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by Huang, Yan; Lu, Yi; Zhang, Lei; Yan, Jia; Jiang, Jue; Jiang, Hong
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This article is from International Journal of Molecular Sciences , volume 15 . Abstract Recent studies have shown that dexmedetomidine exerts an anti-inflammatory effect by reducing serum levels of inflammatory factors, however, the up-stream mechanism is still unknown. The transcription factor NF-κB enters the nucleus and promotes the transcription of its target genes, including those encoding the pro-inflammatory cytokines IL-6 and TNF-α. In this study, we established a rat model that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975383
PubMed Central
by Roncero, Carlos; Vega, Pablo; Martinez-Raga, Jose; Barral, Carmen; Basurte-Villamor, Ignacio; Rodriguez-Cintas, Laia; Mesias, Beatriz; Grau-Lopez, Lara; Casas, Miguel; Szerman, Nestor
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This article is from International Journal of Mental Health Systems , volume 8 . Abstract Background: Since provision of integrated services for patients with dual pathology or dual disorders (coexistence of an addictive disorder and other psychiatric disorders) constitutes an important challenge, this study compared the perceptions of health-care professionals with the existing, current state of specific resources for patients with dual pathology in Spain. Methods: Epidemiological,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158069
PubMed Central
by Min, Jing-jing; Huo, Xin-long; Xiang, ling-yun; Qin, Yan-qing; Chai, Ke-qin; Wu, Bin; Jin, Lu; Wang, Xiao-tong
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This article is from Scientific Reports , volume 4 . Abstract Cognitive impairment is a common finding in patients with chronic obstructive pulmonary disease (COPD), but little attention has been focused on therapeutic intervention for this complication. Chronic intermittent hypoxia hypercapnia (CIHH) exposure is considered to be responsible for the pathogenesis of COPD. Dl-3n-Butylphthalide (NBP), extracted from Apium graveolens Linn, has displayed a broad spectrum of neuroprotective...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080197
PubMed Central
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This article is from Annals of The Royal College of Surgeons of England , volume 94 . Abstract INTRODUCTION: The preliminary results of a pyrocarbon interpositional radiocarpal implant in a small cohort of patients were reviewed. As it is currently only a limited release product, we describe to potential users early complications and negative outcomes. METHODS: Patients were assessed using pain levels, ranges of motion, grip strength, type of and time to return to work as well as pre-operative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954246
PubMed Central
by Hommel, Marcel
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This article is from Malaria Journal , volume 13 . Abstract Contributing reviewers: Malaria Journal would like to thank all reviewers who have contributed to the journal in 2013.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917501
PubMed Central
by Cui, Wenli; Cai, Ying; Wang, Weige; Liu, Zebing; Wei, Ping; Bi, Rui; Chen, Weixiang; Sun, Menghong; Zhou, Xiaoyan
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This article is from Journal of Translational Medicine , volume 12 . Abstract Background: It has been reported that the PI3K/AKT signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL), PI3K constitutive activation plays a crucial role in PI3K/AKT pathway. However, the copy number variations (CNVs) of PI3K subunits on gene level remain unknown in DLBCL. Therefore, the aim of the study is to investigate the CNV of PI3K subunits and their relationship with clinicopathological...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896773
PubMed Central
by Nauck, Michael A.; Kemmeries, Guido; Holst, Jens J.; Meier, Juris J.
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This article is from Diabetes , volume 60 . Abstract OBJECTIVE: Glucagon-like peptide (GLP)-1 lowers postprandial glycemia primarily through inhibition of gastric emptying. We addressed whether the GLP-1–induced deceleration of gastric emptying is subject to rapid tachyphylaxis and if so, how this would alter postprandial glucose control. RESEARCH DESIGN AND METHODS: Nine healthy volunteers (25 ± 4 years old, BMI: 24.6 ± 4.7 kg/m2) were examined with intravenous infusion of GLP-1 (0.8 pmol...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292331
PubMed Central
by Otterbein, Leo E
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This article is from Medical Gas Research , volume 3 . Abstract The articles contained in this review series exemplify the diverse applications and succinct biological relevance of this simple gas. Articles summarizing the important effects of carbon monoxide in preventing the rejection of an organ, in its neuroprotective properties in piglets, regulation of mycobacterial growth, in its anti-inflammatory effects in the gut and in its use in new and innovative modalities and avenues by which to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610149
PubMed Central
by Solera, Dafne
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This article is from BMC Cancer , volume 14 . Abstract Contributing reviewers: The editors of BMC Cancer would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909450
PubMed Central
by Tabrizizadeh, M.; Reuben, J.; Khalesi, M.; Mousavinasab, M.; Ezabadi, MK. Ghane
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This article is from Journal of Dentistry (Tehran, Iran) , volume 7 . Abstract Objective:: Better understanding of the furcation anatomy may serve to decrease the risk of root perforation. The purpose of this study was to measure the thickness of root walls in the danger zone in mandibular first molars. Materials and Methods:: The roots of 53 extracted human mandibular first molars were sectioned in the horizontal plane 4 mm below the orifice of the mesial and distal root canals. For each cut...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184764
PubMed Central
