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Ding, Lei; Zhang, Ling-Li; Gao, Run; Chen, Dan; Wang, Jue-Jin; Gao, Xing-Ya; Kang, Yu-Ming; Zhu, Guo-Qing
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This article is from PLoS ONE , volume 8 . Abstract Background: Adipose afferent reflex (AAR) is a sympatho-excitatory reflex induced by chemical stimulation of white adipose tissue (WAT). Ionotropic glutamate receptors including NMDA receptors (NMDAR) and non-NMDA receptors (non-NMDAR) in paraventricular nucleus (PVN) mediate the AAR. Enhanced AAR contributes to sympathetic activation and hypertension in obesity rats. This study was designed to investigate the role and mechanism of superoxide...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871588
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Chen, Li-Ching; Lee, Wen-Sen
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This article is from PLoS ONE , volume 8 . Abstract Hemorrhagic stroke caused leakage of red blood cells which converts to hemoglobin, heme, and iron accumulated at the lesions. High concentration of ferrous iron from subarachnoid hemorrhage (SAH) induced cerebral vasospasm. Using the two-hemorrhage SAH model in rats, we previously demonstrated that estradiol (E2) significantly attenuated the SAH-induced vasospasm by inhibiting the NOS2 expression. Adding ferrous citrate (FC) complexes to the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871628
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Liu, Limin; Zhao, Ying; Xie, Keming; Sun, Xiaodong; Gao, Yuzhen; Wang, Zufeng
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This article is from PLoS ONE , volume 8 . Abstract Estrogen is traditionally thought to exert genomic actions through members of the nuclear receptor family. Here, we investigated the rapid nongenomic effects of 17β-estradiol (E2) on tumor necrosis factor α (TNF-α) production following lipopolysaccharide (LPS) stimulation in mouse bone marrow-derived macrophages (BMMs). We found that LPS induced TNF-α production in BMMs via phosphorylation of p38 mitogen-activated protein kinase (MAPK). E2...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871562
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Deja, Stanislaw; Dawiskiba, Tomasz; Balcerzak, Waldemar; Orczyk-Pawilowicz, Magdalena; Glod, Mateusz; Pawelka, Dorota; Mlynarz, Piotr
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This article is from PLoS ONE , volume 8 . Abstract Thyroid cancer is the most common endocrine malignancy. However, more than 90% of thyroid nodules are benign. It remains unclear whether thyroid carcinoma arises from preexisting benign nodules. Metabolomics can provide valuable and comprehensive information about low molecular weight compounds present in living systems and further our understanding of the biology regulating pathological processes. Herein, we applied 1H NMR-based metabolic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871661
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Park, Sang-Jin; Lim, Kwang-Hyun; Noh, Jeong-Ho; Jeong, Eun Ju; Kim, Yong-Soon; Han, Byung-Cheol; Lee, Seung-Ho; Moon, Kyoung-Sik
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This article is from Toxicological Research , volume 29 . Abstract Ginseng is a well-known traditional medicine used in Asian countries for several thousand years, and it is currently applied to medicine, cosmetics, and nutritional supplements due to its many healing and energygiving properties. It is well demonstrated that ginsenosides, the main ingredient of ginseng, produce a variety of pharmacological and therapeutic effects on central nerve system (CNS) disorders, cardiovascular disease,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936181
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Vandenbroeck, Philippe; Dechenne, Rachel; Becher, Kim; Eyssen, Maria; Van den Heede, Koen
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This article is from Child and Adolescent Psychiatry and Mental Health , volume 7 . Abstract Background: Despite a high prevalence of mental health problems among children and adolescents Belgium, like many other Western countries, does not have a clear strategy for the organization of child and adolescent mental healthcare services (CAMHS). Methods: This paper describes stakeholders’ views on the organization of CAMHS based on a qualitative study. Ten in-depth interviews with high profile...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942294
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Yazdanpanah, Hassan; Shafaati, Alireza; Foroutan, Seyed Mohsen; Zarghi, Afshin; Aboul-fathi, Farshid; Khoddam, Arash; Shaki, Fatemeh; Nazari, Firoozeh
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract The occurrence of deoxynivalenol (DON) in retail foods in Tehran (Iran) was determined using high-performance liquid chromatography technique and immunoaffinity column as the clean-up step. A method was validated for analysis of DON in rice, bread, puffed corn snack and wheat flour. The average recoveries and precision (RSD) for DON in different foods ranged 84.2-93.1% and 2.9-12.0%, respectively. A...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977057
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Kakhki, Samaneh; Shahosseini, Sorayya; Zarghi, Afshin
