7
7.0
Jun 6, 2021
06/21
by
(sonicdudemg)
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Customized version of http://www.thingiverse.com/thing:40703 Created with Customizer! http://www.thingiverse.com/apps/customizer/run?thing_id=40703
Topics: Mobile Phone, customized, stl, thingiverse
7
7.0
Jun 8, 2021
06/21
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(strainstress)
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eye 7
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Customized version of http://www.thingiverse.com/thing:62800 Created with Customizer! http://www.thingiverse.com/apps/customizer/run?thing_id=62800
Topics: customized, stl, Camera, thingiverse
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Oct 24, 2014
10/14
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Abreu, Mauro Henrique Nogueira Guimaraes; Sanglard-Oliveira, Carla Aparecida; Jaruche, Abdul Rahman Mustafa; Mambrini, Juliana Vaz de Melo; Werneck, Marcos Azeredo Furquim; Lucas, Simone Dutra
texts
eye 36
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This article is from Human Resources for Health , volume 11 . Abstract Background: To describe some sociodemographic and educational characteristics of oral health technicians (OHTs) in public primary health care teams in the state of Minas Gerais, Brazil. Methods: A cross-sectional descriptive study was performed based on the telephone survey of a representative sample comprising 231 individuals. A pre-tested instrument was used for the data collection, including questions on gender, age in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878034
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54
Oct 23, 2014
10/14
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Ahmadi, Fatemeh; Dabirian, Sara; Faizi, Mehrdad; Tabatabai, Sayyed Abbas; Beiki, Davood; Shahhosseini, Soraya
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eye 54
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3, 4-oxadiazolo[a,2,3]-pyrimidine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977056
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53
Oct 21, 2014
10/14
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Apel, Mareike; Maia, Vivian PL; Zeidan, Mohamed; Schinkoethe, Claudia; Wolf, Gunter; Reinhart, Konrad; Sakr, Yasser
texts
eye 53
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This article is from Critical Care , volume 17 . Abstract Introduction: End-stage renal disease (ESRD) is associated with an increased propensity for critical illness, but whether ESRD is independently associated with a greater risk of death after major surgical procedures is unclear. Methods: This was a retrospective analysis of prospectively collected data from all adult (>18 years) patients admitted to a 50-bed surgical intensive care unit (ICU) between January 2004 and January 2009....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057028
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43
Oct 24, 2014
10/14
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Atsukawa, Masanori; Tsubota, Akihito; Shimada, Noritomo; Kondo, Chisa; Itokawa, Norio; Nakagawa, Ai; Hashimoto, Satomi; Fukuda, Takeshi; Matsushita, Yoko; Kidokoro, Hideko; Narahara, Yoshiyuki; Nakatsuka, Katsuhisa; Iwakiri, Katsuhiko; Kawamoto, Chiaki; Sakamoto, Choitsu
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eye 43
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This article is from Hepatitis Monthly , volume 13 . Abstract Background: Serum vitamin D concentration is reported to show a decrease in older age. Patients with chronic hepatitis C (CHC) in Japan are older on average than those in Western countries. Moreover, the outcome of pegylated-interferon (PEG-IFN)/ ribavirin therapy combined with vitamin D in elderly patients is unclear. Objectives: This pilot study explored the efficacy and safety of alfacalcidol as vitamin D source in PEG-IFN/...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877658
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77
Oct 21, 2014
10/14
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Bechir, Markus; Puhan, Milo A; Fasshauer, Mario; Schuepbach, Reto A; Stocker, Reto; Neff, Thomas A
texts
eye 77
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This article is from Critical Care , volume 17 . Abstract Introduction: There are limited data on the efficacy of early fluid resuscitation with third-generation hydroxyethyl starch (HES 130) in burn injury. Adverse effects of HES on survival and organ function have been reported. Methods: In this randomized, controlled, double-blind trial, 48 patients with severe burn injury were assigned to receive either lactated Ringer’s solution plus 6% HES 130/0.4 in a ratio of 2:1 or lactated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057504
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27
Oct 23, 2014
10/14
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Benedek, Mathias; Beaty, Roger; Jauk, Emanuel; Koschutnig, Karl; Fink, Andreas; Silvia, Paul J.; Dunst, Beate; Neubauer, Aljoscha C.
