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Oct 24, 2014
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Abreu, Mauro Henrique Nogueira Guimaraes; Sanglard-Oliveira, Carla Aparecida; Jaruche, Abdul Rahman Mustafa; Mambrini, Juliana Vaz de Melo; Werneck, Marcos Azeredo Furquim; Lucas, Simone Dutra
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This article is from Human Resources for Health , volume 11 . Abstract Background: To describe some sociodemographic and educational characteristics of oral health technicians (OHTs) in public primary health care teams in the state of Minas Gerais, Brazil. Methods: A cross-sectional descriptive study was performed based on the telephone survey of a representative sample comprising 231 individuals. A pre-tested instrument was used for the data collection, including questions on gender, age in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878034
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Oct 21, 2014
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Apel, Mareike; Maia, Vivian PL; Zeidan, Mohamed; Schinkoethe, Claudia; Wolf, Gunter; Reinhart, Konrad; Sakr, Yasser
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This article is from Critical Care , volume 17 . Abstract Introduction: End-stage renal disease (ESRD) is associated with an increased propensity for critical illness, but whether ESRD is independently associated with a greater risk of death after major surgical procedures is unclear. Methods: This was a retrospective analysis of prospectively collected data from all adult (>18 years) patients admitted to a 50-bed surgical intensive care unit (ICU) between January 2004 and January 2009....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057028
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Oct 24, 2014
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Atsukawa, Masanori; Tsubota, Akihito; Shimada, Noritomo; Kondo, Chisa; Itokawa, Norio; Nakagawa, Ai; Hashimoto, Satomi; Fukuda, Takeshi; Matsushita, Yoko; Kidokoro, Hideko; Narahara, Yoshiyuki; Nakatsuka, Katsuhisa; Iwakiri, Katsuhiko; Kawamoto, Chiaki; Sakamoto, Choitsu
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This article is from Hepatitis Monthly , volume 13 . Abstract Background: Serum vitamin D concentration is reported to show a decrease in older age. Patients with chronic hepatitis C (CHC) in Japan are older on average than those in Western countries. Moreover, the outcome of pegylated-interferon (PEG-IFN)/ ribavirin therapy combined with vitamin D in elderly patients is unclear. Objectives: This pilot study explored the efficacy and safety of alfacalcidol as vitamin D source in PEG-IFN/...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877658
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Oct 5, 2014
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Barbetti, V; Morandi, A; Tusa, I; Digiacomo, G; Riverso, M; Marzi, I; Cipolleschi, M G; Bessi, S; Giannini, A; Di Leo, A; Dello Sbarba, P; Rovida, E
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This article is from Oncogene , volume 33 . Abstract The colony-stimulating factor-1 (CSF-1) and its receptor CSF-1R physiologically regulate the monocyte/macrophage system, trophoblast implantation and breast development. An abnormal CSF-1R expression has been documented in several human epithelial tumors, including breast carcinomas. We recently demonstrated that CSF-1/CSF-1R signaling drives proliferation of breast cancer cells via ‘classical' receptor tyrosine kinase signaling, including...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141303
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Oct 23, 2014
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Bauza, Karolis; Malinauskas, Tomas; Pfander, Claudia; Anar, Burcu; Jones, E. Yvonne; Billker, Oliver; Hill, Adrian V. S.; Reyes-Sandoval, Arturo
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This article is from Infection and Immunity , volume 82 . Abstract Plasmodium vivax is the world's most widely distributed malaria parasite and a potential cause of morbidity and mortality for approximately 2.85 billion people living mainly in Southeast Asia and Latin America. Despite this dramatic burden, very few vaccines have been assessed in humans. The clinically relevant vectors modified vaccinia virus Ankara (MVA) and the chimpanzee adenovirus ChAd63 are promising delivery systems for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957994
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Oct 23, 2014
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Behzad, Sahar; Pirani, Atefeh; Mosaddegh, Mahmoud
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and their...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977071
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Oct 25, 2014
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Bidokhti, Mehdi R. M.; Ullman, Karin; Jensen, Trine H.; Chriel, Mariann; Mottahedin, Amin; Munir, Muhammad; Andersson, Anna Maria; Detournay, Olivier; Hammer, Anne Sofie; Baule, Claudia
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This article is from PLoS ONE , volume 8 . Abstract Astroviruses are becoming a growing concern in veterinary and public health. To date there are no registered vaccines against astrovirus-induced disease, mostly due to the difficulty to cultivate astroviruses to high titer for vaccine development using conventional techniques. As means to circumvent this drawback, we have developed stably transfected mink fetal cells and BHK21 cells constitutively expressing the full-length and truncated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871642
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Oct 23, 2014
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Biglar, Mahmood; Sufi, Hessameddin; Bagherzadeh, Kowsar; Amanlou, Massoud; Mojab, Faraz
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Infection with Helicobacter pyloriis the most common cause of stomach and duodenal ulcers. About more than 80 % of people are infected with H. pylori in developing countries. H. pylori uses urease enzyme product “ammonia” in order to neutralize and protect itself from the stomach acidic condition and urease enzyme activity has been shown to be essential to the colonization of H. pylori. Inhibitory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977070
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Oct 24, 2014
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Cherry, Jonathan J.; Rietz, Anne; Malinkevich, Anna; Liu, Yuqi; Xie, Meng; Bartolowits, Matthew; Davisson, V. Jo; Baleja, James D.; Androphy, Elliot J.
