82
82
Oct 27, 2014
10/14
by
Sazlina, Shariff-Ghazali; Browning, Colette; Yasin, Shajahan
texts
eye 82
favorite 0
comment 0
This article is from Frontiers in Public Health , volume 1 . Abstract Introduction: Type 2 diabetes mellitus (T2DM) among people aged 60 years and above is a growing public health problem. Regular physical activity is one of the key elements in the management of T2DM. Recommendations suggest that older people with T2DM will benefit from regular physical activity for better disease control and delaying complications. Despite the known benefits, many remain sedentary. Hence, this review...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870318
116
116
Oct 29, 2014
10/14
by
Peters, Howard; O'Leary, Bethan C.; Hawkins, Julie P.; Carpenter, Kent E.; Roberts, Callum M.
texts
eye 116
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Marine molluscs represent an estimated 23% of all extant marine taxa, but research into their conservation status has so far failed to reflect this importance, with minimal inclusion on the authoritative Red List of the International Union for the Conservation of Nature (IUCN). We assessed the status of all 632 valid species of the tropical marine gastropod mollusc, Conus (cone snails), using Red List standards and procedures to lay the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871662
46
46
Oct 24, 2014
10/14
by
Driesen, Ronald B.; Nagaraju, Chandan K.; Abi-Char, Joelle; Coenen, Tamara; Lijnen, Paul J.; Fagard, Robert H.; Sipido, Karin R.; Petrov, Victor V.
texts
eye 46
favorite 0
comment 0
This article is from Cardiovascular Research , volume 101 . Abstract Aims: Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility. Methods and results: Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation. Fb spontaneously differentiated to proliferating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928002
63
63
Oct 28, 2014
10/14
by
Erb, Wendy M.; Hodges, J. Keith; Hammerschmidt, Kurt
texts
eye 63
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Primate loud calls have the potential to encode information about the identity, arousal, age, or physical condition of the caller, even at long distances. In this study, we conducted an analysis of the acoustic features of the loud calls produced by a species of Asian colobine monkey (simakobu, Simias concolor). Adult male simakobu produce loud calls spontaneously and in response to loud sounds and other loud calls, which are audible more than...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871870
45
45
Oct 24, 2014
10/14
by
Marin, Arturo; Tejero, Hector; Nuno, Juan Carlos; Montero, Francisco
texts
eye 45
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871551
119
119
Oct 8, 2014
10/14
by
Nazarko, Taras Y.; Ozeki, Katharine; Till, Andreas; Ramakrishnan, Geetha; Lotfi, Pouya; Yan, Mingda; Subramani, Suresh
texts
eye 119
favorite 0
comment 0
This article is from The Journal of Cell Biology , volume 204 . Abstract The acyl-CoA–binding protein Atg37 is a new component of the pexophagic receptor protein complex that regulates the recruitment of Atg11 by Atg30 in the peroxisomal membrane during pexophagy
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926955
50
50
Oct 29, 2014
10/14
by
Liu, Lifeng; Cao, Xuexin; Zou, Lin; Li, Zongyu; Cao, Xuecheng; Cai, Jinfang
texts
eye 50
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The anterolateral thigh flap has been used for coverage of defects in the foot and ankle for years. Conventional extended anterolateral thigh flaps do not undergo thinning procedures, which limit their application. Here, a clinical series of 24 patients is reported in which extended anterolateral thigh flaps were used for posttraumatic foot and ankle reconstruction. Of the 24 flaps, 14 were simple extended anterolateral thigh fasciocutaneous...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871676
42
42
Oct 28, 2014
10/14
by
Jung, Mi Jin; Byun, Ha Young; Lee, Chang Hee; Moon, Seung Won; Oh, Min-Kyun; Shin, Heesuk
texts
eye 42
favorite 0
comment 0
This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Medial antebrachial cutaneous (MABC) nerve injury associated with iatrogenic causes has been rarely reported. Local anesthesia may be implicated in the etiology of such injury, but has not been reported. Two patients with numbness and painful paresthesia over the medial aspect of the unilateral forearm were referred for electrodiagnostic study, which revealed MABC nerve lesion in each case. The highly selective nature...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895535
55
55
Oct 24, 2014
10/14
by
Malyshevskaya, Olga; Shiraishi, Yoshihiro; Kimura, Fumitaka; Yamamoto, Nobuhiko
texts
eye 55
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract During development, layer 2/3 neurons in the neocortex extend their axons horizontally, within the same layers, and stop growing at appropriate locations to form branches and synaptic connections. Firing and synaptic activity are thought to be involved in this process, but how neuronal activity regulates axonal growth is not clear. Here, we studied axonal growth of layer 2/3 neurons by exciting cell bodies or axonal processes in organotypic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871609
53
53
Oct 24, 2014
10/14
by
Meir, Jessica U.; Robinson, Patrick W.; Vilchis, L. Ignacio; Kooyman, Gerald L.; Costa, Daniel P.; Ponganis, Paul J.
