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Oct 24, 2014
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Abreu, Mauro Henrique Nogueira Guimaraes; Sanglard-Oliveira, Carla Aparecida; Jaruche, Abdul Rahman Mustafa; Mambrini, Juliana Vaz de Melo; Werneck, Marcos Azeredo Furquim; Lucas, Simone Dutra
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This article is from Human Resources for Health , volume 11 . Abstract Background: To describe some sociodemographic and educational characteristics of oral health technicians (OHTs) in public primary health care teams in the state of Minas Gerais, Brazil. Methods: A cross-sectional descriptive study was performed based on the telephone survey of a representative sample comprising 231 individuals. A pre-tested instrument was used for the data collection, including questions on gender, age in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878034
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Oct 23, 2014
10/14
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Ahmadi, Fatemeh; Dabirian, Sara; Faizi, Mehrdad; Tabatabai, Sayyed Abbas; Beiki, Davood; Shahhosseini, Soraya
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3, 4-oxadiazolo[a,2,3]-pyrimidine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977056
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Oct 25, 2014
10/14
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Ahn, Tae-Gue; Lee, Joo-Young; Cheon, Se-Yun; An, Hyo-Jin; Kook, Yoon-Bum
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This article is from BMC Complementary and Alternative Medicine , volume 13 . Abstract Background: Sam-Hwang-Sa-Sim-Tang (SHSST) is a traditional Oriental medication that has been commonly used in Korea for the treatment of hypertension, insomnia, and chest pain. In addition, some studies reported that administration of SHSST results suppression of hyperlipidemia in rats or lowering lipid plasma level such as total cholesterol (TC). Those results made us find and demonstrate positive effect of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900264
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Sep 20, 2013
09/13
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Alexandr N. Grishkov; Dmitry Logachev
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The analytic rank under consideration is the order of 0 at $U=1$ of the $L$-function of the simplest type $L(M, U)$ of an Anderson T-motive $M$ of ordinary rank 1 over $\Bbb F_q(\theta)$. These T-motives are the twisted tensor powers of the Carlitz module. The natural action of $GL_2(\Bbb F_q)$ on the set of the twisted Carlitz modules gives the similar action on $L(M, U)$, this means that we get essentially the same results for the order of 0 of $L(M, U)$ at $U=c$ for any $c\in \Bbb F_q^*$. A...
Source: http://arxiv.org/abs/1205.2900v3
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Oct 23, 2014
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Amiri, Mohammad Sadegh; Joharchi, Mohammad Reza; TaghavizadehYazdi, Mohammad Ehsan
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Jaundice is the commonest ailments affecting the citizens of both developed and poor Asians countries including Iran. An ethnobotanical survey of plants used by the traditional healers for the treatment of jaundice was conducted in the Mashhad city, Northeastern Iran. A total of 37 plants belonging to 32 genera and 26 families have been documented for their therapeutic use against jaundice. The plant...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985247
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Oct 21, 2014
10/14
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Apel, Mareike; Maia, Vivian PL; Zeidan, Mohamed; Schinkoethe, Claudia; Wolf, Gunter; Reinhart, Konrad; Sakr, Yasser
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This article is from Critical Care , volume 17 . Abstract Introduction: End-stage renal disease (ESRD) is associated with an increased propensity for critical illness, but whether ESRD is independently associated with a greater risk of death after major surgical procedures is unclear. Methods: This was a retrospective analysis of prospectively collected data from all adult (>18 years) patients admitted to a 50-bed surgical intensive care unit (ICU) between January 2004 and January 2009....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057028
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Oct 24, 2014
10/14
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Atsukawa, Masanori; Tsubota, Akihito; Shimada, Noritomo; Kondo, Chisa; Itokawa, Norio; Nakagawa, Ai; Hashimoto, Satomi; Fukuda, Takeshi; Matsushita, Yoko; Kidokoro, Hideko; Narahara, Yoshiyuki; Nakatsuka, Katsuhisa; Iwakiri, Katsuhiko; Kawamoto, Chiaki; Sakamoto, Choitsu
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This article is from Hepatitis Monthly , volume 13 . Abstract Background: Serum vitamin D concentration is reported to show a decrease in older age. Patients with chronic hepatitis C (CHC) in Japan are older on average than those in Western countries. Moreover, the outcome of pegylated-interferon (PEG-IFN)/ ribavirin therapy combined with vitamin D in elderly patients is unclear. Objectives: This pilot study explored the efficacy and safety of alfacalcidol as vitamin D source in PEG-IFN/...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877658
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Oct 23, 2014
10/14