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Two set of 2-aryl-5, 6-dihydropyrrolo [2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithelial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977055
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Peiravian, Farzad; Rasekh, Hamid Reza; Jahani Hashemi, Hasan; Mohammadi, Navid; Jafari, Nahid; Fardi, Kianoosh
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Drug and health literacy is a key determinant of health outcomes. There are several tools to assess drug and health literacy. The objective of this article is to determine drug literacy level and its relationships with other factors using a single item screening tool. A cross-sectional survey was conducted among 1104 people in Qazvin province, Iran. Based on the proportional-to-size method,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977073
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Lin, Li; Hutzen, Brian; Lee, Hsiu-Fang; Peng, Zhengang; Wang, Wenlong; Zhao, Chongqiang; Lin, Huey-Jen; Sun, Duxin; Li, Pui-Kai; Li, Chenglong; Korkaya, Hasan; Wicha, Max S.; Lin, Jiayuh
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This article is from PLoS ONE , volume 8 . Abstract Background: STAT3 activation is frequently detected in breast cancer and this pathway has emerged as an attractive molecular target for cancer treatment. Recent experimental evidence suggests ALDH-positive (ALDH+), or cell surface molecule CD44-positive (CD44+) but CD24-negative (CD24−) breast cancer cells have cancer stem cell properties. However, the role of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24− subpopulations of breast cancer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871589
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Pombo, Maira; Turra, Alexander
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This article is from PLoS ONE , volume 8 . Abstract The use of indirect estimates of ghost-crab populations to assess beach disturbance has several advantages, including non-destructiveness, ease and low cost, although this strategy may add some degree of noise to estimates of population parameters. Resolution of these shortcomings may allow wider use of these populations as an indicator of differences in quality among beaches. This study analyzed to what extent the number of crab burrows may...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871685
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Estrada-Sanchez, Ana Maria; Barton, Scott J.; Burroughs, Courtney L.; Doyle, Amanda R.; Rebec, George V.
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This article is from PLoS ONE , volume 8 . Abstract Palmitoyl acyl transferases (PATs) play a critical role in protein trafficking and function. Huntingtin interacting protein 14 (HIP14) is a PAT that acts on proteins associated with neuronal transmission, suggesting that deficient protein palmitoylation by HIP14, which occurs in the YAC128 model of Huntington’s disease (HD), might have deleterious effects on neurobehavioral processing. HIP14 knockout mice show biochemical and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871627
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Sonntag, Michael; Konnopka, Alexander; Leichsenring, Falk; Salzer, Simone; Beutel, Manfred E; Herpertz, Stephan; Hiller, Wolfgang; Hoyer, Jurgen; Joraschky, Peter; Nolting, Bjorn; Pohlmann, Karin; Stangier, Ulrich; Strauss, Bernhard; Willutzki, Ulrike; Wiltink, Jorg; Leibing, Eric; Konig, Hans-Helmut
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This article is from Health and Quality of Life Outcomes , volume 11 . Abstract Objective: The aim of the study was to analyse the psychometric properties of the EQ-5D in patients with social phobia. Methods: We used a sample of 445 patients with social phobia with five measurement points over a 30 month period. The discriminative ability of the EQ-5D was analysed by comparing the patients’ responses with the general population and between different disease severity levels. For test-retest...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878044
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Oji, Yutaka; Noda, Kazuyuki; Tokugawa, Joji; Yamashiro, Kazuo; Hattori, Nobutaka; Okuma, Yasuyuki
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This article is from Journal of Medical Case Reports , volume 7 . Abstract Introduction: Spinal subarachnoid hemorrhage has many causes including trauma, vascular malformations, aneurysms, spinal cord tumors, coagulation abnormalities, use of anticoagulants, systemic lupus erythematosus, or Behçet’s disease. We report on a rare case of a spontaneous spinal subarachnoid hemorrhage after severe coughing of unknown origin. To the best of our knowledge, this is the first report of spontaneous...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878018
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Konkel, Michael E; Samuelson, Derrick R; Eucker, Tyson P; Shelden, Eric A; O'Loughlin, Jason L
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This article is from Cell Communication and Signaling : CCS , volume 11 . Abstract Caveolae are 25–100 nm flask-like membrane structures enriched in cholesterol and glycosphingolipids. Researchers have proposed that Campylobacter jejuni require caveolae for cell invasion based on the finding that treatment of cells with the cholesterol-depleting compounds filipin III or methyl-β-cyclodextrin (MβCD) block bacterial internalization in a dose-dependent manner. The purpose of this study was to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880046