texts
eye 53
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Although energetics is fundamental to animal ecology, traditional methods of determining metabolic rate are neither direct nor instantaneous. Recently, continuous blood oxygen (O2) measurements were used to assess energy expenditure in diving elephant seals (Mirounga angustirostris), demonstrating that an exceptional hypoxemic tolerance and exquisite management of blood O2 stores underlie the extraordinary diving capability of this consummate...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871621
69
69
Oct 24, 2014
10/14
by
Lee, Jang Woo; Won, Yu Hui; Choi, Won Ah; Lee, Soon Kyu; Kang, Seong Woong
texts
eye 69
favorite 0
comment 0
This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Low vital capacity is a risk factor for scoliosis correction operation in Duchenne muscular dystrophy (DMD) patients, but pulmonary rehabilitation, including noninvasive intermittent positive pressure ventilator application, air stacking exercise, and assisted coughing technique, reduces the pulmonary complications and perioperative mortality risk. In this case, the patient's preoperative forced vital capacity (FVC)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895528
57
57
Oct 25, 2014
10/14
by
Trivedi, Dipesh Kumar; Ansari, Mohammed Wahid; Dutta, Tanima; Singh, Prabhjeet; Tuteja, Narendra
texts
eye 57
favorite 0
comment 0
This article is from BMC Research Notes , volume 6 . Abstract Background: Cyclophilins (CyP), conserved in all genera, are known to have regulatory responses of various cellular processes including stress tolerance. Interestingly, CyP has a crucial role as peptidyl-prolyl cis–trans isomerases (PPIases). Our earlier in silico based approach resulted into the identification of cyclophilin family from rice, Arabidopsis and yeast. In our recent report, we discovered a new OsCYP-25 from rice....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878271
16
16
Oct 23, 2014
10/14
by
Eagle, Dawn M.; Noschang, Cristie; d'Angelo, Laure-Sophie Camilla; Noble, Christie A.; Day, Jacob O.; Dongelmans, Marie Louise; Theobald, David E.; Mar, Adam C.; Urcelay, Gonzalo P.; Morein-Zamir, Sharon; Robbins, Trevor W.
