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Oct 24, 2014
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Atsukawa, Masanori; Tsubota, Akihito; Shimada, Noritomo; Kondo, Chisa; Itokawa, Norio; Nakagawa, Ai; Hashimoto, Satomi; Fukuda, Takeshi; Matsushita, Yoko; Kidokoro, Hideko; Narahara, Yoshiyuki; Nakatsuka, Katsuhisa; Iwakiri, Katsuhiko; Kawamoto, Chiaki; Sakamoto, Choitsu
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This article is from Hepatitis Monthly , volume 13 . Abstract Background: Serum vitamin D concentration is reported to show a decrease in older age. Patients with chronic hepatitis C (CHC) in Japan are older on average than those in Western countries. Moreover, the outcome of pegylated-interferon (PEG-IFN)/ ribavirin therapy combined with vitamin D in elderly patients is unclear. Objectives: This pilot study explored the efficacy and safety of alfacalcidol as vitamin D source in PEG-IFN/...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877658
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Oct 23, 2014
10/14
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Bauza, Karolis; Malinauskas, Tomas; Pfander, Claudia; Anar, Burcu; Jones, E. Yvonne; Billker, Oliver; Hill, Adrian V. S.; Reyes-Sandoval, Arturo
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This article is from Infection and Immunity , volume 82 . Abstract Plasmodium vivax is the world's most widely distributed malaria parasite and a potential cause of morbidity and mortality for approximately 2.85 billion people living mainly in Southeast Asia and Latin America. Despite this dramatic burden, very few vaccines have been assessed in humans. The clinically relevant vectors modified vaccinia virus Ankara (MVA) and the chimpanzee adenovirus ChAd63 are promising delivery systems for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957994
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Oct 25, 2014
10/14
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Bidokhti, Mehdi R. M.; Ullman, Karin; Jensen, Trine H.; Chriel, Mariann; Mottahedin, Amin; Munir, Muhammad; Andersson, Anna Maria; Detournay, Olivier; Hammer, Anne Sofie; Baule, Claudia
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This article is from PLoS ONE , volume 8 . Abstract Astroviruses are becoming a growing concern in veterinary and public health. To date there are no registered vaccines against astrovirus-induced disease, mostly due to the difficulty to cultivate astroviruses to high titer for vaccine development using conventional techniques. As means to circumvent this drawback, we have developed stably transfected mink fetal cells and BHK21 cells constitutively expressing the full-length and truncated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871642
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Oct 24, 2014
10/14
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Blazevic, Tina; Schaible, Anja M.; Weinhaupl, Katharina; Schachner, Daniel; Nikels, Felix; Weinigel, Christina; Barz, Dagmar; Atanasov, Atanas G.; Pergola, Carlo; Werz, Oliver; Dirsch, Verena M.; Heiss, Elke H.
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This article is from Cardiovascular Research , volume 101 . Abstract Aims: The small molecule indirubin-3′-monoxime (I3MO) has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation and neointima formation in vivo. The influence of I3MO on VSMC migration and vascular inflammation, two additional key players during the onset of atherosclerosis and restenosis, should be investigated. Methods and results: We examined the influence of I3MO on VSMC migration, with focus on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928003
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Oct 25, 2014
10/14
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Choi, Ja Young; Kim, Hyo In; Lee, Kil Chan; Han, Zee-A
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Supernumerary phantom limb (SPL) resulting from spinal cord lesions are very rare, with only sporadic and brief descriptions in the literature. Furthermore, the reported cases of SPL typically occurred in neurologically incomplete spinal cord patients. Here, we report a rare case of SPL with phantom limb pain that occurred after traumatic spinal cord injury in a neurologically complete patient. After a traffic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895533
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3.0
Jun 30, 2018
06/18
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Chun-Yang Wang; Xue-Mei Zong; Cui-Feng Sun; Hong Zhang; Zhen-Xue Song
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The quantum thermodynamic property of the fractional damping system is investigated extensively. A fractional power-law decaying entropy function is revealed which presents another evidence for the validity of the third law of thermodynamics in the quantum dissipative region. Several non-trivial characters are excavated such as that the entropy varies from a non-linear diverging function to a semi-linear decaying function of the fractional exponent as the temperature tends to absolute zero.
