55
55
Oct 23, 2014
10/14
by
Ahmadi, Fatemeh; Dabirian, Sara; Faizi, Mehrdad; Tabatabai, Sayyed Abbas; Beiki, Davood; Shahhosseini, Soraya
texts
eye 55
favorite 0
comment 0
This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3, 4-oxadiazolo[a,2,3]-pyrimidine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977056
121
121
Oct 23, 2014
10/14
by
Amiri, Mohammad Sadegh; Joharchi, Mohammad Reza; TaghavizadehYazdi, Mohammad Ehsan
texts
eye 121
favorite 0
comment 0
This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Jaundice is the commonest ailments affecting the citizens of both developed and poor Asians countries including Iran. An ethnobotanical survey of plants used by the traditional healers for the treatment of jaundice was conducted in the Mashhad city, Northeastern Iran. A total of 37 plants belonging to 32 genera and 26 families have been documented for their therapeutic use against jaundice. The plant...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985247
45
45
Oct 24, 2014
10/14
by
Atsukawa, Masanori; Tsubota, Akihito; Shimada, Noritomo; Kondo, Chisa; Itokawa, Norio; Nakagawa, Ai; Hashimoto, Satomi; Fukuda, Takeshi; Matsushita, Yoko; Kidokoro, Hideko; Narahara, Yoshiyuki; Nakatsuka, Katsuhisa; Iwakiri, Katsuhiko; Kawamoto, Chiaki; Sakamoto, Choitsu
texts
eye 45
favorite 0
comment 0
This article is from Hepatitis Monthly , volume 13 . Abstract Background: Serum vitamin D concentration is reported to show a decrease in older age. Patients with chronic hepatitis C (CHC) in Japan are older on average than those in Western countries. Moreover, the outcome of pegylated-interferon (PEG-IFN)/ ribavirin therapy combined with vitamin D in elderly patients is unclear. Objectives: This pilot study explored the efficacy and safety of alfacalcidol as vitamin D source in PEG-IFN/...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877658
74
74
Oct 5, 2014
10/14
by
Barbetti, V; Morandi, A; Tusa, I; Digiacomo, G; Riverso, M; Marzi, I; Cipolleschi, M G; Bessi, S; Giannini, A; Di Leo, A; Dello Sbarba, P; Rovida, E
texts
eye 74
favorite 0
comment 0
This article is from Oncogene , volume 33 . Abstract The colony-stimulating factor-1 (CSF-1) and its receptor CSF-1R physiologically regulate the monocyte/macrophage system, trophoblast implantation and breast development. An abnormal CSF-1R expression has been documented in several human epithelial tumors, including breast carcinomas. We recently demonstrated that CSF-1/CSF-1R signaling drives proliferation of breast cancer cells via ‘classical' receptor tyrosine kinase signaling, including...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141303
57
57
Oct 27, 2014
10/14
by
Bozdag, Sinem Civriz; Namdaroglu, Sinem; Kayikci, Omur; Kaygusuz, Gulsah; Demiriz, Itir; Cinarsoy, Murat; Tekgunduz, Emre; Altuntas, Fevzi
texts
eye 57
favorite 0
comment 0
This article is from Hematology Reports , volume 5 . Abstract Large granular lymphocytic (LGL) leukemia is a lymphoproliferative disease characterized by the clonal expansion of cytotoxic T or natural killer cells. We report on a patient diagnosed with T-cell LGL leukemia two years after the achievement of hematologic remission for acute myeloblastic leukemia.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883061
57
57
Oct 27, 2014
10/14
by
Carlini, Federico; Traore, Karim; Cherouat, Nissem; Roubertoux, Pierre; Buhler, Stephane; Cortey, Marti; Simon, Sophie; Doumbo, Ogobara; Chiaroni, Jacques; Picard, Christophe; Di Cristofaro, Julie
texts
eye 57
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The HLA-G molecule plays an important role in immunomodulation. In a previous study carried out on a southern French population our team showed that HLA-G haplotypes, defined by SNPs in the coding region and specific SNPs located in 5′URR and 3′UTR regulatory regions, are associated with differential soluble HLA-G expression (sHLA-G). Furthermore, the structure of these HLA-G haplotypes appears to be conserved in geographically distant...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871591
58
58
Oct 24, 2014
10/14
by
Cerosaletti, Karen; Schneider, Anya; Schwedhelm, Katharine; Frank, Ian; Tatum, Megan; Wei, Shan; Whalen, Elizabeth; Greenbaum, Carla; Kita, Mariko; Buckner, Jane; Long, S. Alice
texts
eye 58
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4+CD25hiFOXP3+ regulatory T cells (Treg); a cell type that plays an integral role in maintaining tolerance. Thus, we hypothesized that decreased response to IL-2 may be a common phenotype of subjects who have autoimmune diseases associated with variants in the IL2RA locus, including T1D and MS, particularly in cells expressing the high affinity IL-2R alpha...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871703
48
48
Oct 24, 2014
10/14
by
Choi, Soo-Ho; Yin, Huiyong; Ravandi, Amir; Armando, Aaron; Dumlao, Darren; Kim, Jungsu; Almazan, Felicidad; Taylor, Angela M.; McNamara, Coleen A.; Tsimikas, Sotirios; Dennis, Edward A.; Witztum, Joseph L.; Miller, Yury I.
