Search

SHOW DETAILS

SORT BY

RELEVANCE

VIEWS

TITLE

DATE ARCHIVED

CREATOR

Prior Page

PubMed Central

53 53

Follicular Adenomas Exhibit a Unique Metabolic Profile. 1H NMR Studies of Thyroid Lesions.

Oct 28, 2014 10/14

by Deja, Stanislaw; Dawiskiba, Tomasz; Balcerzak, Waldemar; Orczyk-Pawilowicz, Magdalena; Glod, Mateusz; Pawelka, Dorota; Mlynarz, Piotr

eye 53

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Thyroid cancer is the most common endocrine malignancy. However, more than 90% of thyroid nodules are benign. It remains unclear whether thyroid carcinoma arises from preexisting benign nodules. Metabolomics can provide valuable and comprehensive information about low molecular weight compounds present in living systems and further our understanding of the biology regulating pathological processes. Herein, we applied 1H NMR-based metabolic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871661

PubMed Central

57 57

An Extensive Evaluation of Read Trimming Effects on Illumina NGS Data Analysis.

Oct 24, 2014 10/14

by Del Fabbro, Cristian; Scalabrin, Simone; Morgante, Michele; Giorgi, Federico M.

eye 57

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Next Generation Sequencing is having an extremely strong impact in biological and medical research and diagnostics, with applications ranging from gene expression quantification to genotyping and genome reconstruction. Sequencing data is often provided as raw reads which are processed prior to analysis 1 of the most used preprocessing procedures is read trimming, which aims at removing low quality portions while preserving the longest high...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871669

PubMed Central

65 65

Repellent, Irritant and Toxic Effects of 20 Plant Extracts on Adults of the Malaria Vector Anopheles gambiae Mosquito.

Oct 25, 2014 10/14

by Deletre, Emilie; Martin, Thibaud; Campagne, Pascal; Bourguet, Denis; Cadin, Andy; Menut, Chantal; Bonafos, Romain; Chandre, Fabrice

eye 65

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Pyrethroid insecticides induce an excito-repellent effect that reduces contact between humans and mosquitoes. Insecticide use is expected to lower the risk of pathogen transmission, particularly when impregnated on long-lasting treated bednets. When applied at low doses, pyrethroids have a toxic effect, however the development of pyrethroid resistance in several mosquito species may jeopardize these beneficial effects. The need to find...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871167

PubMed Central

62 62

Cophylogenetic relationships between Anicetus parasitoids (Hymenoptera: Encyrtidae) and their scale insect hosts (Hemiptera: Coccidae).

Oct 24, 2014 10/14

by Deng, Jun; Yu, Fang; Li, Hai-Bin; Gebiola, Marco; Desdevises, Yves; Wu, San-An; Zhang, Yan-Zhou

eye 62

favorite 0

comment 0

This article is from BMC Evolutionary Biology , volume 13 . Abstract Background: Numerous studies have investigated cospeciation between parasites and their hosts, but there have been few studies concerning parasitoids and insect hosts. The high diversity and host specialization observed in Anicetus species suggest that speciation and adaptive radiation might take place with species diversification in scale insect hosts. Here we examined the evolutionary history of the association between...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878026

PubMed Central

62 62

Challenges in the Development of an Immunochromatographic Interferon-Gamma Test for Diagnosis of Pleural Tuberculosis.

Oct 24, 2014 10/14

by Denkinger, Claudia M.; Kalantri, Yatiraj; Schumacher, Samuel G.; Michael, Joy S.; Shankar, Deepa; Saxena, Arvind; Sriram, Natarajan; Balamugesh, Thangakunam; Luo, Robert; Pollock, Nira R.; Pai, Madhukar; Christopher, Devasahayam J.

eye 62

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Existing diagnostic tests for pleural tuberculosis (TB) have inadequate accuracy and/or turnaround time. Interferon-gamma (IFNg) has been identified in many studies as a biomarker for pleural TB. Our objective was to develop a lateral flow, immunochromatographic test (ICT) based on this biomarker and to evaluate the test in a clinical cohort. Because IFNg is commonly present in non-TB pleural effusions in low amounts, a diagnostic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871622

PubMed Central

22 22

Comparative evaluation of the canal curvature modifications after instrumentation with One Shape rotary and Wave One reciprocating files.