Topics: Quantum Physics, Statistical Mechanics, Condensed Matter
Source: http://arxiv.org/abs/1401.1425
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Oct 26, 2014
10/14
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Cihalova, Daniela; Hofman, Jakub; Ceckova, Martina; Staud, Frantisek
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This article is from PLoS ONE , volume 8 . Abstract Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine, flavopiridol and SNS-032) with the ABCB1 transporter. Four of the compounds inhibited efflux of two ABCB1...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871618
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Oct 23, 2014
10/14
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DUONG, HONG-QUAN; YI, YONG WEON; KANG, HYO JIN; HONG, YOUNG BIN; TANG, WENXI; WANG, ANTAI; SEONG, YEON-SUN; BAE, INSOO
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This article is from International Journal of Oncology , volume 44 . Abstract We describe the potential benefit of PIK-75 in combination of gemcitabine to treat pancreatic cancer in a preclinical mouse model. The effect of PIK-75 on the level and activity of NRF2 was characterized using various assays including reporter gene, quantitative PCR, DNA-binding and western blot analyses. Additionally, the combinatorial effect of PIK-75 and gemcitabine was evaluated in human pancreatic cancer cell...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928470
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Oct 24, 2014
10/14
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Daniel, Christoph; Vogelbacher, Regina; Stief, Andrea; Grigo, Christina; Hugo, Christian
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This article is from PLoS ONE , volume 8 . Abstract We recently identified Thrombospondin-2 (TSP-2) as a regulator of matrix remodelling and inflammation in experimental kidney disease by using TSP-2 null mice and successfully proved TSP-2 overexpression as a therapeutic concept in a short term glomerulonephritis model in the rat. In this current study, we investigated if long-term TSP-2 overexpression is also capable to ameliorate the progression of chronic kidney disease in the setting of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871554
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Oct 29, 2014
10/14
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Darwish, Omar; Slovin, Janet P; Kang, Chunying; Hollender, Courtney A; Geretz, Aviva; Houston, Sam; Liu, Zhongchi; Alkharouf, Nadim W
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This article is from BMC Plant Biology , volume 13 . Abstract Background: Fragaria vesca, a diploid strawberry species commonly known as the alpine or woodland strawberry, is a versatile experimental plant system and an emerging model for the Rosaceae family. An ancestral F. vesca genome contributed to the genome of the octoploid dessert strawberry (F. ×ananassa), and the extant genome exhibits synteny with other commercially important members of the Rosaceae family such as apple and peach. To...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878773
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Oct 28, 2014
10/14
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Dumoux, Maud; Le Gall, Sylvain M.; Habbeddine, Mohamed; Delarbre, Christiane; Hayward, Richard D.; Kanellopoulos-Langevin, Colette; Verbeke, Philippe
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This article is from PLoS ONE , volume 8 . Abstract The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion’. Alternative persistent intra-cellular forms can be induced in culture by diverse stimuli such as IFNγ or adenosine/EHNA. They do not grow or divide but revive upon withdrawal of the stimulus and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871543
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Oct 28, 2014
10/14
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Erb, Wendy M.; Hodges, J. Keith; Hammerschmidt, Kurt
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This article is from PLoS ONE , volume 8 . Abstract Primate loud calls have the potential to encode information about the identity, arousal, age, or physical condition of the caller, even at long distances. In this study, we conducted an analysis of the acoustic features of the loud calls produced by a species of Asian colobine monkey (simakobu, Simias concolor). Adult male simakobu produce loud calls spontaneously and in response to loud sounds and other loud calls, which are audible more than...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871870
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Oct 27, 2014
10/14
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Evers, Julia JE; Vieth, Volker VV; Hartensuer, Rene RH; Raschke, Michael MJR; Vordemvenne, Thomas TV
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This article is from BMC Research Notes , volume 6 . Abstract Background: Clivus fractures are highly uncommon. The classification by Corradino et al. divides the different lesions in longitudinal, transverse and oblique fractures. Longitudinal types are associated with the highest mortality rate between 67 – 80%. Clivus fractures are often found after high velocity trauma, especially traffic accidents and falls. The risk of neurologic lesions is high, because of the anatomic proximity to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878031
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Oct 23, 2014
10/14
