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Oct 25, 2014
10/14
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Ahn, Tae-Gue; Lee, Joo-Young; Cheon, Se-Yun; An, Hyo-Jin; Kook, Yoon-Bum
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This article is from BMC Complementary and Alternative Medicine , volume 13 . Abstract Background: Sam-Hwang-Sa-Sim-Tang (SHSST) is a traditional Oriental medication that has been commonly used in Korea for the treatment of hypertension, insomnia, and chest pain. In addition, some studies reported that administration of SHSST results suppression of hyperlipidemia in rats or lowering lipid plasma level such as total cholesterol (TC). Those results made us find and demonstrate positive effect of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900264
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Oct 5, 2014
10/14
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Barbetti, V; Morandi, A; Tusa, I; Digiacomo, G; Riverso, M; Marzi, I; Cipolleschi, M G; Bessi, S; Giannini, A; Di Leo, A; Dello Sbarba, P; Rovida, E
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This article is from Oncogene , volume 33 . Abstract The colony-stimulating factor-1 (CSF-1) and its receptor CSF-1R physiologically regulate the monocyte/macrophage system, trophoblast implantation and breast development. An abnormal CSF-1R expression has been documented in several human epithelial tumors, including breast carcinomas. We recently demonstrated that CSF-1/CSF-1R signaling drives proliferation of breast cancer cells via ‘classical' receptor tyrosine kinase signaling, including...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141303
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Oct 25, 2014
10/14
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Bidokhti, Mehdi R. M.; Ullman, Karin; Jensen, Trine H.; Chriel, Mariann; Mottahedin, Amin; Munir, Muhammad; Andersson, Anna Maria; Detournay, Olivier; Hammer, Anne Sofie; Baule, Claudia
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This article is from PLoS ONE , volume 8 . Abstract Astroviruses are becoming a growing concern in veterinary and public health. To date there are no registered vaccines against astrovirus-induced disease, mostly due to the difficulty to cultivate astroviruses to high titer for vaccine development using conventional techniques. As means to circumvent this drawback, we have developed stably transfected mink fetal cells and BHK21 cells constitutively expressing the full-length and truncated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871642
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Oct 25, 2014
10/14
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Blume-Kohout, Margaret E.; Clack, John W.
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This article is from PLoS ONE , volume 8 . Abstract The U.S. National Institutes of Health (NIH) budget expansion from 1998 through 2003 increased demand for biomedical research, raising relative wages and total employment in the market for biomedical scientists. However, because research doctorates in biomedical sciences can often take six years or more to complete, the full labor supply response to such changes in market conditions is not immediate, but rather is observed over a period of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871560
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Oct 27, 2014
10/14
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Bozdag, Sinem Civriz; Namdaroglu, Sinem; Kayikci, Omur; Kaygusuz, Gulsah; Demiriz, Itir; Cinarsoy, Murat; Tekgunduz, Emre; Altuntas, Fevzi
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This article is from Hematology Reports , volume 5 . Abstract Large granular lymphocytic (LGL) leukemia is a lymphoproliferative disease characterized by the clonal expansion of cytotoxic T or natural killer cells. We report on a patient diagnosed with T-cell LGL leukemia two years after the achievement of hematologic remission for acute myeloblastic leukemia.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883061
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Oct 12, 2014
10/14
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Buck, Danielle; Smith, John E.; Chung, Charles S.; Ono, Yasuko; Sorimachi, Hiroyuki; Labeit, Siegfried; Granzier, Henk L.