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Bauza, Karolis; Malinauskas, Tomas; Pfander, Claudia; Anar, Burcu; Jones, E. Yvonne; Billker, Oliver; Hill, Adrian V. S.; Reyes-Sandoval, Arturo
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This article is from Infection and Immunity , volume 82 . Abstract Plasmodium vivax is the world's most widely distributed malaria parasite and a potential cause of morbidity and mortality for approximately 2.85 billion people living mainly in Southeast Asia and Latin America. Despite this dramatic burden, very few vaccines have been assessed in humans. The clinically relevant vectors modified vaccinia virus Ankara (MVA) and the chimpanzee adenovirus ChAd63 are promising delivery systems for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957994
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Oct 25, 2014
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Bidokhti, Mehdi R. M.; Ullman, Karin; Jensen, Trine H.; Chriel, Mariann; Mottahedin, Amin; Munir, Muhammad; Andersson, Anna Maria; Detournay, Olivier; Hammer, Anne Sofie; Baule, Claudia
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This article is from PLoS ONE , volume 8 . Abstract Astroviruses are becoming a growing concern in veterinary and public health. To date there are no registered vaccines against astrovirus-induced disease, mostly due to the difficulty to cultivate astroviruses to high titer for vaccine development using conventional techniques. As means to circumvent this drawback, we have developed stably transfected mink fetal cells and BHK21 cells constitutively expressing the full-length and truncated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871642
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Oct 23, 2014
10/14
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Biglar, Mahmood; Sufi, Hessameddin; Bagherzadeh, Kowsar; Amanlou, Massoud; Mojab, Faraz
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Infection with Helicobacter pyloriis the most common cause of stomach and duodenal ulcers. About more than 80 % of people are infected with H. pylori in developing countries. H. pylori uses urease enzyme product “ammonia” in order to neutralize and protect itself from the stomach acidic condition and urease enzyme activity has been shown to be essential to the colonization of H. pylori. Inhibitory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977070
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Oct 24, 2014
10/14
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Blazevic, Tina; Schaible, Anja M.; Weinhaupl, Katharina; Schachner, Daniel; Nikels, Felix; Weinigel, Christina; Barz, Dagmar; Atanasov, Atanas G.; Pergola, Carlo; Werz, Oliver; Dirsch, Verena M.; Heiss, Elke H.
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This article is from Cardiovascular Research , volume 101 . Abstract Aims: The small molecule indirubin-3′-monoxime (I3MO) has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation and neointima formation in vivo. The influence of I3MO on VSMC migration and vascular inflammation, two additional key players during the onset of atherosclerosis and restenosis, should be investigated. Methods and results: We examined the influence of I3MO on VSMC migration, with focus on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928003
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Oct 28, 2014
10/14
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Boutin, Sebastien; Bernatchez, Louis; Audet, Celine; Derome, Nicolas
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This article is from PLoS ONE , volume 8 . Abstract Interactions between bacteria and their host represent a full continuum from pathogenicity to mutualism. From an evolutionary perspective, host-bacteria relationships are no longer considered a two-component system but rather a complex network. In this study, we focused on the relationship between brook charr (Salvelinus fontinalis) and bacterial communities developing on skin mucus. We hypothesized that stressful conditions such as those...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871659
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Oct 27, 2014
10/14
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Bozdag, Sinem Civriz; Namdaroglu, Sinem; Kayikci, Omur; Kaygusuz, Gulsah; Demiriz, Itir; Cinarsoy, Murat; Tekgunduz, Emre; Altuntas, Fevzi
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This article is from Hematology Reports , volume 5 . Abstract Large granular lymphocytic (LGL) leukemia is a lymphoproliferative disease characterized by the clonal expansion of cytotoxic T or natural killer cells. We report on a patient diagnosed with T-cell LGL leukemia two years after the achievement of hematologic remission for acute myeloblastic leukemia.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883061
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Oct 28, 2014
10/14
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Cadena-Mendez, Miguel; Escalante-Ramirez, Boris; Azpiroz-Leehan, Joaquin; Infante-Vazquez, Oscar
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This article is from SpringerPlus , volume 2 . Abstract The aim of this paper is to understand how to measure the VO2 and VCO2 variabilities in indirect calorimetry (IC) since we believe they can explain the high variation in the resting energy expenditure (REE) estimation. We propose that variabilities should be separately measured from the VO2 and VCO2 averages to understand technological differences among metabolic monitors when they estimate the REE. To prove this hypothesis the mixing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884081