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Flynn, Tanya J; Phipps-Green, Amanda; Hollis-Moffatt, Jade E; Merriman, Marilyn E; Topless, Ruth; Montgomery, Grant; Chapman, Brett; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R
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This article is from Arthritis Research & Therapy , volume 15 . Abstract Introduction: There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study was to test genetic variation across the SLC22A11/SLC22A12 locus for association with risk of gout in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978909
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Oct 23, 2014
10/14
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Haeri, Azadeh; Alinaghian, Behdokht; Daeihamed, Marjan; Dadashzadeh, Simin
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Chemotherapy research highly prioritizes overcoming the multidrug resistance (MDR) in human tumors. Liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. Liposomes were prepared using different active loading techniques. The influence of different...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977048
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Oct 27, 2014
10/14
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Hampton, David W; Serio, Andrea; Pryce, Gareth; Al-Izki, Sarah; Franklin, Robin JM; Giovannoni, Gavin; Baker, David; Chandran, Siddharthan
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This article is from Acta Neuropathologica Communications , volume 1 . Abstract Backgound: Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the absence of therapies for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895761
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Oct 28, 2014
10/14
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Han, Wenxuan; Tang, Luying; Chen, Yahan; Fang, Jingyun
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This article is from PLoS ONE , volume 8 . Abstract Most previous studies have ascribed variations in the resorption of a certain plant nutrient to its corresponding environmental availability or level in tissues, regardless of the other nutrients’ status. However, given that plant growth relies on both sufficient and balanced nutrient supply, the nutrient resorption process should not only be related to the absolute nutrient status, but also be regulated by the relative limitation of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871644
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Oct 23, 2014
10/14
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Hashemi, Mehrdad
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eye 44
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on BCL-2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.In this experimental study, 20 male wistar rats with average weight of 250-300 g were selected and then...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985231
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Oct 20, 2014
10/14
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Hay, Debbie L; Harris, Paul WR; Kowalczyk, Renata; Brimble, Margaret A; Rathbone, Dan L; Barwell, James; Conner, Alex C; Poyner, David R
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This article is from British Journal of Pharmacology , volume 171 . Abstract Background and Purpose: The N-terminus of calcitonin gene-related peptide (CGRP) is important for receptor activation, especially the disulphide-bonded ring (residues 1–7). However, the roles of individual amino acids within this region have not been examined and so the molecular determinants of agonism are unknown. This study has examined the role of residues 1, 3–6 and 8–9, excluding Cys-2 and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904261
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Oct 27, 2014
10/14
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Hedrich, Christian M; Hofmann, Sigrun R; Pablik, Jessica; Morbach, Henner; Girschick, Hermann J
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This article is from Pediatric Rheumatology Online Journal , volume 11 . Abstract Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result of a dysregulated innate immune system, resulting in immune cell infiltration of the bone and subsequent osteoclast differentiation and activation. Interestingly,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881012
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Oct 29, 2014
10/14
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Heinz, Emanuel; Kraft, Philipp; Buchen, Caroline; Frede, Hans-Georg; Aquino, Eugenio; Breuer, Lutz
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This article is from Sensors (Basel, Switzerland) , volume 14 . Abstract We have developed a high-resolution automatic sampling system for continuous in situ measurements of stable water isotopic composition and nitrogen solutes along with hydrological information. The system facilitates concurrent monitoring of a large number of water and nutrient fluxes (ground, surface, irrigation and rain water) in irrigated agriculture. For this purpose we couple an automatic sampling system with a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926554
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Oct 24, 2014
10/14
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Hill, Andrew F.; Pegtel, D. Michiel; Lambertz, Ulrike; Leonardi, Tommaso; O'Driscoll, Lorraine; Pluchino, Stefano; Ter-Ovanesyan, Dmitry; Nolte-'t Hoen, Esther N.M.
