, Yang; Li, Jiran; Hu, Zhenjiang; Zhao, Xuesen
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This article is from Nanoscale Research Letters , volume 9 . Abstract The single scratching test of polymer polycarbonate (PC) sample surface using an atomic force microscope (AFM) diamond tip for fabricating ripple patterns has been studied with the focus on the evaluation of the effect of the tip scratching angle on the pattern formation. The experimental results indicated that the different oriented ripples can be easily machined by controlling the scratching angles of the AFM. And, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124483
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Oct 10, 2014
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Kiani, Mohammad Javad; Harun, Fauzan Khairi Che; Ahmadi, Mohammad Taghi; Rahmani, Meisam; Saeidmanesh, Mahdi; Zare, Moslem
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This article is from Nanoscale Research Letters , volume 9 . Abstract Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125348
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Oct 9, 2014
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Oct 9, 2014
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Said, Sarmad; Alkhateeb, Haider; Cooper, Chad J; Rodriguez, Emmanuel; Trien, Remi; Hernandez, German T; Salameh, Hasan S
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This article is from International Medical Case Reports Journal , volume 7 . Abstract Introduction: Idiopathic cluster of differentiation 4 (CD4+) T-cell lymphocytopenia (ICL) is a rare non human immunodeficiency virus (HIV)-related syndrome with unclear natural history and prognosis that was first reported and defined in 1992. ICL has been observed in patients after the onset of an opportunistic infection without known immunosuppression. Case presentation: A 20-year-old Hispanic male patient...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124073
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Oct 9, 2014
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Lindenblatt, Nicole; El-Rabadi, Karem; Helbich, Thomas H; Czembirek, Heinrich; Deutinger, Maria; Benditte-Klepetko, Heike
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This article is from International Journal of Women's Health , volume 6 . Abstract Background: Silicone gel breast implants may silently rupture without detection. This has been the main reason for magnetic resonance imaging (MRI) of the augmented or reconstructed breast. The aim of the present study was to investigate the accuracy of MRI for implant rupture. Methods: Fifty consecutive patients with 85 silicone gel implants were included in the study. The mean age of the patients was 51 (range...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124066
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Oct 9, 2014
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Oct 9, 2014
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Olsson, Lovisa A; Hurtig-Wennlof, Anita; Nilsson, Torbjorn K
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This article is from Clinical Interventions in Aging , volume 9 . Abstract Background: Physical activity is claimed to be related to well-being and to a lower risk of cardiovascular disease. Therefore, the possible associations of well-being with physical activity and biomarkers of somatic health were studied in a sample of Swedish active seniors to determine the strength of these associations. Methods: Three hundred and eighty-nine community-dwelling senior citizens (127 men and 262 women) of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122258
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Oct 9, 2014
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Oct 9, 2014
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Haw, Randy Tatt Yhew; Tong, Chih Kong; Yew, Andrew; Lee, Han Chung; Phillips, James B; Vidyadaran, Sharmili
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This article is from Journal of Neuroinflammation , volume 11 . Abstract Background: We report a novel method of culturing microglia in three dimension (3D) using collagen as a substrate. By culturing microglia within a matrix, we aim to emulate the physical state of microglia embedded within parenchyma. Methods: BV2 microglia cell suspensions were prepared with type I collagen and cast into culture plates. To characterise the BV2 microglia cultured in 3D, the cultures were evaluated for their...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128540