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eye 27
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This article is from Neuroimage , volume 90 . Abstract Neuroscience research has thoroughly studied how nonliteral language is processed during metaphor comprehension. However, it is not clear how the brain actually creates nonliteral language. Therefore, the present study for the first time investigates the neural correlates of metaphor production. Participants completed sentences by generating novel metaphors or literal synonyms during functional imaging. Responses were spoken aloud in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951481
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90
Oct 23, 2014
10/14
by
Biglar, Mahmood; Sufi, Hessameddin; Bagherzadeh, Kowsar; Amanlou, Massoud; Mojab, Faraz
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eye 90
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Infection with Helicobacter pyloriis the most common cause of stomach and duodenal ulcers. About more than 80 % of people are infected with H. pylori in developing countries. H. pylori uses urease enzyme product “ammonia” in order to neutralize and protect itself from the stomach acidic condition and urease enzyme activity has been shown to be essential to the colonization of H. pylori. Inhibitory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977070
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39
Oct 24, 2014
10/14
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Blazevic, Tina; Schaible, Anja M.; Weinhaupl, Katharina; Schachner, Daniel; Nikels, Felix; Weinigel, Christina; Barz, Dagmar; Atanasov, Atanas G.; Pergola, Carlo; Werz, Oliver; Dirsch, Verena M.; Heiss, Elke H.
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This article is from Cardiovascular Research , volume 101 . Abstract Aims: The small molecule indirubin-3′-monoxime (I3MO) has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation and neointima formation in vivo. The influence of I3MO on VSMC migration and vascular inflammation, two additional key players during the onset of atherosclerosis and restenosis, should be investigated. Methods and results: We examined the influence of I3MO on VSMC migration, with focus on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928003
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63
Oct 28, 2014
10/14
by
Blozik, Eva; Scherer, Martin; Lacruz, Maria E; Ladwig, Karl-Heinz
texts
eye 63
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This article is from BMC Family Practice , volume 14 . Abstract Background: Screening for depressive disorders in the general adult population is recommended, however, it is unclear which instruments combine user friendliness and diagnostic utility. We evaluated the test performance of a yes/no single item screener for depressive disorders (“Have you felt depressed or sad much of the time in the past year?”) in comparison to the depressive disorder module of the Patient Health Questionnaire...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906912
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62
Oct 12, 2014
10/14
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Buck, Danielle; Smith, John E.; Chung, Charles S.; Ono, Yasuko; Sorimachi, Hiroyuki; Labeit, Siegfried; Granzier, Henk L.
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eye 62
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This article is from The Journal of General Physiology , volume 143 . Abstract Changes in titin splicing resulting in decreased size and increased stiffness lead to pathological changes in skeletal muscle.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001778
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56
Oct 27, 2014
10/14
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Carlini, Federico; Traore, Karim; Cherouat, Nissem; Roubertoux, Pierre; Buhler, Stephane; Cortey, Marti; Simon, Sophie; Doumbo, Ogobara; Chiaroni, Jacques; Picard, Christophe; Di Cristofaro, Julie
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This article is from PLoS ONE , volume 8 . Abstract The HLA-G molecule plays an important role in immunomodulation. In a previous study carried out on a southern French population our team showed that HLA-G haplotypes, defined by SNPs in the coding region and specific SNPs located in 5′URR and 3′UTR regulatory regions, are associated with differential soluble HLA-G expression (sHLA-G). Furthermore, the structure of these HLA-G haplotypes appears to be conserved in geographically distant...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871591
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64
Oct 28, 2014
10/14
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Carnie, A; Lin, J; Aicher, B; Leon, B; Courville, A B; Sebring, N G; de Jesus, J; DellaValle, D M; Fitzpatrick, B D; Zalos, G; Powell-Wiley, T M; Chen, K Y; Cannon, R O
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This article is from Nutrition & Diabetes , volume 3 . Abstract Objective:: Obesity in the United States is highly prevalent, approaching 60% for black women. We investigated whether nutrition education sessions at the work place added to internet-based wellness information and exercise resources would facilitate weight and fat mass loss in a racially diverse population of overweight female employees. Methods:: A total of 199 (average body mass index 33.9±6.3 kg m−2) nondiabetic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877430