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This article is from Journal of Extracellular Vesicles , volume 2 . Abstract Extracellular vesicles (EVs) are the collective term for the various vesicles that are released by cells into the extracellular space. Such vesicles include exosomes and microvesicles, which vary by their size and/or protein and genetic cargo. With the discovery that EVs contain genetic material in the form of RNA (evRNA) has come the increased interest in these vesicles for their potential use as sources of disease...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873759
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Oct 28, 2014
10/14
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Ho-Pham, Lan T; Nguyen, Nguyen D; Nguyen, Tuan V
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This article is from BMC Musculoskeletal Disorders , volume 14 . Abstract Background: The study quantified the relative contributions of estrogen (E2) and total testosterone (TT) to variation in bone mineral density in men and women. Methods: This was a cross-sectional study which involved 200 men and 415 women aged 18 to 89 years. BMD at the lumbar spine (LS) and femoral neck (FN) was measured by DXA. Serum levels of E2 and TT were measured by electrochemiluminescence immunoassays. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878025
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Oct 27, 2014
10/14
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Hoarau, Jean-Jacques; Gay, Frederick; Pelle, Olivier; Samri, Assia; Jaffar-Bandjee, Marie-Christine; Gasque, Philippe; Autran, Brigitte
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This article is from PLoS ONE , volume 8 . Abstract To characterize the immunity developed by patients infected by chikungunya virus (CHIKV), we studied the intensity and specificity of CHIKV-specific T cells mediated responses in chronic and recovered patients at 12 to 24 months post-infection. T cells were challenged in vitro against CHIKV synthetic peptides covering the length of three viral proteins, capsid, E2 and nsP1 proteins as well as all inactivated virus particles. Cytokine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871564
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Oct 24, 2014
10/14
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Hong, Seok Ha; Im, Sun; Park, Geun-Young
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To explore the effect of visual and haptic vertical stimulation on standing balance in post-stroke patients. Methods: Twenty-five post-stroke patients were recruited. We measured left/right standing pressure differences and the center of pressure (COP) parameters for each patient under three different conditions: no stimulation, visual, and haptic stimulated conditions. First, patients stood on a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895526
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Oct 23, 2014
10/14
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Hooshfar, Shirin; Mortazavi, Seyed Alireza; Piryaei, Mohammad; Ramandi Darzi, Hossein; Shahsavari, Nahid; Kobarfard, Farzad
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A gradient reversed-phase high performance liquid chromatography (HPLC) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity used in infertility treatment. The HPLC method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ICH guidelines. The chromatographic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977052
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Oct 23, 2014
10/14
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Howard, Thomas P.; Fahy, Brendan; Leigh, Fiona; Howell, Phil; Powell, Wayne; Greenland, Andy; Trafford, Kay; Smith, Alison M.
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eye 13
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This article is from Journal of Cereal Science , volume 59 . Abstract The effects on barley starch and grain properties of four starch synthesis mutations were studied during the introgression of the mutations from diverse backgrounds into an elite variety. The lys5f (ADPglucose transporter), wax (granule-bound starch synthase), isa1 (debranching enzyme isoamylase 1) and sex6 (starch synthase IIa) mutations were introgressed into NFC Tipple to give mutant and wild-type BC2F4 families with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990431
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Oct 25, 2014
10/14
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Huang, Huan; Chen, Jiao; Liu, Hongde; Sun, Xiao
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eye 54
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This article is from BMC Genomics , volume 14 . Abstract Background: It has been reported that 3' end processing is coupled to transcription and nucleosome depletion near the polyadenylation sites in many species. However, the association between nucleosome occupancy and polyadenylation site usage is still unclear. Results: By systematic analysis of high-throughput sequencing datasets from the human genome, we found that nucleosome occupancy patterns are different around the polyadenylation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879661
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Oct 29, 2014
10/14
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Huang, Peirong; Niu, Wenquan; Ni, Zhentian; Wang, Renzuo; Sun, Xiaodong
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This article is from PLoS ONE , volume 8 . Abstract Background: Central retinal vein occlusion (CRVO) associates with severe vision outcome and no proven beneficial treatment. Our meta-analysis intended to appraise the efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) agents in macular edema (ME) following CRVO. Methods: Data were collected and analyzed by Review Manager 5.2.1. We employed a random-effects model to eliminate between-study heterogeneity. Nfs (called...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871640