Oct 23, 2014 10/14

by Dhingra, Anil; Kochar, Rohit; Banerjee, Satyabrat; Srivastava, Punit

eye 22

favorite 0

comment 0

This article is from Journal of Conservative Dentistry : JCD , volume 17 . Abstract Aims:: This study compared the canal curvature modifications after instrumentation with One Shape (Micro Mega) rotary file and Wave One primary reciprocating file (Dentsply Maillefer, Ballaigues, Switzerland). Materials and Methods:: Thirty International Organization for Standardization 15, 0.02 taper, Endo Training Blocks (Dentsply Maillefer) were used. In all specimens working length (WL) was established at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001269

PubMed Central

40 40

Superoxide Anions in Paraventricular Nucleus Modulate Adipose Afferent Reflex and Sympathetic Activity in Rats.

Oct 24, 2014 10/14

by Ding, Lei; Zhang, Ling-Li; Gao, Run; Chen, Dan; Wang, Jue-Jin; Gao, Xing-Ya; Kang, Yu-Ming; Zhu, Guo-Qing

eye 40

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Background: Adipose afferent reflex (AAR) is a sympatho-excitatory reflex induced by chemical stimulation of white adipose tissue (WAT). Ionotropic glutamate receptors including NMDA receptors (NMDAR) and non-NMDA receptors (non-NMDAR) in paraventricular nucleus (PVN) mediate the AAR. Enhanced AAR contributes to sympathetic activation and hypertension in obesity rats. This study was designed to investigate the role and mechanism of superoxide...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871588

PubMed Central

66 66

Comparative inner ear transcriptome analysis between the Rickett's big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx).

Oct 28, 2014 10/14

by Dong, Dong; Lei, Ming; Liu, Yang; Zhang, Shuyi

eye 66

favorite 0

comment 0

This article is from BMC Genomics , volume 14 . Abstract Background: Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results: To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879654

PubMed Central

50 50

Long-Term Effects of Subacute Ruminal Acidosis (SARA) on Milk Quality and Hepatic Gene Expression in Lactating Goats Fed a High-Concentrate Diet.

Oct 24, 2014 10/14

by Dong, Haibo; Wang, Shaoqing; Jia, Yuanyuan; Ni, Yingdong; Zhang, Yuanshu; Zhuang, Su; Shen, Xiangzhen; Zhao, Ruqian

eye 50

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Purpose: The mechanism underlying the decline in milk quality during periods of feeding high-concentrate diets to dairy ruminants is not well documented. The aim of this study was to investigate the metabolic changes in the liver that contribute to the input of substrate precursors to the mammary gland after feeding a high-concentrate diet to lactating goats for a long period. Experimental Design: Eight mid-lactating goats with rumen cannulas...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871605

PubMed Central

29 29

Induction of Paclitaxel Resistance by ER? Mediated Prohibitin Mitochondrial-Nuclear Shuttling.

Oct 28, 2014 10/14

by Dong, Pei; Jiang, Lijuan; Liu, Jianye; Wu, Zhiming; Guo, Shengjie; Zhang, Ziling; Zhou, Fangjian; Liu, Zhuowei

eye 29

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Paclitaxel is a drug within one of the most promising classes of anticancer agents. Unfortunately, clinical success of this drug has been limited by the insurgence of cellular resistance. To address this, Paclitaxel resistance was modeled in an in vitro system using estrogen treated prostate cancer cells. This study demonstrates that emerging resistance to clinically relevant doses of Paclitaxel is associated with 17-β-estradiol (E2)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871534

PubMed Central

70 70

Inference of Gene Regulatory Networks from Genetic Perturbations with Linear Regression Model.

Oct 28, 2014 10/14

by Dong, Zijian; Song, Tiecheng; Yuan, Chuang

eye 70

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract It is an effective strategy to use both genetic perturbation data and gene expression data to infer regulatory networks that aims to improve the detection accuracy of the regulatory relationships among genes. Based on both types of data, the genetic regulatory networks can be accurately modeled by Structural Equation Modeling (SEM). In this paper, a linear regression (LR) model is formulated based on the SEM, and a novel iterative scheme using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871530

PubMed Central

46 46

Reversible and irreversible differentiation of cardiac fibroblasts.

Oct 24, 2014 10/14

by Driesen, Ronald B.; Nagaraju, Chandan K.; Abi-Char, Joelle; Coenen, Tamara; Lijnen, Paul J.; Fagard, Robert H.; Sipido, Karin R.; Petrov, Victor V.

eye 46

favorite 0

comment 0

This article is from Cardiovascular Research , volume 101 . Abstract Aims: Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility. Methods and results: Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation. Fb spontaneously differentiated to proliferating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928002

PubMed Central

49 49

Supporting the improvement and management of prescribing for urinary tract infections (SIMPle): protocol for a cluster randomized trial.