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This article is from The Journal of General Physiology , volume 143 . Abstract Changes in titin splicing resulting in decreased size and increased stiffness lead to pathological changes in skeletal muscle.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001778
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Oct 28, 2014
10/14
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Cadena-Mendez, Miguel; Escalante-Ramirez, Boris; Azpiroz-Leehan, Joaquin; Infante-Vazquez, Oscar
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This article is from SpringerPlus , volume 2 . Abstract The aim of this paper is to understand how to measure the VO2 and VCO2 variabilities in indirect calorimetry (IC) since we believe they can explain the high variation in the resting energy expenditure (REE) estimation. We propose that variabilities should be separately measured from the VO2 and VCO2 averages to understand technological differences among metabolic monitors when they estimate the REE. To prove this hypothesis the mixing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884081
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Oct 27, 2014
10/14
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Carlini, Federico; Traore, Karim; Cherouat, Nissem; Roubertoux, Pierre; Buhler, Stephane; Cortey, Marti; Simon, Sophie; Doumbo, Ogobara; Chiaroni, Jacques; Picard, Christophe; Di Cristofaro, Julie
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This article is from PLoS ONE , volume 8 . Abstract The HLA-G molecule plays an important role in immunomodulation. In a previous study carried out on a southern French population our team showed that HLA-G haplotypes, defined by SNPs in the coding region and specific SNPs located in 5′URR and 3′UTR regulatory regions, are associated with differential soluble HLA-G expression (sHLA-G). Furthermore, the structure of these HLA-G haplotypes appears to be conserved in geographically distant...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871591
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Oct 28, 2014
10/14
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Carnie, A; Lin, J; Aicher, B; Leon, B; Courville, A B; Sebring, N G; de Jesus, J; DellaValle, D M; Fitzpatrick, B D; Zalos, G; Powell-Wiley, T M; Chen, K Y; Cannon, R O
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This article is from Nutrition & Diabetes , volume 3 . Abstract Objective:: Obesity in the United States is highly prevalent, approaching 60% for black women. We investigated whether nutrition education sessions at the work place added to internet-based wellness information and exercise resources would facilitate weight and fat mass loss in a racially diverse population of overweight female employees. Methods:: A total of 199 (average body mass index 33.9±6.3 kg m−2) nondiabetic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877430
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Oct 24, 2014
10/14
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Cerosaletti, Karen; Schneider, Anya; Schwedhelm, Katharine; Frank, Ian; Tatum, Megan; Wei, Shan; Whalen, Elizabeth; Greenbaum, Carla; Kita, Mariko; Buckner, Jane; Long, S. Alice
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This article is from PLoS ONE , volume 8 . Abstract IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4+CD25hiFOXP3+ regulatory T cells (Treg); a cell type that plays an integral role in maintaining tolerance. Thus, we hypothesized that decreased response to IL-2 may be a common phenotype of subjects who have autoimmune diseases associated with variants in the IL2RA locus, including T1D and MS, particularly in cells expressing the high affinity IL-2R alpha...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871703
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Oct 29, 2014
10/14
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Chen, Li-Ching; Lee, Wen-Sen
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This article is from PLoS ONE , volume 8 . Abstract Hemorrhagic stroke caused leakage of red blood cells which converts to hemoglobin, heme, and iron accumulated at the lesions. High concentration of ferrous iron from subarachnoid hemorrhage (SAH) induced cerebral vasospasm. Using the two-hemorrhage SAH model in rats, we previously demonstrated that estradiol (E2) significantly attenuated the SAH-induced vasospasm by inhibiting the NOS2 expression. Adding ferrous citrate (FC) complexes to the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871628
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Oct 24, 2014
10/14
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Cherry, Jonathan J.; Rietz, Anne; Malinkevich, Anna; Liu, Yuqi; Xie, Meng; Bartolowits, Matthew; Davisson, V. Jo; Baleja, James D.; Androphy, Elliot J.
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This article is from PLoS ONE , volume 8 . Abstract Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, “high-risk” HPV E6 proteins bind to and modify the target specificity of the ubiquitin ligase E6AP (E6 associated protein). This E6-dependent loss of p53 enables the virus to bypass host cell defenses and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871595
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Oct 25, 2014
10/14
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Choi, Ja Young; Kim, Hyo In; Lee, Kil Chan; Han, Zee-A
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Supernumerary phantom limb (SPL) resulting from spinal cord lesions are very rare, with only sporadic and brief descriptions in the literature. Furthermore, the reported cases of SPL typically occurred in neurologically incomplete spinal cord patients. Here, we report a rare case of SPL with phantom limb pain that occurred after traumatic spinal cord injury in a neurologically complete patient. After a traffic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895533
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Oct 24, 2014
10/14
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Choi, Soo-Ho; Yin, Huiyong; Ravandi, Amir; Armando, Aaron; Dumlao, Darren; Kim, Jungsu; Almazan, Felicidad; Taylor, Angela M.; McNamara, Coleen A.; Tsimikas, Sotirios; Dennis, Edward A.; Witztum, Joseph L.; Miller, Yury I.