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Oct 28, 2014
10/14
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Carnie, A; Lin, J; Aicher, B; Leon, B; Courville, A B; Sebring, N G; de Jesus, J; DellaValle, D M; Fitzpatrick, B D; Zalos, G; Powell-Wiley, T M; Chen, K Y; Cannon, R O
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This article is from Nutrition & Diabetes , volume 3 . Abstract Objective:: Obesity in the United States is highly prevalent, approaching 60% for black women. We investigated whether nutrition education sessions at the work place added to internet-based wellness information and exercise resources would facilitate weight and fat mass loss in a racially diverse population of overweight female employees. Methods:: A total of 199 (average body mass index 33.9±6.3 kg m−2) nondiabetic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877430
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Oct 24, 2014
10/14
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Cherry, Jonathan J.; Rietz, Anne; Malinkevich, Anna; Liu, Yuqi; Xie, Meng; Bartolowits, Matthew; Davisson, V. Jo; Baleja, James D.; Androphy, Elliot J.
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This article is from PLoS ONE , volume 8 . Abstract Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, “high-risk” HPV E6 proteins bind to and modify the target specificity of the ubiquitin ligase E6AP (E6 associated protein). This E6-dependent loss of p53 enables the virus to bypass host cell defenses and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871595
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Oct 24, 2014
10/14
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Choi, Soo-Ho; Yin, Huiyong; Ravandi, Amir; Armando, Aaron; Dumlao, Darren; Kim, Jungsu; Almazan, Felicidad; Taylor, Angela M.; McNamara, Coleen A.; Tsimikas, Sotirios; Dennis, Edward A.; Witztum, Joseph L.; Miller, Yury I.
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This article is from PLoS ONE , volume 8 . Abstract Oxidation of low-density lipoprotein (LDL) is one of the major causative mechanisms in the development of atherosclerosis. In previous studies, we showed that minimally oxidized LDL (mmLDL) induced inflammatory responses in macrophages, macropinocytosis and intracellular lipid accumulation and that oxidized cholesterol esters (OxCEs) were biologically active components of mmLDL. Here we identified a specific OxCE molecule responsible for the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871536
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Oct 29, 2014
10/14
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Darwish, Omar; Slovin, Janet P; Kang, Chunying; Hollender, Courtney A; Geretz, Aviva; Houston, Sam; Liu, Zhongchi; Alkharouf, Nadim W
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This article is from BMC Plant Biology , volume 13 . Abstract Background: Fragaria vesca, a diploid strawberry species commonly known as the alpine or woodland strawberry, is a versatile experimental plant system and an emerging model for the Rosaceae family. An ancestral F. vesca genome contributed to the genome of the octoploid dessert strawberry (F. ×ananassa), and the extant genome exhibits synteny with other commercially important members of the Rosaceae family such as apple and peach. To...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878773
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Oct 24, 2014
10/14
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Driesen, Ronald B.; Nagaraju, Chandan K.; Abi-Char, Joelle; Coenen, Tamara; Lijnen, Paul J.; Fagard, Robert H.; Sipido, Karin R.; Petrov, Victor V.
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This article is from Cardiovascular Research , volume 101 . Abstract Aims: Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility. Methods and results: Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation. Fb spontaneously differentiated to proliferating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928002
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Oct 23, 2014
10/14
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Faghih Akhlaghi, Masoud; Amidi, Salimeh; Esfahanizadeh, Marjan; Daeihamed, Marjan; Kobarfard, Farzad
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then activated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977051
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Oct 26, 2014
10/14
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Farshid, Ahmad; Pathak, Rajeev; Shadbolt, Bruce; Arnolda, Leonard; Talaulikar, Girish
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This article is from BMC Nephrology , volume 14 . Abstract Background: Cardiovascular disease is a major cause of death in patients with stage 4–5 Chronic Kidney disease (CKD, eGFR 75 years, previous history of MI, diastolic dysfunction and detectable serum troponin T were significant independent predictor of mortality (P 75 years, history of MI, diastolic dysfunction and troponin T were independent predictors of mortality.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878021
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Oct 12, 2014
10/14
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Finol-Urdaneta, Rocio K.; Wang, Yibo; Al-Sabi, Ahmed; Zhao, Chunfeng; Noskov, Sergei Y.; French, Robert J.