Oct 28, 2014 10/14

by Duane, Sinead; Callan, Aoife; Galvin, Sandra; Murphy, Andrew W; Domegan, Christine; O'Shea, Eamon; Cormican, Martin; Bennett, Kathleen; O'Donnell, Martin; Vellinga, Akke

eye 49

favorite 0

comment 0

This article is from Trials , volume 14 . Abstract Background: The overuse of antimicrobials is recognized as the main selective pressure driving the emergence and spread of antimicrobial resistance in human bacterial pathogens. Urinary tract infections (UTIs) are among the most common infections presented in primary care and empirical antimicrobial treatment is currently recommended. Previous research has identified that a substantial proportion of Irish general practitioners (GPs) prescribe...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880352

PubMed Central

52 52

Penicillin Kills Chlamydia following the Fusion of Bacteria with Lysosomes and Prevents Genital Inflammatory Lesions in C. muridarum-Infected Mice.

Oct 28, 2014 10/14

by Dumoux, Maud; Le Gall, Sylvain M.; Habbeddine, Mohamed; Delarbre, Christiane; Hayward, Richard D.; Kanellopoulos-Langevin, Colette; Verbeke, Philippe

eye 52

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion’. Alternative persistent intra-cellular forms can be induced in culture by diverse stimuli such as IFNγ or adenosine/EHNA. They do not grow or divide but revive upon withdrawal of the stimulus and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871543

PubMed Central

44 44

Climatic Niche Evolution in New World Monkeys (Platyrrhini).

Oct 27, 2014 10/14

by Duran, Andressa; Meyer, Andreas L. S.; Pie, Marcio R.

eye 44

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Despite considerable interest in recent years on species distribution modeling and phylogenetic niche conservatism, little is known about the way in which climatic niches change over evolutionary time. This knowledge is of major importance to understand the mechanisms underlying limits of species distributions, as well as to infer how different lineages might be affected by anthropogenic climate change. In this study we investigate the tempo...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871682

PubMed Central

16 16

The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD?

Oct 23, 2014 10/14

by Eagle, Dawn M.; Noschang, Cristie; d'Angelo, Laure-Sophie Camilla; Noble, Christie A.; Day, Jacob O.; Dongelmans, Marie Louise; Theobald, David E.; Mar, Adam C.; Urcelay, Gonzalo P.; Morein-Zamir, Sharon; Robbins, Trevor W.

eye 16

favorite 0

comment 0

This article is from Behavioural Brain Research , volume 264 . Abstract •We validate a novel operant model of compulsive checking, relevant to OCD.•The dopamine D2/3 receptor agonist quinpirole selectively increases checking.•Uncertainty increases checking differently following quinpirole treatment.•Dopamine D2/3 receptors modulate excessive, non-functional checking.•OCD checking may respond to treatment augmentation with D2/3 receptor antagonists.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989029

PubMed Central

45 45

Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans.

Oct 23, 2014 10/14

by Eleazu, Chinedum Ogbonnaya; Eleazu, Kate Chinedum; Chukwuma, Sonia; Essien, Udeme Nelson

eye 45

favorite 0

comment 0

This article is from Journal of Diabetes and Metabolic Disorders , volume 12 . Abstract Streptozotocin (STZ) (2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-D-glucopyranose) is a naturally occurring diabetogenic compound, produced by the soil bacterium streptomyces achromogenes, that exhibits broad spectrum of antibacterial properties. Streptozotocin functions as a DNA synthesis inhibitor in both bacterial and mammalian cells. In mammalian cells, the actual mechanism and metabolic targets...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933000

PubMed Central

63 63

Individual, Contextual, and Age-Related Acoustic Variation in Simakobu (Simias concolor) Loud Calls.

Oct 28, 2014 10/14

by Erb, Wendy M.; Hodges, J. Keith; Hammerschmidt, Kurt

eye 63

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Primate loud calls have the potential to encode information about the identity, arousal, age, or physical condition of the caller, even at long distances. In this study, we conducted an analysis of the acoustic features of the loud calls produced by a species of Asian colobine monkey (simakobu, Simias concolor). Adult male simakobu produce loud calls spontaneously and in response to loud sounds and other loud calls, which are audible more than...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871870

PubMed Central

46 46

Dysregulated Striatal Neuronal Processing and Impaired Motor Behavior in Mice Lacking Huntingtin Interacting Protein 14 (HIP14).