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This article is from PLoS ONE , volume 8 . Abstract Oxidation of low-density lipoprotein (LDL) is one of the major causative mechanisms in the development of atherosclerosis. In previous studies, we showed that minimally oxidized LDL (mmLDL) induced inflammatory responses in macrophages, macropinocytosis and intracellular lipid accumulation and that oxidized cholesterol esters (OxCEs) were biologically active components of mmLDL. Here we identified a specific OxCE molecule responsible for the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871536
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Oct 24, 2014
10/14
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Choudhry, Fahad Riaz; Bokharey, Iram Zehra
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This article is from International Journal of Qualitative Studies on Health and Well-being , volume 8 . Abstract The study was conducted to explore the mental health issues of Pakistani nomads and to uncover their concept, ideation, and perception about mental health and illnesses. It was an exploratory study situated in the qualitative paradigm. The research strategy used was Interpretative Phenomenological Analysis (IPA), as the study was planned to explore the lived experiences of nomads...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873115
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Oct 28, 2014
10/14
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Choulagai, Bishnu; Onta, Sharad; Subedi, Narayan; Mehata, Suresh; Bhandari, Gajananda P; Poudyal, Amod; Shrestha, Binjwala; Mathai, Matthews; Petzold, Max; Krettek, Alexandra
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This article is from BMC International Health and Human Rights , volume 13 . Abstract Background: Skilled birth attendants (SBAs) provide important interventions that improve maternal and neonatal health and reduce maternal and neonatal mortality. However, utilization and coverage of services by SBAs remain poor, especially in rural and remote areas of Nepal. This study examined the characteristics associated with utilization of SBA services in mid- and far-western Nepal. Methods: This...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878020
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3.0
Jun 30, 2018
06/18
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Chun-Yang Wang; Xue-Mei Zong; Cui-Feng Sun; Hong Zhang; Zhen-Xue Song
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The quantum thermodynamic property of the fractional damping system is investigated extensively. A fractional power-law decaying entropy function is revealed which presents another evidence for the validity of the third law of thermodynamics in the quantum dissipative region. Several non-trivial characters are excavated such as that the entropy varies from a non-linear diverging function to a semi-linear decaying function of the fractional exponent as the temperature tends to absolute zero.
Topics: Quantum Physics, Statistical Mechanics, Condensed Matter
Source: http://arxiv.org/abs/1401.1425
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47
Oct 26, 2014
10/14
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Cihalova, Daniela; Hofman, Jakub; Ceckova, Martina; Staud, Frantisek
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This article is from PLoS ONE , volume 8 . Abstract Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine, flavopiridol and SNS-032) with the ABCB1 transporter. Four of the compounds inhibited efflux of two ABCB1...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871618
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5.0
Jun 30, 2018
06/18
by
Claire I. Levaillant
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As part of a protocol, we braid in a certain way six anyons of topological charges $222211$ in the Kauffman-Jones version of $SU(2)$ Chern-Simons theory at level $4$. The gate we obtain is a braid for the usual qutrit $2222$ but with respect to a different basis. With respect to that basis, the Freedman group of \cite{LEV} is identical to the $D$-group $D(18,1,1;2,1,1)$. We give a physical interpretation for each Blichfeld generator of the group $D(18,1,1;2,1,1)$. Inspired by these new...