by Sherrington, David
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This article is from Philosophical transactions. Series A, Mathematical, physical, and engineering sciences , volume 368 . Abstract This paper is concerned with complex macroscopic behaviour arising in many-body systems through the combinations of competitive interactions and disorder, even with simple ingredients at the microscopic level. It attempts to indicate and illustrate the richness that has arisen, in conceptual understanding, in methodology and in application, across a large range of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263799
PubMed Central
by Pafitis, Natalie
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This article is from BMC Public Health , volume 13 . Abstract Contributing reviewers: The editors of BMC Public Health would like to thank all our reviewers who have contributed to the journal in 2012.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751667
PubMed Central
by Harris, Philippa K
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This article is from BMC Microbiology , volume 13 . Abstract Contributing reviewers: The editors of BMC Microbiology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576289
PubMed Central
by Koyama, Susumu; Kawaharada, Mari; Terai, Hiroki; Ohkurano, Masahiro; Mori, Masayoshi; Kanamaru, Syohei; Hirose, Shinichi
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This article is from Physiological Reports , volume 1 . Abstract Palatable food has reinforcing effects on feeding and accelerates obesity. Alteration of food-related behavior in obesity may promote maintenance of obesity. The ventral tegmental area (VTA) of the midbrain is important for food reward. However, it is unknown whether activity of VTA neurons is altered in diet-induced obesity. In this study, we examined VTA neuronal activity using an electrophysiological technique in diet-induced...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841055
PubMed Central
by Krief, Sabrina; Levrero, Florence; Krief, Jean-Michel; Thanapongpichat, Supinya; Imwong, Mallika; Snounou, Georges; Kasenene, John M; Cibot, Marie; Gantier, Jean-Charles
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This article is from Malaria Journal , volume 11 . Abstract Background: Malaria parasites (Plasmodium sp.), including new species, have recently been discovered as low grade mixed infections in three wild chimpanzees (Pan troglodytes schweinfurthii) sampled randomly in Kibale National Park, Uganda. This suggested a high prevalence of malaria infection in this community. The clinical course of malaria in chimpanzees and the species of the vectors that transmit their parasites are not known. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515334
This article is from Genome Biology and Evolution , volume 5 . Abstract The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The “Rhineland hypothesis” depicts Eastern European Jews as a “population isolate” that emerged from a small group of German Jews who migrated eastward and expanded rapidly. Alternatively, the “Khazarian hypothesis” suggests that Eastern European Jews descended from the Khazars, an amalgam of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595026
PubMed Central
by Rice, Catherine M
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This article is from BMC Genomics , volume 14 . Abstract Contributing reviewers: The editors of BMC Genomics would like to thank all our reviewers who have contributed to the journal in volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642022
PubMed Central
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This article is from Nephro-urology monthly , volume 5 . Abstract Background: When using brain dead donors for organ donation, assessment of kidney function before the procedure is essential. Objectives: It would be ideal to find an early marker of viability of donor kidneys that is more accurate than creatinine. Patients and Methods: The present study was conducted from March of 2011 to March of 2012, included 52 deceased donors. Serum and urinary Neutrophil Gelatinase Associated Lipocalin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614329
PubMed Central
by Yari, Mitra; Saeb, Morteza; Golfam, Parisa; Makhloogh, Zahra
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This article is from Journal of Injury and Violence Research , volume 5 . Abstract Background:: Anterior Cruciate Ligament (ACL) tearing is a common injury among football players. The present study aims to determine the best single-dose of intra-articular morphine for pain relief after arthroscopic knee surgery that, in addition to adequate and long-term analgesia, leads to fewer systemic side effects. Methods:: This clinical trial was conducted on 40 ASA-I athletes. After surgery, all...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683418
PubMed Central
by Assani, Abderrazzak; Saadi, Mohamed; Alhakmi, Ghaleb; Houmadi, Elham; El Ammari, Lahcen
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 69 . Abstract The title compound, barium trimanganese tris­(ortho­phosphate), was synthesized hydro­thermally. Its structure is isotypic with the lead and strontium analogues AMnII2MnIII(PO4)3 (A = Pb, Sr). Except for two O atoms on general positions, all atoms are located on special positions. The Ba and one P atom exhibit mm2 symmetry, the MnII atom 2/m symmetry, the MnIII atom and the other P atom .2....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884417
PubMed Central
by Israelsson, Charlotte; Kylberg, Annika; Bengtsson, Henrik; Hillered, Lars; Ebendal, Ted
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This article is from PLoS ONE , volume 9 . Abstract Brain trauma is known to activate inflammatory cells via various chemokine signals although their interactions remain to be characterized. Mice deficient in Ccl3, Ccr2 or Cxcl10 were compared with wildtype mice after controlled cortical impact injury. Expression of Ccl3 in wildtypes was rapidly upregulated in resident, regularly spaced reactive microglia. Ccl3-deficiency enhanced endothelial expression of platelet selectin and invasion of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143236