Oct 25, 2014 10/14

by Estrada-Sanchez, Ana Maria; Barton, Scott J.; Burroughs, Courtney L.; Doyle, Amanda R.; Rebec, George V.

eye 46

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Palmitoyl acyl transferases (PATs) play a critical role in protein trafficking and function. Huntingtin interacting protein 14 (HIP14) is a PAT that acts on proteins associated with neuronal transmission, suggesting that deficient protein palmitoylation by HIP14, which occurs in the YAC128 model of Huntington’s disease (HD), might have deleterious effects on neurobehavioral processing. HIP14 knockout mice show biochemical and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871627

PubMed Central

56 56

$Management of an extended clivus fracture: a case report.$

Management of an extended clivus fracture: a case report.

Oct 27, 2014 10/14

by Evers, Julia JE; Vieth, Volker VV; Hartensuer, Rene RH; Raschke, Michael MJR; Vordemvenne, Thomas TV

eye 56

favorite 0

comment 0

This article is from BMC Research Notes , volume 6 . Abstract Background: Clivus fractures are highly uncommon. The classification by Corradino et al. divides the different lesions in longitudinal, transverse and oblique fractures. Longitudinal types are associated with the highest mortality rate between 67 – 80%. Clivus fractures are often found after high velocity trauma, especially traffic accidents and falls. The risk of neurologic lesions is high, because of the anatomic proximity to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878031

PubMed Central

50 50

Synthesis of N-arylmethyl Substituted Indole Derivatives as New Antiplatelet Aggregation Agents .

Oct 23, 2014 10/14

by Faghih Akhlaghi, Masoud; Amidi, Salimeh; Esfahanizadeh, Marjan; Daeihamed, Marjan; Kobarfard, Farzad

eye 50

favorite 0

comment 0

This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then activated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977051

PubMed Central

67 67

Antioxidant Activity, Total Phenolics and Flavonoid Contents of some Edible Green Seaweeds from Northern Coasts of the Persian Gulf.

Oct 23, 2014 10/14

by Farasat, Massoumeh; Khavari-Nejad, Ramazan-Ali; Nabavi, Seyed Mohammad Bagher; Namjooyan, Foroogh

eye 67

favorite 0

comment 0

This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract The antioxidant activity, contents of total phenolics and flavonoids were quantified in the methanolic extracts of four Ulva species (Ulva clathrata (Roth) C.Agardh, Ulva linza Linnaeus, Ulva flexuosa Wulfen and Ulva intestinalis Linnaeus) grown at different parts of northern coasts of the Persian Gulf in south of Iran. The seaweeds were collected from Dayyer, Taheri and Northern Ouli coasts in April...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985267

PubMed Central

61 61

Diastolic function is a strong predictor of mortality in patients with chronic kidney disease.

Oct 26, 2014 10/14

by Farshid, Ahmad; Pathak, Rajeev; Shadbolt, Bruce; Arnolda, Leonard; Talaulikar, Girish

eye 61

favorite 0

comment 0

This article is from BMC Nephrology , volume 14 . Abstract Background: Cardiovascular disease is a major cause of death in patients with stage 4–5 Chronic Kidney disease (CKD, eGFR 75 years, previous history of MI, diastolic dysfunction and detectable serum troponin T were significant independent predictor of mortality (P 75 years, history of MI, diastolic dysfunction and troponin T were independent predictors of mortality.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878021

PubMed Central

62 62

TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.

Oct 27, 2014 10/14

by Faustman, Denise L.; Davis, Miriam

eye 62

favorite 0

comment 0

This article is from Frontiers in Immunology , volume 4 . Abstract The regulatory cytokine tumor necrosis factor (TNF) exerts its effects through two receptors: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases. One new treatment strategy for autoimmune disease is selective destruction of autoreactive T cells by administration of TNF, TNF inducers, or TNFR2 agonism. A related strategy is to rely on TNFR2 agonism to induce T-regulatory cells (Tregs) that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870411

PubMed Central

53 53

Lattice Model for Influenza Spreading with Spontaneous Behavioral Changes.

Oct 25, 2014 10/14

by Fierro, Annalisa; Liccardo, Antonella

eye 53

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Individual behavioral response to the spreading of an epidemic plays a crucial role in the progression of the epidemic itself. The risk perception induces individuals to adopt a protective behavior, as for instance reducing their social contacts, adopting more restrictive hygienic measures or undergoing prophylaxis procedures. In this paper, starting with a previously developed lattice-gas SIR model, we construct a coupled behavior-disease...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871576

PubMed Central

94 94

Sodium channel selectivity and conduction: Prokaryotes have devised their own molecular strategy.