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57
Oct 24, 2014
10/14
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Cerosaletti, Karen; Schneider, Anya; Schwedhelm, Katharine; Frank, Ian; Tatum, Megan; Wei, Shan; Whalen, Elizabeth; Greenbaum, Carla; Kita, Mariko; Buckner, Jane; Long, S. Alice
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This article is from PLoS ONE , volume 8 . Abstract IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4+CD25hiFOXP3+ regulatory T cells (Treg); a cell type that plays an integral role in maintaining tolerance. Thus, we hypothesized that decreased response to IL-2 may be a common phenotype of subjects who have autoimmune diseases associated with variants in the IL2RA locus, including T1D and MS, particularly in cells expressing the high affinity IL-2R alpha...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871703
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28
Oct 28, 2014
10/14
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Choulagai, Bishnu; Onta, Sharad; Subedi, Narayan; Mehata, Suresh; Bhandari, Gajananda P; Poudyal, Amod; Shrestha, Binjwala; Mathai, Matthews; Petzold, Max; Krettek, Alexandra
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eye 28
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This article is from BMC International Health and Human Rights , volume 13 . Abstract Background: Skilled birth attendants (SBAs) provide important interventions that improve maternal and neonatal health and reduce maternal and neonatal mortality. However, utilization and coverage of services by SBAs remain poor, especially in rural and remote areas of Nepal. This study examined the characteristics associated with utilization of SBA services in mid- and far-western Nepal. Methods: This...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878020
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45
Oct 26, 2014
10/14
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Cihalova, Daniela; Hofman, Jakub; Ceckova, Martina; Staud, Frantisek
texts
eye 45
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This article is from PLoS ONE , volume 8 . Abstract Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine, flavopiridol and SNS-032) with the ABCB1 transporter. Four of the compounds inhibited efflux of two ABCB1...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871618
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55
Oct 26, 2014
10/14
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Cowen, Laura L E; Besbeas, Panagiotis; Morgan, Byron J T; Schwarz, Carl J
texts
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This article is from Ecology and Evolution , volume 4 . Abstract Little attention has been paid to the use of multi-sample batch-marking studies, as it is generally assumed that an individual's capture history is necessary for fully efficient estimates. However, recently, Huggins et al. (2010) present a pseudo-likelihood for a multi-sample batch-marking study where they used estimating equations to solve for survival and capture probabilities and then derived abundance estimates using a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925384
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46
Oct 23, 2014
10/14
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DUONG, HONG-QUAN; YI, YONG WEON; KANG, HYO JIN; HONG, YOUNG BIN; TANG, WENXI; WANG, ANTAI; SEONG, YEON-SUN; BAE, INSOO
texts
eye 46
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This article is from International Journal of Oncology , volume 44 . Abstract We describe the potential benefit of PIK-75 in combination of gemcitabine to treat pancreatic cancer in a preclinical mouse model. The effect of PIK-75 on the level and activity of NRF2 was characterized using various assays including reporter gene, quantitative PCR, DNA-binding and western blot analyses. Additionally, the combinatorial effect of PIK-75 and gemcitabine was evaluated in human pancreatic cancer cell...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928470
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43
Oct 24, 2014
10/14
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Daniel, Christoph; Vogelbacher, Regina; Stief, Andrea; Grigo, Christina; Hugo, Christian
texts
eye 43
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This article is from PLoS ONE , volume 8 . Abstract We recently identified Thrombospondin-2 (TSP-2) as a regulator of matrix remodelling and inflammation in experimental kidney disease by using TSP-2 null mice and successfully proved TSP-2 overexpression as a therapeutic concept in a short term glomerulonephritis model in the rat. In this current study, we investigated if long-term TSP-2 overexpression is also capable to ameliorate the progression of chronic kidney disease in the setting of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871554
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65
Oct 29, 2014
10/14
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Danzeisen, Jessica L.; Calvert, Alamanda J.; Noll, Sally L.; McComb, Brian; Sherwood, Julie S.; Logue, Catherine M.; Johnson, Timothy J.
