43
43
Oct 9, 2014
10/14
by
Wang, Tingting; Liu, Guangwei; Wang, Ruoning
texts
eye 43
favorite 0
comment 0
This article is from Frontiers in Immunology , volume 5 . Abstract Functional and effective immune response requires a metabolic rewiring of immune cells to meet their energetic and anabolic demands. Beyond this, the availability of extracellular and intracellular metabolites may serve as metabolic signals interconnecting with cellular signaling events to influence cellular fate and immunological function. As such, tumor microenvironment represents a dramatic example of metabolic derangement,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112791
60
60
Oct 17, 2014
10/14
by
Du, Wenxin; Gao, Jing; Wang, Tingting; Wang, Jinke
texts
eye 60
favorite 0
comment 0
This article is from PLoS ONE , volume 9 . Abstract In this study, we established a single nucleotide mutation matrix (SNMM) model based on the relative binding affinities of NF-κB p50 homodimer to a wild-type binding site (GGGACTTTCC) and its all single-nucleotide mutants detected with the double-stranded DNA microarray. We evaluated this model by scoring different groups of 10-bp DNA sequences with this model and analyzing the correlations between the scores and the relative binding...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081663
86
86
Oct 24, 2014
10/14
by
Liu, Guangyi; Song, Jinming; Guo, Yunliang; Wang, Tingting; Zhou, Zhen
texts
eye 86
favorite 0
comment 0
This article is from Behavioral and Brain Functions : BBF , volume 9 . Abstract Background: Astragalus is a widely used traditional Chinese medicine and has been proven beneficial for many aspects of human health. It is important to explore the neuroprotective effect and mechanism of astragalus injection in cerebral ischemia reperfusion injury. Methods: The focal cerebral ischemic model with middle cerebral artery occlusion (MCAO) reperfusion was established by Longa’s method in healthy adult...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850702
65
65
Oct 21, 2014
10/14
by
Ning, Shangwei; Zhao, Zuxianglan; Ye, Jingrun; Wang, Peng; Zhi, Hui; Li, Ronghong; Wang, Tingting; Li, Xia
texts
eye 65
favorite 0
comment 0
This article is from BMC Bioinformatics , volume 15 . Abstract Background: Genome-wide association studies (GWAS) have successfully identified a large number of single nucleotide polymorphisms (SNPs) that are associated with a wide range of human diseases. However, many of these disease-associated SNPs are located in non-coding regions and have remained largely unexplained. Recent findings indicate that disease-associated SNPs in human large intergenic non-coding RNA (lincRNA) may lead to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038069
48
48
Oct 22, 2014
10/14
by
Nie, Yunzhong; Du, Leilei; Mou, Yongbin; Xu, Zhenjun; Weng, Leihua; Du, Youwei; Zhu, Yanan; Hou, Yayi; Wang, Tingting
texts
eye 48
favorite 0
comment 0
This article is from BMC Cancer , volume 13 . Abstract Background: We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor. We here investigated whether LF-MF can inhibit the proliferation and metastasis of melanoma and influence immune function. Methods: The effect of MF on the proliferation, cell cycle and ultrastracture of B16-F10 in vitro was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029221
66
66
Oct 11, 2014
10/14
by
Ning, Shangwei; Zhao, Zuxianglan; Ye, Jingrun; Wang, Peng; Zhi, Hui; Li, Ronghong; Wang, Tingting; Wang, Jianjian; Wang, Lihua; Li, Xia
texts
eye 66
favorite 0
comment 0
This article is from PLoS ONE , volume 9 . Abstract Large intergenic non-coding RNAs (lincRNAs) are a new class of functional transcripts, and aberrant expression of lincRNAs was associated with several human diseases. The genetic variants in lincRNA transcription factor binding sites (TFBSs) can change lincRNA expression, thereby affecting the susceptibility to human diseases. To identify and annotate these functional candidates, we have developed a database SNP@lincTFBS, which is devoted to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116217
47
47
Oct 22, 2014
10/14
by
Wang, Tingting; Ji, Yuetong; Wang, Yun; Jia, Jing; Li, Jing; Huang, Shi; Han, Danxiang; Hu, Qiang; Huang, Wei E; Xu, Jian
texts
eye 47
favorite 0
comment 0
This article is from Biotechnology for Biofuels , volume 7 . Abstract Background: Rapid, real-time and label-free measurement of the cellular contents of biofuel molecules such as triacylglycerol (TAG) in populations at single-cell resolution are important for bioprocess control and understanding of the population heterogeneity. Raman microspectroscopy can directly detect the changes of metabolite profile in a cell and thus can potentially serve these purposes. Results: Single-cell Raman...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022372
65
65
Oct 21, 2014
10/14
by
Yan, Fang; Wang, Qi; Xu, Chao; Cao, Mingfeng; Zhou, Xiaoming; Wang, Tingting; Yu, Chunxiao; Jing, Fei; Chen, Wenbin; Gao, Ling; Zhao, Jiajun
texts
eye 65
favorite 0
comment 0
This article is from PLoS ONE , volume 9 . Abstract Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation, ranging from steatosis to steatohepatitis and cirrhosis. NAFLD is a risk factor for cardiovascular diseases and is associated with metabolic syndrome. Antihyperlipidemic drugs are recommended as part of the treatment for NAFLD patients. Although fibrates activate peroxisome proliferator-activated receptor α (PPARα), leading to the reduction of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057124
73
73
Oct 2, 2014
10/14
by
Wei, Ke; Yan, Feng; Xiao, Hui; Yang, Xiaoxu; Xie, Guie; Xiao, Ye; Wang, Tingting; Xun, Yu; Huang, Zhaoqin; Han, Mei; Zhang, Jian; Xiang, Shuanglin
texts
eye 73
favorite 0
comment 0
This article is from International Journal of Molecular Sciences , volume 15 . Abstract Prediction of microRNA–mRNA interaction typically relies on bioinformatic methods, but these methods only suggest the possibility of microRNA binding and may miss important interactions as well as falsely predict others. A major obstacle to the miRNA research has been the lack of experimental procedures for the identification of miRNA–mRNA interactions. Recently, a few studies have attempted to explore...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159880