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Saraoui, Taous; Parayre, Sandrine; Guernec, Gregory; Loux, Valentin; Montfort, Jerome; Cam, Aurelie Le; Boudry, Gaelle; Jan, Gwenael; Falentin, Helene
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This article is from BMC Genomics , volume 14 . Abstract Background: Propionibacterium freudenreichii is a food grade bacterium consumed both in cheeses and in probiotic preparations. Its promising probiotic potential, relying largely on the active release of beneficial metabolites within the gut as well as the expression of key surface proteins involved in immunomodulation, deserves to be explored more deeply. Adaptation to the colon environment is requisite for the active release of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880035
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Hwang, Seung Joon; Kim, Weon
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This article is from Chonnam Medical Journal , volume 49 . Abstract Traditionally, mitochondria have been regarded solely as energy generators for cells; however, accumulating data have demonstrated that these complex organelles play a variety of roles within the cardiomyocyte that extend beyond this classic function. Mitochondrial dynamics involves mitochondrial movements and morphologic alterations by tethering, fusion, and fission, which depend on cellular energy requirements and metabolic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881204
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Bozdag, Sinem Civriz; Namdaroglu, Sinem; Kayikci, Omur; Kaygusuz, Gulsah; Demiriz, Itir; Cinarsoy, Murat; Tekgunduz, Emre; Altuntas, Fevzi
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This article is from Hematology Reports , volume 5 . Abstract Large granular lymphocytic (LGL) leukemia is a lymphoproliferative disease characterized by the clonal expansion of cytotoxic T or natural killer cells. We report on a patient diagnosed with T-cell LGL leukemia two years after the achievement of hematologic remission for acute myeloblastic leukemia.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883061
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de Sa, Amanda Regina Nichi; Steindel, Mario; Demeu, Lara Maria Kalempa; Luckemeyer, Debora Denardin; Grisard, Edmundo Carlos; Neto, Quirino Alves de Lima; de Araujo, Silvana Marques; Toledo, Max Jean de Ornelas; Gomes, Monica Lucia
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This article is from Parasites & Vectors , volume 6 . Abstract Background: The parasites Trypanosoma rangeli and Trypanosoma cruzi share vectors and hosts over a wide geographical area in Latin America. In this study, we propose a single molecular approach for simultaneous detection and typing of T. rangeli and T. cruzi. Methods: A restriction fragment length polymorphism analysis of the mitochondrial cytochrome oxidase II gene (COII-RFLP) using enzyme AluI and different amounts of DNA from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891993
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Abreu, Mauro Henrique Nogueira Guimaraes; Sanglard-Oliveira, Carla Aparecida; Jaruche, Abdul Rahman Mustafa; Mambrini, Juliana Vaz de Melo; Werneck, Marcos Azeredo Furquim; Lucas, Simone Dutra
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This article is from Human Resources for Health , volume 11 . Abstract Background: To describe some sociodemographic and educational characteristics of oral health technicians (OHTs) in public primary health care teams in the state of Minas Gerais, Brazil. Methods: A cross-sectional descriptive study was performed based on the telephone survey of a representative sample comprising 231 individuals. A pre-tested instrument was used for the data collection, including questions on gender, age in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878034
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LIU, CHUN-LEI; HE, YUN-YUN; LI, XIN; LI, RUI-JUN; HE, KUN-LUN; WANG, LI-LI
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This article is from International Journal of Molecular Medicine , volume 33 . Abstract The serine/threonine protein phosphatase PP1 mediates the dephosphorylation of phosphorylated eukaryotic translation initiation factor 2 subunit α (p-eIF2α), which is a central regulator of protein synthesis. In the present study, we examined the protective effects of PP1–12 (an inhibitor of the serine/threonine protein phosphatase PP1) against tunicamycin (TM)-induced apoptosis in cultured...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926518
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Rajesh Chitnis; Marek Cygan; MohammadTaghi Hajiaghayi; Dániel Marx
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Given a graph $G$ and an integer $k$, the Feedback Vertex Set (FVS) problem asks if there is a vertex set $T$ of size at most $k$ that hits all cycles in the graph. The fixed-parameter tractability status of FVS in directed graphs was a long-standing open problem until Chen et al. (STOC '08) showed that it is FPT by giving a $4^{k}k!n^{O(1)}$ time algorithm. In the subset versions of this problems, we are given an additional subset $S$ of vertices (resp., edges) and we want to hit all cycles...