texts
eye 65
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This article is from PeerJ , volume 1 . Abstract Because of concerns related to the use of antibiotics in animal agriculture, antibiotic-free alternatives are greatly needed to prevent disease and promote animal growth. One of the current challenges facing commercial turkey production in Minnesota is difficulty obtaining flock average weights typical of the industry standard, and this condition has been coined “Light Turkey Syndrome” or LTS. This condition has been identified in Minnesota...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883494
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67
Oct 29, 2014
10/14
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Darwish, Omar; Slovin, Janet P; Kang, Chunying; Hollender, Courtney A; Geretz, Aviva; Houston, Sam; Liu, Zhongchi; Alkharouf, Nadim W
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eye 67
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This article is from BMC Plant Biology , volume 13 . Abstract Background: Fragaria vesca, a diploid strawberry species commonly known as the alpine or woodland strawberry, is a versatile experimental plant system and an emerging model for the Rosaceae family. An ancestral F. vesca genome contributed to the genome of the octoploid dessert strawberry (F. ×ananassa), and the extant genome exhibits synteny with other commercially important members of the Rosaceae family such as apple and peach. To...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878773
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55
Oct 24, 2014
10/14
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Del Fabbro, Cristian; Scalabrin, Simone; Morgante, Michele; Giorgi, Federico M.
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eye 55
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This article is from PLoS ONE , volume 8 . Abstract Next Generation Sequencing is having an extremely strong impact in biological and medical research and diagnostics, with applications ranging from gene expression quantification to genotyping and genome reconstruction. Sequencing data is often provided as raw reads which are processed prior to analysis 1 of the most used preprocessing procedures is read trimming, which aims at removing low quality portions while preserving the longest high...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871669
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Oct 24, 2014
10/14
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Denkinger, Claudia M.; Kalantri, Yatiraj; Schumacher, Samuel G.; Michael, Joy S.; Shankar, Deepa; Saxena, Arvind; Sriram, Natarajan; Balamugesh, Thangakunam; Luo, Robert; Pollock, Nira R.; Pai, Madhukar; Christopher, Devasahayam J.
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eye 61
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This article is from PLoS ONE , volume 8 . Abstract Existing diagnostic tests for pleural tuberculosis (TB) have inadequate accuracy and/or turnaround time. Interferon-gamma (IFNg) has been identified in many studies as a biomarker for pleural TB. Our objective was to develop a lateral flow, immunochromatographic test (ICT) based on this biomarker and to evaluate the test in a clinical cohort. Because IFNg is commonly present in non-TB pleural effusions in low amounts, a diagnostic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871622
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21
Oct 23, 2014
10/14
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Dhingra, Anil; Kochar, Rohit; Banerjee, Satyabrat; Srivastava, Punit
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eye 21
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This article is from Journal of Conservative Dentistry : JCD , volume 17 . Abstract Aims:: This study compared the canal curvature modifications after instrumentation with One Shape (Micro Mega) rotary file and Wave One primary reciprocating file (Dentsply Maillefer, Ballaigues, Switzerland). Materials and Methods:: Thirty International Organization for Standardization 15, 0.02 taper, Endo Training Blocks (Dentsply Maillefer) were used. In all specimens working length (WL) was established at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001269
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48
Oct 24, 2014
10/14
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Dong, Haibo; Wang, Shaoqing; Jia, Yuanyuan; Ni, Yingdong; Zhang, Yuanshu; Zhuang, Su; Shen, Xiangzhen; Zhao, Ruqian
texts
eye 48
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This article is from PLoS ONE , volume 8 . Abstract Purpose: The mechanism underlying the decline in milk quality during periods of feeding high-concentrate diets to dairy ruminants is not well documented. The aim of this study was to investigate the metabolic changes in the liver that contribute to the input of substrate precursors to the mammary gland after feeding a high-concentrate diet to lactating goats for a long period. Experimental Design: Eight mid-lactating goats with rumen cannulas...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871605
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66
Oct 28, 2014
10/14
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Dong, Zijian; Song, Tiecheng; Yuan, Chuang
texts
eye 66
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This article is from PLoS ONE , volume 8 . Abstract It is an effective strategy to use both genetic perturbation data and gene expression data to infer regulatory networks that aims to improve the detection accuracy of the regulatory relationships among genes. Based on both types of data, the genetic regulatory networks can be accurately modeled by Structural Equation Modeling (SEM). In this paper, a linear regression (LR) model is formulated based on the SEM, and a novel iterative scheme using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871530
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44
Oct 24, 2014
10/14
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Driesen, Ronald B.; Nagaraju, Chandan K.; Abi-Char, Joelle; Coenen, Tamara; Lijnen, Paul J.; Fagard, Robert H.; Sipido, Karin R.; Petrov, Victor V.
