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Oct 24, 2014
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Atsukawa, Masanori; Tsubota, Akihito; Shimada, Noritomo; Kondo, Chisa; Itokawa, Norio; Nakagawa, Ai; Hashimoto, Satomi; Fukuda, Takeshi; Matsushita, Yoko; Kidokoro, Hideko; Narahara, Yoshiyuki; Nakatsuka, Katsuhisa; Iwakiri, Katsuhiko; Kawamoto, Chiaki; Sakamoto, Choitsu
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This article is from Hepatitis Monthly , volume 13 . Abstract Background: Serum vitamin D concentration is reported to show a decrease in older age. Patients with chronic hepatitis C (CHC) in Japan are older on average than those in Western countries. Moreover, the outcome of pegylated-interferon (PEG-IFN)/ ribavirin therapy combined with vitamin D in elderly patients is unclear. Objectives: This pilot study explored the efficacy and safety of alfacalcidol as vitamin D source in PEG-IFN/...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877658
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Oct 28, 2014
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Cadena-Mendez, Miguel; Escalante-Ramirez, Boris; Azpiroz-Leehan, Joaquin; Infante-Vazquez, Oscar
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This article is from SpringerPlus , volume 2 . Abstract The aim of this paper is to understand how to measure the VO2 and VCO2 variabilities in indirect calorimetry (IC) since we believe they can explain the high variation in the resting energy expenditure (REE) estimation. We propose that variabilities should be separately measured from the VO2 and VCO2 averages to understand technological differences among metabolic monitors when they estimate the REE. To prove this hypothesis the mixing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884081
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Oct 24, 2014
10/14
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Hong, Seok Ha; Im, Sun; Park, Geun-Young
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To explore the effect of visual and haptic vertical stimulation on standing balance in post-stroke patients. Methods: Twenty-five post-stroke patients were recruited. We measured left/right standing pressure differences and the center of pressure (COP) parameters for each patient under three different conditions: no stimulation, visual, and haptic stimulated conditions. First, patients stood on a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895526
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Oct 28, 2014
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Hyakuna, Nobuyuki; Shimomura, Yasuto; Watanabe, Arata; Taga, Takashi; Kikuta, Atsushi; Matsushita, Takeji; Kogawa, Kazuhiro; Kawakami, Chihiro; Horikoshi, Yasuo; Iwai, Tsuyako; Okamoto, Yasuhiro; Tsurusawa, Masahito; Asami, Keiko
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This article is from Journal of Pediatric Hematology/Oncology , volume 36 . Abstract Supplemental Digital Content is available in the text.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872830
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Oct 12, 2014
10/14
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Iijima, Takatoshi; Iijima, Yoko; Witte, Harald; Scheiffele, Peter
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This article is from The Journal of Cell Biology , volume 204 . Abstract Cell type–specific expression of the splicing regulator SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912522
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Oct 23, 2014
10/14
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Inadomi, Toru
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This article is from Indian Journal of Dermatology , volume 59 . Abstract Background:: Androgenetic alopecia (AGA) involves androgen-dependent hair loss and finasteride is an established treatment for the disease. However, reports of the influence of finasteride on hair growth in other areas of the body are lacking. Aims:: To investigate the effects of finasteride on hair, including the head and other areas of the body. Materials and Methods:: Based on whether AGA patients felt they were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969676
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Oct 25, 2014
10/14
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Kirita, Keisuke; Ishii, Genichiro; Matsuwaki, Rie; Matsumura, Yuki; Umemura, Shigeki; Matsumoto, Shingo; Yoh, Kiyotaka; Niho, Seiji; Goto, Koichi; Ohmatsu, Hironobu; Ohe, Yuichiro; Nagai, Kanji; Ochiai, Atsushi
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This article is from PLoS ONE , volume 8 . Abstract Background: Intralymphatic tumors in the extratumoral area are considered to represent the preceding phase of lymph node metastasis. The aim of this study was to clarify the biological properties of intralymphatic tumors susceptible to the development of lymph node metastasis, with special reference to the expression of cancer initiating/stem cell (CIC/CSC) related markers in cancer cells and the number of infiltrating stromal cells. Material...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871680
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Oct 25, 2014
10/14
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Kuhlmann, Franziska; Opitz, Sebastian E. W.; Inselsbacher, Erich; Ganeteg, Ulrika; Nasholm, Torgny; Ninkovic, Velemir
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This article is from PLoS ONE , volume 8 . Abstract Studying plant-aphid interactions is challenging as aphid feeding is a complex process hidden in the plant tissue. Here we propose a combination of two well established methods to study nutrient acquisition by aphids focusing on the uptake of isotopically labelled nitrogen (15N). We combined the Electrical Penetration Graph (EPG) technique that allows detailed recording of aphid feeding behaviour and stable isotope ratio mass spectrometry...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871520
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Oct 27, 2014
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Kurata, Akira; Kawaguchi, Naoto; Kido, Teruhito; Inoue, Katsuji; Suzuki, Jun; Ogimoto, Akiyoshi; Funada, Jun-ichi; Higaki, Jitsuo; Miyagawa, Masao; Vembar, Mani; Mochizuki, Teruhito
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This article is from PLoS ONE , volume 8 . Abstract Background: The aim of this study was to investigate the correlation of the qualitative transmural extent of hypoperfusion areas (HPA) using stress dynamic whole-heart computed tomography perfusion (CTP) imaging by 256-slice CT with CTP-derived myocardial blood flow (MBF) for the estimation of the severity of coronary artery stenosis. Methods and Results: Eleven patients underwent adenosine triphosphate (0.16 mg/kg/min, 5 min) stress dynamic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871670
