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Oct 16, 2014
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Li, Ronghong; Li, Xiang; Ning, Shangwei; Ye, Jingrun; Han, Lei; Kang, Chunsheng; Li, Xia
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This article is from PLoS ONE , volume 9 . Abstract The application of microRNAs (miRNAs) in the therapeutics of glioma and other human diseases is an area of intense interest. However, it’s still a great challenge to interpret the functional consequences of using miRNAs in glioma therapy. Here, we examined paired deep sequencing expression profiles of miRNAs and mRNAs from human glioma cell lines after manipulating the levels of miRNAs miR-181d, -21, and -23b, as well as transcriptional...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090169
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Oct 21, 2014
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Ning, Shangwei; Zhao, Zuxianglan; Ye, Jingrun; Wang, Peng; Zhi, Hui; Li, Ronghong; Wang, Tingting; Li, Xia
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This article is from BMC Bioinformatics , volume 15 . Abstract Background: Genome-wide association studies (GWAS) have successfully identified a large number of single nucleotide polymorphisms (SNPs) that are associated with a wide range of human diseases. However, many of these disease-associated SNPs are located in non-coding regions and have remained largely unexplained. Recent findings indicate that disease-associated SNPs in human large intergenic non-coding RNA (lincRNA) may lead to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038069
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Oct 11, 2014
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Ning, Shangwei; Zhao, Zuxianglan; Ye, Jingrun; Wang, Peng; Zhi, Hui; Li, Ronghong; Wang, Tingting; Wang, Jianjian; Wang, Lihua; Li, Xia
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This article is from PLoS ONE , volume 9 . Abstract Large intergenic non-coding RNAs (lincRNAs) are a new class of functional transcripts, and aberrant expression of lincRNAs was associated with several human diseases. The genetic variants in lincRNA transcription factor binding sites (TFBSs) can change lincRNA expression, thereby affecting the susceptibility to human diseases. To identify and annotate these functional candidates, we have developed a database SNP@lincTFBS, which is devoted to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116217
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Oct 8, 2014
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Yang, Lili; Wang, Jianjian; Sun, Xuesong; Cao, Yuze; Ning, Shangwei; Zhang, Huixue; Chen, Lixia; Li, Ronghong; Tian, Qinghua; Wang, Lihua; Wang, Weizhi; Li, Xia
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This article is from PLoS ONE , volume 9 . Abstract The significant roles of genetic variants in myasthenia gravis (MG) pathogenesis have been demonstrated in many studies, and recently it has been revealed that aberrant level/regulation of microRNAs (miRNAs) might contribute to the initiation and progression of MG. However, the dysfunction of miRNA associated with single nucleotide polymorphisms (miRSNPs) has not been well investigated in MG. In this study, we created a contemporary catalog of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130595