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eye 44
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This article is from Cardiovascular Research , volume 101 . Abstract Aims: Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility. Methods and results: Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation. Fb spontaneously differentiated to proliferating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928002
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59
Oct 26, 2014
10/14
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Farshid, Ahmad; Pathak, Rajeev; Shadbolt, Bruce; Arnolda, Leonard; Talaulikar, Girish
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eye 59
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This article is from BMC Nephrology , volume 14 . Abstract Background: Cardiovascular disease is a major cause of death in patients with stage 4–5 Chronic Kidney disease (CKD, eGFR 75 years, previous history of MI, diastolic dysfunction and detectable serum troponin T were significant independent predictor of mortality (P 75 years, history of MI, diastolic dysfunction and troponin T were independent predictors of mortality.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878021
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Oct 23, 2014
10/14
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Flynn, Tanya J; Phipps-Green, Amanda; Hollis-Moffatt, Jade E; Merriman, Marilyn E; Topless, Ruth; Montgomery, Grant; Chapman, Brett; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R
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eye 62
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This article is from Arthritis Research & Therapy , volume 15 . Abstract Introduction: There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study was to test genetic variation across the SLC22A11/SLC22A12 locus for association with risk of gout in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978909
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Oct 27, 2014
10/14
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Hampton, David W; Serio, Andrea; Pryce, Gareth; Al-Izki, Sarah; Franklin, Robin JM; Giovannoni, Gavin; Baker, David; Chandran, Siddharthan
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eye 42
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This article is from Acta Neuropathologica Communications , volume 1 . Abstract Backgound: Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the absence of therapies for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895761
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Oct 27, 2014
10/14
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Hoarau, Jean-Jacques; Gay, Frederick; Pelle, Olivier; Samri, Assia; Jaffar-Bandjee, Marie-Christine; Gasque, Philippe; Autran, Brigitte
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eye 53
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This article is from PLoS ONE , volume 8 . Abstract To characterize the immunity developed by patients infected by chikungunya virus (CHIKV), we studied the intensity and specificity of CHIKV-specific T cells mediated responses in chronic and recovered patients at 12 to 24 months post-infection. T cells were challenged in vitro against CHIKV synthetic peptides covering the length of three viral proteins, capsid, E2 and nsP1 proteins as well as all inactivated virus particles. Cytokine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871564
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74
Oct 23, 2014
10/14
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Hooshfar, Shirin; Mortazavi, Seyed Alireza; Piryaei, Mohammad; Ramandi Darzi, Hossein; Shahsavari, Nahid; Kobarfard, Farzad
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A gradient reversed-phase high performance liquid chromatography (HPLC) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity used in infertility treatment. The HPLC method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ICH guidelines. The chromatographic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977052
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Oct 23, 2014
10/14
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Howard, Thomas P.; Fahy, Brendan; Leigh, Fiona; Howell, Phil; Powell, Wayne; Greenland, Andy; Trafford, Kay; Smith, Alison M.