Oct 12, 2014 10/14

by Finol-Urdaneta, Rocio K.; Wang, Yibo; Al-Sabi, Ahmed; Zhao, Chunfeng; Noskov, Sergei Y.; French, Robert J.

eye 94

favorite 0

comment 0

This article is from The Journal of General Physiology , volume 143 . Abstract The molecular strategy for alkali cation selectivity by a bacterial sodium channel resembles those of eukaryotic calcium and potassium channels, rather than those of eukaryotic sodium channels.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001777

PubMed Central

63 63

Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects.

Oct 23, 2014 10/14

by Flynn, Tanya J; Phipps-Green, Amanda; Hollis-Moffatt, Jade E; Merriman, Marilyn E; Topless, Ruth; Montgomery, Grant; Chapman, Brett; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R

eye 63

favorite 0

comment 0

This article is from Arthritis Research & Therapy , volume 15 . Abstract Introduction: There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study was to test genetic variation across the SLC22A11/SLC22A12 locus for association with risk of gout in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978909

PubMed Central

51 51

Pain rating schema: three distinct subgroups of individuals emerge when rating mild, moderate, and severe pain.

Oct 27, 2014 10/14

by Frey-Law, Laura A; Lee, Jennifer E; Wittry, Alex M; Melyon, Myles

eye 51

favorite 0

comment 0

This article is from Journal of Pain Research , volume 7 . Abstract Background: While the validity of pain assessment has been well documented, the underlying schema (ie, organized, preconceived ideas) of how individuals interpret numerical pain ratings is not well understood. This study’s objectives were to examine numerical pain intensity ratings, from (0 to 10 cm on the visual analog scale [VAS]) across multiple severities of commonly experienced acute pain conditions to determine whether...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873848

PubMed Central

46 46

Microbioreactor Array Screening of Wnt Modulators and Microenvironmental Factors in Osteogenic Differentiation of Mesenchymal Progenitor Cells.

Oct 28, 2014 10/14

by Frith, Jessica E.; Titmarsh, Drew M.; Padmanabhan, Harish; Cooper-White, Justin J.

eye 46

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Cellular microenvironmental conditions coordinate to regulate stem cell populations and their differentiation. Mesenchymal precursor cells (MPCs), which have significant potential for a wide range of therapeutic applications, can be expanded or differentiated into osteo- chondro- and adipogenic lineages. The ability to establish, screen, and control aspects of the microenvironment is paramount if we are to elucidate the complex interplay of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871528

PubMed Central

53 53

The multiple actions of testosterone in men: nature knows best.

Oct 23, 2014 10/14

by Funder, John W

eye 53

favorite 0

comment 0

This article is from Asian Journal of Andrology , volume 16 . Abstract In male hormone replacement therapy Finkelstein et al. show that testosterone rather than synthetic “pure” androgens should be prescribed. Testosterone is converted to the superactive androgen dihydrotestosterone and to estradiol, and thus has actions via androgen receptors and both estrogen receptors (ERα, ERβ). Although muscle strength is androgen dependent, estradiol has major physiologic effects in men—on bone,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955337

PubMed Central

51 51

An innovative team-based stop smoking competition among M?ori and Pacific Island smokers: rationale and method for the study and its evaluation.

Oct 25, 2014 10/14

by Glover, Marewa; Bosman, Amber; Wagemakers, Annemarie; Kira, Anette; Paton, Chris; Cowie, Nathan

eye 51

favorite 0

comment 0

This article is from BMC Public Health , volume 13 . Abstract Background: Māori and Pacific Island people have significantly higher smoking rates compared to the rest of the New Zealand population. The main aim of this paper is to describe how knowledge of Indigenous people’s practices and principles can be combined with proven effective smoking cessation support into a cessation intervention appropriate for Indigenous people. Methods/Design: A literature review was conducted to identify...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882284

PubMed Central

58 58

Body composition and depressive/anxiety symptoms in overweight and obese individuals with metabolic syndrome.

Oct 26, 2014 10/14

by Guedes, Erika P; Madeira, Eduardo; Mafort, Thiago T; Madeira, Miguel; Moreira, Rodrigo O; Mendonca, Laura MC; Godoy-Matos, Amelio F; Lopes, Agnaldo J; Farias, Maria Lucia F

eye 58

favorite 0

comment 0

This article is from Diabetology & Metabolic Syndrome , volume 5 . Abstract Background: Several studies point to a correlation between obesity and the severity of depressive and anxiety symptoms in children and adults, but there are still some controversial points about this association. The aim of this study is to investigate the relationship between body composition and the severity of anxiety/depressive symptoms in overweight and obese individuals with Metabolic Syndrome (MS). Methods:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913787

PubMed Central

47 47

Oligonucleotide Microarray Identifies Genes Differentially Expressed during Tumorigenesis of DMBA-Induced Pancreatic Cancer in Rats.