texts
eye 48
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Oxidation of low-density lipoprotein (LDL) is one of the major causative mechanisms in the development of atherosclerosis. In previous studies, we showed that minimally oxidized LDL (mmLDL) induced inflammatory responses in macrophages, macropinocytosis and intracellular lipid accumulation and that oxidized cholesterol esters (OxCEs) were biologically active components of mmLDL. Here we identified a specific OxCE molecule responsible for the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871536
63
63
Oct 28, 2014
10/14
by
Coze, Fabien; Gilard, Francoise; Tcherkez, Guillaume; Virolle, Marie-Joelle; Guyonvarch, Armel
texts
eye 63
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Metabolic Flux Analysis is now viewed as essential to elucidate the metabolic pattern of cells and to design appropriate genetic engineering strategies to improve strain performance and production processes. Here, we investigated carbon flux distribution in two Streptomyces coelicolor A3 (2) strains: the wild type M145 and its derivative mutant M1146, in which gene clusters encoding the four main antibiotic biosynthetic pathways were deleted....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871631
48
48
Oct 23, 2014
10/14
by
DUONG, HONG-QUAN; YI, YONG WEON; KANG, HYO JIN; HONG, YOUNG BIN; TANG, WENXI; WANG, ANTAI; SEONG, YEON-SUN; BAE, INSOO
texts
eye 48
favorite 0
comment 0
This article is from International Journal of Oncology , volume 44 . Abstract We describe the potential benefit of PIK-75 in combination of gemcitabine to treat pancreatic cancer in a preclinical mouse model. The effect of PIK-75 on the level and activity of NRF2 was characterized using various assays including reporter gene, quantitative PCR, DNA-binding and western blot analyses. Additionally, the combinatorial effect of PIK-75 and gemcitabine was evaluated in human pancreatic cancer cell...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928470
16
16
Oct 23, 2014
10/14
by
Eagle, Dawn M.; Noschang, Cristie; d'Angelo, Laure-Sophie Camilla; Noble, Christie A.; Day, Jacob O.; Dongelmans, Marie Louise; Theobald, David E.; Mar, Adam C.; Urcelay, Gonzalo P.; Morein-Zamir, Sharon; Robbins, Trevor W.