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This article is from PLoS ONE , volume 8 . Abstract Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, “high-risk” HPV E6 proteins bind to and modify the target specificity of the ubiquitin ligase E6AP (E6 associated protein). This E6-dependent loss of p53 enables the virus to bypass host cell defenses and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871595
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Oct 24, 2014
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Choi, Soo-Ho; Yin, Huiyong; Ravandi, Amir; Armando, Aaron; Dumlao, Darren; Kim, Jungsu; Almazan, Felicidad; Taylor, Angela M.; McNamara, Coleen A.; Tsimikas, Sotirios; Dennis, Edward A.; Witztum, Joseph L.; Miller, Yury I.
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This article is from PLoS ONE , volume 8 . Abstract Oxidation of low-density lipoprotein (LDL) is one of the major causative mechanisms in the development of atherosclerosis. In previous studies, we showed that minimally oxidized LDL (mmLDL) induced inflammatory responses in macrophages, macropinocytosis and intracellular lipid accumulation and that oxidized cholesterol esters (OxCEs) were biologically active components of mmLDL. Here we identified a specific OxCE molecule responsible for the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871536
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Oct 28, 2014
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Choulagai, Bishnu; Onta, Sharad; Subedi, Narayan; Mehata, Suresh; Bhandari, Gajananda P; Poudyal, Amod; Shrestha, Binjwala; Mathai, Matthews; Petzold, Max; Krettek, Alexandra
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This article is from BMC International Health and Human Rights , volume 13 . Abstract Background: Skilled birth attendants (SBAs) provide important interventions that improve maternal and neonatal health and reduce maternal and neonatal mortality. However, utilization and coverage of services by SBAs remain poor, especially in rural and remote areas of Nepal. This study examined the characteristics associated with utilization of SBA services in mid- and far-western Nepal. Methods: This...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878020
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Oct 26, 2014
10/14
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Cowen, Laura L E; Besbeas, Panagiotis; Morgan, Byron J T; Schwarz, Carl J
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This article is from Ecology and Evolution , volume 4 . Abstract Little attention has been paid to the use of multi-sample batch-marking studies, as it is generally assumed that an individual's capture history is necessary for fully efficient estimates. However, recently, Huggins et al. (2010) present a pseudo-likelihood for a multi-sample batch-marking study where they used estimating equations to solve for survival and capture probabilities and then derived abundance estimates using a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925384
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Oct 29, 2014
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Danzeisen, Jessica L.; Calvert, Alamanda J.; Noll, Sally L.; McComb, Brian; Sherwood, Julie S.; Logue, Catherine M.; Johnson, Timothy J.
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This article is from PeerJ , volume 1 . Abstract Because of concerns related to the use of antibiotics in animal agriculture, antibiotic-free alternatives are greatly needed to prevent disease and promote animal growth. One of the current challenges facing commercial turkey production in Minnesota is difficulty obtaining flock average weights typical of the industry standard, and this condition has been coined “Light Turkey Syndrome” or LTS. This condition has been identified in Minnesota...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883494
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Oct 28, 2014
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Deja, Stanislaw; Dawiskiba, Tomasz; Balcerzak, Waldemar; Orczyk-Pawilowicz, Magdalena; Glod, Mateusz; Pawelka, Dorota; Mlynarz, Piotr
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This article is from PLoS ONE , volume 8 . Abstract Thyroid cancer is the most common endocrine malignancy. However, more than 90% of thyroid nodules are benign. It remains unclear whether thyroid carcinoma arises from preexisting benign nodules. Metabolomics can provide valuable and comprehensive information about low molecular weight compounds present in living systems and further our understanding of the biology regulating pathological processes. Herein, we applied 1H NMR-based metabolic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871661
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Oct 24, 2014
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Del Fabbro, Cristian; Scalabrin, Simone; Morgante, Michele; Giorgi, Federico M.