Oct 24, 2014 10/14

by Guo, Jun-Chao; Li, Jian; Yang, Ying-Chi; Zhou, Li; Zhang, Tai-Ping; Zhao, Yu-Pei

eye 47

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract The extremely dismal prognosis of pancreatic cancer (PC) is attributed, at least in part, to lack of early diagnosis. Therefore, identifying differentially expressed genes in multiple steps of tumorigenesis of PC is of great interest. In the present study, a 7,12-dimethylbenzanthraene (DMBA)-induced PC model was established in male Sprague-Dawley rats. The gene expression profile was screened using an oligonucleotide microarray, followed by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871567

PubMed Central

47 47

Training for health services and systems research in Sub-Saharan Africa - a case study at four East and Southern African Universities.

Oct 27, 2014 10/14

by Guwatudde, David; Bwanga, Freddie; Dudley, Lilian; Chola, Lumbwe; Leyna, Germana Henry; Mmbaga, Elia John; Kumwenda, Newton; Protsiv, Myroslava; Atkins, Salla; Zwarenstein, Merrick; Obua, Celestino; Tumwine, James K

eye 47

favorite 0

comment 0

This article is from Human Resources for Health , volume 11 . Abstract Background: The need to develop capacity for health services and systems research (HSSR) in low and middle income countries has been highlighted in a number of international forums. However, little is known about the level of HSSR training in Sub-Saharan Africa (SSA). We conducted an assessment at four major East and Southern African universities to describe: a) the numbers of HSSR PhD trainees at these institutions, b)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878024

PubMed Central

47 47

Preparation and Characterization of Stable Nanoliposomal Formulation of Fluoxetine as a Potential Adjuvant Therapy for Drug-Resistant Tumors .

Oct 23, 2014 10/14

by Haeri, Azadeh; Alinaghian, Behdokht; Daeihamed, Marjan; Dadashzadeh, Simin

eye 47

favorite 0

comment 0

This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Chemotherapy research highly prioritizes overcoming the multidrug resistance (MDR) in human tumors. Liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. Liposomes were prepared using different active loading techniques. The influence of different...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977048

PubMed Central

44 44

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis.

Oct 27, 2014 10/14

by Hampton, David W; Serio, Andrea; Pryce, Gareth; Al-Izki, Sarah; Franklin, Robin JM; Giovannoni, Gavin; Baker, David; Chandran, Siddharthan

eye 44

favorite 0

comment 0

This article is from Acta Neuropathologica Communications , volume 1 . Abstract Backgound: Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the absence of therapies for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895761

PubMed Central

66 66

Relationship between the Relative Limitation and Resorption Efficiency of Nitrogen vs Phosphorus in Woody Plants.

Oct 28, 2014 10/14

by Han, Wenxuan; Tang, Luying; Chen, Yahan; Fang, Jingyun

eye 66

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Most previous studies have ascribed variations in the resorption of a certain plant nutrient to its corresponding environmental availability or level in tissues, regardless of the other nutrients’ status. However, given that plant growth relies on both sufficient and balanced nutrient supply, the nutrient resorption process should not only be related to the absolute nutrient status, but also be regulated by the relative limitation of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871644

PubMed Central

44 44

The Study of Pentoxifylline Drug Effects on Renal Apoptosis and BCL-2 Gene Expression Changes Following Ischemic Reperfusion Injury in Rat.

Oct 23, 2014 10/14

by Hashemi, Mehrdad

eye 44

favorite 0

comment 0

This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on BCL-2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.In this experimental study, 20 male wistar rats with average weight of 250-300 g were selected and then...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985231

PubMed Central

76 76

Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation.

Oct 20, 2014 10/14

by Hay, Debbie L; Harris, Paul WR; Kowalczyk, Renata; Brimble, Margaret A; Rathbone, Dan L; Barwell, James; Conner, Alex C; Poyner, David R

eye 76

favorite 0

comment 0

This article is from British Journal of Pharmacology , volume 171 . Abstract Background and Purpose: The N-terminus of calcitonin gene-related peptide (CGRP) is important for receptor activation, especially the disulphide-bonded ring (residues 1–7). However, the roles of individual amino acids within this region have not been examined and so the molecular determinants of agonism are unknown. This study has examined the role of residues 1, 3–6 and 8–9, excluding Cys-2 and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904261

PubMed Central

57 57

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO).