texts
eye 16
favorite 0
comment 0
This article is from Behavioural Brain Research , volume 264 . Abstract •We validate a novel operant model of compulsive checking, relevant to OCD.•The dopamine D2/3 receptor agonist quinpirole selectively increases checking.•Uncertainty increases checking differently following quinpirole treatment.•Dopamine D2/3 receptors modulate excessive, non-functional checking.•OCD checking may respond to treatment augmentation with D2/3 receptor antagonists.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989029
61
61
Oct 26, 2014
10/14
by
Farshid, Ahmad; Pathak, Rajeev; Shadbolt, Bruce; Arnolda, Leonard; Talaulikar, Girish
texts
eye 61
favorite 0
comment 0
This article is from BMC Nephrology , volume 14 . Abstract Background: Cardiovascular disease is a major cause of death in patients with stage 4–5 Chronic Kidney disease (CKD, eGFR 75 years, previous history of MI, diastolic dysfunction and detectable serum troponin T were significant independent predictor of mortality (P 75 years, history of MI, diastolic dysfunction and troponin T were independent predictors of mortality.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878021
63
63
Oct 23, 2014
10/14
by
Flynn, Tanya J; Phipps-Green, Amanda; Hollis-Moffatt, Jade E; Merriman, Marilyn E; Topless, Ruth; Montgomery, Grant; Chapman, Brett; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R
texts
eye 63
favorite 0
comment 0
This article is from Arthritis Research & Therapy , volume 15 . Abstract Introduction: There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study was to test genetic variation across the SLC22A11/SLC22A12 locus for association with risk of gout in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978909
46
46
Oct 28, 2014
10/14
by
Frith, Jessica E.; Titmarsh, Drew M.; Padmanabhan, Harish; Cooper-White, Justin J.
texts
eye 46
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Cellular microenvironmental conditions coordinate to regulate stem cell populations and their differentiation. Mesenchymal precursor cells (MPCs), which have significant potential for a wide range of therapeutic applications, can be expanded or differentiated into osteo- chondro- and adipogenic lineages. The ability to establish, screen, and control aspects of the microenvironment is paramount if we are to elucidate the complex interplay of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871528
47
47
Oct 27, 2014
10/14
by
Guwatudde, David; Bwanga, Freddie; Dudley, Lilian; Chola, Lumbwe; Leyna, Germana Henry; Mmbaga, Elia John; Kumwenda, Newton; Protsiv, Myroslava; Atkins, Salla; Zwarenstein, Merrick; Obua, Celestino; Tumwine, James K
texts
eye 47
favorite 0
comment 0
This article is from Human Resources for Health , volume 11 . Abstract Background: The need to develop capacity for health services and systems research (HSSR) in low and middle income countries has been highlighted in a number of international forums. However, little is known about the level of HSSR training in Sub-Saharan Africa (SSA). We conducted an assessment at four major East and Southern African universities to describe: a) the numbers of HSSR PhD trainees at these institutions, b)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878024
66
66
Oct 28, 2014
10/14
by
Han, Wenxuan; Tang, Luying; Chen, Yahan; Fang, Jingyun
texts
eye 66
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Most previous studies have ascribed variations in the resorption of a certain plant nutrient to its corresponding environmental availability or level in tissues, regardless of the other nutrients’ status. However, given that plant growth relies on both sufficient and balanced nutrient supply, the nutrient resorption process should not only be related to the absolute nutrient status, but also be regulated by the relative limitation of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871644
46
46
Oct 24, 2014
10/14
by
Hill, Andrew F.; Pegtel, D. Michiel; Lambertz, Ulrike; Leonardi, Tommaso; O'Driscoll, Lorraine; Pluchino, Stefano; Ter-Ovanesyan, Dmitry; Nolte-'t Hoen, Esther N.M.
texts
eye 46
favorite 0
comment 0
This article is from Journal of Extracellular Vesicles , volume 2 . Abstract Extracellular vesicles (EVs) are the collective term for the various vesicles that are released by cells into the extracellular space. Such vesicles include exosomes and microvesicles, which vary by their size and/or protein and genetic cargo. With the discovery that EVs contain genetic material in the form of RNA (evRNA) has come the increased interest in these vesicles for their potential use as sources of disease...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873759
13
13
Oct 23, 2014
10/14
by
Howard, Thomas P.; Fahy, Brendan; Leigh, Fiona; Howell, Phil; Powell, Wayne; Greenland, Andy; Trafford, Kay; Smith, Alison M.