Topics: Quantum Physics, Quantum Algebra, Mathematics, Representation Theory, Group Theory
Source: http://arxiv.org/abs/1401.0506
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45
Oct 25, 2014
10/14
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Contreras-Huerta, Luis Sebastian; Baker, Katharine S.; Reynolds, Katherine J.; Batalha, Luisa; Cunnington, Ross
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This article is from PLoS ONE , volume 8 . Abstract Recent studies have shown that perceiving the pain of others activates brain regions in the observer associated with both somatosensory and affective-motivational aspects of pain, principally involving regions of the anterior cingulate and anterior insula cortex. The degree of these empathic neural responses is modulated by racial bias, such that stronger neural activation is elicited by observing pain in people of the same racial group...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871655
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47
Oct 23, 2014
10/14
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Cooper, Lori A; Page, Stephanie T
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eye 47
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This article is from Asian Journal of Andrology , volume 16 . Abstract A growing body of literature has established the anabolic benefits of testosterone (T) therapy in hypogonadal men. However, there remains a paucity of data regarding the risks of exogenous androgen use in older men and the potential for adverse effects on the prostate gland. Whether T therapy in older, hypogonadal men might worsen lower urinary tract symptoms or exacerbate, unmask, or even incite prostate cancer development...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955334
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Oct 25, 2014
10/14
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Cordon-Obras, Carlos; Cano, Jorge; Gonzalez-Pacanowska, Dolores; Benito, Agustin; Navarro, Miguel; Bart, Jean-Mathieu
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This article is from PLoS ONE , volume 8 . Abstract Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. Thus, fauna could act as reservoir, constraining the elimination of the parasite in hypo-endemic foci. To better understand the possible maintenance of T. b. gambiense in local fauna and investigate the molecular mechanisms underlying adaptation, we generated adapted cells lines (ACLs) by in vitro culture...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871602
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Oct 26, 2014
10/14
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Cowen, Laura L E; Besbeas, Panagiotis; Morgan, Byron J T; Schwarz, Carl J
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This article is from Ecology and Evolution , volume 4 . Abstract Little attention has been paid to the use of multi-sample batch-marking studies, as it is generally assumed that an individual's capture history is necessary for fully efficient estimates. However, recently, Huggins et al. (2010) present a pseudo-likelihood for a multi-sample batch-marking study where they used estimating equations to solve for survival and capture probabilities and then derived abundance estimates using a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925384
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Oct 28, 2014
10/14
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Coze, Fabien; Gilard, Francoise; Tcherkez, Guillaume; Virolle, Marie-Joelle; Guyonvarch, Armel
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This article is from PLoS ONE , volume 8 . Abstract Metabolic Flux Analysis is now viewed as essential to elucidate the metabolic pattern of cells and to design appropriate genetic engineering strategies to improve strain performance and production processes. Here, we investigated carbon flux distribution in two Streptomyces coelicolor A3 (2) strains: the wild type M145 and its derivative mutant M1146, in which gene clusters encoding the four main antibiotic biosynthetic pathways were deleted....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871631
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Oct 29, 2014
10/14
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Danzeisen, Jessica L.; Calvert, Alamanda J.; Noll, Sally L.; McComb, Brian; Sherwood, Julie S.; Logue, Catherine M.; Johnson, Timothy J.
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This article is from PeerJ , volume 1 . Abstract Because of concerns related to the use of antibiotics in animal agriculture, antibiotic-free alternatives are greatly needed to prevent disease and promote animal growth. One of the current challenges facing commercial turkey production in Minnesota is difficulty obtaining flock average weights typical of the industry standard, and this condition has been coined “Light Turkey Syndrome” or LTS. This condition has been identified in Minnesota...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883494
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Oct 23, 2014
10/14
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Davitt, Lina I.; Cristino, Filipe; Wong, Alan C.-N.; Leek, E. Charles
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This article is from Journal of Experimental Psychology. Human Perception and Performance , volume 40 . Abstract This study examines the kinds of shape features that mediate basic- and subordinate-level object recognition. Observers were trained to categorize sets of novel objects at either a basic (between-families) or subordinate (within-family) level of classification. We analyzed the spatial distributions of fixations and compared them to model distributions of different curvature polarity...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977674
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Oct 25, 2014
10/14
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Deletre, Emilie; Martin, Thibaud; Campagne, Pascal; Bourguet, Denis; Cadin, Andy; Menut, Chantal; Bonafos, Romain; Chandre, Fabrice
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This article is from PLoS ONE , volume 8 . Abstract Pyrethroid insecticides induce an excito-repellent effect that reduces contact between humans and mosquitoes. Insecticide use is expected to lower the risk of pathogen transmission, particularly when impregnated on long-lasting treated bednets. When applied at low doses, pyrethroids have a toxic effect, however the development of pyrethroid resistance in several mosquito species may jeopardize these beneficial effects. The need to find...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871167
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Oct 24, 2014
10/14
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Denkinger, Claudia M.; Kalantri, Yatiraj; Schumacher, Samuel G.; Michael, Joy S.; Shankar, Deepa; Saxena, Arvind; Sriram, Natarajan; Balamugesh, Thangakunam; Luo, Robert; Pollock, Nira R.; Pai, Madhukar; Christopher, Devasahayam J.