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This article is from PLoS ONE , volume 8 . Abstract Next Generation Sequencing is having an extremely strong impact in biological and medical research and diagnostics, with applications ranging from gene expression quantification to genotyping and genome reconstruction. Sequencing data is often provided as raw reads which are processed prior to analysis 1 of the most used preprocessing procedures is read trimming, which aims at removing low quality portions while preserving the longest high...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871669
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Oct 25, 2014
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Deletre, Emilie; Martin, Thibaud; Campagne, Pascal; Bourguet, Denis; Cadin, Andy; Menut, Chantal; Bonafos, Romain; Chandre, Fabrice
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This article is from PLoS ONE , volume 8 . Abstract Pyrethroid insecticides induce an excito-repellent effect that reduces contact between humans and mosquitoes. Insecticide use is expected to lower the risk of pathogen transmission, particularly when impregnated on long-lasting treated bednets. When applied at low doses, pyrethroids have a toxic effect, however the development of pyrethroid resistance in several mosquito species may jeopardize these beneficial effects. The need to find...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871167
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Oct 24, 2014
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Denkinger, Claudia M.; Kalantri, Yatiraj; Schumacher, Samuel G.; Michael, Joy S.; Shankar, Deepa; Saxena, Arvind; Sriram, Natarajan; Balamugesh, Thangakunam; Luo, Robert; Pollock, Nira R.; Pai, Madhukar; Christopher, Devasahayam J.
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This article is from PLoS ONE , volume 8 . Abstract Existing diagnostic tests for pleural tuberculosis (TB) have inadequate accuracy and/or turnaround time. Interferon-gamma (IFNg) has been identified in many studies as a biomarker for pleural TB. Our objective was to develop a lateral flow, immunochromatographic test (ICT) based on this biomarker and to evaluate the test in a clinical cohort. Because IFNg is commonly present in non-TB pleural effusions in low amounts, a diagnostic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871622
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Oct 28, 2014
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Duane, Sinead; Callan, Aoife; Galvin, Sandra; Murphy, Andrew W; Domegan, Christine; O'Shea, Eamon; Cormican, Martin; Bennett, Kathleen; O'Donnell, Martin; Vellinga, Akke
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This article is from Trials , volume 14 . Abstract Background: The overuse of antimicrobials is recognized as the main selective pressure driving the emergence and spread of antimicrobial resistance in human bacterial pathogens. Urinary tract infections (UTIs) are among the most common infections presented in primary care and empirical antimicrobial treatment is currently recommended. Previous research has identified that a substantial proportion of Irish general practitioners (GPs) prescribe...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880352
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Oct 27, 2014
10/14
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Duran, Andressa; Meyer, Andreas L. S.; Pie, Marcio R.
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This article is from PLoS ONE , volume 8 . Abstract Despite considerable interest in recent years on species distribution modeling and phylogenetic niche conservatism, little is known about the way in which climatic niches change over evolutionary time. This knowledge is of major importance to understand the mechanisms underlying limits of species distributions, as well as to infer how different lineages might be affected by anthropogenic climate change. In this study we investigate the tempo...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871682
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Oct 23, 2014
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Eagle, Dawn M.; Noschang, Cristie; d'Angelo, Laure-Sophie Camilla; Noble, Christie A.; Day, Jacob O.; Dongelmans, Marie Louise; Theobald, David E.; Mar, Adam C.; Urcelay, Gonzalo P.; Morein-Zamir, Sharon; Robbins, Trevor W.