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This article is from The Journal of General Physiology , volume 143 . Abstract The molecular strategy for alkali cation selectivity by a bacterial sodium channel resembles those of eukaryotic calcium and potassium channels, rather than those of eukaryotic sodium channels.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001777
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Oct 27, 2014
10/14
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Guwatudde, David; Bwanga, Freddie; Dudley, Lilian; Chola, Lumbwe; Leyna, Germana Henry; Mmbaga, Elia John; Kumwenda, Newton; Protsiv, Myroslava; Atkins, Salla; Zwarenstein, Merrick; Obua, Celestino; Tumwine, James K
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This article is from Human Resources for Health , volume 11 . Abstract Background: The need to develop capacity for health services and systems research (HSSR) in low and middle income countries has been highlighted in a number of international forums. However, little is known about the level of HSSR training in Sub-Saharan Africa (SSA). We conducted an assessment at four major East and Southern African universities to describe: a) the numbers of HSSR PhD trainees at these institutions, b)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878024
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47
Oct 23, 2014
10/14
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Haeri, Azadeh; Alinaghian, Behdokht; Daeihamed, Marjan; Dadashzadeh, Simin
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Chemotherapy research highly prioritizes overcoming the multidrug resistance (MDR) in human tumors. Liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. Liposomes were prepared using different active loading techniques. The influence of different...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977048
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Oct 27, 2014
10/14
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Hampton, David W; Serio, Andrea; Pryce, Gareth; Al-Izki, Sarah; Franklin, Robin JM; Giovannoni, Gavin; Baker, David; Chandran, Siddharthan
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This article is from Acta Neuropathologica Communications , volume 1 . Abstract Backgound: Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the absence of therapies for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895761
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Oct 29, 2014
10/14
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Heinz, Emanuel; Kraft, Philipp; Buchen, Caroline; Frede, Hans-Georg; Aquino, Eugenio; Breuer, Lutz
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This article is from Sensors (Basel, Switzerland) , volume 14 . Abstract We have developed a high-resolution automatic sampling system for continuous in situ measurements of stable water isotopic composition and nitrogen solutes along with hydrological information. The system facilitates concurrent monitoring of a large number of water and nutrient fluxes (ground, surface, irrigation and rain water) in irrigated agriculture. For this purpose we couple an automatic sampling system with a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926554
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Oct 27, 2014
10/14
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Hoarau, Jean-Jacques; Gay, Frederick; Pelle, Olivier; Samri, Assia; Jaffar-Bandjee, Marie-Christine; Gasque, Philippe; Autran, Brigitte
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This article is from PLoS ONE , volume 8 . Abstract To characterize the immunity developed by patients infected by chikungunya virus (CHIKV), we studied the intensity and specificity of CHIKV-specific T cells mediated responses in chronic and recovered patients at 12 to 24 months post-infection. T cells were challenged in vitro against CHIKV synthetic peptides covering the length of three viral proteins, capsid, E2 and nsP1 proteins as well as all inactivated virus particles. Cytokine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871564
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Oct 28, 2014
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Hyakuna, Nobuyuki; Shimomura, Yasuto; Watanabe, Arata; Taga, Takashi; Kikuta, Atsushi; Matsushita, Takeji; Kogawa, Kazuhiro; Kawakami, Chihiro; Horikoshi, Yasuo; Iwai, Tsuyako; Okamoto, Yasuhiro; Tsurusawa, Masahito; Asami, Keiko
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This article is from Journal of Pediatric Hematology/Oncology , volume 36 . Abstract Supplemental Digital Content is available in the text.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872830
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Oct 29, 2014
10/14
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Jacquez, Geoffrey M.; Barlow, Janice; Rommel, Robert; Kaufmann, Andy; Rienti, Michael; AvRuskin, Gillian; Rasul, Jawaid
