APOE e4 is the largest genetic risk factor for the development of late-onset Alzheimer’s disease. In healthy older adults, research suggests that carrying a copy of this gene can lead to a poorer performance on a variety of cognitive tasks. However, the relationship between APOE e4 and spatial memory in mid-age is ambiguous. Using a precision memory task, some studies find a short-term memory advantage for mid-aged e4 carriers [1], whilst others report no differences in long term retention...
Source: https://osf.io/szx4y/
Mnemonic discrimination errors are associated with aberrant hippocampal function and characterise the very early stages of Alzheimer’s Disease (AD). Carriers of an Apolipoprotein (APOE) e4 gene, the most well-established risk factor for AD, show differences in hippocampal function from youth. The cognitive consequences of altered brain activation in this group, however, remain poorly understood. We have developed an online web-platform – the APOE Memory Bank, which presents a collection of...
Source: https://osf.io/92pkn/