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Oct 24, 2014
10/14
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Huijing, Peter A; Benard, Menno R; Harlaar, Jaap; Jaspers, Richard T; Becher, Jules G
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This article is from BMC Musculoskeletal Disorders , volume 14 . Abstract Background: In spastic cerebral palsy (SCP), a limited range of motion of the foot (ROM), limits gait and other activities. Assessment of this limitation of ROM and knowledge of active mechanisms is of crucial importance for clinical treatment. Methods: For a comparison between spastic cerebral palsy (SCP) children and typically developing children (TD), medial gastrocnemius muscle-tendon complex length was assessed using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909357
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Oct 27, 2014
10/14
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Humble, Mats B; Uvnas-Moberg, Kerstin; Engstrom, Ingemar; Bejerot, Susanne
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eye 46
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This article is from BMC Psychiatry , volume 13 . Abstract Background: The drug treatments of choice for obsessive-compulsive disorder (OCD) are serotonin reuptake inhibitors (SRIs). However, a correlation between the neuropeptide oxytocin in cerebrospinal fluid and the severity of OCD has previously been shown, and oxytocin and serotonin are interconnected within the brain. Few studies have investigated whether SRIs have any effect on oxytocin; thus, our aim was to explore the possibility that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877985
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Oct 24, 2014
10/14
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Huw, L-Y; O'Brien, C; Pandita, A; Mohan, S; Spoerke, J M; Lu, S; Wang, Y; Hampton, G M; Wilson, T R; Lackner, M R
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This article is from Oncogenesis , volume 2 . Abstract Agents targeting the PI3K/mTOR signaling axis have shown promise in early-phase clinical trials and are currently being studied in later stages of clinical development in multiple indications. Experience with other targeted agents suggests that clinical responses may be short-lived because of acquired resistance to therapy. Here, we report preclinical modeling of acquired resistance in a HER2-positive, PIK3CA mutant breast cancer cell line,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940863
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Oct 24, 2014
10/14
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Hwang, Seung Joon; Kim, Weon
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This article is from Chonnam Medical Journal , volume 49 . Abstract Traditionally, mitochondria have been regarded solely as energy generators for cells; however, accumulating data have demonstrated that these complex organelles play a variety of roles within the cardiomyocyte that extend beyond this classic function. Mitochondrial dynamics involves mitochondrial movements and morphologic alterations by tethering, fusion, and fission, which depend on cellular energy requirements and metabolic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881204
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Oct 28, 2014
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Hyakuna, Nobuyuki; Shimomura, Yasuto; Watanabe, Arata; Taga, Takashi; Kikuta, Atsushi; Matsushita, Takeji; Kogawa, Kazuhiro; Kawakami, Chihiro; Horikoshi, Yasuo; Iwai, Tsuyako; Okamoto, Yasuhiro; Tsurusawa, Masahito; Asami, Keiko
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This article is from Journal of Pediatric Hematology/Oncology , volume 36 . Abstract Supplemental Digital Content is available in the text.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872830
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Oct 23, 2014
10/14
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Kruczek, Cassandra; Qaisar, Uzma; Colmer-Hamood, Jane A; Hamood, Abdul N
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This article is from MicrobiologyOpen , volume 3 . Abstract In response to diverse environmental stimuli at different infection sites, Pseudomonas aeruginosa, a serious nosocomial pathogen, coordinates the production of different virulence factors through a complicated network of the hierarchical quorum-sensing (QS) systems including the las, rhl, and the 2-alkyl-4-quinolone-related QS systems. We recently showed that at early stages of growth serum alters the expression of numerous P....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937730
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Oct 27, 2014
10/14
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Kurata, Akira; Kawaguchi, Naoto; Kido, Teruhito; Inoue, Katsuji; Suzuki, Jun; Ogimoto, Akiyoshi; Funada, Jun-ichi; Higaki, Jitsuo; Miyagawa, Masao; Vembar, Mani; Mochizuki, Teruhito
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This article is from PLoS ONE , volume 8 . Abstract Background: The aim of this study was to investigate the correlation of the qualitative transmural extent of hypoperfusion areas (HPA) using stress dynamic whole-heart computed tomography perfusion (CTP) imaging by 256-slice CT with CTP-derived myocardial blood flow (MBF) for the estimation of the severity of coronary artery stenosis. Methods and Results: Eleven patients underwent adenosine triphosphate (0.16 mg/kg/min, 5 min) stress dynamic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871670