texts
eye 16
favorite 0
comment 0
This article is from Behavioural Brain Research , volume 264 . Abstract •We validate a novel operant model of compulsive checking, relevant to OCD.•The dopamine D2/3 receptor agonist quinpirole selectively increases checking.•Uncertainty increases checking differently following quinpirole treatment.•Dopamine D2/3 receptors modulate excessive, non-functional checking.•OCD checking may respond to treatment augmentation with D2/3 receptor antagonists.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989029
55
55
Oct 25, 2014
10/14
by
Sonntag, Michael; Konnopka, Alexander; Leichsenring, Falk; Salzer, Simone; Beutel, Manfred E; Herpertz, Stephan; Hiller, Wolfgang; Hoyer, Jurgen; Joraschky, Peter; Nolting, Bjorn; Pohlmann, Karin; Stangier, Ulrich; Strauss, Bernhard; Willutzki, Ulrike; Wiltink, Jorg; Leibing, Eric; Konig, Hans-Helmut
texts
eye 55
favorite 0
comment 0
This article is from Health and Quality of Life Outcomes , volume 11 . Abstract Objective: The aim of the study was to analyse the psychometric properties of the EQ-5D in patients with social phobia. Methods: We used a sample of 445 patients with social phobia with five measurement points over a 30 month period. The discriminative ability of the EQ-5D was analysed by comparing the patients’ responses with the general population and between different disease severity levels. For test-retest...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878044
54
54
Oct 28, 2014
10/14
by
Bryson, David M.; Ofria, Charles
texts
eye 54
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract We investigate fundamental decisions in the design of instruction set architectures for linear genetic programs that are used as both model systems in evolutionary biology and underlying solution representations in evolutionary computation. We subjected digital organisms with each tested architecture to seven different computational environments designed to present a range of evolutionary challenges. Our goal was to engineer a general purpose...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871699
68
68
Oct 25, 2014
10/14
by
Sohn, Min Kyun; Jee, Sung Ju; Kim, Yeong Wook
texts
eye 68
favorite 0
comment 0
This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To evaluate the effect of anodal transcranial direct current stimulation (tDCS) over the lesioned leg motor cortex, which can enhance the strength and coordination of the contralateral lower extremity and furthermore, enhance the postural stability of the hemiplegic subject. Methods: Anodal or sham stimulation on the lesioned cortex of a lower extremity was delivered to 11 ambulatory hemiplegic patients....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895515
59
59
Oct 28, 2014
10/14
by
Rampanelli, Elena; Dessing, Mark C.; Claessen, Nike; Teske, Gwendoline J. D.; Joosten, Sander P. J.; Pals, Steven T.; Leemans, Jaklien C.; Florquin, Sandrine
texts
eye 59
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Acute kidney injury (AKI) is a common complication during systemic inflammatory response syndrome (SIRS), a potentially deadly clinical condition characterized by whole-body inflammatory state and organ dysfunction. CD44 is a ubiquitously expressed cell-surface transmembrane receptor with multiple functions in inflammatory processes, including sterile renal inflammation. The present study aimed to assess the role of CD44 in endotoxic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871539
37
37
Oct 24, 2014
10/14
by
Prankerd, Richard J.; Nguyen, Tri-Hung; Ibrahim, Jibriil P.; Bischof, Robert J.; Nassta, Gemma C.; Olerile, Livesey D.; Russell, Adrian S.; Meiser, Felix; Parkington, Helena C.; Coleman, Harold A.; Morton, David A. V.; McIntosh, Michelle P.
texts
eye 37
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Oxytocin is recommended by the World Health Organisation as the most effective uterotonic for the prevention and treatment of postpartum haemorrhage. The requirement for parenteral administration by trained healthcare providers and the need for the drug solution to be maintained under cold-chain storage limit the use of oxytocin in the developing world. In this study, a spray-dried ultrafine formulation of oxytocin was developed with an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871608
56
56
Oct 28, 2014
10/14
by
Kim, Se Yon; Park, Moon-Sung; Yang, Jeong-In; Yim, Shin-Young
texts
eye 56
favorite 0
comment 0
This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To compare effectiveness on correcting cranial and ear asymmetry between helmet therapy and counter positioning for deformational plagiocephaly (DP). Methods: Retrospective data of children diagnosed with DP who visited our clinic from November 2010 to October 2012 were reviewed. Subjects ≤10 months of age who showed ≥10 mm of diagonal difference were included for analysis. For DP treatment, information...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895518