texts
eye 13
favorite 0
comment 0
This article is from Journal of Cereal Science , volume 59 . Abstract The effects on barley starch and grain properties of four starch synthesis mutations were studied during the introgression of the mutations from diverse backgrounds into an elite variety. The lys5f (ADPglucose transporter), wax (granule-bound starch synthase), isa1 (debranching enzyme isoamylase 1) and sex6 (starch synthase IIa) mutations were introgressed into NFC Tipple to give mutant and wild-type BC2F4 families with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990431
73
73
Oct 28, 2014
10/14
by
Hyakuna, Nobuyuki; Shimomura, Yasuto; Watanabe, Arata; Taga, Takashi; Kikuta, Atsushi; Matsushita, Takeji; Kogawa, Kazuhiro; Kawakami, Chihiro; Horikoshi, Yasuo; Iwai, Tsuyako; Okamoto, Yasuhiro; Tsurusawa, Masahito; Asami, Keiko
texts
eye 73
favorite 0
comment 0
This article is from Journal of Pediatric Hematology/Oncology , volume 36 . Abstract Supplemental Digital Content is available in the text.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872830
52
52
Oct 25, 2014
10/14
by
Jones, Dominique Z; Ragin, Camille; Kidd, Nayla C; Flores-Obando, Rafael E; Jackson, Maria; McFarlane-Anderson, Norma; Tulloch-Reid, Marshall; Kimbro, Kevin S; Kidd, LaCreis R
texts
eye 52
favorite 0
comment 0
This article is from Hereditary Cancer in Clinical Practice , volume 11 . Abstract Purpose: Although case–control studies have evaluated the role of variant inflammatory-related loci in prostate cancer, their impact is virtually unknown among men of African descent. To address this, we evaluated the impact of inflammatory cytokine single nucleotide polymorphisms (SNPs) on prostate cancer risk for men of African descent. Methods: Forty-four SNPs in inflammatory cytokine-associated genes were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929257
73
73
Oct 27, 2014
10/14
by
Lambert, Jennifer E.; Ryan, Edmond A.; Thomson, Alan B. R.; Clandinin, Michael T.
texts
eye 73
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: Synthesis of lipid species, including fatty acids (FA) and cholesterol, can contribute to pathological disease. The purpose of this study was to investigate FA and cholesterol synthesis in individuals with type 1 diabetes, a group at elevated risk for vascular disease, using stable isotope analysis. Methods: Individuals with type 1 diabetes (n = 9) and age-, sex-, and BMI-matched non-diabetic subjects (n = 9) were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871159
51
51
Oct 24, 2014
10/14
by
Lin, Yi-Wen; Huang, Chun-Yao; Chen, Yung-Hsiang; Shih, Chun-Ming; Tsao, Nai-Wen; Lin, Cheng-Yen; Chang, Nen-Chung; Tsai, Chien-Sung; Tsai, Hsiao-Ya; Tsai, Jui-Chi; Huang, Po-Hsun; Li, Chi-Yuan; Lin, Feng-Yen
texts
eye 51
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The number and function of endothelial progenitor cells (EPCs) are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. GroEL1 from Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis. However, the actual effects of GroEL1 on EPC function are unclear. In this study, we investigate the EPC function in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871664
58
58
Oct 28, 2014
10/14
by
Luongo, Diomira; Miyamoto, Junki; Bergamo, Paolo; Nazzaro, Filomena; Baruzzi, Federico; Sashihara, Toshihiro; Tanabe, Soichi; Rossi, Mauro
texts
eye 58
favorite 0
comment 0
This article is from BMC Microbiology , volume 13 . Abstract Background: Probiotics species appear to differentially regulate the intestinal immune response. Moreover, we have shown that different immune-modulatory abilities can be found among probiotic strains belonging to the same species. In this study, we further addressed this issue while studying L. gasseri, a species that induces relevant immune activities in human patients. Results: We determined the ability of two strains of L....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879436
110
110
Oct 28, 2014
10/14
by
Mamedov, Ilgar Z.; Britanova, Olga V.; Zvyagin, Ivan V.; Turchaninova, Maria A.; Bolotin, Dmitriy A.; Putintseva, Ekaterina V.; Lebedev, Yuriy B.; Chudakov, Dmitriy M.
