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83
Oct 24, 2014
10/14
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Cherry, Jonathan J.; Rietz, Anne; Malinkevich, Anna; Liu, Yuqi; Xie, Meng; Bartolowits, Matthew; Davisson, V. Jo; Baleja, James D.; Androphy, Elliot J.
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This article is from PLoS ONE , volume 8 . Abstract Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, “high-risk” HPV E6 proteins bind to and modify the target specificity of the ubiquitin ligase E6AP (E6 associated protein). This E6-dependent loss of p53 enables the virus to bypass host cell defenses and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871595
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3.0
Jun 30, 2018
06/18
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Chun-Yang Wang; Xue-Mei Zong; Cui-Feng Sun; Hong Zhang; Zhen-Xue Song
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eye 3
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The quantum thermodynamic property of the fractional damping system is investigated extensively. A fractional power-law decaying entropy function is revealed which presents another evidence for the validity of the third law of thermodynamics in the quantum dissipative region. Several non-trivial characters are excavated such as that the entropy varies from a non-linear diverging function to a semi-linear decaying function of the fractional exponent as the temperature tends to absolute zero.
Topics: Quantum Physics, Statistical Mechanics, Condensed Matter
Source: http://arxiv.org/abs/1401.1425
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42
Oct 24, 2014
10/14
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Liu, Limin; Zhao, Ying; Xie, Keming; Sun, Xiaodong; Gao, Yuzhen; Wang, Zufeng
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This article is from PLoS ONE , volume 8 . Abstract Estrogen is traditionally thought to exert genomic actions through members of the nuclear receptor family. Here, we investigated the rapid nongenomic effects of 17β-estradiol (E2) on tumor necrosis factor α (TNF-α) production following lipopolysaccharide (LPS) stimulation in mouse bone marrow-derived macrophages (BMMs). We found that LPS induced TNF-α production in BMMs via phosphorylation of p38 mitogen-activated protein kinase (MAPK). E2...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871562
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49
Oct 29, 2014
10/14
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Risseeuw, Eddy; Venglat, Prakash; Xiang, Daoquan; Komendant, Kristina; Daskalchuk, Tim; Babic, Vivijan; Crosby, William; Datla, Raju
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This article is from PLoS ONE , volume 8 . Abstract Plants are unique in their ability to continuously produce new meristems and organ primordia. In Arabidopsis, the transcription factor LEAFY (LFY) functions as a master regulator of a gene network that is important for floral meristem and organ specification. UNUSUAL FLORAL ORGANS (UFO) is a co-activator of LEAFY and is required for proper activation of APETALA3 in the floral meristem during the specification of stamens and petals. The ufo...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871548
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51
Oct 27, 2014
10/14
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Shang, Ruofeng; Wang, Shengyu; Xu, Ximing; Yi, Yunpeng; Guo, Wenzhu; YuLiu,; Liang, Jianping
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This article is from PLoS ONE , volume 8 . Abstract Novel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae. Compound 5b showed the highest antibacterial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871055
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62
Oct 28, 2014
10/14
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Sun, Guixiang; Zhou, Yanni; Li, Hongsheng; Guo, Yingjia; Shan, Juan; Xia, Mengjuan; Li, Youping; Li, Shengfu; Long, Dan; Feng, Li
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eye 62
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This article is from Journal of Biomedical Science , volume 20 . Abstract Background: Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the key regulators of hypoxia/ischemia. MicroRNA-494 (miR-494) had cardioprotective effects against ischemia/reperfusion (I/R)-induced injury, but its functional relationship with HIF-1α was unknown. This study was undertaken to determine if miR-494 was involved in the induction of HIF-1α. Results: Quantitative RT-PCR showed that miR-494 was up-regulated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881011
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57
Oct 26, 2014
10/14
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Tan, Jin-zhi; Yan, Yan; Wang, Xiao-xi; Jiang, Yi; Xu, H Eric
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This article is from Acta Pharmacologica Sinica , volume 35 . Abstract EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3. Overexpression of EZH2 has been found in a wide range of cancers, including those of the prostate and breast. In this review, we address the current understanding of the oncogenic role of EZH2, including its PRC2-dependent transcriptional repression and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914023
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48
Oct 25, 2014
10/14
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Wang, Lin; Xie, Li; Wang, Jun; Shen, Jie; Liu, Baorui
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eye 48
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This article is from BMC Gastroenterology , volume 13 . Abstract Background: At present, no study has compared the correlation between SULF2, WRN promoter methylation and clinicopathological parameters of patients with gastric cancer and the sensitivity to irinotecan (CPT-11). Methods: We collected 102 fresh tumor tissues from pathologically diagnosed gastric carcinoma patients. Methylation specific PCR was used to detect the promoter methylation of SULF2 and WRN. The chemosensitivity of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877991