77
77
Oct 23, 2014
10/14
by
Liu, Zhong; Song, Yanrui; Li, Dan; He, Xiangyu; Li, Shishi; Wu, Bifeng; Wang, Wei; Gu, Shulian; Zhu, Xiaoyu; Wang, Xuexiang; Zhou, Qiyin; Dai, Yu; Yan, Qingfeng
texts
eye 77
favorite 0
comment 0
This article is from Journal of Medical Genetics , volume 51 . Abstract Background: Hypertrophic cardiomyopathy (HCM) is a primary disorder characterised by asymmetric thickening of septum and left ventricular wall, with a prevalence of 0.2% in the general population. Objective: To describe a novel mitochondrial DNA mutation and its association with the pathogenesis of HCM. Methods and results: All maternal members of a Chinese family with maternally transmitted HCM exhibited variable severity...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932983
54
54
Oct 25, 2014
10/14
by
Huang, Huan; Chen, Jiao; Liu, Hongde; Sun, Xiao
texts
eye 54
favorite 0
comment 0
This article is from BMC Genomics , volume 14 . Abstract Background: It has been reported that 3' end processing is coupled to transcription and nucleosome depletion near the polyadenylation sites in many species. However, the association between nucleosome occupancy and polyadenylation site usage is still unclear. Results: By systematic analysis of high-throughput sequencing datasets from the human genome, we found that nucleosome occupancy patterns are different around the polyadenylation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879661
92
92
Oct 28, 2014
10/14
by
Cadena-Mendez, Miguel; Escalante-Ramirez, Boris; Azpiroz-Leehan, Joaquin; Infante-Vazquez, Oscar
texts
eye 92
favorite 0
comment 0
This article is from SpringerPlus , volume 2 . Abstract The aim of this paper is to understand how to measure the VO2 and VCO2 variabilities in indirect calorimetry (IC) since we believe they can explain the high variation in the resting energy expenditure (REE) estimation. We propose that variabilities should be separately measured from the VO2 and VCO2 averages to understand technological differences among metabolic monitors when they estimate the REE. To prove this hypothesis the mixing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884081
46
46
Oct 28, 2014
10/14
by
Jang, Seung-Gul; Pyun, Sung-Bom
texts
eye 46
favorite 0
comment 0
This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Kernohan-Woltman notch phenomenon (KWP) is an ipsilateral motor weakness due to compression of the contralateral cerebral peduncle. We report two cases of KWP following traumatic brain injury. In case 1, ipsilateral hemiplegia was noted after right subdural hemorrhage. Although magnetic resonance imaging showed no abnormal signal changes on cerebral peduncle, diffusion tensor tractography (DTT) revealed interruption...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895529
69
69
Oct 28, 2014
10/14
by
Peng, Wang; Kim, Il-Kyu; Cho, Hyun-Young; Pae, Sang-Pill; Jung, Bum-Sang; Cho, Hyun-Woo; Seo, Ji-Hoon
texts
eye 69
favorite 0
comment 0
This article is from Journal of the Korean Association of Oral and Maxillofacial Surgeons , volume 39 . Abstract Objectives: The posterior maxillary region often provides a limited bone volume for dental implants. Maxillary sinus elevation via inserting a bone graft through a window opened in the lateral sinus wall has become the most common surgical procedure for increasing the alveolar bone height in place of dental implants in the posterior maxillary region. The purpose of this article is to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912780
49
49
Oct 23, 2014
10/14
by
Zeighami, Sara; Hadjibabaie, Molouk; Ashouri, Asieh; Sarayani, Amir; Khoee, Seyed Hamid; Mousavi, Sarah; Radfar, Mania; Ghavamzadeh, Ardeshir
texts
eye 49
favorite 0
comment 0
This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for hematological disorders. Cyclosporine (CsA) is one of the major immunosuppressive agents for the prophylaxis against graft versus host disease (GvHD). In this retrospective study, we evaluated the effects of CsA serum levels on the incidence of acute GvHD and transplant outcomes. Retrospective study in 103...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985243
41
41
Oct 23, 2014
10/14
by
Davitt, Lina I.; Cristino, Filipe; Wong, Alan C.-N.; Leek, E. Charles
texts
eye 41
favorite 0
comment 0
This article is from Journal of Experimental Psychology. Human Perception and Performance , volume 40 . Abstract This study examines the kinds of shape features that mediate basic- and subordinate-level object recognition. Observers were trained to categorize sets of novel objects at either a basic (between-families) or subordinate (within-family) level of classification. We analyzed the spatial distributions of fixations and compared them to model distributions of different curvature polarity...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977674