Source: http://arxiv.org/abs/1205.1271v2
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Nespoulet, Hugo; Rupp, Thomas; Bachasson, Damien; Tamisier, Renaud; Wuyam, Bernard; Levy, Patrick; Verges, Samuel
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This article is from PLoS ONE , volume 8 . Abstract Introduction: Positive end-expiratory pressure (PEEP) is commonly used in critical care medicine to improve gas exchange. Altitude sickness is associated with exaggerated reduction in arterial oxygenation. We assessed the effect of PEEP and pursed lips breathing (PLB) on arterial and tissue oxygenation under normobaric and hypobaric hypoxic conditions. Methods: Sixteen healthy volunteers were exposed to acute normobaric hypoxia (Laboratory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871630
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Del Fabbro, Cristian; Scalabrin, Simone; Morgante, Michele; Giorgi, Federico M.
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This article is from PLoS ONE , volume 8 . Abstract Next Generation Sequencing is having an extremely strong impact in biological and medical research and diagnostics, with applications ranging from gene expression quantification to genotyping and genome reconstruction. Sequencing data is often provided as raw reads which are processed prior to analysis 1 of the most used preprocessing procedures is read trimming, which aims at removing low quality portions while preserving the longest high...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871669
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Sommet, Nicolas; Pulfrey, Caroline; Butera, Fabrizio
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This article is from PLoS ONE , volume 8 . Abstract Exams with numerus clausus are very common in Medicine, Business Administration and Law. They are intended to select a predefined number of academic candidates on the basis of their rank rather than their absolute performance. Various scholars and politicians believe that numerus clausus policies are a vector of academic excellence. We argue, however, that they could have ironic epistemic effects. In comparison with selective policies based on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871692
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Deng, Jun; Yu, Fang; Li, Hai-Bin; Gebiola, Marco; Desdevises, Yves; Wu, San-An; Zhang, Yan-Zhou
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This article is from BMC Evolutionary Biology , volume 13 . Abstract Background: Numerous studies have investigated cospeciation between parasites and their hosts, but there have been few studies concerning parasitoids and insect hosts. The high diversity and host specialization observed in Anicetus species suggest that speciation and adaptive radiation might take place with species diversification in scale insect hosts. Here we examined the evolutionary history of the association between...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878026
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Roche, Steven M; Jones-Bitton, Andria; Majowicz, Shannon E; Pintar, Katarina D M; Allison, David
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This article is from BMC Public Health , volume 13 . Abstract Background: The first objective of this study was to investigate the public perceptions of private water and alternative sources with respect to safety, quality, testing and treatment in Newfoundland and Labrador (NL), Canada. The second objective was to provide public health practitioners with recommendations for improving knowledge translation (KT) efforts in NL, based on assessments of respondents’ perceived information needs...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878038
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Duane, Sinead; Callan, Aoife; Galvin, Sandra; Murphy, Andrew W; Domegan, Christine; O'Shea, Eamon; Cormican, Martin; Bennett, Kathleen; O'Donnell, Martin; Vellinga, Akke
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This article is from Trials , volume 14 . Abstract Background: The overuse of antimicrobials is recognized as the main selective pressure driving the emergence and spread of antimicrobial resistance in human bacterial pathogens. Urinary tract infections (UTIs) are among the most common infections presented in primary care and empirical antimicrobial treatment is currently recommended. Previous research has identified that a substantial proportion of Irish general practitioners (GPs) prescribe...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880352
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Zhang, Tingyan; Wang, Xin; Lu, Yongen; Cai, Xiaofeng; Ye, Zhibiao; Zhang, Junhong
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This article is from International Journal of Molecular Sciences , volume 15 . Abstract Cyclins play important roles in cell division and cell expansion. They also interact with cyclin-dependent kinases to control cell cycle progression in plants. Our genome-wide analysis identified 52 expressed cyclin genes in tomato. Phylogenetic analysis of the deduced amino sequences of tomato and Arabidopsis cyclin genes divided them into 10 types, A-, B-, C-, D-, H-, L-, T-, U-, SDS- and J18. Pfam...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907801