texts
eye 110
favorite 0
comment 0
This article is from Frontiers in Immunology , volume 4 . Abstract High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of library preparation and sequencing. Here we report an optimized protocol for the unbiased preparation of TCR and IG...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870325
46
46
Oct 26, 2014
10/14
by
Manea, Simona-Adriana; Todirita, Andra; Manea, Adrian
texts
eye 46
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract High glucose-induced endothelial dysfunction is partially mediated by the down-stream pathophysiological effects triggered by increased expression of endothelin-1 (ET-1). The molecular control mechanisms of ET-1 synthesis are yet to be discovered. Members of the CCAAT/enhancer-binding proteins (C/EBP) family are important regulators of key metabolic processes, cellular differentiation and proinflammatory genes. In this study, we aimed at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871648
45
45
Oct 24, 2014
10/14
by
Marin, Arturo; Tejero, Hector; Nuno, Juan Carlos; Montero, Francisco
texts
eye 45
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871551
58
58
Oct 23, 2014
10/14
by
Matsubara, Atsushi; Nishizawa, Hisanori; Kurose, Akira; Nakagawa, Takashi; Takahata, Junko; Sasaki, Akira
texts
eye 58
favorite 0
comment 0
This article is from Acta Oto-Laryngologica , volume 134 . Abstract Conclusion:: As the periods of intratympanic injection of ovalbumin (OVA) to the middle ear became longer, marked eosinophil infiltration in the perilymphatic space was observed. Moreover severe morphological damage of the organ of Corti was observed in the 28-day antigen-stimulation side. These results indicate that eosinophilic inflammation occurred in the inner ear and caused profound hearing loss. Objective:: The purpose of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971771
12
12
Oct 28, 2014
10/14
by
Mettler, Tobias; Stump, Reto; Haueis, Silvia; Kalt, Nicola; Tschuor, Christoph; Limani, Perparim; Raptis, Dimitri A; Puhan, Milo A; Breitenstein, Stefan
texts
eye 12
favorite 0
comment 0
This article is from JMIR Research Protocols , volume 2 . Abstract Background: Hepatic metastases of neuroendocrine tumors (NETs) are considered a major prognostic factor associated with significantly reduced survival compared to patients without liver metastases. Several surgical and nonsurgical strategies are present to treat resectable and nonresectable liver metastases, some of which have the potential to cure liver mestatases. Objective: The aims of the four systematic reviews presented in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875902
102
102
Oct 28, 2014
10/14
by
Moret, Ines; Sanchez-Izquierdo, Dolors; Iborra, Marisa; Tortosa, Luis; Navarro-Puche, Ana; Nos, Pilar; Cervera, Jose; Beltran, Belen
texts
eye 102
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The first step in biomarkers discovery is to identify the best protocols for their purification and analysis. This issue is critical when considering peripheral blood samples (plasma and serum) that are clinically interesting but meet several methodological problems, mainly complexity and low biomarker concentration. Analysis of small molecules, such as circulating microRNAs, should overcome these disadvantages. The present study describes an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871541
119
119
Oct 8, 2014
10/14
by
Nazarko, Taras Y.; Ozeki, Katharine; Till, Andreas; Ramakrishnan, Geetha; Lotfi, Pouya; Yan, Mingda; Subramani, Suresh
texts
eye 119
favorite 0
comment 0
This article is from The Journal of Cell Biology , volume 204 . Abstract The acyl-CoA–binding protein Atg37 is a new component of the pexophagic receptor protein complex that regulates the recruitment of Atg11 by Atg30 in the peroxisomal membrane during pexophagy
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926955
35
35
Oct 24, 2014
10/14
by
Nespoulet, Hugo; Rupp, Thomas; Bachasson, Damien; Tamisier, Renaud; Wuyam, Bernard; Levy, Patrick; Verges, Samuel
texts
eye 35
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Introduction: Positive end-expiratory pressure (PEEP) is commonly used in critical care medicine to improve gas exchange. Altitude sickness is associated with exaggerated reduction in arterial oxygenation. We assessed the effect of PEEP and pursed lips breathing (PLB) on arterial and tissue oxygenation under normobaric and hypobaric hypoxic conditions. Methods: Sixteen healthy volunteers were exposed to acute normobaric hypoxia (Laboratory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871630
56
56
Oct 25, 2014
10/14
by
Oji, Yutaka; Noda, Kazuyuki; Tokugawa, Joji; Yamashiro, Kazuo; Hattori, Nobutaka; Okuma, Yasuyuki
texts
eye 56
favorite 0
comment 0