Oct 27, 2014 10/14

by Hedrich, Christian M; Hofmann, Sigrun R; Pablik, Jessica; Morbach, Henner; Girschick, Hermann J

eye 57

favorite 0

comment 0

This article is from Pediatric Rheumatology Online Journal , volume 11 . Abstract Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result of a dysregulated innate immune system, resulting in immune cell infiltration of the bone and subsequent osteoclast differentiation and activation. Interestingly,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881012

PubMed Central

50 50

Set Up of an Automatic Water Quality Sampling System in Irrigation Agriculture.

Oct 29, 2014 10/14

by Heinz, Emanuel; Kraft, Philipp; Buchen, Caroline; Frede, Hans-Georg; Aquino, Eugenio; Breuer, Lutz

eye 50

favorite 0

comment 0

This article is from Sensors (Basel, Switzerland) , volume 14 . Abstract We have developed a high-resolution automatic sampling system for continuous in situ measurements of stable water isotopic composition and nitrogen solutes along with hydrological information. The system facilitates concurrent monitoring of a large number of water and nutrient fluxes (ground, surface, irrigation and rain water) in irrigated agriculture. For this purpose we couple an automatic sampling system with a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926554

PubMed Central

47 47

ISEV position paper: extracellular vesicle RNA analysis and bioinformatics.

Oct 24, 2014 10/14

by Hill, Andrew F.; Pegtel, D. Michiel; Lambertz, Ulrike; Leonardi, Tommaso; O'Driscoll, Lorraine; Pluchino, Stefano; Ter-Ovanesyan, Dmitry; Nolte-'t Hoen, Esther N.M.

eye 47

favorite 0

comment 0

This article is from Journal of Extracellular Vesicles , volume 2 . Abstract Extracellular vesicles (EVs) are the collective term for the various vesicles that are released by cells into the extracellular space. Such vesicles include exosomes and microvesicles, which vary by their size and/or protein and genetic cargo. With the discovery that EVs contain genetic material in the form of RNA (evRNA) has come the increased interest in these vesicles for their potential use as sources of disease...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873759

PubMed Central

67 67

Quantification of the relative contribution of estrogen to bone mineral density in men and women.

Oct 28, 2014 10/14

by Ho-Pham, Lan T; Nguyen, Nguyen D; Nguyen, Tuan V

eye 67

favorite 0

comment 0

This article is from BMC Musculoskeletal Disorders , volume 14 . Abstract Background: The study quantified the relative contributions of estrogen (E2) and total testosterone (TT) to variation in bone mineral density in men and women. Methods: This was a cross-sectional study which involved 200 men and 415 women aged 18 to 89 years. BMD at the lumbar spine (LS) and femoral neck (FN) was measured by DXA. Serum levels of E2 and TT were measured by electrochemiluminescence immunoassays. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878025

PubMed Central

54 54

Identical Strength of the T Cell Responses against E2, nsP1 and Capsid CHIKV Proteins in Recovered and Chronic Patients after the Epidemics of 2005-2006 in La Reunion Island.

Oct 27, 2014 10/14

by Hoarau, Jean-Jacques; Gay, Frederick; Pelle, Olivier; Samri, Assia; Jaffar-Bandjee, Marie-Christine; Gasque, Philippe; Autran, Brigitte

eye 54

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract To characterize the immunity developed by patients infected by chikungunya virus (CHIKV), we studied the intensity and specificity of CHIKV-specific T cells mediated responses in chronic and recovered patients at 12 to 24 months post-infection. T cells were challenged in vitro against CHIKV synthetic peptides covering the length of three viral proteins, capsid, E2 and nsP1 proteins as well as all inactivated virus particles. Cytokine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871564

PubMed Central

62 62

The Effects of Visual and Haptic Vertical Stimulation on Standing Balance in Stroke Patients.

Oct 24, 2014 10/14

by Hong, Seok Ha; Im, Sun; Park, Geun-Young

eye 62

favorite 0

comment 0

This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To explore the effect of visual and haptic vertical stimulation on standing balance in post-stroke patients. Methods: Twenty-five post-stroke patients were recruited. We measured left/right standing pressure differences and the center of pressure (COP) parameters for each patient under three different conditions: no stimulation, visual, and haptic stimulated conditions. First, patients stood on a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895526

PubMed Central

76 76

Development and Validation of a Reversed-phase HPLC Method for Assay of the Decapeptide Cetrorelix Acetate in Bulk and Pharmaceutical Dosage Forms .

Oct 23, 2014 10/14

by Hooshfar, Shirin; Mortazavi, Seyed Alireza; Piryaei, Mohammad; Ramandi Darzi, Hossein; Shahsavari, Nahid; Kobarfard, Farzad

eye 76

favorite 0

comment 0

This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A gradient reversed-phase high performance liquid chromatography (HPLC) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity used in infertility treatment. The HPLC method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ICH guidelines. The chromatographic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977052

PubMed Central

13 13

Use of advanced recombinant lines to study the impact and potential of mutations affecting starch synthesis in barley☆.

