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Oct 29, 2014
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Kojima, Motohiro; Yokota, Mitsuru; Saito, Norio; Nomura, Shogo; Ochiai, Atsushi
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This article is from Frontiers in Oncology , volume 2 . Abstract Primary tumors of the colorectal cancers are assessed pathologically based on the tumor spread into the bowel wall. The assessment of serosal involvement, which may be relevant to pT4, can be challenging for pathologists, making the consistency of diagnoses questionable. As solutions to this problem, the following two strategies could be adopted. One would be to use special staining or immunohistochemical staining techniques for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518832
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43
Oct 27, 2014
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Kojima, Motohiro; Higuchi, Youichi; Yokota, Mitsuru; Ishii, Genichiro; Saito, Norio; Aoyagi, Kazuhiko; Sasaki, Hiroki; Ochiai, Atsushi
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This article is from PLoS ONE , volume 9 . Abstract Backgrounds: Peritoneal invasion in colon cancer is an important prognostic factor. Peritoneal invasion can be objectively identified as periotoneal elastic laminal invasion (ELI) by using elastica stain, and the cancer microenvironment formed by the peritoneal invasion (CMPI) can also be observed. Cases with ELI more frequently show distant metastasis and recurrence. Therefore, CMPI may represent a particular milieu that facilitates tumor...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913740
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50
Oct 21, 2014
10/14
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Kaneko, Kazuhiro; Yamaguchi, Hiroshi; Saito, Takaaki; Yano, Tomonori; Oono, Yasuhiro; Ikematsu, Hiroaki; Nomura, Shogo; Sato, Akihiro; Kojima, Motohiro; Esumi, Hiroyasu; Ochiai, Atsushi
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This article is from PLoS ONE , volume 9 . Abstract A goal in next-generation endoscopy is to develop functional imaging techniques to open up new opportunities for cancer diagnosis. Although spatial and temporal information on hypoxia is crucial for understanding cancer physiology and expected to be useful for cancer diagnosis, existing techniques using fluorescent indicators have limitations due to low spatial resolution and invasive administration. To overcome these problems, we developed an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051687
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Oct 25, 2014
10/14
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Kirita, Keisuke; Ishii, Genichiro; Matsuwaki, Rie; Matsumura, Yuki; Umemura, Shigeki; Matsumoto, Shingo; Yoh, Kiyotaka; Niho, Seiji; Goto, Koichi; Ohmatsu, Hironobu; Ohe, Yuichiro; Nagai, Kanji; Ochiai, Atsushi
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This article is from PLoS ONE , volume 8 . Abstract Background: Intralymphatic tumors in the extratumoral area are considered to represent the preceding phase of lymph node metastasis. The aim of this study was to clarify the biological properties of intralymphatic tumors susceptible to the development of lymph node metastasis, with special reference to the expression of cancer initiating/stem cell (CIC/CSC) related markers in cancer cells and the number of infiltrating stromal cells. Material...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871680