This article is from Journal of Medical Case Reports , volume 7 . Abstract Introduction: Spinal subarachnoid hemorrhage has many causes including trauma, vascular malformations, aneurysms, spinal cord tumors, coagulation abnormalities, use of anticoagulants, systemic lupus erythematosus, or Behçet’s disease. We report on a rare case of a spontaneous spinal subarachnoid hemorrhage after severe coughing of unknown origin. To the best of our knowledge, this is the first report of spontaneous...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878018
78
78
Oct 23, 2014
10/14
by
Oliver, Bonamy R.; Trzaskowski, Maciej; Plomin, Robert
texts
eye 78
favorite 0
comment 0
This article is from Developmental Psychology , volume 50 . Abstract Reviews of behavioral genetic studies note that “control” aspects of parenting yield low estimates of heritability, while “affective” aspects (parental feelings) yield moderate estimates. Research to date has not specifically considered whether positive and negative aspects of parenting—for both feelings and control—may explain these etiological distinctions. We addressed this issue using parent reports of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977675
55
55
Oct 28, 2014
10/14
by
Pombo, Maira; Turra, Alexander
texts
eye 55
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The use of indirect estimates of ghost-crab populations to assess beach disturbance has several advantages, including non-destructiveness, ease and low cost, although this strategy may add some degree of noise to estimates of population parameters. Resolution of these shortcomings may allow wider use of these populations as an indicator of differences in quality among beaches. This study analyzed to what extent the number of crab burrows may...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871685
67
67
Oct 28, 2014
10/14
by
Qin, Xian-Yang; Wei, Feifei; Tanokura, Masaru; Ishibashi, Naoto; Shimizu, Masahito; Moriwaki, Hisataka; Kojima, Soichi
texts
eye 67
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background/Purpose: Acyclic retinoid (ACR) is a promising chemopreventive agent for hepatocellular carcinoma (HCC) that selectively inhibits the growth of HCC cells (JHH7) but not normal hepatic cells (Hc). To better understand the molecular basis of the selective anti-cancer effect of ACR, we performed nuclear magnetic resonance (NMR)-based and capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS)-based metabolome analyses in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871542
59
59
Oct 28, 2014
10/14
by
Rampanelli, Elena; Dessing, Mark C.; Claessen, Nike; Teske, Gwendoline J. D.; Joosten, Sander P. J.; Pals, Steven T.; Leemans, Jaklien C.; Florquin, Sandrine
texts
eye 59
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Acute kidney injury (AKI) is a common complication during systemic inflammatory response syndrome (SIRS), a potentially deadly clinical condition characterized by whole-body inflammatory state and organ dysfunction. CD44 is a ubiquitously expressed cell-surface transmembrane receptor with multiple functions in inflammatory processes, including sterile renal inflammation. The present study aimed to assess the role of CD44 in endotoxic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871539
58
58
Oct 27, 2014
10/14
by
Redmann, Veronika; Gardner, Thomas; Lau, Zerlina; Morohashi, Keita; Felsenfeld, Dan; Tortorella, Domenico
texts
eye 58
favorite 0
comment 0
This article is from Toxins , volume 6 . Abstract Ricin toxin, an A-B toxin from Ricinus communis, induces cell death through the inhibition of protein synthesis. The toxin binds to the cell surface via its B chain (RTB) followed by its retrograde trafficking through intracellular compartments to the ER where the A chain (RTA) is transported across the membrane and into the cytosol. Ricin A chain is transported across the ER membrane utilizing cellular proteins involved in the disposal of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920248
55
55
Oct 23, 2014
10/14
by
Rezaee Zavareh, Elham; Hedayati, Mahdi; Hoghooghi Rad, Laleh; Shahhosseini, Soraya; Faizi, Mehrdad; Tabatabai, Sayyed Abbas
texts
eye 55
favorite 0
comment 0
This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Inhibitors of soluble epoxide hydrolase (sEH) represent one of the novel pharmaceutical approaches for treating hypertension, vascular inflammation, pain and other cardiovascular related diseases. Most of the potent sEH inhibitors reported in literature often suffer from poor solubility and bioavailability. Toward improving pharmacokinetic profile beside favorable potency, two series of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977053
59
59
Oct 24, 2014
10/14
by
Rodionova, Irina A.; Li, Xiaoqing; Thiel, Vera; Stolyar, Sergey; Stanton, Krista; Fredrickson, James K.; Bryant, Donald A.; Osterman, Andrei L.; Best, Aaron A.; Rodionov, Dmitry A.