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Oct 28, 2014
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Lal, Aparna; Ikeda, Takayoshi; French, Nigel; Baker, Michael G.; Hales, Simon
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This article is from PLoS ONE , volume 8 . Abstract Background: Evaluating the influence of climate variability on enteric disease incidence may improve our ability to predict how climate change may affect these diseases. Objectives: To examine the associations between regional climate variability and enteric disease incidence in New Zealand. Methods: Associations between monthly climate and enteric diseases (campylobacteriosis, salmonellosis, cryptosporidiosis, giardiasis) were investigated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871872
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Oct 27, 2014
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Mabood, Fazle; Khan, Waqar A.; Ismail, Ahmad Izani
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This article is from PLoS ONE , volume 8 . Abstract In this article, an approximate analytical solution of flow and heat transfer for a viscoelastic fluid in an axisymmetric channel with porous wall is presented. The solution is obtained through the use of a powerful method known as Optimal Homotopy Asymptotic Method (OHAM). We obtained the approximate analytical solution for dimensionless velocity and temperature for various parameters. The influence and effect of different parameters on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871629
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Oct 28, 2014
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Moret, Ines; Sanchez-Izquierdo, Dolors; Iborra, Marisa; Tortosa, Luis; Navarro-Puche, Ana; Nos, Pilar; Cervera, Jose; Beltran, Belen
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This article is from PLoS ONE , volume 8 . Abstract The first step in biomarkers discovery is to identify the best protocols for their purification and analysis. This issue is critical when considering peripheral blood samples (plasma and serum) that are clinically interesting but meet several methodological problems, mainly complexity and low biomarker concentration. Analysis of small molecules, such as circulating microRNAs, should overcome these disadvantages. The present study describes an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871541
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Oct 24, 2014
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Prankerd, Richard J.; Nguyen, Tri-Hung; Ibrahim, Jibriil P.; Bischof, Robert J.; Nassta, Gemma C.; Olerile, Livesey D.; Russell, Adrian S.; Meiser, Felix; Parkington, Helena C.; Coleman, Harold A.; Morton, David A. V.; McIntosh, Michelle P.
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This article is from PLoS ONE , volume 8 . Abstract Oxytocin is recommended by the World Health Organisation as the most effective uterotonic for the prevention and treatment of postpartum haemorrhage. The requirement for parenteral administration by trained healthcare providers and the need for the drug solution to be maintained under cold-chain storage limit the use of oxytocin in the developing world. In this study, a spray-dried ultrafine formulation of oxytocin was developed with an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871608
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Oct 28, 2014
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Qin, Xian-Yang; Wei, Feifei; Tanokura, Masaru; Ishibashi, Naoto; Shimizu, Masahito; Moriwaki, Hisataka; Kojima, Soichi
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This article is from PLoS ONE , volume 8 . Abstract Background/Purpose: Acyclic retinoid (ACR) is a promising chemopreventive agent for hepatocellular carcinoma (HCC) that selectively inhibits the growth of HCC cells (JHH7) but not normal hepatic cells (Hc). To better understand the molecular basis of the selective anti-cancer effect of ACR, we performed nuclear magnetic resonance (NMR)-based and capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS)-based metabolome analyses in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871542
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Oct 24, 2014
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Ushio, Hiroyuki; Ishibuchi, Seigo; Oshita, Koichi; Seki, Noriyasu; Kataoka, Hirotoshi; Sugahara, Kunio; Adachi, Kunitomo; Chiba, Kenji
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This article is from Pharmaceuticals , volume 7 . Abstract Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immunomodulator. Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915191
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Oct 26, 2014
10/14
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Watanabe, Hitomi; Kohaya, Natsuki; Kamoshita, Maki; Fujiwara, Katsuyoshi; Matsumura, Kazuaki; Hyon, Suong-Hyu; Ito, Junya; Kashiwazaki, Naomi
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This article is from PLoS ONE , volume 8 . Abstract In cryopreservation of mammalian germ cells, unfertilized oocytes are one of the most available stages because these cryopreserved oocytes can be used for assisted reproductive technologies, including in vitro fertilization (IVF) and intracytoplasmic sperm injection. However, it has been generally reported that the fertility and developmental ability of the oocytes are reduced by cryopreservation. Therefore further improvement will be...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871522
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Oct 26, 2014
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Wildenschild, Cathrine; Mehnert, Frank; Thomsen, Reimar Wernich; Iversen, Helle Klingenberg; Vestergaard, Karsten; Ingeman, Annette; Johnsen, S?ren Paaske
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This article is from Clinical Epidemiology , volume 6 . Abstract Background: The validity of the registration of patients in stroke-specific registries has seldom been investigated, nor compared with administrative hospital discharge registries. The objective of this study was to examine the validity of the registration of patients in a stroke-specific registry (The Danish Stroke Registry [DSR]) and a hospital discharge registry (The Danish National Patient Registry [DNRP]). Methods: Assuming...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875194