PubMed Central
by Yeganeh, Omid; Jeddi-Tehrani, Mahmood; Yaghmaie, Farhad; Kamali, Kourosh; Heidari-Vala, Hamed; Zeraati, Hojjat; Shakhssalim, Nasser; Zarei, Saeed; Chamani-Tabriz, Leili
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This article is from Iranian Red Crescent Medical Journal , volume 15 . Abstract Background: Chlamydia trachomatis and Mycoplasma genitalium infections are the most prevalent sexually transmitted bacterial infections in the world that cause urogenital infections in both men and women. It appears that infertility is a complication of these infections. Objective: This study was designed to estimate the prevalence of Chlamydia trachomatis and Mycoplasma genitalium in symptomatic and asymptomatic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785911
PubMed Central
by Gholami, Jaleh; Ahghari, Sharareh; Motevalian, Abbas; Yousefinejad, Vahid; Moradi, Ghobad; Keshtkar, Abbasali; Alami, Ali; Mazloomzadeh, Saeideh; Vakili, Mohammad Masoud; Chaman, Reza; Salehi, Bahman; Fazelzadeh, Omid; Majdzadeh, Reza
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This article is from Health Research Policy and Systems , volume 11 . Abstract Background: The aim of this study was to assess the status of knowledge translation (KT) in Iranian medical science universities in order to assess the strengths and weaknesses of the most important organizations responsible for producing knowledge in the country. Methods: The KT activities were assessed qualitatively and quantitatively in nine universities using the Self-Assessment Tool for Research Institutes....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835863
PubMed Central
by Nejabat, M; Maleki, B; Nimrouzi, M; Mahbodi, A; Salehi, A
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This article is from Iranian Red Crescent Medical Journal , volume 14 . Abstract Background: Physicians in ancient Persia played an important role in the development of medicine in the medieval era. One of the most influential figures of this era was Abu Ali Sina or Ibn Sina, known as Avicenna in the western world. The author of more than 200 books on medicine and philosophy, Avicenna followed and further expanded on the tradition of western philosophy and medicine introduced by Aristotle,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398632
PubMed Central
by Bozok, S; Ilhan, G; Yilmaz, Y; Dokumcu, Z; Tumkaya, L; Karamustafa, H; Karakisi, S Ozan; Ergene, S; Sener, E
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This article is from European Journal of Medical Research , volume 17 . Abstract Background: The role of multiorgan damage in the mortality caused by ischemic limb injury is still not clarified. The objective of this study was to examine the potential protective effects of hyperbaric oxygen (HBO) and iloprost (IL) therapy on lung damage induced by limb ischemia/reperfusion injury in a rabbit model, using both biochemical and histopathological aspects. Methods: Forty New Zealand white rabbits...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406985
PubMed Central
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This article is from Journal of Extracellular Vesicles , volume 2 . Abstract Cells are constantly subjected to various types of endogenous and exogenous stressful stimuli, which can cause serious and even permanent damage. The ability of a cell to sense and adapt to environmental alterations is thus vital to maintain tissue homeostasis during development and adult life. Here, we review some of the major phenotypic characteristics of the hostile tumour microenvironment and the emerging roles of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760648
PubMed Central
by Li, Tun; Tian, Cuiping; Scalmani, Paolo; Frassoni, Carolina; Mantegazza, Massimo; Wang, Yonghong; Yang, Mingpo; Wu, Si; Shu, Yousheng
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This article is from PLoS Biology , volume 12 . Abstract : Sodium channels add variety to inhibitory interneurons Different populations of inhibitory interneurons in the cerebral cortex express distinct subtypes of sodium channels, resulting in diverse action potential thresholds and network excitability.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159120
PubMed Central
by Wang, Chao; Pecot, Thierry; Zynger, Debra L; Machiraju, Raghu; Shapiro, Charles L; Huang, Kun
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This article is from Journal of the American Medical Informatics Association : JAMIA , volume 20 . Abstract Background and objective: Biomarkers for subtyping triple negative breast cancer (TNBC) are needed given the absence of responsive therapy and relatively poor prediction of survival. Morphology of cancer tissues is widely used in clinical practice for stratifying cancer patients, while genomic data are highly effective to classify cancer patients into subgroups. Thus integration of both...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721170
PubMed Central
by Tuzovic, Lea; Yu, Lan; Zeng, Wenqi; Li, Xiang; Lu, Hong; Lu, Hsiao-Mei; Gonzalez, Kelly DF; Chung, Wendy K
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This article is from Rare Diseases , volume 1 . Abstract We used whole exome sequence analysis to investigate a possible genetic etiology for a patient with the phenotype of intrauterine growth restriction, microcephaly, developmental delay, failure to thrive, congenital bilateral hip dysplasia, cerebral and cerebellar atrophy, hydrocephalus, and congenital diaphragmatic hernia (CDH). Whole exome sequencing identified a novel de novo c.2722G > T (p.E908X) mutation in the Myosin Heavy Chain...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927488
PubMed Central
by Howell, Lisa A; Sinicrope, Pamela S; Brockman, Tabetha A; Patten, Christi A; Decker, Paul A; Ehlers, Shawna L; Nadeau, Ashley; Rabe, Kari G; Breitkopf, Carmen Radecki; Petersen, Gloria M
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This article is from Hereditary Cancer in Clinical Practice , volume 11 . Abstract Background: Cancer is a shared family experience that might provide an opportunity for lifestyle change among at-risk family members. The purpose of this study was to assess receptivity and preferences for cancer risk reduction programs among at-risk family members with two or more relatives affected with pancreas cancer. Methods: We surveyed 401 at-risk family members in an existing pancreatic cancer family...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691837