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This article is from International Journal of Environmental Research and Public Health , volume 11 . Abstract Marin County (California, USA) has among the highest incidences of breast cancer in the U.S. A previously conducted case-control study found eight significant risk factors in participants enrolled from 1997–1999. These included being premenopausal, never using birth control pills, lower highest lifetime body mass index, having four or more mammograms from 1990–1994, beginning...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924444
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Oct 24, 2014
10/14
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Kamath, Manjunath Srinivas; Ahmed, Shiek SSJ; Dhanasekaran, M; Santosh, S Winkins
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This article is from International Journal of Nanomedicine , volume 9 . Abstract Biomaterials-based three-dimensional scaffolds are being extensively investigated in bone tissue engineering. A potential scaffold should be osteoconductive, osteoinductive, and osteogenic for enhanced bone formation. In this study, a three-dimensional porous polycapro-lactone (PCL) scaffold was engineered for prolonged release of resveratrol. Resveratrol-loaded albumin nanoparticles (RNP) were synthesized and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875521
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Oct 25, 2014
10/14
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Lee, Ah Young; Kim, Eun Hyuk; Cho, Yun Woo; Kwon, Sun Oh; Son, Su Min; Ahn, Sang Ho
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To examine using surface electromyography whether stair climbing with abdominal hollowing (AH) is better at facilitating local trunk muscle activity than stair climbing without AH. Methods: Twenty healthy men with no history of low back pain participated in the study. Surface electrodes were attached to the multifidus (MF), lumbar erector spinae, thoracic erector spinae, transverse abdominus - internal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895520
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Oct 27, 2014
10/14
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Lee, Hyun Jung; An, Young-Sil; Ahn, Young-Whan; Yim, Shin-Young
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This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To examine whether the clinical severity of cervical dystonia (CD) significantly correlates with 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) findings as well as to determine the threshold of the clinical severity of CD for positive 18F-FDG PET/CT study findings. Methods: Forty-seven subjects with torticollis as one of the symptoms of CD were included. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895517
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Oct 28, 2014
10/14
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Maacha, Selma; Planque, Nathalie; Laurent, Cecile; Pegoraro, Caterina; Anezo, Oceane; Maczkowiak, Frederique; Monsoro-Burq, Anne H.; Saule, Simon
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This article is from PLoS ONE , volume 8 . Abstract Uveal melanoma is the most common intraocular malignancy in adults, representing between about 4% and 5% of all melanomas. High expression levels of Protein Tyrosine Phosphatase 4A3, a dual phosphatase, is highly predictive of metastasis development and PTP4A3 overexpression in uveal melanoma cells increases their in vitro migration and in vivo invasiveness. Melanocytes, including uveal melanocytes, are derived from the neural crest during...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871671
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Oct 23, 2014
10/14
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Martin-Blondel, Guillaume; Brassat, David; Dumas, Herve; Uro-Coste, Emmanuelle; Adoue, Daniel; Lassmann, Hans; Clanet, Michel
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This article is from F1000Research , volume 2 . Abstract We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of this emerging inflammatory neurological condition in this immunocompromised patient with a severe rheumatic disease. We highlight that, in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968897
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Oct 22, 2014
10/14
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Munywoki, Patrick K.; Koech, Dorothy C.; Agoti, Charles N.; Lewa, Clement; Cane, Patricia A.; Medley, Graham F.; Nokes, D. J.
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This article is from The Journal of Infectious Diseases , volume 209 . Abstract Background. Respiratory syncytial virus (RSV) vaccine development for direct protection of young infants faces substantial obstacles. Assessing the potential of indirect protection using different strategies, such as targeting older children or mothers, requires knowledge of the source of infection to the infants.Methods. We undertook a prospective study in rural Kenya. Households with a child born after the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017365
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Oct 24, 2014
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Nagaraja, Tavarekere N.; Aryal, Madhava P.; Brown, Stephen L.; Bagher-Ebadian, Hassan; Mikkelsen, Tom; Yang, James J.; Panda, Swayamprava; Keenan, Kelly A.; Cabral, Glauber; Ewing, James R.