41
41
Oct 24, 2014
10/14
by
Kamath, Manjunath Srinivas; Ahmed, Shiek SSJ; Dhanasekaran, M; Santosh, S Winkins
texts
eye 41
favorite 0
comment 0
This article is from International Journal of Nanomedicine , volume 9 . Abstract Biomaterials-based three-dimensional scaffolds are being extensively investigated in bone tissue engineering. A potential scaffold should be osteoconductive, osteoinductive, and osteogenic for enhanced bone formation. In this study, a three-dimensional porous polycapro-lactone (PCL) scaffold was engineered for prolonged release of resveratrol. Resveratrol-loaded albumin nanoparticles (RNP) were synthesized and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875521
57
57
Oct 27, 2014
10/14
by
Hedrich, Christian M; Hofmann, Sigrun R; Pablik, Jessica; Morbach, Henner; Girschick, Hermann J
texts
eye 57
favorite 0
comment 0
This article is from Pediatric Rheumatology Online Journal , volume 11 . Abstract Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result of a dysregulated innate immune system, resulting in immune cell infiltration of the bone and subsequent osteoclast differentiation and activation. Interestingly,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881012
44
44
Oct 27, 2014
10/14
by
Hampton, David W; Serio, Andrea; Pryce, Gareth; Al-Izki, Sarah; Franklin, Robin JM; Giovannoni, Gavin; Baker, David; Chandran, Siddharthan
texts
eye 44
favorite 0
comment 0
This article is from Acta Neuropathologica Communications , volume 1 . Abstract Backgound: Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the absence of therapies for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895761
58
58
Oct 26, 2014
10/14
by
Guedes, Erika P; Madeira, Eduardo; Mafort, Thiago T; Madeira, Miguel; Moreira, Rodrigo O; Mendonca, Laura MC; Godoy-Matos, Amelio F; Lopes, Agnaldo J; Farias, Maria Lucia F
texts
eye 58
favorite 0
comment 0
This article is from Diabetology & Metabolic Syndrome , volume 5 . Abstract Background: Several studies point to a correlation between obesity and the severity of depressive and anxiety symptoms in children and adults, but there are still some controversial points about this association. The aim of this study is to investigate the relationship between body composition and the severity of anxiety/depressive symptoms in overweight and obese individuals with Metabolic Syndrome (MS). Methods:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913787
44
44
Oct 28, 2014
10/14
by
Laurent, Carine; Leduc, Alexandre; Pottier, Ivannah; Prevost, Virginie; Sichel, Francois; Lefaix, Jean-Louis
texts
eye 44
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Skin complications were recently reported after carbon-ion (C-ion) radiation therapy. Oxidative stress is considered an important pathway in the appearance of late skin reactions. We evaluated oxidative stress in normal human skin fibroblasts after carbon-ion vs. X-ray irradiation. Survival curves and radiobiological parameters were calculated. DNA damage was quantified, as were lipid peroxidation (LPO), protein carbonylation and antioxidant...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871598
45
45
Oct 23, 2014
10/14
by
Eleazu, Chinedum Ogbonnaya; Eleazu, Kate Chinedum; Chukwuma, Sonia; Essien, Udeme Nelson
texts
eye 45
favorite 0
comment 0
This article is from Journal of Diabetes and Metabolic Disorders , volume 12 . Abstract Streptozotocin (STZ) (2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-D-glucopyranose) is a naturally occurring diabetogenic compound, produced by the soil bacterium streptomyces achromogenes, that exhibits broad spectrum of antibacterial properties. Streptozotocin functions as a DNA synthesis inhibitor in both bacterial and mammalian cells. In mammalian cells, the actual mechanism and metabolic targets...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933000
87
87
Oct 25, 2014
10/14
by
Shen, Fuhai; Yuan, Juxiang; Sun, Zhiqian; Hua, Zhengbing; Qin, Tianbang; Yao, Sanqiao; Fan, Xueyun; Chen, Weihong; Liu, Hongbo; Chen, Jie
texts
eye 87
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: Prior to 1970, coal mining technology and prevention measures in China were poor. Mechanized coal mining equipment and advanced protection measures were continuously installed in the mines after 1970. All these improvements may have resulted in a change in the incidence of coal workers’ pneumoconiosis (CWP). Therefore, it is important to identify the characteristics of CWP today and trends for the incidence of CWP in the future....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871577
48
48
Oct 24, 2014
10/14
by
Choi, Soo-Ho; Yin, Huiyong; Ravandi, Amir; Armando, Aaron; Dumlao, Darren; Kim, Jungsu; Almazan, Felicidad; Taylor, Angela M.; McNamara, Coleen A.; Tsimikas, Sotirios; Dennis, Edward A.; Witztum, Joseph L.; Miller, Yury I.