Oct 23, 2014 10/14

by Howard, Thomas P.; Fahy, Brendan; Leigh, Fiona; Howell, Phil; Powell, Wayne; Greenland, Andy; Trafford, Kay; Smith, Alison M.

eye 13

favorite 0

comment 0

This article is from Journal of Cereal Science , volume 59 . Abstract The effects on barley starch and grain properties of four starch synthesis mutations were studied during the introgression of the mutations from diverse backgrounds into an elite variety. The lys5f (ADPglucose transporter), wax (granule-bound starch synthase), isa1 (debranching enzyme isoamylase 1) and sex6 (starch synthase IIa) mutations were introgressed into NFC Tipple to give mutant and wild-type BC2F4 families with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990431

PubMed Central

54 54

The nucleosome regulates the usage of polyadenylation sites in the human genome.

Oct 25, 2014 10/14

by Huang, Huan; Chen, Jiao; Liu, Hongde; Sun, Xiao

eye 54

favorite 0

comment 0

This article is from BMC Genomics , volume 14 . Abstract Background: It has been reported that 3' end processing is coupled to transcription and nucleosome depletion near the polyadenylation sites in many species. However, the association between nucleosome occupancy and polyadenylation site usage is still unclear. Results: By systematic analysis of high-throughput sequencing datasets from the human genome, we found that nucleosome occupancy patterns are different around the polyadenylation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879661

PubMed Central

55 55

A Meta-Analysis of Anti-Vascular Endothelial Growth Factor Remedy for Macular Edema Secondary to Central Retinal Vein Occlusion.

Oct 29, 2014 10/14

by Huang, Peirong; Niu, Wenquan; Ni, Zhentian; Wang, Renzuo; Sun, Xiaodong

eye 55

favorite 0

comment 0

This article is from PLoS ONE , volume 8 . Abstract Background: Central retinal vein occlusion (CRVO) associates with severe vision outcome and no proven beneficial treatment. Our meta-analysis intended to appraise the efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) agents in macular edema (ME) following CRVO. Methods: Data were collected and analyzed by Review Manager 5.2.1. We employed a random-effects model to eliminate between-study heterogeneity. Nfs (called...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871640

PubMed Central

53 53

Movement within foot and ankle joint in children with spastic cerebral palsy: a 3-dimensional ultrasound analysis of medial gastrocnemius length with correction for effects of foot deformation.

Oct 24, 2014 10/14

by Huijing, Peter A; Benard, Menno R; Harlaar, Jaap; Jaspers, Richard T; Becher, Jules G

eye 53

favorite 0

comment 0

This article is from BMC Musculoskeletal Disorders , volume 14 . Abstract Background: In spastic cerebral palsy (SCP), a limited range of motion of the foot (ROM), limits gait and other activities. Assessment of this limitation of ROM and knowledge of active mechanisms is of crucial importance for clinical treatment. Methods: For a comparison between spastic cerebral palsy (SCP) children and typically developing children (TD), medial gastrocnemius muscle-tendon complex length was assessed using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909357

MORE RESULTS
Fetching more results

Search

Filters (1) 288 RESULTS

Media TypeMedia Type

AvailabilityAvailability

YearYear

Topics & SubjectsTopics & Subjects

CollectionCollection

CreatorCreator

LanguageLanguage

eye 53

favorite 0

comment 0

eye 57

favorite 0

comment 0

eye 65

favorite 0

comment 0

eye 62

favorite 0

comment 0

eye 62

favorite 0

comment 0

eye 22

favorite 0

comment 0

eye 40

favorite 0

comment 0

eye 66

favorite 0

comment 0

eye 50

favorite 0

comment 0

eye 29

favorite 0

comment 0

eye 70

favorite 0

comment 0

eye 46

favorite 0

comment 0

eye 49

favorite 0

comment 0

eye 52

favorite 0

comment 0

eye 44

favorite 0

comment 0

eye 16

favorite 0

comment 0

eye 45

favorite 0

comment 0

eye 63

favorite 0

comment 0

eye 46

favorite 0

comment 0

eye 56

favorite 0

comment 0

eye 50

favorite 0

comment 0

eye 67

favorite 0

comment 0

eye 61

favorite 0

comment 0

eye 62

favorite 0

288
RESULTS

Media Type

Availability

Year

Topics & Subjects

Collection

Creator

Language