PubMed Central
by Motzfeldt, Iben; Andreasen, Sabina; Pedersen, Amalia Lynge; Pedersen, Michael Lynge
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This article is from International Journal of Circumpolar Health , volume 72 . Abstract Objective: The aim of this study is to estimate the prevalence of postnatal depression in Nuuk, Greenland. Study design: Cross-sectional study. Methods: The primary health care system in Nuuk initiated a project aiming to screen new mothers for depression using the Edinburgh Postnatal Depression Scale (EPDS). EPDS has a range on a scale from 0 to 30. All mothers residing in Nuuk who had given birth in 2011...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753142
PubMed Central
by Lu, H; Sun, J; Wang, F; Feng, L; Ma, Y; Shen, Q; Jiang, Z; Sun, X; Wang, X; Jin, H
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This article is from Cell Death & Disease , volume 4 . Abstract Through silencing tumor suppressor genes, epigenetic changes can activate signaling pathways important to cancer development. In this report, we found an epigenetic contribution to the aberrant activation of wnt signaling in human gastric cancer. CXXC4 (CXXC finger protein 4) was identified as a novel target of EZH2 (enhancer of zeste homolog 2), and EZH2 promotes the activation of wnt singaling by downregulating CXXC4...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763454
PubMed Central
by Damaj, Gandhi; Joris, Magalie; Chandesris, Olivia; Hanssens, Katia; Soucie, Erinn; Canioni, Danielle; Kolb, Brigitte; Durieu, Isabelle; Gyan, Emanuel; Livideanu, Cristina; Cheze, Stephane; Diouf, Momar; Garidi, Reda; Georgin-Lavialle, Sophie; Asnafi, Vahid; Lhermitte, Ludovic; Lavigne, Christian; Launay, David; Arock, Michel; Lortholary, Olivier; Dubreuil, Patrice; Hermine, Olivier
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This article is from PLoS ONE , volume 9 . Abstract Systemic mastocytosis with associated hematologic clonal non-mast cell disease (SM-AHNMD) is a rare and heterogeneous subtype of SM and few studies on this specific entity have been reported. Sixty two patients with Systemic mastocytosis with associated hematologic clonal non-mast cell disease (SM-AHNMD) were presented. Myeloid AHNMD was the most frequent (82%) cases. This subset of patients were older, had more cutaneous lesions,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897447
PubMed Central
by Shimizu, Kumiko; Sano, Tomoharu; Kubota, Reiji; Kobayashi, Norihiro; Tahara, Maiko; Obama, Tomoko; Sugimoto, Naoki; Nishimura, Tetsuji; Ikarashi, Yoshiaki
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This article is from Toxins , volume 6 . Abstract Microcystins, which are cyclic heptapeptides produced by some cyanobacterial species from algal blooms, strongly inhibit serine/threonine protein phosphatase and are known as hepatotoxins. Microcystins have many structural variations, yet insufficient information is available on the differences in the cytotoxic potentials among the structural variants. In this study, the cytotoxicities of 16 microcystin variants at concentrations of 0.03–10...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920255
PubMed Central
by Tsubouchi, Taishi; Nishi, Shinro; Usui, Keiko; Shimane, Yasuhiro; Takaki, Yoshihiro; Maruyama, Tadashi; Hatada, Yuji
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This article is from Genome Announcements , volume 1 . Abstract We report the 3.0-Mb draft genome sequence of Brevundimonas abyssalis strain TAR-001T, isolated from deep-sea floor sediment. The draft genome sequence of strain TAR-001T consists of 2,979,700 bp in 128 contigs, with a G+C content of 68.2%, 2,946 potential coding sequences (CDS), 3 rRNAs, and 41 tRNAs.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798453
PubMed Central
by Tao, Chang-Juan; Liu, Xu; Tang, Ling-Long; Mao, Yan-Ping; Chen, Lei; Li, Wen-Fei; Yu, Xiao-Li; Liu, Li-Zhi; Zhang, Rong; Lin, Ai-Hua; Ma, Jun; Sun, Ying
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This article is from Chinese Journal of Cancer , volume 32 . Abstract The application of simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) in pediatric and adolescent nasopharyngeal carcinoma (NPC) is underevaluated. This study aimed to evaluate long-term outcome and late toxicities in pediatric and adolescent NPC after SIB-IMRT combined with chemotherapy. Thirty-four patients (aged 8–20 years) with histologically proven, non-disseminated NPC treated with SIB-IMRT were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845542
PubMed Central
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This article is from BMC Bioinformatics , volume 14 . Abstract Background: Recent developments in high-throughput genomic technologies make it possible to have a comprehensive view of genomic alterations in tumors on a whole genome scale. Only a small number of somatic alterations detected in tumor genomes are driver alterations which drive tumorigenesis. Most of the somatic alterations are passengers that are neutral to tumor cell selection. Although most research efforts are focused on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903072
PubMed Central
by Ayd?n, Mennan Ece; Kaya, Ahmet Hilmi; Kopuz, Cem; Demir, Mehmet Tevfik; Corumlu, Ufuk; Dagcinar, Adnan
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This article is from Anatomy & Cell Biology , volume 44 . Abstract The superior cerebellar artery is the most consistent branch of the basilar artery and arises near the bifurcation of the basilar artery. A bilateral origin of the superior cerebellar arteries from the posterior cerebral arteries has been rarely reported in the literature. Reporting variations in brain vessels is important for neurosurgeons to safely and confidently treat pathologies in this region. We report on a specimen...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145846
PubMed Central