texts
eye 48
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Oxidation of low-density lipoprotein (LDL) is one of the major causative mechanisms in the development of atherosclerosis. In previous studies, we showed that minimally oxidized LDL (mmLDL) induced inflammatory responses in macrophages, macropinocytosis and intracellular lipid accumulation and that oxidized cholesterol esters (OxCEs) were biologically active components of mmLDL. Here we identified a specific OxCE molecule responsible for the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871536
52
52
Oct 28, 2014
10/14
by
Dumoux, Maud; Le Gall, Sylvain M.; Habbeddine, Mohamed; Delarbre, Christiane; Hayward, Richard D.; Kanellopoulos-Langevin, Colette; Verbeke, Philippe
texts
eye 52
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion’. Alternative persistent intra-cellular forms can be induced in culture by diverse stimuli such as IFNγ or adenosine/EHNA. They do not grow or divide but revive upon withdrawal of the stimulus and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871543
84
84
Oct 28, 2014
10/14
by
Boutin, Sebastien; Bernatchez, Louis; Audet, Celine; Derome, Nicolas
texts
eye 84
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Interactions between bacteria and their host represent a full continuum from pathogenicity to mutualism. From an evolutionary perspective, host-bacteria relationships are no longer considered a two-component system but rather a complex network. In this study, we focused on the relationship between brook charr (Salvelinus fontinalis) and bacterial communities developing on skin mucus. We hypothesized that stressful conditions such as those...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871659
51
51
Oct 24, 2014
10/14
by
Lin, Yi-Wen; Huang, Chun-Yao; Chen, Yung-Hsiang; Shih, Chun-Ming; Tsao, Nai-Wen; Lin, Cheng-Yen; Chang, Nen-Chung; Tsai, Chien-Sung; Tsai, Hsiao-Ya; Tsai, Jui-Chi; Huang, Po-Hsun; Li, Chi-Yuan; Lin, Feng-Yen
texts
eye 51
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The number and function of endothelial progenitor cells (EPCs) are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. GroEL1 from Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis. However, the actual effects of GroEL1 on EPC function are unclear. In this study, we investigate the EPC function in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871664
61
61
Oct 28, 2014
10/14
by
van de Weert - van Leeuwen, Pauline B.; de Vrankrijker, Angelica M. M.; Fentz, Joachim; Ciofu, Oana; Wojtaszewski, J?rgen F. P.; Arets, Hubertus G. M.; Hulzebos, Hendrikus J.; van der Ent, Cornelis K.; Beekman, Jeffrey M.; Johansen, Helle K.