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Ahmadi, Fatemeh; Dabirian, Sara; Faizi, Mehrdad; Tabatabai, Sayyed Abbas; Beiki, Davood; Shahhosseini, Soraya
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3, 4-oxadiazolo[a,2,3]-pyrimidine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977056
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Morowvat, Mohammad Hossein; Babaeipour, Valiollah; Rajabi-Memari, Hamid; Vahidi, Hossein; Maghsoudi, Nader
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Human Interferon β (INF-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. In this study an expression vector was designed and constructed for expression of human INF-β-1b either in shake flasks or bench top bioreactor. The designed vector was constructed based upon pET-25b(+) with T7 promoter. Recombinant human beta interferon...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977065
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Salmannejad, Faranak; Nafissi-Varcheh, Nastaran; Shafaati, Alireza; Aboofazeli, Reza
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFNα2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40–70 °C and for up to 240 h at 50 °C...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977050
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Ahn, Tae-Gue; Lee, Joo-Young; Cheon, Se-Yun; An, Hyo-Jin; Kook, Yoon-Bum
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This article is from BMC Complementary and Alternative Medicine , volume 13 . Abstract Background: Sam-Hwang-Sa-Sim-Tang (SHSST) is a traditional Oriental medication that has been commonly used in Korea for the treatment of hypertension, insomnia, and chest pain. In addition, some studies reported that administration of SHSST results suppression of hyperlipidemia in rats or lowering lipid plasma level such as total cholesterol (TC). Those results made us find and demonstrate positive effect of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900264
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Moret, Ines; Sanchez-Izquierdo, Dolors; Iborra, Marisa; Tortosa, Luis; Navarro-Puche, Ana; Nos, Pilar; Cervera, Jose; Beltran, Belen
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This article is from PLoS ONE , volume 8 . Abstract The first step in biomarkers discovery is to identify the best protocols for their purification and analysis. This issue is critical when considering peripheral blood samples (plasma and serum) that are clinically interesting but meet several methodological problems, mainly complexity and low biomarker concentration. Analysis of small molecules, such as circulating microRNAs, should overcome these disadvantages. The present study describes an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871541
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Yan, Qing; Chen, Pin; Lu, Ailin; Zhao, Peng; Gu, Aihua
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This article is from PLoS ONE , volume 8 . Abstract Purpose: CTLA-4 is one of the most fundamental immunosuppressive cotykines which belongs to the immunoglobulin super-family, and is expressed mainly on activated T cells. Previous studies have reported the existence of CTLA4 60G/A and CTLA4 -1661A/G polymorphism in cancers. However, the effects remain conflicting. Hence, we performed a meta-analysis to investigate the association between these polymorphisms and cancer risk. Methods: We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871533
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Xia, Sujian; Zhang, Weidong; Huang, Liting; Jiang, Hong
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This article is from PLoS ONE , volume 8 . Abstract Objective: A meta-analysis was conducted to investigate the efficacy and safety of three main iron chelators, namely, deferoxamine (DFO), deferiprone (DFP) and deferasirox (DFX) for thalassemia major (TM) patients. Methods: Randomized controlled trials comparing mono-therapy DFO, DFP, DFX and combined DFP with DFO therapy in TM patients from January 1990 to December 2012 were searched and selected. Two independent authors assessed data from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871701
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Salas, Ramiro; Steele, Kenya; Lin, Amy; Loe, Claire; Gauna, Leslie; Jafar-Nejad, Paymaan
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This article is from Medical Education Online , volume 18 . Abstract Playback Theatre (PT) is an improvisational form of theatre in which a group of actors “play back” real life stories told by audience members. In PT, a conductor elicits moments, feelings and stories from audience members, and conducts mini-interviews with those who volunteer a moment of their lives to be re-enacted or “played” for the audience. A musician plays music according to the theme of each story, and 4-5...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873757
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Meyer, Arndt; Hilgen, Gerrit; Dorgau, Birthe; Sammler, Esther M.; Weiler, Reto; Monyer, Hannah; Dedek, Karin; Hormuzdi, Sheriar G.