by Lotfi, Razieh; Tehrani, Fahimeh Ramezani; Yaghmaei, Farideh; Hajizadeh, Ebrahim
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This article is from BMC Women's Health , volume 12 . Abstract Background: The growing trend of women infected with HIV through sexual transmission is alarming. Factors influencing condom use have not yet been fully identified, especially in countries with conservative cultures and backgrounds. The present study aimed to explore the barriers of condom use in Iranian women at risk of HIV. Methods: Using the grounded theory methodology, participants’ experiences and their perceptions regarding...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519504
This article is from Molecular Vision , volume 18 . Abstract Purpose: In our previous study, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) played a neuroprotective role in retinal ischemia/reperfusion (I/R) injury in rats. However, the mechanism of NF-κB neuroprotection is still unclear. We hypothesize that p38 mitogen-activated protein kinase (MAPK) is expressed and NF-κB activity induced by p38 MAPK plays a neuroprotective role through antiapoptotic genes (B-cell...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413424
PubMed Central
by Hovi, Petteri; Kajantie, Eero; Soininen, Pasi; Kangas, Antti J; Jarvenpaa, Anna-Liisa; Andersson, Sture; Eriksson, Johan G; Ala-Korpela, Mika; Wehkalampi, Karoliina
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This article is from Lipids in Health and Disease , volume 12 . Abstract Background: Adults born preterm at very low birth weight (VLBW ≤ 1500g) have increased risk factors for cardiovascular diseases including high blood pressure and impaired glucose regulation. Non-optimal lipoprotein profile is generally also likely to affect the increased cardiovascular risk, but lipoprotein subclass level data on adults born at VLBW are sparse. Subjects and methods: We studied 162 subjects born at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661387
PubMed Central
by Lehrer, Paul M.; Gevirtz, Richard
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This article is from Frontiers in Psychology , volume 5 . Abstract In recent years there has been substantial support for heart rate variability biofeedback (HRVB) as a treatment for a variety of disorders and for performance enhancement (Gevirtz, 2013). Since conditions as widely varied as asthma and depression seem to respond to this form of cardiorespiratory feedback training, the issue of possible mechanisms becomes more salient. The most supported possible mechanism is the strengthening of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104929
PubMed Central
by Cheng, Hongbin; Liu, Xuebin; Hua, Rongrong; Dai, Guanghui; Wang, Xiaodong; Gao, Jianhua; An, Yihua
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This article is from Journal of Translational Medicine , volume 12 . Abstract Background: Umbilical cord mesenchymal stem cells (UCMSCs) have a considerable advantage and potential in treating for central nervous system diseases and have become a novel alternative treatment for spinal cord injury. This study aims to compare the neurological function outcome of stem cell transplantation, rehabilitation therapy, and self-healing for sequelae of spinal cord injury. Methods: Thirty-four cases of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172930
PubMed Central
by Marchionni, Luigi; Afsari, Bahman; Geman, Donald; Leek, Jeffrey T
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This article is from BMC Genomics , volume 14 . Abstract Background: A small number of prognostic and predictive tests based on gene expression are currently offered as reference laboratory tests. In contrast to such success stories, a number of flaws and errors have recently been identified in other genomic-based predictors and the success rate for developing clinically useful genomic signatures is low. These errors have led to widespread concerns about the protocols for conducting and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662649
PubMed Central
by Haile, Rahel Tesfaye; Kebeta, Negussie Deyessa; Kassie, Getnet Mitike
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This article is from BMC International Health and Human Rights , volume 13 . Abstract Background: Sexual abuse of boys is a neglected problem in many developing countries including Ethiopia. As a result, its prevalence, contributing factors and circumstance in which sexual abuse occurs are largely unknown. The objective of this study is to determine the prevalence and factors associated with sexual abuse of male high school students in Addis Ababa city administration. Methods: A cross-sectional...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682909
PubMed Central
by Gujral, Unjali P; Pradeepa, R; Weber, Mary Beth; Narayan, KM Venkat; Mohan, V
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This article is from Annals of the New York Academy of Sciences , volume 1281 . Abstract Type 2 diabetes mellitus (T2DM) is one of the leading causes of morbidity and mortality. While all ethnic groups are affected, the prevalence of T2DM in South Asians, both in their home countries and abroad, is extremely high and is continuing to rise rapidly. Innate biological susceptibilities coupled with rapid changes in physical activity, diet, and other lifestyle behaviors are contributing factors...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715105
PubMed Central
by Zhestovskaja, Anna S; Kukes, Vladimir G; Sychev, Dmitry A
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This article is from The EPMA Journal , volume 4 . Abstract A personalized medicine, a recent trend of clinical pharmacology, makes possible the individual approach to the choice of the drugs and their dosage. According to the results of a study of the activity of different biomarkers, particularly the isoenzymes of the cytochrome P-450, they provide the efficiency and safety of the pharmacotherapy. The activity of the isoenzymes of the cytochrome P-450 determines an individual pharmacological...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726329
PubMed Central
by Sasai, Masaki; Kawabata, Yudai; Makishi, Koh; Itoh, Kazuhito; Terada, Tomoki P.