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This article is from PLoS ONE , volume 8 . Abstract Increased efficacy of radiotherapy (RT) 4-8 h after Cilengitide treatment has been reported. We hypothesized that the effects of Cilengitide on tumor transvascular transfer parameters might underlie, and thus predict, this potentiation. Athymic rats with orthotopic U251 glioma were studied at ~21 days after implantation using dynamic contrast-enhanced (DCE)-MRI. Vascular parameters, viz: plasma volume fraction (vp), forward volume transfer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871527
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Oct 24, 2014
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Niegowski, Damian; Kleinschmidt, Thea; Olsson, Ulrika; Ahmad, Shabbir; Rinaldo-Matthis, Agnes; Haeggstrom, Jesper Z.
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This article is from The Journal of Biological Chemistry , volume 289 . Abstract Background: Leukotriene (LT) C4 synthase (LTC4S) is a membrane protein catalyzing the formation of pathogenic mediators of asthma.Results: Crystal structures of complexes of WT and mutated LTC4S with three product analogs.Conclusion: Evidence for the binding mode of LTA4 and LTC4 at the active site of LTC4S and a mechanistic model.Significance: New insights into the molecular mechanism of LTC4S.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931076
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Oct 29, 2014
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Pignatelli, Jaime; Alonso-Padilla, Julio; Rodriguez, Dolores
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This article is from Veterinary Research , volume 44 . Abstract Hemagglutinin-esterases (HE) are viral envelope proteins present in some members from the toro-, corona- and orthomyxovirus families, all related with enteric and/or respiratory tract infections. HE proteins mediate reversible binding to sialic acid receptor determinants, very abundant glycan residues in the enteric and respiratory tracts. The role of the HE protein during the torovirus infection cycle remains unknown, although it...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878402
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Oct 28, 2014
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Raoov, Muggundha; Mohamad, Sharifah; Abas, Mhd Radzi
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This article is from International Journal of Molecular Sciences , volume 15 . Abstract β-Cyclodextrin-ionic liquid polymer (CD-ILP) was first synthesized by functionalized β-cyclodextrin (CD) with 1-benzylimidazole (BIM) to form monofunctionalized CD (βCD-BIMOTs) and was further polymerized using a toluene diisocyanate (TDI) linker to form insoluble CD-ILP (βCD-BIMOTs-TDI). The βCD-BIMOTs-TDI polymer was characterized using various tools and the results obtained were compared with those...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907800
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Oct 28, 2014
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Roche, Steven M; Jones-Bitton, Andria; Majowicz, Shannon E; Pintar, Katarina D M; Allison, David
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This article is from BMC Public Health , volume 13 . Abstract Background: The first objective of this study was to investigate the public perceptions of private water and alternative sources with respect to safety, quality, testing and treatment in Newfoundland and Labrador (NL), Canada. The second objective was to provide public health practitioners with recommendations for improving knowledge translation (KT) efforts in NL, based on assessments of respondents’ perceived information needs...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878038
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Oct 26, 2014
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Roos, Anna M.; Agren, Erik O.
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This article is from PLoS ONE , volume 8 . Abstract The spermatic ducts (vasa deferentia) of 235 otters (Lutra lutra) found dead between 1999 and 2012 in Sweden were examined for presence of paraductular cysts. Single or multiple elongated uni- or bilateral cysts parallel to the spermatic duct were noted in 72% of the examined males. The cysts were adjacent to, but did not communicate with the lumen of the spermatic duct, and were usually located within a few centimeters of the testis and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871573
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Oct 23, 2014
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Salmannejad, Faranak; Nafissi-Varcheh, Nastaran; Shafaati, Alireza; Aboofazeli, Reza
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFNα2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40–70 °C and for up to 240 h at 50 °C...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977050
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Oct 27, 2014
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Sand, Jannie Marie; Larsen, Lise; Hogaboam, Cory; Martinez, Fernando; Han, MeiLan; R?ssel Larsen, Martin; Nawrocki, Arkadiusz; Zheng, Qinlong; Asser Karsdal, Morten; Leeming, Diana Julie
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This article is from PLoS ONE , volume 8 . Abstract Objectives: Fibrosis is characterized by excessive tissue remodeling resulting from altered expression of various growth factors, cytokines and proteases. We hypothesized that matrix metalloproteinase (MMP) mediated degradation of type IV collagen, a main component of the basement membrane, will release peptide fragments (neo-epitopes) into the circulation. Here we present the development of two competitive enzyme-linked immunosorbent assays...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871599
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Oct 25, 2014
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Sfara, Valeria; Mougabure-Cueto, Gaston A.; Zerba, Eduardo N.; Alzogaray, Raul A.