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58
Oct 24, 2014
10/14
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Wu, Haibin; Qin, Jinxia; Han, Jun; Zhao, Xiaojie; Ouyang, Shuhong; Liang, Yong; Zhang, Dong; Wang, Zhenzhong; Wu, Qiuhong; Xie, Jingzhong; Cui, Yu; Peng, Huiru; Sun, Qixin; Liu, Zhiyong
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This article is from PLoS ONE , volume 8 . Abstract The wax (glaucousness) on wheat leaves and stems is mainly controlled by two sets of genes: glaucousness loci (W1 and W2) and non-glaucousness loci (Iw1 and Iw2). The non-glaucousness (Iw) loci act as inhibitors of the glaucousness loci (W). High-resolution comparative genetic linkage maps of the wax inhibitors Iw1 originating from Triticum dicoccoides, and Iw2 from Aegilops tauschii were developed by comparative genomics analyses of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871689
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45
Oct 25, 2014
10/14
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Xia, Sujian; Zhang, Weidong; Huang, Liting; Jiang, Hong
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eye 45
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This article is from PLoS ONE , volume 8 . Abstract Objective: A meta-analysis was conducted to investigate the efficacy and safety of three main iron chelators, namely, deferoxamine (DFO), deferiprone (DFP) and deferasirox (DFX) for thalassemia major (TM) patients. Methods: Randomized controlled trials comparing mono-therapy DFO, DFP, DFX and combined DFP with DFO therapy in TM patients from January 1990 to December 2012 were searched and selected. Two independent authors assessed data from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871701
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48
Oct 25, 2014
10/14
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Xiao, Wenhua; Dong, Weiwei; Zhang, Caihong; Saren, Gaowa; Geng, Paili; Zhao, Huixia; Li, Quiwen; Zhu, Jianhua; Li, Guanghui; Zhang, Shufang; Ye, Ming
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eye 48
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This article is from European Journal of Medical Research , volume 18 . Abstract Background: Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce anti-tumor immune responses. In the current study, we aim to investigate the regulatory effect of the epigenetic drug MS-275 on hepatoma G2 (HepG2) cell-derived exosomes, especially for their immunostimulatory properties and alteration of some non-specific immune protein expression, such as heat shock...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881022
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6.0
Jun 30, 2018
06/18
by
Xiaomin Bao
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eye 6
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We use derivatives to prove the equivalences between MacWilliams identity and its four equivalent forms, and present new interpretations for the four equivalent forms. Our results explicitly give out the relationships between MacWilliams identity and its four equivalent forms.
Topics: Mathematics, Computing Research Repository, Information Theory
Source: http://arxiv.org/abs/1401.3582
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39
Oct 28, 2014
10/14
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Xing, Xiaojing; Yang, Ji; Yang, Xiaoqin; Wei, Yi; Zhu, Lubing; Gao, Di; Li, Ming
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This article is from PLoS ONE , volume 8 . Abstract Recent reports have demonstrated that endothelial cells are involved in vascular inflammatory injury in systemic sclerosis (SSc) and interleukin-17A (IL-17A) plays a crucial role in the pathogenesis of SSC. However, little is known about the effects of IL-17A on endothelial cell inflammation in SSC. The aim of our study was to investigate the role of IL-17A in endothelial inflammation. Here, we showed that IL-17A mRNA and protein levels were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871633
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49
Oct 28, 2014
10/14
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Ye, Dongmei; Xu, Yiming; Fu, Tengfei; Zhang, Han; Feng, Xianxuan; Wang, Gang; Jiang, Lan; Bai, Yuehong
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eye 49
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This article is from BMC Musculoskeletal Disorders , volume 14 . Abstract Background: Research studies on the influence of radiofrequency electromagnetic radiation on implants in vitro have failed to investigate temperature changes in the tissues adjacent to the implants under microwave therapy. We therefore, used a rabbit model in an effort to determine the impact of microwave therapy on temperature changes in tissues adjacent to the titanium alloy implants and the safety profile thereof....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880173
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Oct 27, 2014
10/14
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Zhou, Jian; Mo, Yifei; Li, Hong; Ran, Xingwu; Yang, Wenying; Li, Qiang; Peng, Yongde; Li, Yanbing; Gao, Xin; Luan, Xiaojun; Wang, Weiqing; Xie, Yun; Jia, Weiping
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eye 52
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This article is from PLoS ONE , volume 8 . Abstract Objective: Since there is a paucity of reference data in the literature to indicate the relationship between HbA1c, and 24 h mean blood glucose (MBG) from continuous glucose monitoring (CGM) in Chinese populations, we described the above relationship in adult Chinese subjects with different glucose tolerance status. Methods: Seven-hundred-and-forty-two individuals without history of diabetes were included to the study at 11 hospitals in urban...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871656