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This article is from PLoS Computational Biology , volume 9 . Abstract A remarkable feature of the self-renewing population of embryonic stem cells (ESCs) is their phenotypic heterogeneity: Nanog and other marker proteins of ESCs show large cell-to-cell variation in their expression level, which should significantly influence the differentiation process of individual cells. The molecular mechanism and biological implication of this heterogeneity, however, still remain elusive. We address this...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861442
PubMed Central
by Luz, Marta; Spannl-Muller, Stephanie; Ozhan, Gunes; Kagermeier-Schenk, Birgit; Rhinn, Muriel; Weidinger, Gilbert; Brand, Michael
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This article is from PLoS ONE , volume 9 . Abstract Background: Wnt proteins are conserved signaling molecules that regulate pattern formation during animal development. Many Wnt proteins are post-translationally modified by addition of lipid adducts. Wnt8a provides a crucial signal for patterning the anteroposterior axis of the developing neural plate in vertebrates. However, it is not clear how this protein propagates from its source, the blastoderm margin, to the target cells in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888416
PubMed Central
by Mustafa, Mumtaz Begum; Salim, Siti Salwah; Mohamed, Noraini; Al-Qatab, Bassam; Siong, Chng Eng
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This article is from PLoS ONE , volume 9 . Abstract Automatic speech recognition (ASR) is currently used in many assistive technologies, such as helping individuals with speech impairment in their communication ability. One challenge in ASR for speech-impaired individuals is the difficulty in obtaining a good speech database of impaired speakers for building an effective speech acoustic model. Because there are very few existing databases of impaired speech, which are also limited in size, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900508
PubMed Central
by Morawska, Magdalena
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This article is from BMC Oral Health , volume 14 . Abstract Contributing reviewers: The editors of BMC Oral Health would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921989
PubMed Central
by Ma, Yina; Wang, Youhua; Liu, Jingran; Lv, Fengjuan; Chen, Ji; Zhou, Zhiguo
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This article is from PLoS ONE , volume 9 . Abstract Cotton (Gossypium hirsutum L.) boll positions on a fruiting branch vary in their contribution to yield and fiber quality. Fiber properties are dependent on deposition of cellulose in the fiber cell wall, but information about the enzymatic differences in sucrose metabolism between these fruiting positions is lacking. Therefore, two cotton cultivars with different sensitivities to low temperature were tested in 2010 and 2011 to quantify the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930748
PubMed Central
by Li, Xiao-Hong; Gao, Chun-Ji; Da, Wan-Ming; Cao, Yong-Bin; Wang, Zhi-Hong; Xu, Li-Xin; Wu, Ya-Mei; Liu, Bei; Liu, Zhou-Yang; Yan, Bei; Li, Song-Wei; Yang, Xue-Liang; Wu, Xiao-Xiong; Han, Zhong-Chao
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This article is from PLoS ONE , volume 9 . Abstract We examined if transplantation of combined haploidentical hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) affected graft failure and graft-versus-host disease (GVHD) in patients with severe aplastic anemia (SAA). Patients with SAA-I (N = 17) received haploidentical HSCT plus MSC infusion. Stem cell grafts used a combination of granulocyte colony-stimulating factor (G-CSF)-primed bone marrow and G-CSF-mobilized peripheral...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940616
PubMed Central
by Moon, Yeonsil; Kim, Hee-Jin; Choi, Hojin; Oh, Seong-il; Han, Seol-Heui
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This article is from Journal of Korean Medical Science , volume 29 . Abstract Anticipatory dementia is related to anxiety, which is a clinical predictor of early conversion to Alzheimer's disease. The Fear of Alzheimer's Disease Scale (FADS) is a reliable and valid instrument to address anticipatory dementia. The aim of the present investigation was to develop the Korean version of the Fear of Alzheimer's Disease Scale (K-FADS) and to verify its reliability and validity. We developed the K-FADS...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945138
PubMed Central
by Wang, Ping; Suo, Zhenhe; Wang, Mengyu; H?if?dt, Hanne K; Fodstad, ?ystein; Gaudernack, Gustav; Kvalheim, Gunnar
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This article is from Experimental Hematology & Oncology , volume 2 . Abstract Background: Tumor development is recently hypothesized to depend on a rare cell population with stem cell properties, such cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs). From various cancer tissues or cancer cell lines, CD133 expressing cells were found to define a unique CSC/TIC phenotype. To study whether that also could be the case in lung cancer, we examined different lung cancer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734134
PubMed Central
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This article is from BMC Health Services Research , volume 13 . Abstract Background: Low literacy is a significant problem across the developed world. A considerable body of research has reported associations between low literacy and less appropriate access to healthcare services, lower likelihood of self-managing health conditions well, and poorer health outcomes. There is a need to explore the previously neglected perspectives of people with low literacy to help explain how low literacy can...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751726
PubMed Central
by Ding, C. H.; Hussin, S.; Tzar, M. N.; Rahman, M. M.; Ramli, S. R.