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This article is from PLoS ONE , volume 8 . Abstract Existing diagnostic tests for pleural tuberculosis (TB) have inadequate accuracy and/or turnaround time. Interferon-gamma (IFNg) has been identified in many studies as a biomarker for pleural TB. Our objective was to develop a lateral flow, immunochromatographic test (ICT) based on this biomarker and to evaluate the test in a clinical cohort. Because IFNg is commonly present in non-TB pleural effusions in low amounts, a diagnostic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871622
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Oct 24, 2014
10/14
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Ding, Lei; Zhang, Ling-Li; Gao, Run; Chen, Dan; Wang, Jue-Jin; Gao, Xing-Ya; Kang, Yu-Ming; Zhu, Guo-Qing
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This article is from PLoS ONE , volume 8 . Abstract Background: Adipose afferent reflex (AAR) is a sympatho-excitatory reflex induced by chemical stimulation of white adipose tissue (WAT). Ionotropic glutamate receptors including NMDA receptors (NMDAR) and non-NMDA receptors (non-NMDAR) in paraventricular nucleus (PVN) mediate the AAR. Enhanced AAR contributes to sympathetic activation and hypertension in obesity rats. This study was designed to investigate the role and mechanism of superoxide...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871588
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Oct 24, 2014
10/14
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Driesen, Ronald B.; Nagaraju, Chandan K.; Abi-Char, Joelle; Coenen, Tamara; Lijnen, Paul J.; Fagard, Robert H.; Sipido, Karin R.; Petrov, Victor V.
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This article is from Cardiovascular Research , volume 101 . Abstract Aims: Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility. Methods and results: Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation. Fb spontaneously differentiated to proliferating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928002
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Oct 28, 2014
10/14
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Duane, Sinead; Callan, Aoife; Galvin, Sandra; Murphy, Andrew W; Domegan, Christine; O'Shea, Eamon; Cormican, Martin; Bennett, Kathleen; O'Donnell, Martin; Vellinga, Akke
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This article is from Trials , volume 14 . Abstract Background: The overuse of antimicrobials is recognized as the main selective pressure driving the emergence and spread of antimicrobial resistance in human bacterial pathogens. Urinary tract infections (UTIs) are among the most common infections presented in primary care and empirical antimicrobial treatment is currently recommended. Previous research has identified that a substantial proportion of Irish general practitioners (GPs) prescribe...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880352
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Oct 23, 2014
10/14
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Eleazu, Chinedum Ogbonnaya; Eleazu, Kate Chinedum; Chukwuma, Sonia; Essien, Udeme Nelson
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This article is from Journal of Diabetes and Metabolic Disorders , volume 12 . Abstract Streptozotocin (STZ) (2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-D-glucopyranose) is a naturally occurring diabetogenic compound, produced by the soil bacterium streptomyces achromogenes, that exhibits broad spectrum of antibacterial properties. Streptozotocin functions as a DNA synthesis inhibitor in both bacterial and mammalian cells. In mammalian cells, the actual mechanism and metabolic targets...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933000
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Oct 23, 2014
10/14
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Flynn, Tanya J; Phipps-Green, Amanda; Hollis-Moffatt, Jade E; Merriman, Marilyn E; Topless, Ruth; Montgomery, Grant; Chapman, Brett; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R
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This article is from Arthritis Research & Therapy , volume 15 . Abstract Introduction: There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study was to test genetic variation across the SLC22A11/SLC22A12 locus for association with risk of gout in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978909
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Oct 28, 2014
10/14
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Frith, Jessica E.; Titmarsh, Drew M.; Padmanabhan, Harish; Cooper-White, Justin J.