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eye 12
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This article is from Journal of Cereal Science , volume 59 . Abstract The effects on barley starch and grain properties of four starch synthesis mutations were studied during the introgression of the mutations from diverse backgrounds into an elite variety. The lys5f (ADPglucose transporter), wax (granule-bound starch synthase), isa1 (debranching enzyme isoamylase 1) and sex6 (starch synthase IIa) mutations were introgressed into NFC Tipple to give mutant and wild-type BC2F4 families with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990431
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Oct 25, 2014
10/14
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Huang, Huan; Chen, Jiao; Liu, Hongde; Sun, Xiao
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eye 53
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This article is from BMC Genomics , volume 14 . Abstract Background: It has been reported that 3' end processing is coupled to transcription and nucleosome depletion near the polyadenylation sites in many species. However, the association between nucleosome occupancy and polyadenylation site usage is still unclear. Results: By systematic analysis of high-throughput sequencing datasets from the human genome, we found that nucleosome occupancy patterns are different around the polyadenylation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879661
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Oct 29, 2014
10/14
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Huang, Peirong; Niu, Wenquan; Ni, Zhentian; Wang, Renzuo; Sun, Xiaodong
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eye 53
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This article is from PLoS ONE , volume 8 . Abstract Background: Central retinal vein occlusion (CRVO) associates with severe vision outcome and no proven beneficial treatment. Our meta-analysis intended to appraise the efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) agents in macular edema (ME) following CRVO. Methods: Data were collected and analyzed by Review Manager 5.2.1. We employed a random-effects model to eliminate between-study heterogeneity. Nfs (called...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871640
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48
Oct 24, 2014
10/14
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Huw, L-Y; O'Brien, C; Pandita, A; Mohan, S; Spoerke, J M; Lu, S; Wang, Y; Hampton, G M; Wilson, T R; Lackner, M R
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This article is from Oncogenesis , volume 2 . Abstract Agents targeting the PI3K/mTOR signaling axis have shown promise in early-phase clinical trials and are currently being studied in later stages of clinical development in multiple indications. Experience with other targeted agents suggests that clinical responses may be short-lived because of acquired resistance to therapy. Here, we report preclinical modeling of acquired resistance in a HER2-positive, PIK3CA mutant breast cancer cell line,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940863
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Oct 28, 2014
10/14
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Hyakuna, Nobuyuki; Shimomura, Yasuto; Watanabe, Arata; Taga, Takashi; Kikuta, Atsushi; Matsushita, Takeji; Kogawa, Kazuhiro; Kawakami, Chihiro; Horikoshi, Yasuo; Iwai, Tsuyako; Okamoto, Yasuhiro; Tsurusawa, Masahito; Asami, Keiko
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This article is from Journal of Pediatric Hematology/Oncology , volume 36 . Abstract Supplemental Digital Content is available in the text.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872830
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Oct 12, 2014
10/14
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Iijima, Takatoshi; Iijima, Yoko; Witte, Harald; Scheiffele, Peter
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This article is from The Journal of Cell Biology , volume 204 . Abstract Cell type–specific expression of the splicing regulator SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912522
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Oct 28, 2014
10/14
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Jung, Mi Jin; Byun, Ha Young; Lee, Chang Hee; Moon, Seung Won; Oh, Min-Kyun; Shin, Heesuk
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Medial antebrachial cutaneous (MABC) nerve injury associated with iatrogenic causes has been rarely reported. Local anesthesia may be implicated in the etiology of such injury, but has not been reported. Two patients with numbness and painful paresthesia over the medial aspect of the unilateral forearm were referred for electrodiagnostic study, which revealed MABC nerve lesion in each case. The highly selective nature...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895535
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Oct 23, 2014
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Kakhki, Samaneh; Shahosseini, Sorayya; Zarghi, Afshin
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Two set of 2-aryl-5, 6-dihydropyrrolo [2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithelial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977055
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Oct 24, 2014
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Kamath, Manjunath Srinivas; Ahmed, Shiek SSJ; Dhanasekaran, M; Santosh, S Winkins
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This article is from International Journal of Nanomedicine , volume 9 . Abstract Biomaterials-based three-dimensional scaffolds are being extensively investigated in bone tissue engineering. A potential scaffold should be osteoconductive, osteoinductive, and osteogenic for enhanced bone formation. In this study, a three-dimensional porous polycapro-lactone (PCL) scaffold was engineered for prolonged release of resveratrol. Resveratrol-loaded albumin nanoparticles (RNP) were synthesized and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875521
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Oct 23, 2014
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Khatibi, Mohsen; Rasekh, Hamid Reza; Shahverdi, Zohreh; jamshidi, Hamid Reza