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This article is from Pakistan Journal of Medical Sciences , volume 29 . Abstract Burkholderia pseudomallei is an free-living gram-negative bacterium causing melioidosis and is endemic in Southeast Asia. A 56-year-old diabetic construction worker with a 1-month history of abdominal pain and 1-day history of high-grade fever was found to have a left non-dissecting infrarenal mycotic aortic aneurysm by abdominal computerized tomography scan. Bacteriological examination of his blood yielded...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809241
PubMed Central
by Shen, Huibin; Zamboni, Nicola; Heinonen, Markus; Rousu, Juho
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This article is from Metabolites , volume 3 . Abstract Metabolite identification is a major bottleneck in metabolomics due to the number and diversity of the molecules. To alleviate this bottleneck, computational methods and tools that reliably filter the set of candidates are needed for further analysis by human experts. Recent efforts in assembling large public mass spectral databases such as MassBank have opened the door for developing a new genre of metabolite identification methods that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901273
PubMed Central
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This article is from Eplasty , volume 14 . Abstract Introduction: Clinical trials seeking to establish long-term efficacy of injectable collagenase clostridium histolyticum for treatment of Dupuytren disease are ongoing. In this quality improvement study, the efficacy, recurrence rate, and complications of collagenase injection for Dupuytren disease are reviewed in a population of Veteran patients. Materials and Methods: A retrospective chart review was performed for patients who underwent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977593
PubMed Central
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This article is from BMC Biology , volume 11 . Abstract Background: In most modern bony fishes (teleosts) hearing improvement is often correlated with a close morphological relationship between the swim bladder or other gas-filled cavities and the saccule or more rarely with the utricle. A connection of an accessory hearing structure to the third end organ, the lagena, has not yet been reported. A recent study in the Asian cichlid Etroplus maculatus provided the first evidence that a swim...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720219
PubMed Central
by KASUYA, Kazufumi; YOSHIDA, Eiji; HARADA, Rieko; HASEGAWA, Mio; OSAKA, Hiroyuki; KATO, Masaharu; SHIBAHARA, Tomoyuki
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This article is from The Journal of Veterinary Medical Science , volume 76 . Abstract An 18-week-old female breeding Yorkshire pig displayed symptoms of astasia and subsequently died. Histologically, severe disseminated suppurative meningoencephalomyelitis was detected, as were numerous myocardial microabscesses. Gram-positive cocci were detected in these suppurative lesions, and these cocci reacted with an antibody against Streptococcus C group species. Gram-positive cocci were isolated from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073340
PubMed Central
by Cookson, Camilla; Strang, John; Ratschen, Elena; Sutherland, Gay; Finch, Emily; McNeill, Ann
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This article is from BMC Health Services Research , volume 14 . Abstract Background: High smoking prevalence has been observed among those misusing other substances. This study aimed to establish smoking behaviours and attitudes towards nicotine dependence treatment among clients and staff in substance abuse treatment settings. Methods: Cross-sectional questionnaire survey of staff and clients in a convenience sample of seven community and residential addiction services in, or with links to,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108960
PubMed Central
by Zeng, Lu; Liu, Wenqiang; Feng, Wenguo; Wang, Xing; Dang, Hui; Gao, Luna; Yao, Jing; Zhang, Xianqin
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This article is from Molecular Vision , volume 19 . Abstract Purpose: To identify the disease-causing gene in a Chinese family with autosomal dominant congenital cataract. Methods: Clinical and ophthalmologic examinations were performed on all members of a Chinese family with congenital cataract. Nine genes associated with congenital cataract were screened using direct DNA sequencing. Mutations were confirmed using restriction fragment length polymorphism (RFLP) analysis. The mutated major...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834598
PubMed Central
by Halsby, Kate D.; Walsh, Amanda L.; Campbell, Colin; Hewitt, Kirsty; Morgan, Dilys
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This article is from PLoS ONE , volume 9 . Abstract Background: Around 67 million pets are owned by households in the United Kingdom, and an increasing number of these are exotic animals. Approximately a third of pets are purchased through retail outlets or direct from breeders. A wide range of infections can be associated with companion animals. Objectives: This study uses a systematic literature review to describe the transmission of zoonotic disease in humans associated with a pet shop or...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935869
PubMed Central
by Mauracher, Stephan Gerhard; Molitor, Christian; Al-Oweini, Rami; Kortz, Ulrich; Rompel, Annette
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This article is from Acta Crystallographica. Section F, Structural Biology Communications , volume 70 . Abstract Polyphenol oxidase 4 (PPO4) from the natural source A. bisporus was crystallized in its latent precursor form (pro-tyrosinase; Ser2–Thr565) using the 6-tungstotellurate(VI) salt Na6[TeW6O24]·22H2O as a crystallization additive.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936457
PubMed Central
by Willems, Marian M J H P; Zom, Gijs G; Meeuwenoord, Nico; Ossendorp, Ferry A; Overkleeft, Herman S; van der Marel, Gijsbert A; Codee, Jeroen D C; Filippov, Dmitri V
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This article is from Beilstein Journal of Organic Chemistry , volume 10 . Abstract The covalent attachment of an innate immune system stimulating agent to an antigen can provide active vaccine modalities capable of eliciting a potent immune response against the incorporated antigen. Here we describe the design, automated synthesis and immunological evaluation of a set of four muramyl dipeptide–peptide antigen conjugates. Muramyl dipeptide (MDP) represents a well-known ligand for the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077378
PubMed Central
by Tsalafouta, A.; Papandroulakis, N.; Gorissen, M.; Katharios, P.; Flik, G.; Pavlidis, M.