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Oct 23, 2014
10/14
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LIU, CHUN-LEI; HE, YUN-YUN; LI, XIN; LI, RUI-JUN; HE, KUN-LUN; WANG, LI-LI
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This article is from International Journal of Molecular Medicine , volume 33 . Abstract The serine/threonine protein phosphatase PP1 mediates the dephosphorylation of phosphorylated eukaryotic translation initiation factor 2 subunit α (p-eIF2α), which is a central regulator of protein synthesis. In the present study, we examined the protective effects of PP1–12 (an inhibitor of the serine/threonine protein phosphatase PP1) against tunicamycin (TM)-induced apoptosis in cultured...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926518
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Oct 28, 2014
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Lal, Aparna; Ikeda, Takayoshi; French, Nigel; Baker, Michael G.; Hales, Simon
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This article is from PLoS ONE , volume 8 . Abstract Background: Evaluating the influence of climate variability on enteric disease incidence may improve our ability to predict how climate change may affect these diseases. Objectives: To examine the associations between regional climate variability and enteric disease incidence in New Zealand. Methods: Associations between monthly climate and enteric diseases (campylobacteriosis, salmonellosis, cryptosporidiosis, giardiasis) were investigated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871872
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Oct 25, 2014
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Lin, Li; Hutzen, Brian; Lee, Hsiu-Fang; Peng, Zhengang; Wang, Wenlong; Zhao, Chongqiang; Lin, Huey-Jen; Sun, Duxin; Li, Pui-Kai; Li, Chenglong; Korkaya, Hasan; Wicha, Max S.; Lin, Jiayuh
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This article is from PLoS ONE , volume 8 . Abstract Background: STAT3 activation is frequently detected in breast cancer and this pathway has emerged as an attractive molecular target for cancer treatment. Recent experimental evidence suggests ALDH-positive (ALDH+), or cell surface molecule CD44-positive (CD44+) but CD24-negative (CD24−) breast cancer cells have cancer stem cell properties. However, the role of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24− subpopulations of breast cancer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871589
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Oct 24, 2014
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Lin, Yi-Wen; Huang, Chun-Yao; Chen, Yung-Hsiang; Shih, Chun-Ming; Tsao, Nai-Wen; Lin, Cheng-Yen; Chang, Nen-Chung; Tsai, Chien-Sung; Tsai, Hsiao-Ya; Tsai, Jui-Chi; Huang, Po-Hsun; Li, Chi-Yuan; Lin, Feng-Yen
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This article is from PLoS ONE , volume 8 . Abstract The number and function of endothelial progenitor cells (EPCs) are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. GroEL1 from Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis. However, the actual effects of GroEL1 on EPC function are unclear. In this study, we investigate the EPC function in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871664
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Oct 27, 2014
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Liu, Jung-Sen; Jung, Fang; Yang, Shih-Hsing; Chou, Shang-Shing P.; Huang, Jhih-Liang; Lu, Chang-Lin; Huang, Guan-Lin; Yang, Pan-Chyr; Lin, Jau-Chen; Jow, Guey-Mei
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This article is from PLoS ONE , volume 8 . Abstract Despite advances in antibiotic therapy and intensive care, the mortality caused by systemic inflammatory response syndrome and severe sepsis remains high. The use of anti-inflammatory agents to attenuate inflammatory response during acute systemic inflammatory reactions may improve survival rates. Here we show that a newly synthesized 2-pyridone compound (FJU-C4) can suppress the expression of late inflammatory mediators such as iNOS and COX-2...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871526
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Oct 23, 2014
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Liu, Zhong; Song, Yanrui; Li, Dan; He, Xiangyu; Li, Shishi; Wu, Bifeng; Wang, Wei; Gu, Shulian; Zhu, Xiaoyu; Wang, Xuexiang; Zhou, Qiyin; Dai, Yu; Yan, Qingfeng
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This article is from Journal of Medical Genetics , volume 51 . Abstract Background: Hypertrophic cardiomyopathy (HCM) is a primary disorder characterised by asymmetric thickening of septum and left ventricular wall, with a prevalence of 0.2% in the general population. Objective: To describe a novel mitochondrial DNA mutation and its association with the pathogenesis of HCM. Methods and results: All maternal members of a Chinese family with maternally transmitted HCM exhibited variable severity...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932983
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Oct 25, 2014
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Madec, Yoann; Leroy, Sandrine; Rey-Cuille, Marie-Anne; Huber, Florence; Calmy, Alexandra
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This article is from PLoS ONE , volume 8 . Abstract Objectives: Switching to second-line antiretroviral therapy (ART) largely depends on careful clinical assessment and access to biological measurements. We performed a systematic review and meta-analysis to estimate the incidence of switching to second-line ART in sub-Saharan Africa and its main programmatic determinants. Methods: We searched 2 databases for studies reporting the incidence rate of switching to second-line ART in adults living...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871158