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This article is from PLoS ONE , volume 8 . Abstract Cellular microenvironmental conditions coordinate to regulate stem cell populations and their differentiation. Mesenchymal precursor cells (MPCs), which have significant potential for a wide range of therapeutic applications, can be expanded or differentiated into osteo- chondro- and adipogenic lineages. The ability to establish, screen, and control aspects of the microenvironment is paramount if we are to elucidate the complex interplay of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871528
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Oct 25, 2014
10/14
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Glover, Marewa; Bosman, Amber; Wagemakers, Annemarie; Kira, Anette; Paton, Chris; Cowie, Nathan
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This article is from BMC Public Health , volume 13 . Abstract Background: Māori and Pacific Island people have significantly higher smoking rates compared to the rest of the New Zealand population. The main aim of this paper is to describe how knowledge of Indigenous people’s practices and principles can be combined with proven effective smoking cessation support into a cessation intervention appropriate for Indigenous people. Methods/Design: A literature review was conducted to identify...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882284
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Oct 27, 2014
10/14
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Guwatudde, David; Bwanga, Freddie; Dudley, Lilian; Chola, Lumbwe; Leyna, Germana Henry; Mmbaga, Elia John; Kumwenda, Newton; Protsiv, Myroslava; Atkins, Salla; Zwarenstein, Merrick; Obua, Celestino; Tumwine, James K
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This article is from Human Resources for Health , volume 11 . Abstract Background: The need to develop capacity for health services and systems research (HSSR) in low and middle income countries has been highlighted in a number of international forums. However, little is known about the level of HSSR training in Sub-Saharan Africa (SSA). We conducted an assessment at four major East and Southern African universities to describe: a) the numbers of HSSR PhD trainees at these institutions, b)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878024
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Oct 27, 2014
10/14
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Hampton, David W; Serio, Andrea; Pryce, Gareth; Al-Izki, Sarah; Franklin, Robin JM; Giovannoni, Gavin; Baker, David; Chandran, Siddharthan
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This article is from Acta Neuropathologica Communications , volume 1 . Abstract Backgound: Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the absence of therapies for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895761
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Oct 28, 2014
10/14
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Han, Wenxuan; Tang, Luying; Chen, Yahan; Fang, Jingyun
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This article is from PLoS ONE , volume 8 . Abstract Most previous studies have ascribed variations in the resorption of a certain plant nutrient to its corresponding environmental availability or level in tissues, regardless of the other nutrients’ status. However, given that plant growth relies on both sufficient and balanced nutrient supply, the nutrient resorption process should not only be related to the absolute nutrient status, but also be regulated by the relative limitation of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871644
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Oct 20, 2014
10/14
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Hay, Debbie L; Harris, Paul WR; Kowalczyk, Renata; Brimble, Margaret A; Rathbone, Dan L; Barwell, James; Conner, Alex C; Poyner, David R
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This article is from British Journal of Pharmacology , volume 171 . Abstract Background and Purpose: The N-terminus of calcitonin gene-related peptide (CGRP) is important for receptor activation, especially the disulphide-bonded ring (residues 1–7). However, the roles of individual amino acids within this region have not been examined and so the molecular determinants of agonism are unknown. This study has examined the role of residues 1, 3–6 and 8–9, excluding Cys-2 and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904261
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Oct 25, 2014
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Huang, Huan; Chen, Jiao; Liu, Hongde; Sun, Xiao
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This article is from BMC Genomics , volume 14 . Abstract Background: It has been reported that 3' end processing is coupled to transcription and nucleosome depletion near the polyadenylation sites in many species. However, the association between nucleosome occupancy and polyadenylation site usage is still unclear. Results: By systematic analysis of high-throughput sequencing datasets from the human genome, we found that nucleosome occupancy patterns are different around the polyadenylation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879661
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Oct 25, 2014
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Kim, Mi-Young; Chung, Cho-Yun; Kim, Jong-Sun; Myung, Dae-Seong; Cho, Sung-Bum; Park, Chang-Hwan; Kim, Young; Joo, Young-Eun
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This article is from Chonnam Medical Journal , volume 49 . Abstract We report the first case of hypercalcemia-induced acute pancreatitis caused by a functioning parathyroid cyst in a 67-year-old man. Laboratory investigation revealed increased serum amylase and lipase, increased serum ionized calcium and parathyroid hormone (PTH) levels, and decreased serum phosphate, indicating pancreatitis and primary hyperparathyroidism (PHPT). Abdominal computed tomography (CT) revealed mild swelling of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881208
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Oct 24, 2014
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Kim, Soo Yeon; Park, Hye Kyung; Song, Dae Heon; Chung, Myung Eun; Kim, Young Moon; Woo, Jae Hyun
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Ptosis could be caused by oculomotor nerve palsy in the midbrain infarction. Bilateral ptosis has been reported in several reports, which focused on clinical characteristics of midbrain infarction. Little research attention has been paid to the treatment of patients with bilateral ptosis in midbrain infarction. We experienced a case of severe bilateral ptosis occurring after midbrain infarction. The patient could not...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895531
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Oct 28, 2014
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Ko, Sung Hwa; Shin, Yong Beom; Min, Ji Hong; Shin, Myung Jun; Chang, Jae Hyeok; Shin, Yong-Il; Ko, Hyun-Yoon
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To investigate the effect of botulinum toxin type A (BTA) injection into the salivary gland and to evaluate the changes of drooling in varied postures in tetraplegic patients with brain injury. Methods: Eight tetraplegic patients with brain injury were enrolled. BTA was injected into each parotid and submandibular gland of both sides under ultrasonographic guidance. Drooling was measured by a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895519
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Oct 24, 2014
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Kotecha, Rishi S.; Buckland, Amy; Phillips, Marianne B.; Cole, Catherine H.; Gottardo, Nicholas G.