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This article is from Behavioural Brain Research , volume 264 . Abstract •We validate a novel operant model of compulsive checking, relevant to OCD.•The dopamine D2/3 receptor agonist quinpirole selectively increases checking.•Uncertainty increases checking differently following quinpirole treatment.•Dopamine D2/3 receptors modulate excessive, non-functional checking.•OCD checking may respond to treatment augmentation with D2/3 receptor antagonists.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989029
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Oct 23, 2014
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Flynn, Tanya J; Phipps-Green, Amanda; Hollis-Moffatt, Jade E; Merriman, Marilyn E; Topless, Ruth; Montgomery, Grant; Chapman, Brett; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R
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This article is from Arthritis Research & Therapy , volume 15 . Abstract Introduction: There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study was to test genetic variation across the SLC22A11/SLC22A12 locus for association with risk of gout in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978909
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Oct 27, 2014
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Frey-Law, Laura A; Lee, Jennifer E; Wittry, Alex M; Melyon, Myles
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This article is from Journal of Pain Research , volume 7 . Abstract Background: While the validity of pain assessment has been well documented, the underlying schema (ie, organized, preconceived ideas) of how individuals interpret numerical pain ratings is not well understood. This study’s objectives were to examine numerical pain intensity ratings, from (0 to 10 cm on the visual analog scale [VAS]) across multiple severities of commonly experienced acute pain conditions to determine whether...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873848
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Oct 26, 2014
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Guedes, Erika P; Madeira, Eduardo; Mafort, Thiago T; Madeira, Miguel; Moreira, Rodrigo O; Mendonca, Laura MC; Godoy-Matos, Amelio F; Lopes, Agnaldo J; Farias, Maria Lucia F
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This article is from Diabetology & Metabolic Syndrome , volume 5 . Abstract Background: Several studies point to a correlation between obesity and the severity of depressive and anxiety symptoms in children and adults, but there are still some controversial points about this association. The aim of this study is to investigate the relationship between body composition and the severity of anxiety/depressive symptoms in overweight and obese individuals with Metabolic Syndrome (MS). Methods:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913787
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Oct 27, 2014
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Guwatudde, David; Bwanga, Freddie; Dudley, Lilian; Chola, Lumbwe; Leyna, Germana Henry; Mmbaga, Elia John; Kumwenda, Newton; Protsiv, Myroslava; Atkins, Salla; Zwarenstein, Merrick; Obua, Celestino; Tumwine, James K
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This article is from Human Resources for Health , volume 11 . Abstract Background: The need to develop capacity for health services and systems research (HSSR) in low and middle income countries has been highlighted in a number of international forums. However, little is known about the level of HSSR training in Sub-Saharan Africa (SSA). We conducted an assessment at four major East and Southern African universities to describe: a) the numbers of HSSR PhD trainees at these institutions, b)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878024
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Oct 27, 2014
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Hedrich, Christian M; Hofmann, Sigrun R; Pablik, Jessica; Morbach, Henner; Girschick, Hermann J
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This article is from Pediatric Rheumatology Online Journal , volume 11 . Abstract Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result of a dysregulated innate immune system, resulting in immune cell infiltration of the bone and subsequent osteoclast differentiation and activation. Interestingly,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881012
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Oct 23, 2014
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Hooshfar, Shirin; Mortazavi, Seyed Alireza; Piryaei, Mohammad; Ramandi Darzi, Hossein; Shahsavari, Nahid; Kobarfard, Farzad
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A gradient reversed-phase high performance liquid chromatography (HPLC) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity used in infertility treatment. The HPLC method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ICH guidelines. The chromatographic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977052
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Oct 24, 2014
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Huw, L-Y; O'Brien, C; Pandita, A; Mohan, S; Spoerke, J M; Lu, S; Wang, Y; Hampton, G M; Wilson, T R; Lackner, M R
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This article is from Oncogenesis , volume 2 . Abstract Agents targeting the PI3K/mTOR signaling axis have shown promise in early-phase clinical trials and are currently being studied in later stages of clinical development in multiple indications. Experience with other targeted agents suggests that clinical responses may be short-lived because of acquired resistance to therapy. Here, we report preclinical modeling of acquired resistance in a HER2-positive, PIK3CA mutant breast cancer cell line,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940863
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Oct 28, 2014
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Hyakuna, Nobuyuki; Shimomura, Yasuto; Watanabe, Arata; Taga, Takashi; Kikuta, Atsushi; Matsushita, Takeji; Kogawa, Kazuhiro; Kawakami, Chihiro; Horikoshi, Yasuo; Iwai, Tsuyako; Okamoto, Yasuhiro; Tsurusawa, Masahito; Asami, Keiko
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This article is from Journal of Pediatric Hematology/Oncology , volume 36 . Abstract Supplemental Digital Content is available in the text.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872830
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Oct 24, 2014
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Jacobs, James E.; Wagner, Mark; Dhahbi, Joseph; Boffelli, Dario; Martin, David I. K.
