This article is from BMC Bioinformatics , volume 15 . Abstract Background: Genome-wide association studies (GWAS) have successfully identified a large number of single nucleotide polymorphisms (SNPs) that are associated with a wide range of human diseases. However, many of these disease-associated SNPs are located in non-coding regions and have remained largely unexplained. Recent findings indicate that disease-associated SNPs in human large intergenic non-coding RNA (lincRNA) may lead to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038069
This article is from PLoS ONE , volume 9 . Abstract Large intergenic non-coding RNAs (lincRNAs) are a new class of functional transcripts, and aberrant expression of lincRNAs was associated with several human diseases. The genetic variants in lincRNA transcription factor binding sites (TFBSs) can change lincRNA expression, thereby affecting the susceptibility to human diseases. To identify and annotate these functional candidates, we have developed a database SNP@lincTFBS, which is devoted to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116217