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This article is from Journal of Pediatric Hematology/Oncology , volume 36 . Abstract Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease, is a well-recognized toxic complication after autologous and allogeneic hematopoietic stem cell transplant, during treatment of Wilms tumor and rhabdomyosarcoma associated with actinomycin-D, and during acute lymphoblastic leukemia therapy due to oral 6-thioguanine. However, its occurrence in the context of chemotherapy...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872829
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Oct 23, 2014
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Kruczek, Cassandra; Qaisar, Uzma; Colmer-Hamood, Jane A; Hamood, Abdul N
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This article is from MicrobiologyOpen , volume 3 . Abstract In response to diverse environmental stimuli at different infection sites, Pseudomonas aeruginosa, a serious nosocomial pathogen, coordinates the production of different virulence factors through a complicated network of the hierarchical quorum-sensing (QS) systems including the las, rhl, and the 2-alkyl-4-quinolone-related QS systems. We recently showed that at early stages of growth serum alters the expression of numerous P....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937730
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Oct 27, 2014
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Lambert, Jennifer E.; Ryan, Edmond A.; Thomson, Alan B. R.; Clandinin, Michael T.
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This article is from PLoS ONE , volume 8 . Abstract Background: Synthesis of lipid species, including fatty acids (FA) and cholesterol, can contribute to pathological disease. The purpose of this study was to investigate FA and cholesterol synthesis in individuals with type 1 diabetes, a group at elevated risk for vascular disease, using stable isotope analysis. Methods: Individuals with type 1 diabetes (n = 9) and age-, sex-, and BMI-matched non-diabetic subjects (n = 9) were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871159
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Oct 21, 2014
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Leducq, Jean-Baptiste; Gosset, Celia C; Gries, Rita; Calin, Kevin; Schmitt, Eric; Castric, Vincent; Vekemans, Xavier
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This article is from G3: Genes|Genomes|Genetics , volume 4 . Abstract Self-incompatibility (SI) is a genetic system that prevents self-fertilization in many Angiosperms. Although plants from the Brassicaceae family present an apparently unique SI system that is ancestral to the family, investigations at the S-locus responsible for SI have been mostly limited to two distinct lineages (Brassica and Arabidopsis-Capsella, respectively). Here, we investigated SI in a third deep-branching lineage of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065267
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Oct 25, 2014
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Lee, Ah Young; Kim, Eun Hyuk; Cho, Yun Woo; Kwon, Sun Oh; Son, Su Min; Ahn, Sang Ho
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To examine using surface electromyography whether stair climbing with abdominal hollowing (AH) is better at facilitating local trunk muscle activity than stair climbing without AH. Methods: Twenty healthy men with no history of low back pain participated in the study. Surface electrodes were attached to the multifidus (MF), lumbar erector spinae, thoracic erector spinae, transverse abdominus - internal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895520
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Oct 28, 2014
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Lee, Hyo-Seol; Lee, Jongeun; Kim, Seong-Oh; Song, Je-Seon; Lee, Jae-Ho; Lee, Syng-Ill; Jung, Han-Sung; Choi, Byung-Jai
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This article is from PLoS ONE , volume 8 . Abstract The human dental follicle partially differentiates into the periodontal ligament (PDL), but their biological functions are different. The gene-expression profiles of the dental follicle and PDL were compared using the cDNA microarray technique. Microarray analysis identified 490 genes with a twofold or greater difference in expression, 365 and 125 of which were more abundant in the dental follicle and PDL, respectively. The most strongly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871683
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Oct 24, 2014
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Lee, Jang Woo; Won, Yu Hui; Choi, Won Ah; Lee, Soon Kyu; Kang, Seong Woong
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Low vital capacity is a risk factor for scoliosis correction operation in Duchenne muscular dystrophy (DMD) patients, but pulmonary rehabilitation, including noninvasive intermittent positive pressure ventilator application, air stacking exercise, and assisted coughing technique, reduces the pulmonary complications and perioperative mortality risk. In this case, the patient's preoperative forced vital capacity (FVC)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895528