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Oct 26, 2014
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Mama, Khursheed R; Gaynor, James S; Harvey, Ralph C; Robertson, Sheilah A; Koenig, Robbin L; Cozzi, Elizabeth M
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This article is from BMC Veterinary Research , volume 9 . Abstract Background: Propofol is a widely used injectable anesthetic agent for induction and short-term maintenance in dogs. A multi-dose formulation of propofol (MDP) has been developed which includes 2% benzyl alcohol as a preservative. In order to document the use of the product under clinical conditions, MDP was tested in a prospective clinical trial conducted at six sites within the United States. One hundred thirty-eight healthy,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901023
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Oct 28, 2014
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Martins, Tanimola; Hamilton, William; Ukoumunne, Obioha C
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This article is from BMC Family Practice , volume 14 . Abstract Background: Minimising diagnostic delays in cancer may help improve survival. Ethnic minorities have worse outcomes in some cancer types when compared to the majority; this may relate in part to differences during the diagnostic phase. Only a few British studies have specifically explored this relationship, and no synthesis of these exists. The present study aimed to systematically review evidence on ethnic inequalities in cancer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878039
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Oct 28, 2014
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Mettler, Tobias; Stump, Reto; Haueis, Silvia; Kalt, Nicola; Tschuor, Christoph; Limani, Perparim; Raptis, Dimitri A; Puhan, Milo A; Breitenstein, Stefan
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This article is from JMIR Research Protocols , volume 2 . Abstract Background: Hepatic metastases of neuroendocrine tumors (NETs) are considered a major prognostic factor associated with significantly reduced survival compared to patients without liver metastases. Several surgical and nonsurgical strategies are present to treat resectable and nonresectable liver metastases, some of which have the potential to cure liver mestatases. Objective: The aims of the four systematic reviews presented in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875902
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Oct 22, 2014
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Meyer, Arndt; Hilgen, Gerrit; Dorgau, Birthe; Sammler, Esther M.; Weiler, Reto; Monyer, Hannah; Dedek, Karin; Hormuzdi, Sheriar G.
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This article is from Journal of Cell Science , volume 127 . Abstract Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (Cx36) is the most abundant isoform; however, the mechanisms underlying formation of Cx36-containing electrical synapses are unknown. We focus on homocellular and heterocellular gap junctions formed by an AII amacrine cell, a key interneuron found in all mammalian retinas. In mice lacking native...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953814
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Oct 24, 2014
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Niegowski, Damian; Kleinschmidt, Thea; Olsson, Ulrika; Ahmad, Shabbir; Rinaldo-Matthis, Agnes; Haeggstrom, Jesper Z.
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This article is from The Journal of Biological Chemistry , volume 289 . Abstract Background: Leukotriene (LT) C4 synthase (LTC4S) is a membrane protein catalyzing the formation of pathogenic mediators of asthma.Results: Crystal structures of complexes of WT and mutated LTC4S with three product analogs.Conclusion: Evidence for the binding mode of LTA4 and LTC4 at the active site of LTC4S and a mechanistic model.Significance: New insights into the molecular mechanism of LTC4S.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931076
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Oct 23, 2014
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Oberdorfer, Bernd; Setman, Daria; Steyskal, Eva-Maria; Hohenwarter, Anton; Sprengel, Wolfgang; Zehetbauer, Michael; Pippan, Reinhard; Wurschum, Roland
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This article is from Acta Materialia , volume 68 . Abstract The release of excess volume upon recrystallization of ultrafine-grained Cu deformed by high-pressure torsion (HPT) was studied by means of the direct technique of high-precision difference dilatometry in combination with differential scanning calorimetry (DSC) and scanning electron microscopy. From the length change associated with the removal of grain boundaries in the wake of crystallite growth, a structural key quantity of grain...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990421
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Oct 25, 2014
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Oji, Yutaka; Noda, Kazuyuki; Tokugawa, Joji; Yamashiro, Kazuo; Hattori, Nobutaka; Okuma, Yasuyuki
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This article is from Journal of Medical Case Reports , volume 7 . Abstract Introduction: Spinal subarachnoid hemorrhage has many causes including trauma, vascular malformations, aneurysms, spinal cord tumors, coagulation abnormalities, use of anticoagulants, systemic lupus erythematosus, or Behçet’s disease. We report on a rare case of a spontaneous spinal subarachnoid hemorrhage after severe coughing of unknown origin. To the best of our knowledge, this is the first report of spontaneous...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878018