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Human Papilloma Virus (HPV) vaccine has been added recently to the Iran Drug List. So, decision makers need information beyond that available from RCTs to recommend funding for this vaccination program to add it to the National Immunization program in Iran. Modeling and economic studies have addressed some of those information needs in foreign countries. In order to determine the long term benefit of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977074
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Oct 25, 2014
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Kim, Myung-Sunny; Yamamoto, Yasuhiko; Kim, Kyungjin; Kamei, Nozomu; Shimada, Takeshi; Liu, Libin; Moore, Kristin; Woo, Ju Rang; Shoelson, Steven E.; Lee, Jongsoon
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This article is from PLoS ONE , volume 8 . Abstract It is increasingly accepted that chronic inflammation participates in obesity-induced insulin resistance and type 2 diabetes (T2D). Salicylates and thiazolidinediones (TZDs) both have anti-inflammatory and anti-hyperglycemic properties. The present study compared the effects of these drugs on obesity-induced inflammation in adipose tissue (AT) and AT macrophages (ATMs), as well as the metabolic and immunological phenotypes of the animal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871540
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Oct 24, 2014
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Kim, Soo Yeon; Park, Hye Kyung; Song, Dae Heon; Chung, Myung Eun; Kim, Young Moon; Woo, Jae Hyun
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Ptosis could be caused by oculomotor nerve palsy in the midbrain infarction. Bilateral ptosis has been reported in several reports, which focused on clinical characteristics of midbrain infarction. Little research attention has been paid to the treatment of patients with bilateral ptosis in midbrain infarction. We experienced a case of severe bilateral ptosis occurring after midbrain infarction. The patient could not...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895531
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Oct 24, 2014
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Ko, Hsin-Kuo; Yu, Wen-Kuang; Lien, Te-Cheng; Wang, Jia-Horng; Slutsky, Arthur S.; Zhang, Haibo; Kou, Yu Ru
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This article is from PLoS ONE , volume 8 . Abstract Intensive care unit (ICU)-acquired bacteremia (IAB) is associated with high medical expenditure and mortality. Mechanically ventilated patients represent one third of all patients admitted to ICU, but the clinical features and outcomes in mechanically ventilated patients who develop IAB remain unknown. We conducted a 3-year retrospective observational cohort study, and 1,453 patients who received mechanical ventilation on ICU admission were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871544
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Oct 28, 2014
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Ko, Sung Hwa; Shin, Yong Beom; Min, Ji Hong; Shin, Myung Jun; Chang, Jae Hyeok; Shin, Yong-Il; Ko, Hyun-Yoon
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To investigate the effect of botulinum toxin type A (BTA) injection into the salivary gland and to evaluate the changes of drooling in varied postures in tetraplegic patients with brain injury. Methods: Eight tetraplegic patients with brain injury were enrolled. BTA was injected into each parotid and submandibular gland of both sides under ultrasonographic guidance. Drooling was measured by a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895519
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Oct 26, 2014
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Konkel, Michael E; Samuelson, Derrick R; Eucker, Tyson P; Shelden, Eric A; O'Loughlin, Jason L
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This article is from Cell Communication and Signaling : CCS , volume 11 . Abstract Caveolae are 25–100 nm flask-like membrane structures enriched in cholesterol and glycosphingolipids. Researchers have proposed that Campylobacter jejuni require caveolae for cell invasion based on the finding that treatment of cells with the cholesterol-depleting compounds filipin III or methyl-β-cyclodextrin (MβCD) block bacterial internalization in a dose-dependent manner. The purpose of this study was to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880046
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Oct 27, 2014
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Kurata, Akira; Kawaguchi, Naoto; Kido, Teruhito; Inoue, Katsuji; Suzuki, Jun; Ogimoto, Akiyoshi; Funada, Jun-ichi; Higaki, Jitsuo; Miyagawa, Masao; Vembar, Mani; Mochizuki, Teruhito
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This article is from PLoS ONE , volume 8 . Abstract Background: The aim of this study was to investigate the correlation of the qualitative transmural extent of hypoperfusion areas (HPA) using stress dynamic whole-heart computed tomography perfusion (CTP) imaging by 256-slice CT with CTP-derived myocardial blood flow (MBF) for the estimation of the severity of coronary artery stenosis. Methods and Results: Eleven patients underwent adenosine triphosphate (0.16 mg/kg/min, 5 min) stress dynamic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871670
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Oct 27, 2014
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Lam, Monika My-Y; Martin-Creuzburg, Dominik; Rothhaupt, Karl-Otto; Safi, Kamran; Yohannes, Elizabeth; Salvarina, Ioanna
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This article is from PLoS ONE , volume 8 . Abstract Stable isotope and fatty acid signatures of biomaterials can provide important information about the dietary niche of animals. Stable isotope and fatty acid signatures differ between aquatic and terrestrial food webs, and therefore can be used to assess the aquatic and terrestrial contributions to the diets of species. We studied faecal samples of three co-occurring bat species with known differences in feeding preferences. The aim was to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871553