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This article is from PLoS ONE , volume 8 . Abstract N,N-diethyl-3-methylbenzamide (DEET) is the active principle of most insect repellents used worldwide. However, its toxicity on insects has not been widely studied. The aim of this work is to study the effects of DEET on the locomotor activity of Blattella germanica. DEET has a dose-dependent repellent activity on B. germanica. Locomotor activity was significantly lower when insects were pre-exposed to 700 µg/cm2 of DEET for 20 or 30 minutes,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871674
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Oct 23, 2014
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Sharif-kashani, Babak; Hamraghani, Ali; Salamzadeh, Jamshid; Abbasi Nazari, Mohammad; Malekmohammad, Majid; Behzadnia, Neda; Fahimi, Fanak
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Pulmonary hypertension (PH) is an important cause of heart failure in chronic obstructive pulmonary disease (COPD). The pro brain natriuretic peptide N-terminal (NT-proBNP) has been suggested as a noninvasive marker to evaluate ventricular function. However, there is no evidence to support the use of NT-proBNP in monitoring the benefits of vasodilators in COPD induced PH. Thus, we used NT-proBNP as a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977066
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Oct 24, 2014
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Somenahally, Anil C.; Mosher, Jennifer J.; Yuan, Tong; Podar, Mircea; Phelps, Tommy J.; Brown, Steven D.; Yang, Zamin K.; Hazen, Terry C.; Arkin, Adam P.; Palumbo, Anthony V.; Van Nostrand, Joy D.; Zhou, Jizhong; Elias, Dwayne A.
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This article is from PLoS ONE , volume 8 . Abstract Microbial reduction of toxic hexavalent chromium (Cr(VI)) in-situ is a plausible bioremediation strategy in electron-acceptor limited environments. However, higher [Cr(VI)] may impose stress on syntrophic communities and impact community structure and function. The study objectives were to understand the impacts of Cr(VI) concentrations on community structure and on the Cr(VI)-reduction potential of groundwater communities at Hanford, WA....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871698
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Oct 23, 2014
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Tabarzad, Maryam; Kazemi, Bahram; Vahidi, Hossein; Aboofazeli, Reza; Shahhosseini, Soraya; Nafissi-Varcheh, Nastaran
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Aptamers, or single stranded oligonucleotides, are produced by systematic evolution of ligands by exponential enrichment, abbreviated as SELEX. In the amplification and regeneration step of SELEX technique, dsDNA is conversed to ssDNA. Asymmetric PCR is one of the methods used for the generation of ssDNA. The purpose of this study was to design a random DNA library for selection of aptamers with high...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977063
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Oct 25, 2014
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Trivedi, Dipesh Kumar; Ansari, Mohammed Wahid; Dutta, Tanima; Singh, Prabhjeet; Tuteja, Narendra
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This article is from BMC Research Notes , volume 6 . Abstract Background: Cyclophilins (CyP), conserved in all genera, are known to have regulatory responses of various cellular processes including stress tolerance. Interestingly, CyP has a crucial role as peptidyl-prolyl cis–trans isomerases (PPIases). Our earlier in silico based approach resulted into the identification of cyclophilin family from rice, Arabidopsis and yeast. In our recent report, we discovered a new OsCYP-25 from rice....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878271
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Oct 24, 2014
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Ushio, Hiroyuki; Ishibuchi, Seigo; Oshita, Koichi; Seki, Noriyasu; Kataoka, Hirotoshi; Sugahara, Kunio; Adachi, Kunitomo; Chiba, Kenji
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This article is from Pharmaceuticals , volume 7 . Abstract Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immunomodulator. Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915191
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Oct 23, 2014
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Yazdanpanah, Hassan; Shafaati, Alireza; Foroutan, Seyed Mohsen; Zarghi, Afshin; Aboul-fathi, Farshid; Khoddam, Arash; Shaki, Fatemeh; Nazari, Firoozeh
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract The occurrence of deoxynivalenol (DON) in retail foods in Tehran (Iran) was determined using high-performance liquid chromatography technique and immunoaffinity column as the clean-up step. A method was validated for analysis of DON in rice, bread, puffed corn snack and wheat flour. The average recoveries and precision (RSD) for DON in different foods ranged 84.2-93.1% and 2.9-12.0%, respectively. A...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977057
