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Oct 27, 2014
10/14
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Braun, Andrew P.
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This article is from Channels , volume 6 . Abstract We have long appreciated that the controlled movement of ions and solutes across the cell surface or plasma membrane affects every aspect of cell function, ranging from membrane excitability to metabolism to secretion, and is also critical for the long-term maintenance of cell viability. Studies examining these physiological transport processes have revealed a vast array of ion channels, transporters and ATPase-driven pumps that underlie these...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536723
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Oct 21, 2014
10/14
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Braun, Andrew P
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This article is from Channels , volume 7 . Abstract Many of us were taught in high school biology that the action potential waveform in nerves and other excitable tissues was generated by an initial rapid influx of external Na+ ions across the plasma membrane, followed by an outward movement of intracellular K+ ions. The former event, mediated by voltage-gated Na+ channels, is responsible for the fast depolarizing upstroke of the action potential, while voltage-gated K+ channels are responsible...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042476
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Oct 23, 2014
10/14
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Braun, Andrew P
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This article is from Channels , volume 7 . Abstract It is well recognized clinically that fever in young children ( < 6 y of age) may lead to seizure activity in a small, but significant percentage of these individuals, which may have negative consequences for the developing brain and progressive cognitive function. In rodent models, exposure of acute brain slices to hyperthermic temperatures (i.e., 38–41°C) is reported to evoke membrane depolarization and increased neuronal firing,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989350
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Oct 4, 2014
10/14
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Kyle, Barry D.; Braun, Andrew P.
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This article is from Frontiers in Physiology , volume 5 . Abstract Large conductance, Ca2+-activated K+ (BK) channels represent an important pathway for the outward flux of K+ ions from the intracellular compartment in response to membrane depolarization, and/or an elevation in cytosolic free [Ca2+]. They are functionally expressed in a range of mammalian tissues (e.g., nerve and smooth muscles), where they can either enhance or dampen membrane excitability. The diversity of BK channel activity...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141542
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Oct 21, 2014
10/14
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Nourian, Zahra; Li, Min; Leo, M. Dennis; Jaggar, Jonathan H.; Braun, Andrew P.; Hill, Michael A.
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This article is from PLoS ONE , volume 9 . Abstract Previous studies report functional differences in large conductance Ca2+ activated-K+ channels (BKCa) of smooth muscle cells (VSMC) from rat cerebral and cremaster muscle resistance arteries. The present studies aimed to determine if this complexity in BKCa activity may, in part, be due to splice variants in the pore-forming α-subunit. BKCa variants in the intracellular C terminus of the α-subunit, and their relative expression to total...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055454