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This article is from Journal of Cell Science , volume 127 . Abstract Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (Cx36) is the most abundant isoform; however, the mechanisms underlying formation of Cx36-containing electrical synapses are unknown. We focus on homocellular and heterocellular gap junctions formed by an AII amacrine cell, a key interneuron found in all mammalian retinas. In mice lacking native...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953814
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Oto, Jun; Li, Qian; Kimball, William R; Wang, Jingping; Sabouri, Abdolnabi S; Harrell, Priscilla G; Kacmarek, Robert M; Jiang, Yandong
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This article is from Critical Care , volume 17 . Abstract Introduction: Upper airway obstruction (UAO) is a major problem in unconscious subjects, making full face mask ventilation difficult. The mechanism of UAO in unconscious subjects shares many similarities with that of obstructive sleep apnea (OSA), especially the hypotonic upper airway seen during rapid eye movement sleep. Continuous positive airway pressure (CPAP) via nasal mask is more effective at maintaining airway patency than a full...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056076
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Yan V. Fyodorov; Jonathan P. Keating
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We argue that the freezing transition scenario, previously conjectured to occur in the statistical mechanics of 1/f-noise random energy models, governs, after reinterpretation, the value distribution of the maximum of the modulus of the characteristic polynomials p_N(\theta) of large N\times N random unitary (CUE) matrices; i.e. the extreme value statistics of p_N(\theta) when N \rightarrow\infty. In addition, we argue that it leads to multifractal-like behaviour in the total length \mu_N(x) of...
Source: http://arxiv.org/abs/1211.6063v2
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Blume-Kohout, Margaret E.; Clack, John W.
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This article is from PLoS ONE , volume 8 . Abstract The U.S. National Institutes of Health (NIH) budget expansion from 1998 through 2003 increased demand for biomedical research, raising relative wages and total employment in the market for biomedical scientists. However, because research doctorates in biomedical sciences can often take six years or more to complete, the full labor supply response to such changes in market conditions is not immediate, but rather is observed over a period of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871560
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Shang, Ruofeng; Wang, Shengyu; Xu, Ximing; Yi, Yunpeng; Guo, Wenzhu; YuLiu,; Liang, Jianping
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This article is from PLoS ONE , volume 8 . Abstract Novel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae. Compound 5b showed the highest antibacterial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871055
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Zhou, Jian; Mo, Yifei; Li, Hong; Ran, Xingwu; Yang, Wenying; Li, Qiang; Peng, Yongde; Li, Yanbing; Gao, Xin; Luan, Xiaojun; Wang, Weiqing; Xie, Yun; Jia, Weiping
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This article is from PLoS ONE , volume 8 . Abstract Objective: Since there is a paucity of reference data in the literature to indicate the relationship between HbA1c, and 24 h mean blood glucose (MBG) from continuous glucose monitoring (CGM) in Chinese populations, we described the above relationship in adult Chinese subjects with different glucose tolerance status. Methods: Seven-hundred-and-forty-two individuals without history of diabetes were included to the study at 11 hospitals in urban...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871656
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Dong, Pei; Jiang, Lijuan; Liu, Jianye; Wu, Zhiming; Guo, Shengjie; Zhang, Ziling; Zhou, Fangjian; Liu, Zhuowei
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This article is from PLoS ONE , volume 8 . Abstract Paclitaxel is a drug within one of the most promising classes of anticancer agents. Unfortunately, clinical success of this drug has been limited by the insurgence of cellular resistance. To address this, Paclitaxel resistance was modeled in an in vitro system using estrogen treated prostate cancer cells. This study demonstrates that emerging resistance to clinically relevant doses of Paclitaxel is associated with 17-β-estradiol (E2)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871534
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Denkinger, Claudia M.; Kalantri, Yatiraj; Schumacher, Samuel G.; Michael, Joy S.; Shankar, Deepa; Saxena, Arvind; Sriram, Natarajan; Balamugesh, Thangakunam; Luo, Robert; Pollock, Nira R.; Pai, Madhukar; Christopher, Devasahayam J.