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This article is from PLoS ONE , volume 8 . Abstract Piwi proteins and their small non-coding RNA partners are involved in the maintenance of stem cell character and genome integrity in the male germ cells of mammals. MIWI2, one of the mouse Piwi-like proteins, is expressed in the prepachytene phase of spermatogenesis during the period of de novo methylation. Absence of this protein leads to meiotic defects and a progressive loss of germ cells. There is an accumulation of evidence that Piwi...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871168
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Oct 25, 2014
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Jones, Dominique Z; Ragin, Camille; Kidd, Nayla C; Flores-Obando, Rafael E; Jackson, Maria; McFarlane-Anderson, Norma; Tulloch-Reid, Marshall; Kimbro, Kevin S; Kidd, LaCreis R
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This article is from Hereditary Cancer in Clinical Practice , volume 11 . Abstract Purpose: Although case–control studies have evaluated the role of variant inflammatory-related loci in prostate cancer, their impact is virtually unknown among men of African descent. To address this, we evaluated the impact of inflammatory cytokine single nucleotide polymorphisms (SNPs) on prostate cancer risk for men of African descent. Methods: Forty-four SNPs in inflammatory cytokine-associated genes were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929257
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Oct 28, 2014
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Jung, Mi Jin; Byun, Ha Young; Lee, Chang Hee; Moon, Seung Won; Oh, Min-Kyun; Shin, Heesuk
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Medial antebrachial cutaneous (MABC) nerve injury associated with iatrogenic causes has been rarely reported. Local anesthesia may be implicated in the etiology of such injury, but has not been reported. Two patients with numbness and painful paresthesia over the medial aspect of the unilateral forearm were referred for electrodiagnostic study, which revealed MABC nerve lesion in each case. The highly selective nature...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895535
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Oct 25, 2014
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Kim, Mi-Young; Chung, Cho-Yun; Kim, Jong-Sun; Myung, Dae-Seong; Cho, Sung-Bum; Park, Chang-Hwan; Kim, Young; Joo, Young-Eun
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This article is from Chonnam Medical Journal , volume 49 . Abstract We report the first case of hypercalcemia-induced acute pancreatitis caused by a functioning parathyroid cyst in a 67-year-old man. Laboratory investigation revealed increased serum amylase and lipase, increased serum ionized calcium and parathyroid hormone (PTH) levels, and decreased serum phosphate, indicating pancreatitis and primary hyperparathyroidism (PHPT). Abdominal computed tomography (CT) revealed mild swelling of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881208
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Oct 25, 2014
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Kim, Myung-Sunny; Yamamoto, Yasuhiko; Kim, Kyungjin; Kamei, Nozomu; Shimada, Takeshi; Liu, Libin; Moore, Kristin; Woo, Ju Rang; Shoelson, Steven E.; Lee, Jongsoon
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This article is from PLoS ONE , volume 8 . Abstract It is increasingly accepted that chronic inflammation participates in obesity-induced insulin resistance and type 2 diabetes (T2D). Salicylates and thiazolidinediones (TZDs) both have anti-inflammatory and anti-hyperglycemic properties. The present study compared the effects of these drugs on obesity-induced inflammation in adipose tissue (AT) and AT macrophages (ATMs), as well as the metabolic and immunological phenotypes of the animal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871540
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Oct 25, 2014
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Kirita, Keisuke; Ishii, Genichiro; Matsuwaki, Rie; Matsumura, Yuki; Umemura, Shigeki; Matsumoto, Shingo; Yoh, Kiyotaka; Niho, Seiji; Goto, Koichi; Ohmatsu, Hironobu; Ohe, Yuichiro; Nagai, Kanji; Ochiai, Atsushi
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This article is from PLoS ONE , volume 8 . Abstract Background: Intralymphatic tumors in the extratumoral area are considered to represent the preceding phase of lymph node metastasis. The aim of this study was to clarify the biological properties of intralymphatic tumors susceptible to the development of lymph node metastasis, with special reference to the expression of cancer initiating/stem cell (CIC/CSC) related markers in cancer cells and the number of infiltrating stromal cells. Material...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871680
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Oct 28, 2014
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Ko, Sung Hwa; Shin, Yong Beom; Min, Ji Hong; Shin, Myung Jun; Chang, Jae Hyeok; Shin, Yong-Il; Ko, Hyun-Yoon
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To investigate the effect of botulinum toxin type A (BTA) injection into the salivary gland and to evaluate the changes of drooling in varied postures in tetraplegic patients with brain injury. Methods: Eight tetraplegic patients with brain injury were enrolled. BTA was injected into each parotid and submandibular gland of both sides under ultrasonographic guidance. Drooling was measured by a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895519
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Oct 27, 2014