texts
eye 59
favorite 0
comment 0
This article is from Frontiers in Microbiology , volume 4 . Abstract L-rhamnose (L-Rha) is a deoxy-hexose sugar commonly found in nature. L-Rha catabolic pathways were previously characterized in various bacteria including Escherichia coli. Nevertheless, homology searches failed to recognize all the genes for the complete L-Rha utilization pathways in diverse microbial species involved in biomass decomposition. Moreover, the regulatory mechanisms of L-Rha catabolism have remained unclear in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870299
63
63
Oct 27, 2014
10/14
by
Senbeto, Meseret; Tadesse, Sebsibe; Tadesse, Takele; Melesse, Tesfahun
texts
eye 63
favorite 0
comment 0
This article is from BMC Public Health , volume 13 . Abstract Background: Tuberculosis remains the major debilitating public health problem in Ethiopia. However, studies to understand the patients’ perspectives on the illness and their health-seeking behavior have been few in the country. In this study, we seek to investigate the magnitude of appropriate health-seeking behavior and factors associated with tuberculosis among people who had cough for at least two weeks. Methods: A...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890638
60
60
Oct 28, 2014
10/14
by
Seto, Shintaro; Tsujimura, Kunio; Horii, Toshinobu; Koide, Yukio
texts
eye 60
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Mycobacterium tuberculosis is an intracellular pathogen that can survive within phagocytic cells by inhibiting phagolysosome biogenesis. However, host cells can control the intracellular M. tuberculosis burden by the induction of autophagy. The mechanism of autophagosome formation to M. tuberculosis has been well studied in macrophages, but remains unclear in dendritic cells. We therefore characterized autophagosome formation in response to M....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871604
82
82
Oct 23, 2014
10/14
by
Stevens, Misty W; Tawney, Rachel L; West, C Michael; Kight, Alicia D; Henry, Ralph L; Owens, S Michael; Gentry, W Brooks
texts
eye 82
favorite 0
comment 0
This article is from mAbs , volume 6 . Abstract Ch-mAb7F9, a human-mouse chimeric monoclonal antibody (mAb) designed to bind (+)-methamphetamine (METH) with high affinity and specificity, was produced as a treatment medication for METH abuse. In these studies, we present the preclinical characterization that provided predictive evidence that ch-mAb7F9 may be safe and effective in humans. In vitro ligand binding studies showed that ch-mAb7F9 is specific for and only binds its target ligands...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984342
51
51
Oct 29, 2014
10/14
by
Strotmann, Barbara; Kogler, Carsten; Bazin, Pierre-Louis; Weiss, Marcel; Villringer, Arno; Turner, Robert
texts
eye 51
favorite 0
comment 0
This article is from Frontiers in Human Neuroscience , volume 7 . Abstract The habenula is a small but important nucleus located next to the third ventricle in front of the pineal body. It helps to control the human reward system and is considered to play a key role in emotion, showing increased activation in major depressive disorders. Its dysfunction may underlie several neurological and psychiatric disorders. It is now possible to visualize the habenula and its anatomical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870283
52
52
Oct 27, 2014
10/14
by
Sumner, Anne E; Furtado, Jeremy D; Courville, Amber B; Ricks, Madia; Younger-Coleman, Novie; Tulloch-Reid, Marshall K; Sacks, Frank M
texts
eye 52
favorite 0
comment 0
This article is from Nutrition & Metabolism , volume 10 . Abstract Background: African-Americans are more insulin-resistant than whites but have lower triglyceride (TG) concentrations. The metabolic basis for this is unknown. Our goal was to determine in a cross-sectional study the effect of insulin resistance, visceral adipose tissue (VAT) and the apolipoproteins, B, C-III and E, on race differences in TG content of very low density lipoproteins (VLDL). Methods: The participants were 31...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878037