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This article is from PLoS ONE , volume 8 . Abstract Existing diagnostic tests for pleural tuberculosis (TB) have inadequate accuracy and/or turnaround time. Interferon-gamma (IFNg) has been identified in many studies as a biomarker for pleural TB. Our objective was to develop a lateral flow, immunochromatographic test (ICT) based on this biomarker and to evaluate the test in a clinical cohort. Because IFNg is commonly present in non-TB pleural effusions in low amounts, a diagnostic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871622
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Nagaraja, Tavarekere N.; Aryal, Madhava P.; Brown, Stephen L.; Bagher-Ebadian, Hassan; Mikkelsen, Tom; Yang, James J.; Panda, Swayamprava; Keenan, Kelly A.; Cabral, Glauber; Ewing, James R.
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This article is from PLoS ONE , volume 8 . Abstract Increased efficacy of radiotherapy (RT) 4-8 h after Cilengitide treatment has been reported. We hypothesized that the effects of Cilengitide on tumor transvascular transfer parameters might underlie, and thus predict, this potentiation. Athymic rats with orthotopic U251 glioma were studied at ~21 days after implantation using dynamic contrast-enhanced (DCE)-MRI. Vascular parameters, viz: plasma volume fraction (vp), forward volume transfer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871527
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Naidoo, Shalinee; Olaniran, Ademola O.
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This article is from International Journal of Environmental Research and Public Health , volume 11 . Abstract Since 1990, more than 1.8 billion people have gained access to potable water and improved sanitation worldwide. Whilst this represents a vital step towards improving global health and well-being, accelerated population growth coupled with rapid urbanization has further strained existing water supplies. Whilst South Africa aims at spending 0.5% of its GDP on improving sanitation,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924443
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Jacquez, Geoffrey M.; Barlow, Janice; Rommel, Robert; Kaufmann, Andy; Rienti, Michael; AvRuskin, Gillian; Rasul, Jawaid
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This article is from International Journal of Environmental Research and Public Health , volume 11 . Abstract Marin County (California, USA) has among the highest incidences of breast cancer in the U.S. A previously conducted case-control study found eight significant risk factors in participants enrolled from 1997–1999. These included being premenopausal, never using birth control pills, lower highest lifetime body mass index, having four or more mammograms from 1990–1994, beginning...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924444
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Mammitzsch, Kerstin; Jost, Gunter; Jurgens, Klaus
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This article is from MicrobiologyOpen , volume 3 . Abstract Epsilonproteobacteria have been found globally distributed in marine anoxic/sulfidic areas mediating relevant transformations within the sulfur and nitrogen cycles. In the Baltic Sea redox zones, chemoautotrophic epsilonproteobacteria mainly belong to the Sulfurimonas gotlandica GD17 cluster for which recently a representative strain, S. gotlandica GD1T, could be established as a model organism. In this study, the potential effects of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937731
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Hashemi, Mehrdad
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 13 . Abstract Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on BCL-2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.In this experimental study, 20 male wistar rats with average weight of 250-300 g were selected and then...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985231