texts
eye 61
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Regular moderate exercise has been suggested to exert anti-inflammatory effects and improve immune effector functions, resulting in reduced disease incidence and viral infection susceptibility. Whether regular exercise also affects bacterial infection susceptibility is unknown. The aim of this study was to investigate whether regular voluntary exercise wheel running prior to a pulmonary infection with bacteria (P. aeruginosa) affects lung...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871638
61
61
Oct 23, 2014
10/14
by
Khatibi, Mohsen; Rasekh, Hamid Reza; Shahverdi, Zohreh; jamshidi, Hamid Reza
texts
eye 61
favorite 0
comment 0
This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Human Papilloma Virus (HPV) vaccine has been added recently to the Iran Drug List. So, decision makers need information beyond that available from RCTs to recommend funding for this vaccination program to add it to the National Immunization program in Iran. Modeling and economic studies have addressed some of those information needs in foreign countries. In order to determine the long term benefit of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977074
48
48
Oct 25, 2014
10/14
by
Lee, Ah Young; Kim, Eun Hyuk; Cho, Yun Woo; Kwon, Sun Oh; Son, Su Min; Ahn, Sang Ho
texts
eye 48
favorite 0
comment 0
This article is from Annals of Rehabilitation Medicine , volume 37 . Abstract Objective: To examine using surface electromyography whether stair climbing with abdominal hollowing (AH) is better at facilitating local trunk muscle activity than stair climbing without AH. Methods: Twenty healthy men with no history of low back pain participated in the study. Surface electrodes were attached to the multifidus (MF), lumbar erector spinae, thoracic erector spinae, transverse abdominus - internal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895520
87
87
Oct 25, 2014
10/14
by
Madec, Yoann; Leroy, Sandrine; Rey-Cuille, Marie-Anne; Huber, Florence; Calmy, Alexandra
texts
eye 87
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Objectives: Switching to second-line antiretroviral therapy (ART) largely depends on careful clinical assessment and access to biological measurements. We performed a systematic review and meta-analysis to estimate the incidence of switching to second-line ART in sub-Saharan Africa and its main programmatic determinants. Methods: We searched 2 databases for studies reporting the incidence rate of switching to second-line ART in adults living...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871158
46
46
Oct 24, 2014
10/14
by
Daniel, Christoph; Vogelbacher, Regina; Stief, Andrea; Grigo, Christina; Hugo, Christian
texts
eye 46
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract We recently identified Thrombospondin-2 (TSP-2) as a regulator of matrix remodelling and inflammation in experimental kidney disease by using TSP-2 null mice and successfully proved TSP-2 overexpression as a therapeutic concept in a short term glomerulonephritis model in the rat. In this current study, we investigated if long-term TSP-2 overexpression is also capable to ameliorate the progression of chronic kidney disease in the setting of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871554
67
67
Oct 28, 2014
10/14
by
Qin, Xian-Yang; Wei, Feifei; Tanokura, Masaru; Ishibashi, Naoto; Shimizu, Masahito; Moriwaki, Hisataka; Kojima, Soichi
texts
eye 67
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background/Purpose: Acyclic retinoid (ACR) is a promising chemopreventive agent for hepatocellular carcinoma (HCC) that selectively inhibits the growth of HCC cells (JHH7) but not normal hepatic cells (Hc). To better understand the molecular basis of the selective anti-cancer effect of ACR, we performed nuclear magnetic resonance (NMR)-based and capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS)-based metabolome analyses in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871542
60
60
Oct 29, 2014
10/14
by
Simon, Richard
texts
eye 60
favorite 0
comment 0
This article is from Frontiers in Oncology , volume 3 . Abstract Developments in genomics are providing a biological basis for the heterogeneity of clinical course and response to treatment that have long been apparent to clinicians. The ability to molecularly characterize human diseases presents new opportunities to develop more effective treatments and new challenges for the design and analysis of clinical trials. In oncology, treatment of broad populations with regimens that benefit a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870296