56
56
Oct 23, 2014
10/14
by
Tabarzad, Maryam; Kazemi, Bahram; Vahidi, Hossein; Aboofazeli, Reza; Shahhosseini, Soraya; Nafissi-Varcheh, Nastaran
texts
eye 56
favorite 0
comment 0
This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Aptamers, or single stranded oligonucleotides, are produced by systematic evolution of ligands by exponential enrichment, abbreviated as SELEX. In the amplification and regeneration step of SELEX technique, dsDNA is conversed to ssDNA. Asymmetric PCR is one of the methods used for the generation of ssDNA. The purpose of this study was to design a random DNA library for selection of aptamers with high...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977063
74
74
Oct 24, 2014
10/14
by
Takahashi, Nozomu; Watanabe, Seiji; Wakasugi, Keisuke
texts
eye 74
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Mammalian neuroglobin (Ngb) protects neuronal cells under conditions of oxidative stress. We previously showed that human Ngb acts as a guanine nucleotide dissociation inhibitor (GDI) for the α-subunits of heterotrimeric Gi/o proteins and inhibits reductions in cAMP concentration, leading to protection against cell death. In the present study, we created human E60Q Ngb mutant and clarified that Glu60 of human Ngb is a crucial residue for its...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871547
57
57
Oct 26, 2014
10/14
by
Tan, Jin-zhi; Yan, Yan; Wang, Xiao-xi; Jiang, Yi; Xu, H Eric
texts
eye 57
favorite 0
comment 0
This article is from Acta Pharmacologica Sinica , volume 35 . Abstract EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3. Overexpression of EZH2 has been found in a wide range of cancers, including those of the prostate and breast. In this review, we address the current understanding of the oncogenic role of EZH2, including its PRC2-dependent transcriptional repression and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914023
51
51
Oct 29, 2014
10/14
by
Tan, Soon Sim; Yin, Yijun; Lee, Tricia; Lai, Ruenn Chai; Yeo, Ronne Wee Yeh; Zhang, Bin; Choo, Andre; Lim, Sai Kiang
texts
eye 51
favorite 0
comment 0
This article is from Journal of Extracellular Vesicles , volume 2 . Abstract Background: Mesenchymal stem cell (MSC) was previously shown to secrete lipid vesicles that when purified by high performance liquid chromatography as a population of homogenously sized particles with a hydrodynamic radius of 55–65 nm reduce infarct size in a mouse model of myocardial ischemia/reperfusion injury. As these vesicles exhibit many biophysical and biochemical properties of exosomes, they were identified...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873122
83
83
Oct 14, 2014
10/14
by
Tavakkoli-Kakhki, Mandana; Motavasselian, Malihe; Mosaddegh, Mahmoud; Esfahani, Mohammad Mahdi; Kamalinejad, Mohammad; Nematy, Mohsen; Eslami, Saeid
texts
eye 83
favorite 0
comment 0
This article is from Avicenna Journal of Phytomedicine , volume 4 . Abstract Objectives: Considering the increasing prevalence of depression in modern societies and the positive effects of omega-3 polyunsaturated fatty acids on depression, this study aims to investigate the omega-3 and omega-6 content of various foodstuffs, prescribed or prohibited by Iranian Traditional Medicine (ITM).Materials and Methods: Firstly, reliable sources of Iranian Traditional Medicine were reviewed in order to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110782
60
60
Oct 25, 2014
10/14
by
Theunissen, Leslie M.; Durr, Volker
texts
eye 60
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: Adaptive, context-dependent control of locomotion requires modulation of centrally generated rhythmic motor patterns through peripheral control loops and postural reflexes. Thus assuming that the modulation of rhythmic motor patterns accounts for much of the behavioural variability observed in legged locomotion, investigating behavioural variability is a key to the understanding of context-dependent control mechanisms in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871641