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This article is from Scientific Reports , volume 4 . Abstract The cortisol stress response and the molecular programming of the corticoid axis were characterized for the first time during early ontogeny in a Mediterranean marine teleost, the European sea bass (Dicentrarchus labrax). Sea bass embryos, pre-larvae and larvae at specific points of development were exposed to acute stressors and the temporal patterns of cortisol whole body concentrations and the expression of genes involved in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078316
PubMed Central
by Chinello, Clizia; Cazzaniga, Marta; De Sio, Gabriele; Smith, Andrew James; Gianazza, Erica; Grasso, Angelica; Rocco, Francesco; Signorini, Stefano; Grasso, Marco; Bosari, Silvano; Zoppis, Italo; Dakna, Mohammed; van der Burgt, Yuri E. M.; Mauri, Giancarlo; Magni, Fulvio
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This article is from PLoS ONE , volume 9 . Abstract Renal Cell Carcinoma (RCC) is typically asymptomatic and surgery usually increases patient's lifespan only for early stage tumours. Moreover, solid renal masses cannot be confidently differentiated from RCC. Therefore, markers to distinguish malignant kidney tumours and for their detection are needed. Two different peptide signatures were obtained by a MALDI-TOF profiling approach based on urine pre-purification by C8 magnetic beads. One...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159280
PubMed Central
by Kwak, Kyung Won; Jo, Dae Jin; Lee, Eun Hee; Ryu, Dong Soo; Oh, Tae Hee
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This article is from Korean Journal of Urology , volume 52 . Abstract Prostatic stromal tumor of uncertain malignant potential (STUMP) is a rare neoplasm with distinctive clinical and pathological characteristics. Here we report a case of laparoscopic radical prostatectomy performed in a patient with prostatic STUMP.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162226
PubMed Central
by Hsiao, Wei-Ting; Tsai, Ming-Dar; Jow, Guey-Mei; Tien, Lu-Tai; Lee, Yih-Jing
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This article is from Molecular Vision , volume 18 . Abstract Purpose: Retinoblastoma is a malignant tumor of the retina usually occurring in young children. To date, the conventional treatments for retinoblastoma have been enucleation, cryotherapy, external beam radiotherapy, or chemotherapy. Most of these treatments, however, have possible side effects, including blindness, infections, fever, gastrointestinal toxicity, and neurotoxicity. More effective treatments are therefore imperative....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413436
PubMed Central
by Dionne, Isabelle; Larose, Stephanie; Dandjinou, Alain T.; Abou Elela, Sherif; Wellinger, Raymund J.
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This article is from RNA , volume 19 . Abstract Because telomere elongation by telomerase is strictly regulated across the cell cycle, occurring only in S phase, it has long been expected that telomerase subunit expression would also be cell cycle regulated. Here the authors contribute the first definitive support for cell cycle regulation of telomerase RNA transcription in budding yeast. Using a modified chromatin immunopurification approach to detect RNA transcripts still at the telomerase...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683933
PubMed Central
by Siriwardhana, Chesmal; Pannala, Gayani; Siribaddana, Sisira; Sumathipala, Athula; Stewart, Robert
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This article is from BMC Public Health , volume 13 . Abstract Background: Armed conflicts and natural disasters are common. Millions of people, including children are killed, injured, disabled and displaced as a result. The effects of conflict and natural disaster on mental health, especially of children are well established but effects on education have received less attention. This study investigated associations between conflict and/or tsunami exposure in Sri Lanka and their associations...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698150
PubMed Central
by Chen, Dengyu; Zhang, Yunxia; Wang, Jing; Chen, Junsong; Yang, Cuiping; Cai, Kai; Wang, Xiaoying; Shi, Fangfang; Dou, Jun
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This article is from Journal of Ovarian Research , volume 6 . Abstract Background: Cancer stem cells (CSCs) are believed to be ‘seed cell’ in cancer recurrence and metastasis. MicroRNAs (miRNAs) can play an important role in the progression of primary tumor towards metastasis by regulating the epithelial-mesenchymal transition (EMT). The goal of this study was to investigate the effect of miRNA-200c overexpression on the EMT, tumorigenicity and metastasis of epithelial ovarian cancer (EOC)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729499
PubMed Central
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This article is from The Libyan Journal of Medicine , volume 9 . Abstract Domestic violence (DV) is quite prevalent and negatively impacts the health and mental wellbeing of those affected. Victims of DV are frequent users of health service, yet they are infrequently recognized. Physicians tend to treat the presenting complaints without addressing the root cause of the problem. Lack of knowledge on adequately managing cases of DV and on appropriate ways to help survivors is commonly presented...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957738
PubMed Central
by Scully, Ingrid L.; Liberator, Paul A.; Jansen, Kathrin U.; Anderson, Annaliesa S.
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This article is from Frontiers in Immunology , volume 5 . Abstract A key aspect of the pathogenesis of the Gram positive bacterium Staphylococcus aureus is its ability to rapidly adapt to the host environment during the course of an infection. To successfully establish infection, the organism deploys a variety of survival and immune evasion strategies, ranging from the acquisition of essential nutrients and expression of adhesins, which promote colonization and survival, to the elaboration of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970019