47
47
Oct 27, 2014
10/14
by
Guwatudde, David; Bwanga, Freddie; Dudley, Lilian; Chola, Lumbwe; Leyna, Germana Henry; Mmbaga, Elia John; Kumwenda, Newton; Protsiv, Myroslava; Atkins, Salla; Zwarenstein, Merrick; Obua, Celestino; Tumwine, James K
texts
eye 47
favorite 0
comment 0
This article is from Human Resources for Health , volume 11 . Abstract Background: The need to develop capacity for health services and systems research (HSSR) in low and middle income countries has been highlighted in a number of international forums. However, little is known about the level of HSSR training in Sub-Saharan Africa (SSA). We conducted an assessment at four major East and Southern African universities to describe: a) the numbers of HSSR PhD trainees at these institutions, b)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878024
54
54
Oct 23, 2014
10/14
by
Noubarani, Maryam; Rostamkhani, Hossein; Erfan, Mohammad; Kamalinejad, Mohammad; Eskandari, Mohammad Reza; Babaeian, Mohammad; Salamzadeh, Jamshid
texts
eye 54
favorite 0
comment 0
This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Androgenetic alopecia is the most common form of hair loss in men. The present study was designed to evaluate the hair growth-promoting activity of a preparation of the Adiantum capillus-veneris Linn. (A. capillus-veneris) on albino mice using a testosterone-induced alopecia model. Five groups of albino mice were studied: (A) Testosterone solution only (n=6); (B) Testosterone + Finasteride solution...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977060
72
72
Oct 27, 2014
10/14
by
Sand, Jannie Marie; Larsen, Lise; Hogaboam, Cory; Martinez, Fernando; Han, MeiLan; R?ssel Larsen, Martin; Nawrocki, Arkadiusz; Zheng, Qinlong; Asser Karsdal, Morten; Leeming, Diana Julie
texts
eye 72
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Objectives: Fibrosis is characterized by excessive tissue remodeling resulting from altered expression of various growth factors, cytokines and proteases. We hypothesized that matrix metalloproteinase (MMP) mediated degradation of type IV collagen, a main component of the basement membrane, will release peptide fragments (neo-epitopes) into the circulation. Here we present the development of two competitive enzyme-linked immunosorbent assays...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871599
49
49
Oct 28, 2014
10/14
by
Sadatsafavi, Mohsen; Lynd, Larry D; FitzGerald, J Mark
texts
eye 49
favorite 0
comment 0
This article is from Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology , volume 9 . Abstract Background: Post-hospital syndrome refers to the period of generalized risk of adverse health outcomes among patients who are recently discharged from hospital. This period is associated with a short-term increased risk of readmission which may not be related to the original condition. While the majority of studies of post-hospital...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880050
42
42
Sep 20, 2013
09/13
by
Alexandr N. Grishkov; Dmitry Logachev
texts
eye 42
favorite 0
comment 0
The analytic rank under consideration is the order of 0 at $U=1$ of the $L$-function of the simplest type $L(M, U)$ of an Anderson T-motive $M$ of ordinary rank 1 over $\Bbb F_q(\theta)$. These T-motives are the twisted tensor powers of the Carlitz module. The natural action of $GL_2(\Bbb F_q)$ on the set of the twisted Carlitz modules gives the similar action on $L(M, U)$, this means that we get essentially the same results for the order of 0 of $L(M, U)$ at $U=c$ for any $c\in \Bbb F_q^*$. A...
Source: http://arxiv.org/abs/1205.2900v3
43
43
Oct 24, 2014
10/14
by
Nagaraja, Tavarekere N.; Aryal, Madhava P.; Brown, Stephen L.; Bagher-Ebadian, Hassan; Mikkelsen, Tom; Yang, James J.; Panda, Swayamprava; Keenan, Kelly A.; Cabral, Glauber; Ewing, James R.
texts
eye 43
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Increased efficacy of radiotherapy (RT) 4-8 h after Cilengitide treatment has been reported. We hypothesized that the effects of Cilengitide on tumor transvascular transfer parameters might underlie, and thus predict, this potentiation. Athymic rats with orthotopic U251 glioma were studied at ~21 days after implantation using dynamic contrast-enhanced (DCE)-MRI. Vascular parameters, viz: plasma volume fraction (vp), forward volume transfer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871527