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Kurata, Akira; Kawaguchi, Naoto; Kido, Teruhito; Inoue, Katsuji; Suzuki, Jun; Ogimoto, Akiyoshi; Funada, Jun-ichi; Higaki, Jitsuo; Miyagawa, Masao; Vembar, Mani; Mochizuki, Teruhito
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This article is from PLoS ONE , volume 8 . Abstract Background: The aim of this study was to investigate the correlation of the qualitative transmural extent of hypoperfusion areas (HPA) using stress dynamic whole-heart computed tomography perfusion (CTP) imaging by 256-slice CT with CTP-derived myocardial blood flow (MBF) for the estimation of the severity of coronary artery stenosis. Methods and Results: Eleven patients underwent adenosine triphosphate (0.16 mg/kg/min, 5 min) stress dynamic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871670
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Oct 27, 2014
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Lam, Monika My-Y; Martin-Creuzburg, Dominik; Rothhaupt, Karl-Otto; Safi, Kamran; Yohannes, Elizabeth; Salvarina, Ioanna
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This article is from PLoS ONE , volume 8 . Abstract Stable isotope and fatty acid signatures of biomaterials can provide important information about the dietary niche of animals. Stable isotope and fatty acid signatures differ between aquatic and terrestrial food webs, and therefore can be used to assess the aquatic and terrestrial contributions to the diets of species. We studied faecal samples of three co-occurring bat species with known differences in feeding preferences. The aim was to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871553
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Oct 24, 2014
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Luksic, Ivana; Mulic, Rosanda; Falconer, Rachel; Orban, Mirjana; Sidhu, Simrita; Rudan, Igor
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This article is from Croatian Medical Journal , volume 54 . Abstract Aim: To estimate global morbidity from acute bacterial meningitis in children. Methods: We conducted a systematic review of the PubMed and Scopus databases to identify both community-based and hospital registry-based studies that could be useful in estimation of the global morbidity from bacterial meningitis in children. We were primarily interested in the availability and quality of the information on incidence rates and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893986
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Oct 28, 2014
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Luongo, Diomira; Miyamoto, Junki; Bergamo, Paolo; Nazzaro, Filomena; Baruzzi, Federico; Sashihara, Toshihiro; Tanabe, Soichi; Rossi, Mauro
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This article is from BMC Microbiology , volume 13 . Abstract Background: Probiotics species appear to differentially regulate the intestinal immune response. Moreover, we have shown that different immune-modulatory abilities can be found among probiotic strains belonging to the same species. In this study, we further addressed this issue while studying L. gasseri, a species that induces relevant immune activities in human patients. Results: We determined the ability of two strains of L....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879436
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Oct 28, 2014
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Maacha, Selma; Planque, Nathalie; Laurent, Cecile; Pegoraro, Caterina; Anezo, Oceane; Maczkowiak, Frederique; Monsoro-Burq, Anne H.; Saule, Simon
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This article is from PLoS ONE , volume 8 . Abstract Uveal melanoma is the most common intraocular malignancy in adults, representing between about 4% and 5% of all melanomas. High expression levels of Protein Tyrosine Phosphatase 4A3, a dual phosphatase, is highly predictive of metastasis development and PTP4A3 overexpression in uveal melanoma cells increases their in vitro migration and in vivo invasiveness. Melanocytes, including uveal melanocytes, are derived from the neural crest during...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871671
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Oct 27, 2014
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Mabood, Fazle; Khan, Waqar A.; Ismail, Ahmad Izani
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This article is from PLoS ONE , volume 8 . Abstract In this article, an approximate analytical solution of flow and heat transfer for a viscoelastic fluid in an axisymmetric channel with porous wall is presented. The solution is obtained through the use of a powerful method known as Optimal Homotopy Asymptotic Method (OHAM). We obtained the approximate analytical solution for dimensionless velocity and temperature for various parameters. The influence and effect of different parameters on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871629
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Oct 25, 2014
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Madec, Yoann; Leroy, Sandrine; Rey-Cuille, Marie-Anne; Huber, Florence; Calmy, Alexandra
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This article is from PLoS ONE , volume 8 . Abstract Objectives: Switching to second-line antiretroviral therapy (ART) largely depends on careful clinical assessment and access to biological measurements. We performed a systematic review and meta-analysis to estimate the incidence of switching to second-line ART in sub-Saharan Africa and its main programmatic determinants. Methods: We searched 2 databases for studies reporting the incidence rate of switching to second-line ART in adults living...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871158
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Oct 24, 2014
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Malyshevskaya, Olga; Shiraishi, Yoshihiro; Kimura, Fumitaka; Yamamoto, Nobuhiko
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This article is from PLoS ONE , volume 8 . Abstract During development, layer 2/3 neurons in the neocortex extend their axons horizontally, within the same layers, and stop growing at appropriate locations to form branches and synaptic connections. Firing and synaptic activity are thought to be involved in this process, but how neuronal activity regulates axonal growth is not clear. Here, we studied axonal growth of layer 2/3 neurons by exciting cell bodies or axonal processes in organotypic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871609
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Oct 26, 2014
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Mama, Khursheed R; Gaynor, James S; Harvey, Ralph C; Robertson, Sheilah A; Koenig, Robbin L; Cozzi, Elizabeth M
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This article is from BMC Veterinary Research , volume 9 . Abstract Background: Propofol is a widely used injectable anesthetic agent for induction and short-term maintenance in dogs. A multi-dose formulation of propofol (MDP) has been developed which includes 2% benzyl alcohol as a preservative. In order to document the use of the product under clinical conditions, MDP was tested in a prospective clinical trial conducted at six sites within the United States. One hundred thirty-eight healthy,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901023
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Oct 28, 2014
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Mamedov, Ilgar Z.; Britanova, Olga V.; Zvyagin, Ivan V.; Turchaninova, Maria A.; Bolotin, Dmitriy A.; Putintseva, Ekaterina V.; Lebedev, Yuriy B.; Chudakov, Dmitriy M.
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This article is from Frontiers in Immunology , volume 4 . Abstract High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of library preparation and sequencing. Here we report an optimized protocol for the unbiased preparation of TCR and IG...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870325
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Oct 23, 2014
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Mammitzsch, Kerstin; Jost, Gunter; Jurgens, Klaus
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This article is from MicrobiologyOpen , volume 3 . Abstract Epsilonproteobacteria have been found globally distributed in marine anoxic/sulfidic areas mediating relevant transformations within the sulfur and nitrogen cycles. In the Baltic Sea redox zones, chemoautotrophic epsilonproteobacteria mainly belong to the Sulfurimonas gotlandica GD17 cluster for which recently a representative strain, S. gotlandica GD1T, could be established as a model organism. In this study, the potential effects of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937731
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Oct 26, 2014
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Manea, Simona-Adriana; Todirita, Andra; Manea, Adrian
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This article is from PLoS ONE , volume 8 . Abstract High glucose-induced endothelial dysfunction is partially mediated by the down-stream pathophysiological effects triggered by increased expression of endothelin-1 (ET-1). The molecular control mechanisms of ET-1 synthesis are yet to be discovered. Members of the CCAAT/enhancer-binding proteins (C/EBP) family are important regulators of key metabolic processes, cellular differentiation and proinflammatory genes. In this study, we aimed at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871648
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Oct 24, 2014
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Marin, Arturo; Tejero, Hector; Nuno, Juan Carlos; Montero, Francisco
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This article is from PLoS ONE , volume 8 . Abstract We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871551
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Oct 23, 2014
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Martin-Blondel, Guillaume; Brassat, David; Dumas, Herve; Uro-Coste, Emmanuelle; Adoue, Daniel; Lassmann, Hans; Clanet, Michel
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This article is from F1000Research , volume 2 . Abstract We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of this emerging inflammatory neurological condition in this immunocompromised patient with a severe rheumatic disease. We highlight that, in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968897
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Oct 28, 2014
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Martins, Tanimola; Hamilton, William; Ukoumunne, Obioha C
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This article is from BMC Family Practice , volume 14 . Abstract Background: Minimising diagnostic delays in cancer may help improve survival. Ethnic minorities have worse outcomes in some cancer types when compared to the majority; this may relate in part to differences during the diagnostic phase. Only a few British studies have specifically explored this relationship, and no synthesis of these exists. The present study aimed to systematically review evidence on ethnic inequalities in cancer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878039
